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Id: biblio-1000066
Autor: Tapia Cárdenas, Jeanneth Patricia; Salazar Torres, Zoila Katherine; Ferreira, Luis Augusto; Orellana Izquierda, Máximo Gregorio; Tapia Cárdenas, Byron Sebastián; Tapia Cárdenas, Carlos Fernando; Tapia Cárdenas, Mayra Jamileth; Tapia Cárdenas, María Auxiliadora.
Título: MANEJO DEL DOLOR POSTOPERATORIO CON MORFINA EN ANESTESIA ESPINAL EN CIRUGÍA GINECO-OBSTÉTRICA DE LA FUNDACIÓN PABLO JARAMILLO CRESPO / . MANAGEMENT OF POSTOPERATIVE PAIN WITH MORPHINE IN SPINAL ANESTHESIA IN GYNECOLOGY-OBSTETRICS SURGERY OF THE "FUNDACIÓN PABLO JARAMILLO CRESPO"
Fonte: Rev. Fac. Cienc. Méd. Univ. Cuenca;33(2):48-62, Octubre 2015. tab, ilus.
Idioma: es.
Resumo: Objetivo: Evaluar la eficacia del tratamiento del dolor postoperatorio con el uso de la morfina en anestesia conductiva en pa-cientes con cirugía ginecológica, obstétrica. Fundación Pablo Jaramillo Crespo; septiem-bre-diciembre de 2011.Métodos: Estudio observacional, analítico, prospectivo y cuantitativo. Se incluyeron, con la clasificación de la Sociedad Americana de Anestesiología (ASA) I y II a 231 pacientes, entre 15 y 65 años, hospitalizadas en la Fundación Pablo Jaramillo Crespo, por cirugía ginecológica-obstétrica, realizadas desde septiembre a diciembre de 2011. Se administraron dosis de morfina: 2 mg para epidural y 0,2 mg para anestesia raquídea. El dolor fue evaluado a las 12 y 24 horas, con la escala visual analógica de la intensidad del dolor (EVA).Resultados: La morfina utilizada no tuvo pre-servantes; se observó que la anestesia raquí-dea muestra una ligera ventaja a la epidu-ral, con mejor tolerancia al dolor a las 12 y 24 horas (p<0.05). No hubo relación entre la etiología de las cirugías ginecológicas y obstétricas con el dolor a las 12 y 24 horas (p>0.05). En 25.78 % de los casos, la analgesia de la morfina, por administración raquídea, se complementó con el uso de ketorolaco por vía intravenosa. Un 49.2% de las pacientes no mostró efectos secundarios; de estos, los más observados fueron: el prurito (13.14 %), retención urinaria (11.3%), náuseas (9.8%) y vómitos (6.9%).Conclusión: el uso de morfina en dosis: 2 mg para epidural y 0.2 mg para anestesia raquí-dea, proporciona una favorable recupera-ción del dolor en las pacientes con cirugía ginecológica y obstétrica. Los efectos se-cundarios provocados por su administración pueden manejarse de manera eficiente sin alterar la recuperación postoperatoria.

Objective: To evaluate the efficacy of the treatment in postoperative pain with the use of morphine in conductive anesthesia in patients with gynecological obstetric surgery. Pablo Jaramillo Crespo Foundation; September-December 2011, Cuenca 2015.Methods: It is an observational, analytical, prospective and quantitative study. They included, with the classification of the American Society of Anesthesiologists (ASA) I and II, to 231 patients between 15 and 65 years, who were hospitalized in the Pablo Jaramillo Crespo Foundation for gynecological-obstetric surgery, conducted from September to December 2011. Doses of morphine were administered: 2 mg for epidural and 0.2 mg for spinal anesthesia. The pain was assessed at 12 and 24 hours, with the visual analog scale of pain intensity (VAS).Results: The morphine used did not have preservatives. It was observed that spinal anesthesia shows a slight advantage to the epidural, with better tolerance to pain at 12 and 24 hours (p <0.05). There was no a relationship between the etiology of obstetric and gynecological surgeries with pain at 12 and 24 hours (p>0.05).In 25.78% of cases, the morphine analgesia for spinal administration was supplemented using ketorolac intravenously. A 49.2% of patients did not show side effects of these. The most observed were: pruritus (13.14%), urinary retention (11. 3%), nausea (9.8%) and vomiting (6.9%).Conclusion: The use of morphine dose: 2 mg for epidural and 0,2 mg for spinal anesthesia, provides a favorable recovery of pain in patients with gynecological and obstetric surgery. The side effects caused by their administration can be handled efficiently without altering the postoperative recovery.
Descritores: Dor Pós-Operatória
Anestesia Epidural
Raquianestesia
-Cirurgia Geral
Morfina
Obstetrícia
Limites: Seres Humanos
Feminino
Gravidez
Adolescente
Adulto
Meia-Idade
Tipo de Publ: Estudo Observacional
Responsável: EC3.1 - Biblioteca


