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Id: biblio-1008000
Autor: Arellano, J; Vargas, P; Urrutia, M.
Título: Primer reporte de caso autóctono de tinea nigra en Chile / First autochthonous case report of tinea nigra in Chile
Fonte: Medwave;19(6):e7666, 2019.
Idioma: en; es.
Resumo: Resumen La tinea nigra es una infrecuente micosis superficial causada por el hongo dematiáceo Hortaea werneckii. Se presenta habitualmente en zonas costeras tropicales, siendo muy escasos los reportes en países sudamericanos con climas más templados. Habitualmente corresponde a infecciones importadas por viajeros. Se presenta el caso de una paciente adulta chilena, sin historia previa de viajes recientes, cursando con cuadro clínico y microbiológico compatible con tinea nigra palmar, tratado con itraconazol oral y sertaconazol tópico con respuesta favorable. Esta paciente corresponde al primer caso reportado en Chile de origen autóctono.

Abstract Tinea nigra is an infrequent superficial mycosis caused by the dematiaceous fungus Hortaea werneckii. It usually occurs in tropical coastal areas, with very few reports in South American countries with temperate climates, generally corresponding to infections imported by travelers. We present the case of a Chilean adult patient, with no previous history of recent trips, with clinical and microbiological background consistent with palmar tinea nigra, treated with oral itraconazole and topical sertaconazole with a favorable response. This article is the first case reported in Chile, of autochthonous origin.
Descritores: Tiofenos/administração & dosagem
Tinha/diagnóstico
Itraconazol/administração & dosagem
Imidazóis/administração & dosagem
Antifúngicos/administração & dosagem
-Tinha/tratamento farmacológico
Chile
Resultado do Tratamento
Limites: Humanos
Feminino
Adolescente
Tipo de Publ: Relatos de Casos
Responsável: CL1.1 - Biblioteca Central


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Texto completo SciELO Brasil
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Id: biblio-975668
Autor: Polat, Emre Can; Besiroglu, Huseyin; Ozcan, Levent; Otunctemur, Alper; Eruyar, Ahmet Tugrul; Somay, Adnan; Ozbay, Nurver; Cekmen, Mustafa; Eraldemir, Ceyla; Ozbek, Emin.
Título: Beneficial effects of Oltipraz, nuclear factor - erythroid - 2 - related factor 2 (Nrf2), on renal damage in unilateral ureteral obstruction rat model
Fonte: Int. braz. j. urol;44(6):1243-1251, Nov.-Dec. 2018. tab, graf.
Idioma: en.
Resumo: ABSTRACT Introduction: We investigated whether Oltipraz (OPZ) attenuated renal fibrosis in a unilateral ureteral obstruction (UUO) rat model. Materials and Methods: We randomly divided 32 rats into four groups, each consisting of eight animals as follows: Rats in group 1 underwent a sham operation and received no treatment. Rats in group 2 underwent a sham operation and received OPZ. Rats in group 3 underwent unilateral ureteral ligation and received no treatment. Group 4 rats were subjected to unilateral ureteral ligation plus OPZ administration. Transforming growth factor beta-1 (TGF-β1), E-cadherin, nitric oxide (NO) and hydroxyproline levels were measured. Histopathological and immunohistochemical examinations were carried out. Results: TGF-β1, NO and E-cadherin levels in the UUO group were significantly higher than the sham group and these values were significantly different in treated groups compared to the UUO group. In rats treated with UUO + OPZ, despite the presence of mild tubular degeneration and less severe tubular necrosis, glomeruli maintained a better morphology when compared to the UUO group. Expressions of α-SMA in immunohistochemistry showed that the staining positivity decreased in the tubules of the OPZ-treated group. Conclusions: While the precise mechanism of action remains unknown, our results demonstrated that OPZ exerted a protective role in the UUO-mediated renal fibrosis rat model highlighting a promising therapeutic potency of Nrf2-activators for alleviating the detrimental effects of unilateral obstruction in kidneys.
Descritores: Pirazinas/uso terapêutico
Obstrução Ureteral/complicações
Fator 2 Relacionado a NF-E2/uso terapêutico
Nefropatias/tratamento farmacológico
-Tionas
Tiofenos
Obstrução Ureteral/patologia
Obstrução Ureteral/tratamento farmacológico
Fibrose/etiologia
Fibrose/tratamento farmacológico
Imuno-Histoquímica
Caderinas/sangue
Ratos Wistar
Modelos Animais de Doenças
Fator de Crescimento Transformador beta1/sangue
Hidroxiprolina/sangue
Nefropatias/etiologia
Nefropatias/patologia
Óxido Nítrico/sangue
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


