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Id: biblio-1249173
Autor: Wang, Fang; Mo, Zhaohui.
Título: NLRP3 inflammasome in metabolic syndrome
Fonte: Braz. J. Pharm. Sci. (Online);56:e18968, 2020.
Idioma: en.
Projeto: Third Xiangya Hospital of Central South University.
Resumo: Metabolic syndrome (MS) is a serious health problem worldwide; it is characterized by a group of metabolic disorders, including central obesity, insulin resistance/type 2 diabetes, hyperlipidemia with accelerated atherosclerosis, hypertension, non-alcoholic fatty liver disease, and elevated uric acid with increased risk of gout. The incidence of MS has increased considerably in recent decades and has attracted considerable attention. A number of clinical and translational laboratory studies have implicated the activation of nucleotide-binding domain and leucine-rich repeat protein 3 (NLRP3) inflammasome in the development of MS, therefore establishing a strong link between chronic inflammation and metabolic diseases. This paper aims to review new developments on NLRP3 inflammasome in MS for better understanding of chronic inflammation in metabolic diseases. We will also provide new insights into using NLRP3 inflammasome as an innovative therapeutic target.
Descritores: Inflamassomos/farmacologia
Doenças Metabólicas/patologia
-Ácido Úrico/efeitos adversos
Resistência à Insulina/fisiologia
Síndrome Metabólica/patologia
Diabetes Mellitus Tipo 2/patologia
Aterosclerose/patologia
Obesidade Abdominal/patologia
Hipertensão/patologia
Responsável: BR40.1 - DBD - Divisão de Biblioteca e Documentacão do Conjunto das Químicas


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Id: biblio-1093423
Autor: Céspedes Miranda, Ela María; Rodríguez Guzmán, Roger; Suárez Castillo, Niurelkis.
Título: Ácido úrico en la disfunción endotelial y la insulinorresistencia en la enfermedad cardiovascular / Uric acid in endothelial dysfunction and insulin resistance in cardiovascular disease
Fonte: Rev. cuba. invest. bioméd;38(4):e241, oct.-dic. 2019. graf.
Idioma: es.
Resumo: .La determinación de la concentración de ácido úrico se realiza con frecuencia en los servicios de salud. Los niveles plasmáticos de ácido úrico se han asociado con las enfermedades cardiovasculares, y con sus factores de riesgo. Sin embargo, la relevancia de esta asociación aún es controvertida, razón por la que se propone fundamentar la relación entre el ácido úrico, el estrés oxidativo y mecanismos involucrados en la enfermedad cardiovascular. Se realizó la búsqueda de la información mediante las bases de datos de diferentes buscadores (Medline-PubMed, Cochrane, Scielo). La hiperuricemia estimula la producción de especies reactivas oxidantes intracelulares y la reacción del ácido úrico con el óxido nítrico se relaciona con la disfunción endotelial y la resistencia a la insulina. Los niveles de ácido úrico se asocian con la hipertensión arterial, la diabetes mellitus, el síndrome metabólico y la enfermedad cardiovascular. Se considera además, que el ácido úrico es un factor de riesgo independiente para eventos cardiovasculares y un predictor de la morbilidad y la mortalidad por estas enfermedades, aunque se requiere de estudios de intervención con hipouricémicos o uricosúricos para el análisis de los beneficios que pudiera representar modificar la concentración de ácido úrico en sangre en determinadas condiciones(AU)

. The determination of the concentration of uric acid is often performed in health services. Plasma uric acid levels have been associated with cardiovascular diseases, and with their risk factors. However, the relevance of this association is still controversial, which is why it is proposed to base the relationship between uric acid, oxidative stress and mechanisms involved in cardiovascular disease. The information was searched through the databases of different search engines (Medline-PubMed, Cochrane, Scielo). Hyperuricemia stimulates the production of intracellular oxidizing reactive species and the reaction of uric acid with nitric oxide is related to endothelial dysfunction and insulin resistance. Uric acid levels are associated with high blood pressure, diabetes mellitus, metabolic syndrome and cardiovascular disease. It is also considered that uric acid is an independent risk factor for cardiovascular events and a predictor of morbidity and mortality from these diseases, although intervention studies with hypouricemic or uricosuric tests are required for the analysis of the benefits that could represent modify the concentration of uric acid in blood under certain conditions(AU)
Descritores: Ácido Úrico
Resistência à Insulina
Doenças Cardiovasculares
Síndrome Metabólica
Hiperuricemia
Óxido Nítrico
Limites: Humanos
Tipo de Publ: Revisão
Responsável: CU1.1 - Biblioteca Médica Nacional


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Id: biblio-1282099
Autor: Nwankwo, Victor Omoha; Uraku, Anayo Joseph; Famurewa, Ademola Clement; Uraku, Oluchi Helen.