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Id: biblio-830444
Autor: Gonzalez Brizuela, Yasel; Velázquez González, Katia; Tamargo Barbeito, Teddy Osmin.
Título: Eficacia analgésica y seguridad de dosis única de morfina intratecal / Analgesic effectiveness and safety of single-dose intrathecal morphine
Fonte: Rev. cuba. anestesiol. reanim;15(3):174-186, sept.-dic. 2016. graf, tab.
Idioma: es.
Resumo: Introducción: el dolor posoperatorio del hemiabdomen superior es intenso y su control es imprescindible para evitar complicaciones. Objetivos: evaluar la eficacia analgésica y seguridad de dosis única de morfina intratecal en el posoperatorio de la cirugía de hemiabdomen superior de gran envergadura. Método: ensayo clínico aleatorizado a simple ciegas en 40 pacientes, tras intervenciones de hemiabdomen superior. Se emplearon dosis única de morfina intratecal (MIT) de 1 o 2 µg/kg de peso del paciente de acuerdo al grupo de tratamiento. Análisis estadístico con las pruebas Chi cuadrado (x2), exacta de Fisher, análisis de varianza univariado, la prueba de W de Mauchly y la prueba F univariada; nivel de significación de 0,05. Resultados: la administración de opioides durante el acto quirúrgico fue similar en ambos grupos (3,1 ± 2,2 mL vs. 4,1 ± 2,7 mL). En el grupo de dosis de 2 µg/kg de peso de MIT a las 12 y 24 h los pacientes no refirieron dolor; existieron diferencias entre los tratamientos en cuanto al alivio del dolor (p< 0,001) y también entre los momentos en que se midió el mismo (p= 0,001). Se utilizó analgesia de rescate en 25 por ciento de los pacientes. Solo se presentó como complicación la depresión respiratoria. Conclusiones: la dosis única de 2 µg/kg de morfina intratecal es un método eficaz para la analgesia posoperatoria en la cirugía de hemiabdomen superior, la incidencia de complicaciones fue baja y se demostró que ambas dosis son seguras(AU)

Introduction: The superior hemiabdomen postoperative pain is severe and essential to be managed in order to avoid complications. Objectives: To assess the analgesic effectiveness and safety of single-dose intrathecal morphine in the postoperative period of the upper hemiabdomen major surgery. Method: Single-blind randomized clinical trial in 40 patients, after upper hemiabdomen interventions. We used single doses of intrathecal morphine (ITM) of 1 or 2 mg/kg per patient weight according to the treatment group. The statistical analysis used the Chi-square test, Fisher's exact test, univariate analysis of variance, Mauchly's test and Univariate F-test; the significance level was 0.05. Results: Opioids administration during surgery was similar in both groups (3.1 ± 2.2 mL vs. 4.1 ± 2.7 mL). In the 2 mg/kg of ITM dose group, the patients reported no pain after 12 and 14 hours; there were differences between treatments regarding pain relief (p< 0.001) and also between the time when it was measured (p= 0.001). Rescue analgesia was used in 25 percent of the patients. Respiratory depression was the only onset complication. Conclusions: ITM at a single dose of 2 µg/kg is an effective method for postoperative analgesia in upper hemiabdomen surgery, the incidence of complications was low and both doses proved safe(AU)
Descritores: Dor Pós-Operatória/tratamento farmacológico
Dose Única/efeitos dos fármacos
Morfina/uso terapêutico
-Analgesia/normas
Tipo de Publ: Ensaio Clínico Controlado Aleatório
Responsável: CU1.1 - Biblioteca Médica Nacional


