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Id: biblio-1054687
Autor: Cai, Yi; Huang, Penghan; Xie, Yizu.
Título: Effects of huperzine A on hippocampal inflammatory response and neurotrophic factors in aged rats after anesthesia
Fonte: Acta cir. bras;34(12):e201901205, 2019. graf.
Idioma: en.
Resumo: Abstract Purpose To investigate the effects of huperzine A (HupA) on hippocampal inflammatory response and neurotrophic factors in aged rats after anesthesia. Methods Thirty-six Sprague Dawley rats (20-22 months old) were randomly divided into control, isofluran, and isoflurane+HupA groups; 12 rats in each group. The isoflurane+HupA group was intraperitoneally injected with 0.2 mg/kg of HupA. After 30 min, isoflurane inhalation anesthesia was performed in the isoflurane and isoflurane+HupA groups. After 24 h from anesthesia, Morris water maze experiment and open-field test were performed. Hippocampal inflammatory and neurotrophic factors were determined. Results Compared with isoflurane group, in isofluran+HupA group the escape latency of rats was significantly decreased (P < 0.05), the original platform quadrant residence time and traversing times were significantly increased (P < 0.05), the central area residence time was significantly increased (P < 0.05), the hippocampal tumor necrosis factor α, interleukin 6 and interleukin 1β levels were significantly decreased (P < 0.05), and the hippocampal nerve growth factor, brain derived neurotrophic factor and neurotrophin-3 levels were significantly increased (P < 0.05). Conclusion HupA may alleviate the cognitive impairment in rats after isoflurane anesthesia by decreasing inflammatory factors and increasing hippocampal neurotrophic factors in hippocampus tissue.
Descritores: Sesquiterpenos/farmacologia
Fármacos Neuroprotetores/farmacologia
Anestésicos Inalatórios/efeitos adversos
Alcaloides/farmacologia
Hipocampo/efeitos dos fármacos
Fatores de Crescimento Neural/efeitos dos fármacos
-Ensaio de Imunoadsorção Enzimática
Distribuição Aleatória
Reprodutibilidade dos Testes
Interleucina-6/análise
Ratos Sprague-Dawley
Aprendizagem em Labirinto
Interleucina-1beta/análise
Hipocampo/metabolismo
Isoflurano/efeitos adversos
Anestesia/efeitos adversos
Fatores de Crescimento Neural/análise
Limites: Humanos
Animais
Masculino
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Id: biblio-886274
Autor: Wu, Jing; Pan, Lin; Jin, Xueqin; Li, Weihua; Li, Hongbing; Chen, Jianmao; Yang, Wen.
Título: The role of oxymatrine in regulating TGF-ß1 in rats with hepatic fibrosis
Fonte: Acta cir. bras;33(3):207-215, Mar. 2018. tab, graf.
Idioma: en.
Projeto: Ningxia Natural Science Foundation; . School Level Project of Ningxia Medical University.
Resumo: Abstract Purpose: To investigate whether oxymatrine (OMT) prevents hepatic fibrosis in rats by regulating liver transforming growth factor β1 (TGF-β1) level. Methods: Hepatic fibrosis was induced in rats by thioacetamide (TAA). Blood was collected at the end of week 12 to determine the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and glutathione (GSH). Changes in liver tissue were observed after hematoxylin-eosin (HE) staining. Results: Fibrosis was confirmed by Masson's collagen staining. Liver TGF-β1 level was determined by ELISA. OMT significantly reduced serum ALT and AST but increased GSH levels in rats with hepatic fibrosis. Moreover, it significantly improved liver histology in rats with TAA-induced hepatic fibrosis. It significantly decreased liver TGF-β1 level compared to that in the untreated group. It also significantly reduced collagen deposition in rats. Conclusion: Oxymatrine is effective in protecting rats from thioacetamide-induced hepatic fibrosis by regulating TGF-β1 expression.
Descritores: Quinolizinas/farmacologia
Substâncias Protetoras/farmacologia
Alcaloides/farmacologia
Fator de Crescimento Transformador beta1/metabolismo
Cirrose Hepática Experimental/prevenção & controle
-Aspartato Aminotransferases/sangue
Ratos Sprague-Dawley
Fator de Crescimento Transformador beta1/efeitos dos fármacos
Cirrose Hepática Experimental/induzido quimicamente
Cirrose Hepática Experimental/metabolismo
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