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Id: biblio-887237
Autor: Niijima, Katsura; Niijima, Yawara; Okada, Shuichi; Yamada, Masanobu.
Título: Drug-induced Liver Injury Caused by Ipragliflozin Administration with Causality Established by a Positive Lymphocyte Transformation Test (LTT) and the Roussel Uclaf Causality Assessment Method (RUCAM): A Case Report
Fonte: Ann. hepatol;16(2):308-311, Mar.-Apr. 2017. tab.
Idioma: en.
Resumo: ABSTRACT A 75-year old male patient had been regularly visiting our hospital for the management of his type 2 diabetes mellitus since he was diagnosed at age 64 years. When he developed hypoglycemic episodes with sulfonylurea, ipragliflozin (50 mg/day) was started to replace the sulfonylurea therapy. However, 49 days after starting ipragliflozin, his AST increased from 13 to 622 U/L, ALT increased from 9 to 266 U/L, ALP increased from 239 to 752 U/L, and γ-GTP increased from 19 to 176 U/L. ZTT was 3.5 U, TTT was 0.4 U, and total bilirubin was 0.7 mg/dL. IgM hepatitis A antibody, hepatitis B antigen, hepatitis C virus antibody, IgM CMV antibody, and IgM EB VCA antibody were negative, whereas a lymphocyte transformation test for ipragliflozin was positive. Abdominal CT scan showed mild fatty liver but no sign of nodular lesions. Following admission to our hospital, he received liver supportive therapy with the discontinuation of ipragliflozin therapy. He was discharged from the hospital 18 days later with AST and ALT levels reduced to 20 U/L and 13 U/L, respectively. Based on the clinical presentation of this patient, it is highly important to monitor liver function along with other possible clinical complications (e.g., dehydration, ketosis, and urinary tract infection) associated with SGLT2 inhibitor therapy.
Descritores: Ativação Linfocitária/efeitos dos fármacos
Diabetes Mellitus Tipo 2/tratamento farmacológico
Doença Hepática Induzida por Substâncias e Drogas/diagnóstico
Doença Hepática Induzida por Substâncias e Drogas/etiologia
Doença Hepática Induzida por Substâncias e Drogas/imunologia
Glucosídeos/efeitos adversos
Hipoglicemiantes/efeitos adversos
-Tiofenos/efeitos adversos
Valor Preditivo dos Testes
Fatores de Risco
Diabetes Mellitus Tipo 2/diagnóstico
Diabetes Mellitus Tipo 2/sangue
Doença Hepática Induzida por Substâncias e Drogas/terapia
Testes de Função Hepática
Limites: Humanos
Masculino
Idoso
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