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Id: biblio-1038401
Autor: Yazde Puleio, María L; Gómez, Karina V; Majdalani, Ana; Pigliapoco, Vilma; Santos Chocler, Gisella.
Título: Tratamiento opioide del dolor mixto en pacientes pediátricos asistidos por el equipo de Cuidados Paliativos: Cinco años de experiencia / Opioid treatment for mixed pain in pediatric patients assisted by the Palliative Care team: Five years of experience
Fonte: Arch. argent. pediatr;116(1):62-65, feb. 2018.
Idioma: en; es.
Resumo: Introducción: El dolor se define como una experiencia sensorial y emocional desagradable, relacionada con daño tisular actual o potencial. Según su mecanismo fisiopatológico, se clasifica en dolor nociceptivo, neuropático y mixto. Cuando su intensidad es de moderada a grave, se debe administrar un opioide potente, y la morfina es el fármaco de elección. Si resulta ineficaz o aparecen efectos adversos intolerables, se recomienda la rotación de opioide. Nuestro objetivo fue describir el tratamiento farmacológico del dolor mixto en los pacientes asistidos por el equipo de Cuidados Paliativos del Hospital General de Niños Pedro de Elizalde entre agosto de 2011 y septiembre de 2015. Se incluyeron 72 pacientes, con edad media de 10,1 años y la enfermedad de base más frecuente fue patología oncológica. El opioide de inicio fue morfina en 57 casos; 48 recibieron fármacos adyuvantes. La rotación de opioides ocurrió en la mitad de los casos y la más frecuente fue de morfina a metadona.

Pain is defined as an unpleasant sensory and emotional experience associated with actual or potential tissue damage. Depending on its pathophysiological mechanism, it may be classified into nociceptive, neuropathic, and mixed pain. If pain is moderate to severe, a strong opioid should be administered and, when this is the case, morphine is the drug of choice. If morphine is ineffective or causes intolerable adverse effects, opioid rotation is recommended. Our objective was to describe the drug management for mixed pain used in patients assisted by the Palliative Care team of Hospital General de Niños Pedro de Elizalde between August 2011 and September 2015. A total of 72 patients were included. Their mean age was 10.1 years, and the most common underlying disease was cancer. The initial opioid was morphine in 57 cases; 48 patients received adjuvant drugs. Opioid rotation was indicated in half of cases, and the most common switch was from morphine to methadone.
Descritores: Dor
Cuidados Paliativos
Criança
Analgésicos Opioides
Metadona
Morfina
Limites: Seres Humanos
Criança
Tipo de Publ: Relatos de Casos
Responsável: AR94.1 - Centro de Información Pediatrica


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Id: biblio-991014
Autor: Busto Lugo, Patricia I; Montero Quesada, Néstor; Hernández Pérez, José M.
Título: Efectividad de la anestesia espinal con morfina y bupivacaína en la cirugía de próstata / Effectiveness of spinal anesthesia with morphine and bupivacaine in prostate surgery
Fonte: Rev. cuba. anestesiol. reanim;17(1):1-9, ene.-abr. 2018. ilus, tab.
Idioma: es.
Resumo: Introducción: El dolor posoperatorio constituye la principal causa de dolor agudo en el mundo. Brindar analgesia adecuada en el posquirúrgico garantiza la disminución del tiempo de estancia hospitalaria y tiene un impacto positivo en el resultado final de los pacientes. Objetivo: Evaluar la calidad de la analgesia posoperatoria con bupivacaína más morfina intratecal en la cirugía electiva de próstata, así como la incidencia de efectos adversos. Métodos: Se realizó una investigación cuasiexperimental, entre enero de 2014 y julio de 2017. La muestra quedó conformada de manera no probabilística por los pacientes que dieron su consentimiento informado y reunieron criterios para entrar en el estudio. Quedaron distribuidos de manera aleatoria en dos grupos denominados bupivacaína (B) y morfina-bupivacaína (MB). Para recolectar la información se emplearon las historias clínicas anestésicas y un formulario elaborado al efecto. Los datos se mostraron en tablas y gráficos, los resultados se expresaron numéricamente y en porcientos, se determinaron algunas medidas descriptivas de interés que mostraron el comportamiento de las variables que lo requirieron. Resultados: El resultado más relevante fue el efecto analgésico muy significativo en el grupo MB en las primeras 24 h del posoperatorio. La reacción adversa más frecuente fue el prurito y solo se presentó en el grupo que recibió morfina. Conclusiones: La anestesia espinal con morfina y bupivacaína es efectiva y segura, proporcionando mejor analgesia en el posoperatorio inmediato cuando se compara con bupivacaína sola(AU)