Título: Assessment of nephrotoxicity and histopathological lesions of albino rats exposure to DD-force and baygon insecticides / Evaluación de la nefrotoxicidad y lesiones histopatológicas tras la exposición de ratas Albino a los insecticidas DD-Force y Baygon
Fonte: Int. j. med. surg. sci. (Print);4(4):1251-1258, dic. 2017. ilus, graf.
Idioma: en.
Resumo: Although studies suggest adverse effects of pesticides, human exposure to insecticides in homes is increasing and reports on their health effects are limited. The study investigated nephrotoxic effects of organo phosphate and carbamate insecticides, DD-Force and Baygon, in albino rats. Forty-five albino rats divided into groups were exposed to DD-Force (dichlorvos) or Baygon (propoxur) indoor insecticidein wooden boxes in separate exposure duration of 1, 2, 3 and 4 hours/day for 14 consecutive days. Serum and kidney tissue obtained after sacrifice were used to determine markers of renal damage and histopathological analysis, respectively. Exposure of rats to the insecticides showed duration-dependent significant increases (p<0.05) in serum levels of urea, uric acid and creatinine compared to control. However, rats exposed to DD-Force insecticide induced significantly higher levels of urea, uric acid and creatinine compared to Baygon (p<0.05). Histopathological lesions were observed in rats exposed to the insecticides, particularly in the exposure duration of 3 or 4 hours/day. These findings suggest that acute exposure to DD-Force and Baygonis nephrotoxic and may induce renal damage in rats.

Aunque los estudios sugieren efectos adversos de los pesticidas, la exposición humana a los insecticidas en los hogares está aumentando y los informes sobre sus efectos sobre la salud son limitados. Este estudio investigó los efectos nefrotóxicos de los insecticidas órgano fosfato y carbamato, DD-Force y Baygon, en ratas albinas. Cuarenta y cinco ratas albinas divididas en grupos fueron expuestas a DD-Force (diclorvos) o Baygon (propoxur) insecticidas de interior en cajas de madera en una duración de exposición separada de 1, 2, 3 y 4 horas / día durante 14 días consecutivos. Muestras séricas y de tejido renal obtenidas después del sacrificio se utilizaron para determinar los marcadores de daño renal y el análisis histopatológico, respectivamente. La exposición de las ratas a los insecticidas mostró aumentos significativos dependientes de la duración (p<0.05) en los niveles séricos de urea, ácido úrico y creatinina en comparación con el control. Sin embargo, las ratas expuestas al insecticida DD-Force indujeron niveles significativamente más altos de urea, ácido úrico y creatinina en comparación con Baygon (p<0.05). Se observaron lesiones histopatológicas en ratas expuestas a los insecticidas, particularmente en la duración de exposición de 3 o 4 horas/día. Estos hallazgos sugieren que la exposición aguda a DD-Force y Baygonis nephrotóxico y puede inducir daño renal en ratas.