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Id: biblio-973475
Autor: Deng, Ni; Xie, Lili; Li, Yongwei; Lin, Haishu; Luo, Renhui.
Título: Oxymatrine alleviates periodontitis in rats by inhibiting inflammatory factor secretion and regulating MMPs/TIMP protein expression
Fonte: Acta cir. bras;33(11):945-953, Nov. 2018. tab, graf.
Idioma: en.
Resumo: Abstract Purpose: To investigate the effect of oxymatrine on periodontitis in rats and related mechanism. Methods: Ninety SD rats were divided into control, model, 10, 20 and 40 mg/kg oxymatrine and tinidazole groups. The periodontitis model was established in later 5 groups. The 10, 20 and 40 mg/kg oxymatrine groups were intragastrically administrated with 10, 20 and 40 mg/kg oxymatrine, respectively. The tinidazole group was intragastrically administrated with 100 mg/kg tinidazole. The treatment duration was 4 weeks. The tooth mobility, gingival and plaque indexes, serum inflammatory factor levels and gingival tissue matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinase (TIMP) protein levels were detected. Results: After treatment, compared with model group, in 40 mg/kg oxymatrine group the rat general conditions were obviously improved, the tooth mobility, gingival index and plaque index were significantly decreased (P<0.05), the serum tumor necrosis factor-α, interleukin-1β and prostaglandin E2 levels were significantly decreased (P<0.05), the MMP-2 and MMP-9 protein levels were significantly decreased (P<0.05), and the TIMP-2 protein level was significantly increased (P<0.05). Conclusions: Oxymatrine can alleviate the experimental periodontitis in rats. The mechanism may be related to its inhibiting inflammatory factor secretion and regulating MMPs/TIMP protein expression.
Descritores: Periodontite/tratamento farmacológico
Quinolizinas/farmacologia
Inibidores Teciduais de Metaloproteinases/efeitos dos fármacos
Metaloproteinases da Matriz/efeitos dos fármacos
Alcaloides/farmacologia
Anti-Inflamatórios/farmacologia
-Periodontite/metabolismo
Valores de Referência
Tinidazol
Dinoprostona/sangue
Distribuição Aleatória
Índice de Placa Dentária
Reprodutibilidade dos Testes
Fator de Necrose Tumoral alfa/sangue
Resultado do Tratamento
Ratos Sprague-Dawley
Inibidores Teciduais de Metaloproteinases/análise
Metaloproteinases da Matriz/análise
Interleucina-1beta/sangue
Gengiva/patologia
Limites: Animais
Masculino
Feminino
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Id: biblio-907030
Autor: Gamarra, Vidal; Fuertes, César; Chávez, Nadia; Contreras, Dennis; Goya, Eri; Huamantumba, Kelly; Retuerto, Fernando; Ruiz Pacco, Gustavo.
Título: Metabolitos en las hojas de Erythroxylum coca Lam y Erithroxylum novogranatense (Morris) Hieron y evaluacón de sus propiedades biológicas mediante bioensayos / Metabolites detected in Erythroxylum coca Lam y Erythroxylum novogranatense (Morris) Hieron leaves and evaluation of their biological activities by bioessay
Fonte: Rev. peru. med. integr;2(4):828-834, 2017. tab, graf.
Idioma: es.
Resumo: Objetivo: Realizar el screening fitoquímico y determinar la actividad antioxidante y antibacteriana de los flavonoides y alcaloides aislados de extractos etanólicos de las hojas de Erythroxylum coca Lam y Erythroxylum novogranatense (Morris) Hieron. Materiales y Métodos: La capacidad antioxidante de los flavonoides y alcaloides aislados fue evaluada mediante el ensayo de DPPH, utilizando como control positivo a la vitamina C, y la actividad antibacteriana mediante el cálculo del halo de inhibición (mm) ante S. epidermidis, P. aeruginosa, S. aureus y E. coli. Resultados: Los alcaloides de E. coca presentaron mayor actividad antibacteriana frente a S. epidermidis y P. aeruginosa, y los flavonoides de E. novogranatense tuvieron mayor actividad frente a S. epidermidis, P. aeruginosa y S. aureus. E. novogranatense mostroun EC50 de 271,20 µg/mL para extracto crudo y 250,29 µg/mL para flavonoides, mientras que E. coca presento un EC50 de 172,59 µg/mL para extracto crudo y 611,29 µg/mL para flavonoides. Conclusión: En ambas especies se identificaron alcaloides (cocaína y benzoilecgonina), flavonoides (chalconas y flavonoles), fenoles y carbohidratos. Los flavonoides de Erythroxylum novogranatense (Morris) Hieron, y el extracto de Erythroxylum coca Lam presentaron mayor actividad antioxidante. El extracto de Erythroxylum coca Lam mostro mayor actividad antibacteriana frente a S. aureus, S. epidermidis y E. coli, excepto para P. aeruginosa. Los alcaloides de Erythroxylum coca Lam, exhibieron buena actividad frente a S. epidermidis y P. aeruginosa; excepto para E. coli, donde Erythroxylum novogranatense (Morris) Hieron tuvo mejor desempeño. Los flavonoides aislados de Erythroxylum novogranatense (Morris) Hieron mostraron actividad frente a S. epidermidis.
Descritores: Flavonoides
Coca
Alcaloides
Compostos Fitoquímicos
Antibacterianos
Antioxidantes
-Peru
Bioensaio
Extratos Vegetais
Programas de Rastreamento
Limites: Humanos
Tipo de Publ: Técnicas In Vitro
Responsável: BR1.1 - BIREME