Introduction: Postoperative pain is the main cause of acute pain worldwide. Providing adequate analgesia postoperatively guarantees hospital stay reduction and positively affects patient outcome. Objective: To evaluate the quality of postoperative analgesia with bupivacaine plus intrathecal morphine in elective prostate surgery, as well as the incidence of adverse effects. Methods: A quasiexperimental research was carried out between January 2014 and July 2017. The sample was chosen in a non-probabilistic way and made up by the patients who gave their informed consent and met the inclusion criteria to enter the study. They were randomly distributed into two groups identified as bupivacaine (B) and morphine-bupivacaine (MB). To collect the information, the anesthetic medical records were used, together with a form prepared for such purpose. The data were shown in charts and graphs, the results were expressed numerically and in percentages, some descriptive measures of interest were determined that showed the behavior of the variables that required it. Results: The most relevant outcome was the very significant analgesic effect in the MB group in the first 24 hours after surgery. The most common adverse reaction was pruritus and only occurred in the group that received morphine. Conclusions: Spinal anesthesia with morphine and bupivacaine is effective and safe because it provides better analgesia in the immediate postoperative period in comparison to bupivacaine alone(AU)
Descritores: Dor Pós-Operatória/tratamento farmacológico
Bupivacaína/uso terapêutico
Analgésicos Opioides/uso terapêutico
Morfina/uso terapêutico
-Prostatectomia/métodos
Estudos Prospectivos
Estudos Longitudinais
Efeitos Adversos de Longa Duração/epidemiologia
Limites: Seres Humanos
Masculino
Meia-Idade
Idoso
Responsável: CU1.1 - Biblioteca Médica Nacional


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Id: biblio-951926
Autor: María, Espinosa Bosch; Fuensanta, Sánchez Rojas; Catalina, Bosch Ojeda.
Título: Determination of compatibility and stability of haloperidol and morphine mixtures used in palliative care
Fonte: Braz. J. Pharm. Sci. (Online);54(2):e17352, 2018. tab, graf.
Idioma: en.
Projeto: Consejería de Igualdad Salud y Políticas Sociales.
Resumo: Abstract With the aim of controlling various symptoms, possible to use mixtures of different drugs within infusion devices. This should take into account the compatibility of the mixture. Factors influence the compatibility and stability of the mixtures are: drug type, concentration, solvent, temperature and light. When evaluating the compatibility of the mixtures for infusion for subcutaneous via is important to consider infusion devices used and the conditions of light and temperature should simulate as far as possible the conditions in practice assistance. There are diverse studies that analyze the compatibility of drug mixtures, but there are still many possible combinations of drugs for which evidence is not available. The objective of this work is to study the compatibility and stability of several mixtures of haloperidol and morphine that can be used in solution for subcutaneous infusion.
Descritores: Haloperidol/análise
Morfina/análise
-Cuidados Paliativos/classificação
Combinação de Medicamentos
Estabilidade de Medicamentos
Responsável: BR1.1 - BIREME