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Id: biblio-1117027
Autor: Costanzo, Pablo R; Salerni, Helena; Sánchez, Ariel.
Título: Efecto del ranelato de estroncio sobre la densidad mineral ósea en hombres con osteoporosis / Effect of strontium ranelate on bone mineral density in men with osteoporosis
Fonte: Actual. osteol;13(3):198-206, Sept - DIc. 2017. graf, tab.
Idioma: es.
Resumo: La osteoporosis afecta al 6-7% de la población masculina. Es alta la proporción de pacientes con fracturas sin diagnóstico previo de esta enfermedad. La mortalidad luego de una fractura es mayor en hombres que en población femenina; a pesar de esto, la mayoría de los pacientes no reciben tratamiento. Los fármacos aprobados, en nuestro medio, para tratar la osteoporosis masculina son: bifosfonatos, teriparatida y ranelato de estroncio. El objetivo de este estudio fue evaluar el efecto del ranelato de estroncio sobre la densidad mineral ósea en hombres después de 1 año de tratamiento. Se incluyeron los registros de 20 hombres de 67,8±3,0 años, tratados con ranelato de estroncio (2 g/día) durante 1 año. Todos los pacientes presentaban un T-score inferior a -2,5 en cadera o columna vertebral o un T-score inferior a -2,0 y factores de riesgo de fractura. No hubo modificación de parámetros de laboratorio luego del tratamiento (calcemia, calciuria, fósforo sérico, parathormona, 25(OH)vitamina D, fosfatasa alcalina y desoxipiridinolina) en relación a los basales. Luego del tratamiento con ranelato de estroncio se observó incremento de la densidad mineral ósea en columna lumbar: 0,953±0,029 versus 0,997±0,030 g/cm2 (p=0,0068), cuello femoral: 0,734±0,013 versus 0,764±0,016 g/cm2 (p=0,0084) y cadera total: 0,821±0,02 versus 0,834±0,02 g/cm2 (p=0,0419). Conclusión: el tratamiento con ranelato de estroncio produjo un incremento significativo de la densidad mineral ósea en columna lumbar y fémur proximal en hombres con osteoporosis. (AU)

Osteoporosis affects 6-7% of the male population. The proportion of patients with fragility fractures but without diagnosis of the disease is high. Mortality after hip fracture is higher in men than in women; in spite of this, most patients are left without treatment for osteoporosis. Drugs approved, for the treatment of osteoporosis in our country are bisphosphonates, teriparatide, and strontium ranelate (SrR). The objective of this study was to evaluate the effect of SrR on axial BMD in men after one year of treatment. We obtained pertinent data from medical registries of 20 men aged 67,8±3,0 years, treated with oral SrR (2 g/day) for 12 months. All patients had a T-score below -2,5 at the hip or the lumbar spine, or a T-score below -2,0 and one or more risk factors for fracture. The levels of serum calcium, phosphate, alkaline phosphatase, 25-hydroxyvitamin D, or PTH, or urinary calcium and desoxipyridinoline remained unchanged following SrR administration. After treatment with SrR there were significant increases in BMD at the lumbar spine: 0,953±0,029 versus 0,997±0,030 g/cm2 (p=0,0068), femoral neck: 0,734±0,013 versus 0,764±0,016 g/cm2 (p=0.0084), and total hip: 0,821±0,02 versus 0,834±0,02 g/cm2 (p=0,0419). Conclusion: in osteoporotic men, treatment with SrR significantly increases BMD in the lumbar spine and the proximal femur. (AU)
Descritores: Osteoporose/tratamento farmacológico
Estrôncio/química
Doenças Ósseas Metabólicas/tratamento farmacológico
Densidade Óssea/efeitos dos fármacos
-Compostos Organometálicos
Osteoporose/diagnóstico
Argentina
Estrôncio/administração & dosagem
Testosterona/uso terapêutico
Tiofenos
Vitamina D/administração & dosagem
Doenças Ósseas Metabólicas/metabolismo
Doenças Ósseas Metabólicas/sangue
Índice de Massa Corporal
Fatores Sexuais
Cálcio/administração & dosagem
Estudos Retrospectivos
Fatores de Risco
Conservadores da Densidade Óssea/uso terapêutico
Fraturas por Osteoporose
Hipogonadismo/complicações
Limites: Humanos
Masculino
Idoso
Tipo de Publ: Ensaio Clínico
Responsável: AR2.1 - Biblioteca Central