  5 / 155 LILACS  
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Id: lil-219980
Autor: Sanabria, Luis; Ferreira, María Elena; Kasamatsu, Elena; González, Nilsa; Schinini, Alicia; Fournet, Alain; Rojas de Arias, Antonieta.
Título: Acción tripanocida y toxicidad de alcaloides bisbenzylisouinqlicos y de un derivado fenolico (FC.108), en ensayos in vivo en ratones c3h infectados con T.cruzi experimentalmente.
Fonte: Asunción; EDUNA; 1995. 100-13 p.
Idioma: en.
Resumo: Un total de sesenta ratones C3H infectados con la cepa epsilon, fueron tratados con alcaloides bisbenzylisoquinolicos (50 ratones) y un derivado fenólico (Fc.108), (10 ratones) con el propósito de determinar la actividad tripanocida in vivo contra el T.cruzi de estas sustancias. También se evaluaron otros efectos como: (actividad protectiva y/o toxicidad) al comparar las lesiones del miocardio por medio de estudios histopatológicos en los ratones tratados y no tratados con estos alcaloides. Se encontraron lesiones histopatogicas en todos los ratones tratados y no tratados pero sólo en estos últimos (grupos controles), se hallaron daños mas severos y nidos de amastigotes de T. cruzi en el miocardio. Se encontraron marcadas diferencias entre el grupo control y el grupo de ratones tratados con cycleanine y curine. Todos los ratones tratados presentaron menor parasitemia y una mayor sobrevida
Descritores: Trypanosoma cruzi
Testes de Toxicidade
Alcaloides
Responsável: PY2.1 - Centro de Documentación
PY3.1 SR 616.9363 An78a 1994


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Id: biblio-1007944
Autor: García, Javier; Alvarenga, Nelson.
Título: Actividad sinérgica in vitro de los alcaloides Crotsparina y Esparsiflorina aislados de Croton bomplandianum frente a Pseudomonas aeruginosa / In vitro synergic activity of the alkaloids Crotsparine and Sparsiflorine, isolated from Croton bomplandianum, against Pseudomonas aeruginosa
Fonte: Mem. Inst. Invest. Cienc. Salud (Impr.);17(1):47-53, abr. 2019. ilus, tab.
Idioma: es.
Resumo: Se evaluó la actividad sinérgica de los alcaloides crotsparina y esparsiflorina, aislados de Croton bomplandianum Baill. con los antibacterianos gentamicina y ciprofloxacina frente a Pseudomonas aeruginosa, microorganismo frecuentemente responsable de infecciones intrahospitalarias. Se empleó el método del "tablero de damas". Se encontraron combinaciones que presentaban efecto sinérgico, logrando la reducción de 87,5% de la CMI de gentamicina, mientras que para ciprofloxacina se logró una reducción del 25,0%. Esto abre interesantes perspectivas sobre el uso combinado de productos naturales puros y fármacos en uso clínico para el tratamiento de infecciones producidas por este microrganismo(AU)
Descritores: Pseudomonas aeruginosa/efeitos dos fármacos
Gentamicinas/farmacologia
Ciprofloxacino/farmacologia
Croton
Alcaloides/farmacologia
Antibacterianos/farmacologia
-Gentamicinas/isolamento & purificação
Sinergismo Farmacológico
Alcaloides/química
Responsável: PY3.1 - Biblioteca