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Id: biblio-951914
Autor: Pires, Júlia Movilla; Mendes, Fúlvio Rieli; Pires, Ana Paula Salum; Yonamine, Maurício; Amaral, José Luiz Gomes do; Carlini, Elisaldo Araújo.
Título: Pre-clinical interaction of ayahuasca, a brew used in spiritual movements, with morphine and propofol
Fonte: Braz. J. Pharm. Sci. (Online);54(1):e17174, 2018. tab, graf.
Idioma: en.
Projeto: FAPESP.
Resumo: ABSTRACT Ayahuasca is a beverage with psychoactive properties used in religious and ceremonial rituals by some religious groups. The main active components of ayahuasca are dimethyltryptamine and the harmala alkaloids with ß-carboline structure acting as monoamine oxidase A inhibitors. This combination produces a pronounced activation of serotonergic pathways and presents potential interaction with other psychotropics. The objective of this study was to investigate the possible interactions between ayahuasca and agents employed in general anesthesia. The pharmacological interactions between ayahuasca and morphine or propofol were evaluated in mice using doses of 12, 120 and 1200 mg/kg (0.1 to 10 times the average dose consumed by humans in religious rituals). Ayahuasca alone showed an antinociceptive effect in the writhing and formalin tests, and intensified the analgesic effect of morphine in the hot plate test. Concerning the pharmacological interactions between ayahuasca and propofol, the results were opposite; ayahuasca intensified the depressant effect of propofol in the rotarod test, but decreased the sleeping time induced by propofol. These set of results showed the occurrence of some interactions between ayahuasca and the drugs morphine and propofol, possibly by both pharmacokinetics and pharmacodynamics mechanisms
Descritores: Interações Medicamentosas
Avaliação Pré-Clínica de Medicamentos
Morfina/análise
-Bebidas/efeitos adversos
Propofol/análise
Banisteriopsis/efeitos adversos
Psychotria/efeitos adversos
Analgésicos/efeitos adversos
Limites: Animais
Masculino
Camundongos
Responsável: BR1.1 - BIREME


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Id: biblio-893150
Autor: Jalili, Cyrus; Makalani, Fatemeh; Roshankhah, Shiva; Sohrabi, Khadije; Salahshoor, Mohammad Reza.
Título: Protective effect of resveratrol against morphine damage to kidneys of mice / Efecto protector de resveratrol contra el daño de la morfina en riñones de ratones
Fonte: Int. j. morphol;35(4):1409-1415, Dec. 2017. graf.
Idioma: en.
Projeto: Kermanshah University of Medical Sciences.
Resumo: SUMMARY: Morphine produces free radicals and cause apoptosis in some cell. Resveratrol (RSV) is a stilbenoid, a type of natural phenol, and a phytoalexin produced by several plants in response to injury. 48 male mice were randomly assigned to 8 groups. In this study, various doses of RSV (2, 8 and 20 mg/kg) and RSV plus Morphine (2, 8 and 20 mg/kg) were administered intraperitoneally to male mice for 20 consequent days and weight of kidneys, biochemical characteristics, morphometric markers and blood serum nitric oxide level were studied. The results indicated that morphine administration significantly increased the mean diameter of glomerulus and distal and proximal convoluted tubule, Lactate dehydrogenase (LDH), Blood urea nitrogen (BUN), creatinine and nitric oxide levels compared to the saline group (P<0.05). However, RSV and RSV plus morphine in all doses significantly decreased glomeruli number and LDH, BUN, creatinine and nitric oxide levels compared to morphine groups (p<0.05). Thus, it seems that resveratrol improved kidney damages induced by morphine in mice.