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Texto completo SciELO Brasil
Texto completo
Id: biblio-886176
Autor: Barlas, Aziz Mutlu; Kismet, Kemal; Erel, Serap; Kuru, Serdar; Cavusoglu, Turgut; Senes, Mehmet; Adiyaman, Zeynep; Celepli, Pinar; Hucumenoglu, Sema; Pekcici, Recep.
Título: Erdosteine ameliorates the harmful effects of ischemia-reperfusion injury on the liver of rats
Fonte: Acta cir. bras;32(10):796-806, Oct. 2017. tab, graf.
Idioma: en.
Resumo: Abstract Purpose: To investigate the potential protective effects of erdosteine against the harmful effects of ischemia-reperfusion injury on the liver in an experimental rat model. Methods: Forty rats were divided into 4 groups. In the sham group, only the hepatic pedicle was mobilized. No other manipulation or treatment was performed. In the other groups, ischemia was achieved by clamping the hepatic pedicle for 60 min. After that, 90 min reperfusion was provided. In the control group, no treatment was given. In the perioperative treatment group, 100 mg/kg erdosteine was administered 2 hours before ischemia induction. In the preoperative treatment group, 100 mg/kg/day erdosteine was administered daily for ten days before the operation. At the end of the procedures, blood and liver samples were obtained for biochemical and histopathological assessment. Results: Treatment with erdosteine ameliorated the histopathological abnormalities when compared with the control group. Furthermore, this treatment significantly decreased the serum liver function test values. It was also found that erdosteine ameliorated the oxidative stress parameters in both the perioperative and preoperative treatment groups. Conclusion: The current study is the first to have shown the favorable effects of erdosteine on the harmful effects of experimental hepatic ischemia-reperfusion injury.
Descritores: Tioglicolatos/administração & dosagem
Tiofenos/administração & dosagem
Traumatismo por Reperfusão/tratamento farmacológico
Substâncias Protetoras/administração & dosagem
Fígado/irrigação sanguínea
-Ratos Wistar
Modelos Animais de Doenças
Fígado/patologia
Limites: Animais
Feminino
Ratos
Responsável: BR1.1 - BIREME


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Id: lil-621521
Autor: Teles, Juliana Souto; Fukuda, Ellen Yukie; Feder, David.
Título: Warfarin: pharmacological profile and drug interactions with antidepressants / Varfarina: perfil farmacológico e interações medicamentosas com antidepressivos
Fonte: Einstein (Säo Paulo);10(1):110-115, jan.-mar. 2012. graf, ilus.
Idioma: en; pt.
Resumo: Oral anticoagulants are among the drugs with the greatest number of drug interactions. The concomitant use of several medications is a common practice in patients with cardiovascular problems, who often also present with depression; therefore, the probability of an interaction occurring between warfarin and the antidepressants is high, and may result in increased or decreased anticoagulant activity. Since the possible interactions between these two classes of drugs have been poorly explored in literature, with a risk to the patients who use them, we reviewed the pharmacology of warfarin and its possible interactions with antidepressants. Of the antidepressants analyzed, those that showed relevant effects on the interaction with warfarin were, in decreasing order: paroxetine, venlafaxine, fluoxetine, and duloxetine.