Descritores: Propoxur/toxicidade
Diclorvós/toxicidade
Inseticidas Organoclorados/efeitos adversos
Inseticidas/toxicidade
Nefropatias/induzido quimicamente
-Ureia/sangue
Ácido Úrico/sangue
Creatinina/sangue
Nefropatias/patologia
Limites: Ratos
Responsável: CL61.1 - Biblioteca Central Campus Sur


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Id: lil-785740
Autor: Oguz, Ural; Takci, Zennure; Oguz, Isil Deniz; Resorlu, Berkan; Balta, Ilknur; Unsal, Ali.
Título: Are patients with lichen planus really prone to urolithiasis? Lichen planus and urolithiasis
Fonte: Int. braz. j. urol;42(3):571-577tab.
Idioma: en.
Resumo: ABSTRACT Purpose to investigate whether patients with lichen planus (LP) are really prone to urolithiasis or not. Patients and Methods We performed a prospective analysis of 40 patients diagnosed with lichen planus (LP) (group I), and 40 volunteers did not have LP before (group II). Participants were all checked for urolithiasis by radiological investigations. Blood samples were analyzed for biochemistry parameters including calcium and uric acid. 24-h urine samples were analyzed to investigate oxalate, citrate calcium, uric acid, magnesium, sodium and creatinine. Results Men/women ratio and mean age were similar between group I and II (p>0.05). A presence or history of urolithiasis was detected in 8 (20%) and 2 (%5) patients in group I and II, respectively (p<0.05). Hypocitraturia was the most common anomaly with 35% (n:14) in group I. The rate of hypocitraturia in group II was 12.5% (n:5) and the difference was statistically significantly different (p=0.036). In group I, hyperuricosuria and hyperoxaluria followed with rates of 27.5% (n:11) and 25% (n:10), respectively. The rate of hyperuricosuria and hyperoxaluria were both 5% (n:2) in group II and the differences were significant (p<0.05). Hyperuricemia was another important finding in the patients with LP. It was detected in 13 (32.5%) patients in group I and in 1 (2.5%) participant in group II (p=0.001). Conclusion According to our results, metabolic disorders of urolithiasis were highly detected in the patients with LP. However, similar to the etiology of LP, the exact reasons for these metabolic abnormalities in LP remain a mystery.
Descritores: Urolitíase/etiologia
Líquen Plano/complicações
-Oxalatos/urina
Valores de Referência
Sódio/urina
Ácido Úrico/urina
Ácido Úrico/sangue
Estudos de Casos e Controles
Cálcio/sangue
Estudos Prospectivos
Fatores de Risco
Urinálise
Citrato de Cálcio/urina
Creatinina/urina
Urolitíase/urina
Líquen Plano/urina
Magnésio/urina
Doenças Metabólicas/complicações
Doenças Metabólicas/urina
Pessoa de Meia-Idade
Limites: Humanos
Masculino
Feminino
Adulto
Idoso
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: biblio-954079
Autor: Pucci, Nidia D; Marchini, Giovanni S; Mazzucchi, Eduardo; Reis, Sabrina T; Srougi, Miguel; Evazian, Denise; Nahas, William C.
Título: Effect of phyllanthus niruri on metabolic parameters of patients with kidney stone: a perspective for disease prevention
Fonte: Int. braz. j. urol;44(4):758-764, July-Aug. 2018. tab.
Idioma: en.