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Id: lil-623953
Autor: Pilli, R. A; Murta, M. M.
Título: Stereoselective total synthesis of some insect pheromones: (±)-serricornine and (±)-invictolide
Fonte: Mem. Inst. Oswaldo Cruz;86(supl.2):117-120, 1991. ilus.
Idioma: en.
Conferência: Apresentado em: Brazilian-Sino Symposium on Chemistry and Pharmacology of Natural Products, Rio de Janeiro, Dec. 10-14, 1989.
Resumo: An efficient (12 steps, 12% overallyield) and stereoselective total synthesis of (±)-serricornine (1) the sex pheromone of the cigarette beetle (Lasioderma serricornine F) is described. The preparation of intermediate 5, which encompasses the proper relative configuration of three contiguous chiral centers of (±)-invictolide, (3), is discussed.
Descritores: Feromônios/análise
Alcaloides
Insetos/fisiologia
-Fatores de Iniciação em Eucariotos
Fatores de Iniciação em Procariotos
Micronúcleos com Defeito Cromossômico
Limites: Animais
Responsável: BR1.1 - BIREME


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Id: lil-623944
Autor: Henriques, J. A. P; Moreno, P. R. H; Von Poser, G. L; Querol, C. C; Henriques, A. T.
Título: Genotoxic effect of alkaloids
Fonte: Mem. Inst. Oswaldo Cruz;86(supl.2):71-74, 1991. tab.
Idioma: en.
Conferência: Apresentado em: Brazilian-Sino Symposium on Chemistry and Pharmacology of Natural Products, Rio de Janeiro, Dec. 10-14, 1989.
Resumo: Because of the increase use of alkaloids in general medical practice in recent years, it is of interest to determine genotoxic, mutagenic and recombinogenic response to different groups of alkaloids in prokaryotic and eucaryotic organisms. Reserpine, boldine and chelerythrine did not show genotoxicity response in the SOS-Chromotest whereas skimmianine showed genotixicity in the presence of a metabolic activation mixture. Voacristine isolated fromthe leaves of Ervatamia coronaria shows in vivo cytostatic and mutagenic effects in Saccharomyces cerevisiae hapioids cells. The Rauwolfia alkaloid (reserpine) was not able to induce reverse mutation and recombinational mitotic events (crossing-over and gene conversion) in yeast diploid strain XS2316.
Descritores: Recombinação Genética
Saccharomyces cerevisiae/fisiologia
Alcaloides
-Mutação
Responsável: BR1.1 - BIREME


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Id: biblio-954136
Autor: Núñez-R, Daniela; Balboa-P, Natalia; Quilaqueo-P, Nelson; Alvear-Z, Marysol; Paredes-H, Marco.
Título: Evaluación de la actividad inmunomoduladora de extractos metanólicos y de alcaloides de Berberis darwinii H. (Berberidaceae) / Evaluation of the immunomodulatory activity of methanolic extracts and alkaloids of Berberis darwinii H. (Berberidaceae)
Fonte: Int. j. morphol;36(2):454-459, jun. 2018. graf.
Idioma: es.
Projeto: Departamento de Ciencias Básicas, de Ciencias Químicas y Recursos Naturales y al BIOREN de la Universidad de La Frontera; . CONICYT.
Resumo: Berberis darwinii Hook es una especie que habita el sur de Chile y la Patagonia, utilizada por la etnia mapuche para el tratamiento de procesos inflamatorios, estados febriles y dolor de estomacal. El propósito del siguiente estudio fue evaluar in vitro las propiedades del extracto total y de alcaloides de raíz de B. darwinii sobre viabilidad celular y la translocación del factor nuclear NF-kB en línea celular RAW 264.7. Se observó que los extractos no afectan negativamente la viabilidad en las células e inhibieron la translocación del factor nuclear NF-kB asociado a la modulación de la inflamación solo frente al extracto total. Estos resultados indicarían que B. darwinii podría inhibir algunos mecanismos específicos de la defensa celular al modular la translocación de NF- kB.