Os anticoagulantes orais estão entre as drogas com maior número de interações medicamentosas. O uso concomitante de vários medicamentos é uma prática comum em pacientes com problemas cardiovasculares, os quais frequentemente também apresentam depressão; assim, a probabilidade de ocorrer alguma interação entre a varfarina e os antidepressivos é bem expressiva, podendo resultar em um aumento ou uma diminuição da atividade anticoagulante. Como as possíveis interações entre essas duas classes de medicamentos se mostraram pouco exploradas na literatura, com risco aos pacientes que fazem uso delas, revisamos a farmacologia da varfarina e suas possíveis interações com antidepressivos. Dos antidepressivos analisados, os que apresentaram efeitos relevantes na interação com a varfarina foram, em ordem decrescente: paroxetina, venlafaxina, fluoxetina e duloxetina.
Descritores: Anticoagulantes/farmacologia
Antidepressivos/farmacologia
Varfarina/farmacologia
-Administração Oral
Anticoagulantes/efeitos adversos
Anticoagulantes/farmacocinética
Anticoagulantes/uso terapêutico
Biotransformação/efeitos dos fármacos
Cicloexanóis/farmacologia
/metabolismo
CYTOCHROME P-ALDEHYDES ENZYME SYSTEM/metabolismo
Interações Medicamentosas
Fluoxetina/farmacologia
Hemorragia/induzido quimicamente
Paroxetina/farmacologia
Tiofenos/farmacologia
Trombofilia/tratamento farmacológico
Vitamina K/antagonistas & inibidores
Varfarina/efeitos adversos
Varfarina/farmacocinética
Varfarina/uso terapêutico
Limites: Humanos
Tipo de Publ: Revisão
Responsável: BR1.1 - BIREME


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Texto completo SciELO Chile
Texto completo
Id: biblio-893136
Autor: Xuan, Jing; Wu, Xiu-Ping; Kwon, Tae-Geon; Kyung, Hee-Moon; Bing, Li.
Título: Effects of strontium ranelate on alveolar ridge morphology augmentation / Efectos del ranelato de estroncio en el aumento del rebforde alveolar
Fonte: Int. j. morphol;35(4):1328-1331, Dec. 2017. tab.
Idioma: en.
Projeto: Shanxi Province International Science and Technology; . Shanxi Province returned overseas students research.
Resumo: SUMMARY: The objective of this study was to compare the Primary and Secondary stability of immediate implant placement with Alveolar Ridge Augmentation (ARA) and Strontium Ranelate (SR) as aids to enhance the stability using Resonance Frequency Analysis (RFA). Fifty eight subjects ideal for immediate implants were assigned to two groups to compare the primary and secondary stability of the implant using Alveolar Ridge Augmentation and oral strontium ranelate. They were tested for primary stability on placement of the implant and after eight weeks of placement for secondary stability. The stability was measured using resonance frequency analysis. Both the procedures showed an improvement in the stability but the Alveolar Ridge Augmentation procedure showed a significantly better primary stability (P< .03) and the secondary stability (P<.00). The means of the implant stability quotient value (ISQ) for the Alveolar ridge augmentation procedure was 74.2 for primary stability, and 83.34 for secondary stability. With the enhancement of stability with both the procedures Alveolar Ridge Augmentation proved to be a better procedure to achieve successful results of an immediately placed implant.

RESUMEN: El objetivo de este estudio fue comparar la estabilidad primaria y secundaria de la colocación inmediata del implante con el aumento de reborde alveolar (ARA) y el ranelato de estroncio (SR) como ayudas para mejorar la estabilidad mediante el análisis de frecuencia de resonancia (RFA). Cincuenta y ocho sujetos, ideales para implantes inmediatos, fueron asignados a dos grupos para comparar las estabilidades primaria y secundaria del implante usando el aumento del reborde alveolar y el ranelato de estroncio oral. Se efectuaron pruebas de estabilidad primaria en la colocación del implante, y después de ocho semanas para la estabilidad secundaria. La estabilidad se midió utilizando análisis de frecuencia de resonancia. Ambos procedimientos mostraron una mejora en la estabilidad, sin embargo el procedimiento del aumento del reborde alveolar mostró una estabilidad primaria significativamente mejor (P <0,03) que la estabilidad secundaria (P <0,00). Las medias del valor de cociente de estabilidad del implante (ISQ) para el procedimiento de aumento de reborde alveolar fueron 74,2 para la estabilidad primaria y 83,34 para la estabilidad secundaria. Se observó una mejora de la estabilidad en ambos procedimientos, el aumento del reborde alveolar demostró ser un mejor procedimiento para lograr resultados exitosos del posicionamiento de implante inmediato.
Descritores: Tiofenos/farmacologia
Implantes Dentários
Retenção em Prótese Dentária
Aumento do Rebordo Alveolar/métodos
-Osseointegração
Responsável: CL1.1 - Biblioteca Central