RESUMEN: La morfina produce radicales libres y causa apoptosis en algunas células. El resveratrol (RSV) es un tipo de fenol natural y una fitoalexina producida por varias plantas en respuesta a una lesión. Se asignaron al azar 48 ratones machos a 8 grupos. En este estudio se administraron varias dosis de RSV (2, 8 y 20 mg/kg) y RSV más morfina (2, 8 y 20 mg/kg) intraperitoneal en ratones machos durante 20 días consecutivos y se estudió el peso de los riñones, las características bioquímicas, los marcadores morfométricos y el nivel de óxido nítrico en suero sanguíneo. Los resultados indicaron que la administración de morfina aumentó significativamente el diámetro medio del glomérulo y de los túbulos distal y proximal, los niveles de lactato deshidrogenasa (LDH), nitrógeno ureico en sangre (BUN), la creatinina y el óxido nítrico en comparación con el grupo salino (p <0,05). Sin embargo, el RSV y el RSV más morfina en todas las dosis redujeron significativamente el número de glomérulos y LDH, BUN, la creatinina y el óxido nítrico en comparación con los grupos de morfina (p <0,05). Por lo tanto, los resultados podrían indicar que el resveratrol mejoró el daño renal inducido por la morfina en ratones.
Descritores: Estilbenos/administração & dosagem
Rim/efeitos dos fármacos
Morfina/toxicidade
-Creatinina/sangue
Glomérulos Renais/efeitos dos fármacos
Camundongos Endogâmicos BALB C
Óxido Nítrico/sangue
Limites: Animais
Masculino
Camundongos
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-893139
Autor: Jalili, Cyrus; Salahshoor, Mohammad Reza; Jalili, Faramarz; Kakabaraei, Seyran; Akrami, Ali; Sohrabi, Maryam; Ahookhash, Maryam; Ghanbari, Ali.
Título: Therapeutic effect of resveratrol on morphine-induced damage in male reproductive system of mice by reducing nitric oxide serum level / Efecto terapéutico de resveratrol sobre el daño inducido por la morfina en el sistema reproductor masculino de ratones reduciendo el nivel de óxido nítrico del suero
Fonte: Int. j. morphol;35(4):1342-1347, Dec. 2017. tab, graf.
Idioma: en.
Projeto: Kermanshah University of Medical Sciences.
Resumo: SUMMARY: Morphine is one of the naturally occurring phenanthrene alkaloids of opium that induces adverse effects on male reproductive system. Resveratrol is a phytoestrogen and antioxidant of red grape. The main goal is to investigate whether resveratrol could inhibit adverse effects of morphine on sperm cell viability, count, motility as well as testis histology, testosterone hormone and nitric oxide levels in mice. In the present study, 48 male rats were randomly divided into 8 groups (n=6) and were treated intraperitoneally for 14 days with normal saline, resveratrol (2, 8, 20 mg/kg/day), morphine (20 mg/kg/day) and morphine (20 mg/kg/day) + resveratrol (2, 8, 20 mg/kg/day). At the end of experiments, sperm parameters (sperm cell viability, count, motility and morphology), testis weight, the diameter of seminiferous tubules, testosterone hormone level and nitric oxide were analyzed. The data were analyzed by SPSS software for windows (version 20) using one-way ANOVA test followed by Tukey's post hoc test, and P<0.05 was considered significant. The results indicated that morphine administration significantly decreased testosterone level, count, viability and motility of sperm cells and testis weight and increased nitric oxide compared to the saline group (P=0.000). Administration of resveratrol and resveratrol plus morphine significantly increased motility, count and viability of sperm cells, somniferous tubule diameter and testosterone, while it decreased nitric oxide level compared to morphine group (P=0.025). It seems that resveratrol administration could increase the quality of spermatozoa and prevented morphine-induced adverse effects on sperm parameters.