Berberis darwinii Hook is a species that inhabits southern Chile and Patagonia, used by the Mapuche ethnic group for the treatment of inflammatory processes, febrile states and stomach pain. The purpose of the following study was to evaluate in vitro the properties of the total extract and alkaloids of the root of B. darwinii on cell viability and the translocation of the nuclear factor NF-kB in cell line RAW 264.7. It was observed that the extracts did not negatively affect the viability in the cells and inhibited the translocation of the nuclear factor NF-kB associated with the modulation of inflammation only against the total extract. These results indicate that B. darwinii could inhibit some specific mechanisms of cell defense by modulating the translocation of NF-kB.
Descritores: Extratos Vegetais/farmacologia
NF-kappa B/efeitos dos fármacos
Berberis
Células RAW 264.7/efeitos dos fármacos
-Sobrevivência Celular/efeitos dos fármacos
Imunofluorescência
Raízes de Plantas
Metanol
Alcaloides/farmacologia
Citometria de Fluxo
Fatores Imunológicos/farmacologia
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-915349
Autor: Núñez, Daniela; Balboa, Natalia; Carvajal, Fernando; Alvear, Marysol; Paredes, Marco.
Título: Efecto del extracto de alcaloides de Berberis darwinii Hook sobre respuestas celulares innatas en fagocitos murinos / Effect of the extract of Berberis darwinii Hook alkaloids on innate cellular responses in murine phagocytes
Fonte: Bol. latinoam. Caribe plantas med. aromát;17(3):259-269, mayo 2018. tab, ilus, graf.
Idioma: es.
Projeto: CONICYT.
Resumo: Berberis darwinii Hook es una especie que habita el sur de Chile y la Patagonia. Siendo utilizada por la etnia mapuche para el tratamiento de procesos inflamatorios, estados febriles, y dolor estomacal. El propósito del siguiente estudio fue evaluar in vitro las propiedades del extracto de alcaloides de raíz de B. darwinii sobre respuestas celulares en monocitos desde sangre periférica de rata. Los resultados de la cuantificación del extracto muestran una concentración de alcaloides totales de 1,67 mg/g y la caracterización por HPLC- MS determinó la presencia de berberina y palmatina. In vitro se observó que los extractos disminuyeron la capacidad de adhesión y la actividad fagocítica de los monocitos e inhibieron la translocación del factor nuclear NF-κB asociado a la modulación de la inflamación, pero no así la producción de anión superóxido. Estos resultados indicarían que los alcaloides totales de B. darwinii inhiben algunos mecanismos específicos de defensa celular.

Berberis darwinii Hook is a species that inhabits southern Chile and Patagonia. This is being used by the Mapuche ethnic group for the treatment of inflammatory processes, febrile states, and stomach pain. The purpose of the following study was to evaluate in vitro the properties of an alkaloid extract of B. darwinii root on cellular responses in monocytes from the rat peripheral blood. The results of the quantification of the extract showed a total alkaloid concentration of 1.67 mg/g and the characterization by HPLC-MS determined the presence of berberine and palmatine. In vitro, it was observed that the extracts decreased the adhesion capacity and phagocytic activity of the monocytes and inhibited the translocation of the nuclear factor NF-κB associated with the modulation of inflammation, but not the production of superoxide anion. These results indicate that the total alkaloids of B. darwinii inhibit some specific mechanisms of cellular defense.
Descritores: Extratos Vegetais/farmacologia
Raízes de Plantas/química
Berberis/química
-Extratos Vegetais/química
Monócitos/efeitos dos fármacos
Adesão Celular/efeitos dos fármacos
Cromatografia Líquida de Alta Pressão/métodos
NF-kappa B/efeitos dos fármacos
Ratos Sprague-Dawley
Alcaloides/análise
Limites: Animais
Masculino
Ratos
Responsável: CL1.1 - Biblioteca Central



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