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Texto completo
Texto completo
Id: biblio-1001583
Autor: El-Sharkawy, Karam Ahmed; AlBratty, Mohammed Mofreh; Alhazmi, Hassan Ahmad.
Título: Synthesis of some novel pyrimidine, thiophene, coumarin, pyridine and pyrrole derivatives and their biological evaluation as analgesic, antipyretic and anti-inflammatory agents
Fonte: Braz. J. Pharm. Sci. (Online);54(4):e00153, 2018. tab, graf.
Idioma: en.
Resumo: Pyrimidine derivative 3 was afforded through the reaction of compound (1) with 5-ureidohydantion (2). Product 3 underwent a cyclization to produce fused pyrimidine derivative 7, although the latter product 7 was synthesized through one step via the reaction of compound (1) with 5-ureidohydantion (2) using another catalyst. Compound 3 was oriented to react with cyclic ketones 8a,b in the presence of elemental sulfur, salicylaldehyde (10), aryldiazonium chlorides 12a,b and ω-bromo-4-methoxy- acetophenone (14), which afforded, fused thiophene derivatives 9a,b, coumarin derivative 11, arylhdrazono derivatives 13a,b and 4-methoxyphenyl butenyl derivative 15, respectively. The latter product 15 was reacted with either potassium cyanide (16a) or potassium thiocyanide (16b) to form cyano and thiocyano derivatives 17a,b, respectively. Compound 17a underwent further cyclization to afford pyridopyrimidine derivative 19. Compound 15 was reacted with either hydrazine (20a) or phenylhydrazine (20b) to produce hydrazo derivatives 21a,b and these products were cyclize to produce pyrrole derivatives 23a,b. Finally, 5-ureidohydantion (2) was reacted with compounds 24a,b,c to afford pyrimidine derivatives 25a,b,c. The structures of the synthesized compounds were confirmed using IR, 1H NMR, 13C NMR and mass spectrometry techniques. Compounds 11 and 19 have promising as analgesic and antipyretic activities
Descritores: Piridinas/análise
Pirimidinas/agonistas
Pirróis
Tiofenos/análise
Cumarínicos/análise
-Antipiréticos
Analgésicos/classificação
Responsável: BR40.1 - DBD - Divisão de Biblioteca e Documentacão do Conjunto das Químicas


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Id: biblio-888989
Autor: Rodrigues, TA; Sampaio Junior, AJB; Nunes, IDP; Cartágenes, MSS; Garcia, JBS.
Título: Effect of strontium ranelate on pain behavior in an experimental model of osteoarthritis
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;50(9):e6314, 2017. graf.
Idioma: en.
Resumo: Strontium ranelate (SrRan) is a drug usually prescribed to treat osteoporosis, with proven effects of decreasing the risk of fractures and an indication of reducing the progression of osteoarthritis (OA). This study aimed to investigate the effects of SrRan as either a prophylactic or a treatment drug, using an OA rat model to assess pain behavior. A monoiodoacetate (MIA)-induced knee joint OA model in Wistar rats was used. Thirty Wistar rats (both sexes, 60 days old) were distributed in five groups of 6 rats each: the control group, that received no intervention; a prophylactic group, that received oral administration of 25 mg·kg-1·day-1 of SrRan for 28 days before induction of OA; a group treated with 25 mg·kg-1·day-1 of SrRan for 28 days after OA induction; a group treated with 50 mg·kg-1·day-1 during 28 days after OA induction; and a group that received oral saline for 28 days after induction. The assessment of pain behavior was performed considering articular incapacitation (weight-bearing test), mechanical hyperalgesia (Randall Selitto test) and motor activity (rotarod test), on days 0, 7, 14, 21, and 28. This experiment did not yield a significant difference when comparing the group that received SrRan prophylactically with the groups treated with 25 or 50 mg·kg-1·day-1 and the group that received oral saline. Thus, SrRan did not provide analgesia in either treated rats or as a prophylactic drug with the tested doses. Higher doses should be tested further to achieve possible significant results.
Descritores: Conservadores da Densidade Óssea/uso terapêutico
Hiperalgesia/tratamento farmacológico
Osteoartrite do Joelho/tratamento farmacológico
Tiofenos/uso terapêutico
-Modelos Animais de Doenças
Ratos Wistar
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