RESUMEN: La morfina es uno de los alcaloides fenantreno del opio que induce efectos adversos en el sistema reproductivo masculino. El resveratrol es un fitoestrógeno y antioxidante de la uva roja. El objetivo principal de este trabajo fue investigar si el resveratrol puede inhibir los efectos adversos de la morfina sobre la viabilidad celular de los espermatozoides, el recuento y la motilidad, así como la histología de los testículos, la hormona testosterona y los niveles de óxido nítrico en ratones. Se dividieron, aleatoriamente, 48 ratas machos en 8 grupos (n = 6) y se trataron de forma intraperitoneal durante 14 días con solución salina normal, resveratrol (2, 8, 20 mg / kg / día), morfina (20 mg / kg / día ) y morfina (20 mg / kg / día) + resveratrol (2, 8, 20 mg / kg / día). Al final de los experimentos, se analizaron los parámetros espermáticos (viabilidad celular, recuento, motilidad y morfología), el peso de los testículos, el diámetro de los túbulos seminíferos, el nivel de la hormona testosterona y el óxido nítrico. Los datos fueron analizados con el software de SPSS para Windows (versión 20) usando una prueba de ANOVA de una vía seguida de la prueba post hoc de Tukey, y P <0,05 se consideró significativo. Los resultados indicaron que la administración de morfina disminuyó significativamente el nivel de testosterona, el recuento, la viabilidad y la motilidad de los espermatozoides y el peso de los testículos, además del aumento de óxido nítrico en comparación con el grupo salino (p = 0,000). La administración de resveratrol y resveratrol más morfina aumentó significativamente la motilidad, el recuento y la viabilidad de los espermatozoides, el diámetro de los túbulos seminíferos y la testosterona, mientras que disminuyó el nivel de óxido nítrico comparado con el grupo morfina (p = 0,025). En conclusión, la administración de resveratrol podría aumentar la calidad de los espermatozoides y prevenir los efectos adversos inducidos por la morfina sobre los parámetros espermáticos.
Descritores: Estilbenos/administração & dosagem
Genitália Masculina/efeitos dos fármacos
Morfina/toxicidade
-Motilidade Espermática
Espermatogênese/efeitos dos fármacos
Testículo/efeitos dos fármacos
Testosterona/sangue
Óxido Nítrico/sangue
Limites: Animais
Masculino
Ratos
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1011275
Autor: Andrade, N. R; Santos, B. C. P; Caires, L. P; Azevedo, M. C; Martins Filho, E. F; Sande, J. Q; Costa Neto, J. M; Barbosa, V. F.
Título: Ropivacaína isolada ou associada à metadona ou à morfina, pela via epidural, em cadelas submetidas à ovário-histerectomia / Ropivacaine sole or associated to methadone or morphine, by epidural route, in bitches undergoing ovariohysterectomy
Fonte: Arq. bras. med. vet. zootec. (Online);71(2):430-438, mar.-abr. 2019. tab, ilus.
Idioma: pt.
Resumo: Objetivou-se avaliar os efeitos fisiológicos, sedativos e analgésicos da administração peridural de ropivacaína isolada ou associada à morfina ou à metadona. Para tal, 24 cadelas submetidas à ovário-histerectomia receberam acepromazina, e a anestesia foi induzida e mantida com propofol e isoflurano (FiO2 = 1,0), respectivamente. De acordo com o protocolo peridural, formaram-se três grupos de igual número: GR (ropivacaína - 2,0mg/kg); GRMETA (ropivacaína - 2,0mg/kg e metadona - 0,3mg/kg) e GRMORF (ropivacaína - 2,0mg/kg e morfina - 0,1mg/kg). Registraram-se os parâmetros fisiológicos intraoperatórios e os graus de sedação e analgesia pós-operatórios. No GR constataram-se maiores médias de pressões arteriais 30 minutos após a anestesia epidural em relação ao GRMETA (sistólica e média) e ao final do procedimento cirúrgico comparativamente ao GRMORF (sistólica, diastólica e média). Não foram observadas diferenças significativas entre os grupos relativamente à analgesia e ao grau de sedação pós-operatórios. A administração epidural de ropivacaína é segura e eficaz e proporciona boa analgesia, independentemente da sua associação com morfina ou metadona.(AU)

The aim of this study was to evaluate the physiological, sedative and analgesic effects of epidural administration of ropivacaine sole or associated to morphine or methadone. Twenty-four bitches were submitted to ovariohysterectomy and received acepromazine and after, propofol and isoflurane (FiO 2 = 1.0) for anesthesia induction and maintenance, respectively. Based on established epidural protocol (L7-S1), three groups were formed: GR (ropivacaine - 2.0mg/kg); GRMETA (ropivacaine - 2.0mg/kg and methadone - 0.3mg/kg) and GRMORF (ropivacaine - 2.0mg/kg and morphine - 0.1mg/kg). Intraoperative physiological parameters and degrees of postoperative sedation and analgesia were recorded. In the GR, the means of arterial pressures, 30 minutes after epidural anesthesia, were higher compared with GRMETA (systolic and mean) and, at the end of the clinical procedure, compared to GRMORF (systolic, diastolic and mean). Differences between groups were not observed for postoperative analgesia and degree of sedation. Epidural administration of ropivacaine is safe and effective and provides good analgesia regardless of its association with morphine or methadone.(AU)
Descritores: Ovariectomia/veterinária
FRESH WATERABDOMINAL INJURIES
Histerectomia/veterinária
Anestesia Epidural/veterinária
Metadona
Morfina
-Analgésicos Opioides/administração & dosagem
Limites: Animais
Feminino
Cães
Responsável: BR68.1 - Biblioteca Virginie Buff D'Ápice


