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Id: lil-245928
Autor: Canas, Patricio E.
Título: The role of xanthine oxidase and the effects of antioxidants in ischemia reperfusion cell injury
Fonte: Acta physiol. pharmacol. ther. latinoam;49(1):13-20, 1999. tab.
Idioma: en.
Resumo: During last years considerable interest has been devoted to understand the role of oxugen radicals in the inschemia induced cell injury associated with reperfusion. In the brain and in others tissues, free radicals play a role as modulators of vascular tone as well as a cytotoxic role as part of the ischemia associated pathology. This review discusses methods for free radical detection in brain and in other tissues, mechanisms of radical production in the course of the ischemia reperfusion process, and the efficacy of potential antioxidant agents in post ischemia therapy, especially with respect to allopurinol, an inhibitor of xanthine oxidase, and the role of taurine and its derivatives as antioxidants in different organs including the brain.
Descritores: Antioxidantes/farmacologia
Inibidores Enzimáticos/farmacologia
Traumatismo por Reperfusão/metabolismo
Xantina Oxidase/antagonistas & inibidores
Xantina Oxidase/fisiologia
Niacinato de Xantinol
-Radicais Livres/metabolismo
Espécies Reativas de Oxigênio/metabolismo
Traumatismo por Reperfusão/enzimologia
Traumatismo por Reperfusão/patologia
Tipo de Publ: Revisão
Responsável: BR1.1 - BIREME

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