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ARANA-CHAVEZ, Victor Elias
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Id: biblio-828046
Autor: Rosa, Jucely Aparecida da; Sakane, Kumiko Koibuchi; Santos, Karina Cecília Panelli; Corrêa, Vivian Bradaschia; Arana-Chavez, Victor Elias; Oliveira, Jefferson Xavier de.
Título: Strontium Ranelate Effect on the Repair of Bone Defects and Molecular Components of the Cortical Bone of Rats
Fonte: Braz. dent. j;27(5):502-507, Sept.-Oct. 2016. tab, graf.
Idioma: en.
Resumo: Abstract This study was conducted to evaluate the effects of treatment with strontium ranelate (SR) on the repair of bone defects and molecular components of bones in femurs. Adult female rats (n=27) were subjected to ovariectomy (OVX) or Sham surgery. Thirty days after surgery, a defect was made in the femur and the animals were then divided into three groups: OVX, SHAM and OVX+SR. Euthanasia was performed four weeks after the bone defect surgery. Repair in bone defect was assessed by computed microtomography (μCT) and chemical composition of cortical bone was analyzed by Fourier transform infrared (FTIR) spectroscopy and energy dispersive X-ray spectroscopy (EDS). The trabecular thickness (Tb.Th) of the newly formed bone in the OVX+SR group was significantly higher than that for the OVX group. The collagen maturity in the OVX+SR group was smaller than in the other two groups. In this group, a significant increase in the amount of strontium (Sr) and a decrease in the amount of calcium (Ca) embedded to bone tissue were also observed. Systemic treatment with SR improved microarchitecture of the newly formed bone inside the defect, but decreased cross-linking of mature collagen in cortical bone.

Resumo Este estudo foi conduzido para avaliar os efeitos do tratamento com ranelato de estrôncio (RE) na reparação de defeitos ósseos e componentes moleculares de ossos nos fêmures. Ratas adultas (n = 27) foram submetidas a ovariectomia (OVX) ou cirurgia Sham. Trinta dias após a cirurgia, um defeito foi feito no fêmur e os animais foram então divididos em três grupos: OVX, SHAM e OVX+RE. A eutanásia foi realizada quatro semanas após a cirurgia de preparo do defeito ósseo. A reparação do defeito ósseo foi avaliada por microtomografia computorizada (μCT) e a composição química do osso cortical foi analisada por espectroscopia de infravermelho de transformada de Fourier (FTIR) e espectroscopia por energia dispersiva de raios X (EDS). A espessura do osso trabecular (Tb.Th) recém formado no grupo OVX+SR foi significativamente maior que a do grupo OVX. A maturidade do colágeno no grupo OVX+SR foi menor do que nos outros dois grupos. Neste grupo, observou-se também um aumento significativo na quantidade de estrôncio (Sr) e uma diminuição na quantidade de cálcio (Ca) no tecido ósseo. O tratamento sistêmico com RE melhorou a microarquitetura do osso recém formado dentro do defeito, mas diminuiu a reticulação do colágeno maduro no osso cortical.
Descritores: Osso e Ossos/efeitos dos fármacos
Tiofenos/farmacologia
-Ovariectomia
Ratos Wistar
Espectroscopia de Infravermelho com Transformada de Fourier
Análise Espectral/métodos
Limites: Animais
Feminino
Ratos
Responsável: BR1.1 - BIREME



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