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Id: biblio-1021003
Autor: Costa, Paula Ferreira da; Moro, Juliana Vitti; Ortiz, Edna Mireya Gómez; Chung, Denise Granato; Nunes, Newton.
Título: Parâmetros ventilométricos e hemogasométricos em cadelas submetidas à ovário-histerectomia, pré-medicadas com tramadol ou morfina e anestesiadas com isofluorano / Ventilometric parameters and arterial blood gases in bitches undergoing ovariohisterectomy, pre-medicated with morphine or tramadol and anesthetized with isoflurane
Fonte: Rev. bras. ciênc. vet;21(4):167-172, out.-dez.2014. il..
Idioma: pt.
Resumo: Avaliaram-se os efeitos nos parâmetros ventilométricos e hemogasométricos em cadelas submetidas à ovário-histerectomia (OHE), pré-medicadas com tramadol ou morfina e anestesiadas com isofluorano. Utilizaram-se 12 cadelas sem raça definida (SRD), divididas em dois grupos (n= 6 para cada grupo), todas com indução anestésica com propofol e manutenção com isofluorano em O2 a 100%, sendo que a diferença entre os grupos se deu pela pré-medicação com tramadol (GT ­ 4mg/kg IM) ou morfina (GM ­ 0,4 mg/kg IM). As observações das variáveis iniciaram-se 30 minutos após a administração do bolus de propofol (M0). As demais colheitas dos dados foram realizadas em intervalos de 15 minutos, por um período de 60 minutos (M15, M30, M45 e M60, respectivamente). Não foram encontradas diferenças significativas entre os grupos ou momentos para as variáveis hemogasométricas, entretanto, as médias de pH, déficit de base (DB) e pressão parcial de dióxido de carbono no sangue arterial (PaCO2 ) ficaram fora da faixa normal para a espécie canina. Foram encontradas diferenças significativas para as variáveis: volume corrente (GM > GT de M0 a M60), pico de fluxo inspiratório e expiratório (GM > GT) e pressão de pico inspiratório, sendo que GM foi maior que GT em M0. Concluiu-se que ambos os opioides são seguros, não causando alterações importantes na ventilometria quando utilizados na pré-medicação em cadelas anestesiadas com isofluorano e submetidas à OHE, porém, a anestesia inalatória com isofluorano deve ser utilizada com cautela em animais com propensão à acidemia.

We evaluated the effects on blood gas and ventilometric parameters in bitches undergoing ovariohysterectomy (OHE), pre-medicated with morphine or tramadol and anesthetized with isoflurane. We used 12 mongrel dogs, distributed into two groups (n = 6 for each group), all with induction of anesthesia with propofol and maintained with isoflurane in 100% O2, and the difference between groups was given by premedication with tramadol (GT - 4mg/kg IM) or morphine (GM - 0.4 mg / kg IM). The measurement of all variables was performed 30 minutes after propofol bolus (M0), and then, in intervals of 15 minutes, during 60 minutes (M15, M30, M45 and M60). No significant differences were found between groups or times for the gas variables, however pH, PaCO2 and DB were outside the normal range for dogs. Significant differences were found for the variables: tidal volume (GM> GT M0 to M60), peak inspiratory and expiratory flow (GM> GT) and peak inspiratory pressure (GM was higher than GT in M0). It was concluded that both opioids are safe and will not cause major changes in ventilometry when used in premedication in dogs anesthetized with isoflurane and submitted to OHE, however, inhalation anesthesia with isoflurane should be used with caution in animals with a tendency to acidemia. .
Descritores: Ovário
Tramadol
Gasometria
Analgésicos Opioides
Histerectomia
Isoflurano
Anestésicos
Morfina
Limites: Animais
Responsável: BR409.1 - Biblioteca



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