Resumo: ABSTRACT Phyllanthus niruri (P.niruri) or stone breaker is a plant commonly used to reduce stone risk, however, clinical studies on this issue are lacking. Objective: To prospectively evaluate the effect of P. niruri on the urinary metabolic parameters of patients with urinary lithiasis. Materials and Methods: We studied 56 patients with kidney stones <10mm. Clinical, metabolic, and ultrasonography assessment was conducted before (baseline) the use of P. niruri infusion for 12-weeks (P. niruri) and after a 12-week (wash out) Statistical analysis included ANOVA for repeated measures and Tukey's/McNemar's test for categorical variables. Significance was set at 5%. Results: Mean age was 44±9.2 and BMI was 27.2±4.4kg/m2. Thirty-six patients (64%) were women. There were no significant changes in all periods for anthropometric and several serum measurements, including total blood count, creatinine, uric acid, sodium, potassium, calcium, urine volume and pH; a significant increase in urinary potassium from 50.5±20.4 to 56.2±21.8 mg/24-hour (p=0.017); magnesium/creatinine ratio 58±22.5 to 69.1±28.6mg/gCr24-hour (p=0.013) and potassium/creatinine ratio 39.3±15.1 to 51.3±34.7mg/gCr24-hour (p=0.008) from baseline to wash out. The kidney stones decreased from 3.2±2 to 2.0±2per patient (p<0.001). In hyperoxaluria patients, urinary oxalate reduced from 59.0±11.7 to 28.8±16.0mg/24-hour (p=0.0002), and in hyperuricosuria there was a decrease in urinary uric acid from 0.77±0.22 to 0.54±0.07mg/24-hour (p=0.0057). Conclusions: P.niruri intake is safe and does not cause significant adverse effects on serum metabolic parameters. It increases urinary excretion of magnesium and potassium caused a significant decrease in urinary oxalate and uric acid in patients with hyperoxaluria and hyperuricosuria. The consumption of P.niruri contributed to the elimination of urinary calculi.
Descritores: Cálculos Renais/metabolismo
Cálculos Renais/prevenção & controle
Phyllanthus/química
Chás de Ervas
-Oxalatos/urina
Potássio/urina
Potássio/sangue
Valores de Referência
Sódio/urina
Sódio/sangue
Ureia/urina
Ureia/sangue
Ácido Úrico/urina
Ácido Úrico/sangue
Cálculos Renais/diagnóstico por imagem
Cálcio/urina
Cálcio/sangue
Estudos Prospectivos
Reprodutibilidade dos Testes
Análise de Variância
Resultado do Tratamento
Creatinina/urina
Creatinina/sangue
Magnésio/urina
Pessoa de Meia-Idade
Limites: Humanos
Masculino
Feminino
Adulto
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: biblio-1130574
Autor: Servetto, Cristina; Bidegain, Estela; Da Rosa, Laura; Lopez, Elizabeth; Pintos, Cristina; Yametti, Laura; Pereyra, Natalia; Lena, Ana; Fernandez, Lucia.
Título: Valores de referencia de analitos en orina en la edad pediatrica / Reference values of analytes in urine in the pediatric age / Valores de referência de analitos na urina na idade pediátrica
Fonte: Acta bioquím. clín. latinoam;54(1):13-18, mar. 2020. graf, tab.
Idioma: es.
Resumo: La deteccion de trastornos metabolicos minerales puede explicar diversas anomalias fisiologicas que exigen para su interpretacion la comparacion con valores de referencia validados. El objetivo de este trabajo fue la determinacion de valores de referencia en la poblacion infantil uruguaya, de los analitos sodio, potasio, calcio, magnesio, fosforo y urato relacionados con la creatinina en muestras de la segunda miccion de la manana en 470 escolares (240 ninas y 230 ninos) con edades comprendidas entre 7 y 12 anos. Las medianas obtenidas fueron: Na/Crea: 139 mmol/g, K/Crea: 78 mmol/g, Ca/Crea: 77 mg/g, Mg/Crea: 71 mg/g, P/Crea: 500 mg/g, Ur/Crea: 554 mg/g, Crea: 117 mg/dL. A excepcion de los cocientes Na/Crea y K/Crea se encontro una disminucion de la excrecion de estos analitos con la edad, independientemente del sexo. Los valores obtenidos resultaron ser analogos a los de otras poblaciones con tipo de alimentacion similar.

The detection of mineral metabolic disorders can explain several pathologies which require the comparison with reference values for their interpretation. The aim of this study was to determine the reference values of 470 Uruguayan school children with ages between 7 and 12 for sodium, potassium, calcium, magnesium, phosporous and urate and their relationship with creatinine in urine samples of the second urination of the morning. The median obtained were: Na/Crea: 139 mmol/g, K/Crea: 78 mmol/g, Ca/Crea: 77 mg/g, Mg/Crea: 71 mg/g, P/Crea: 500 mg/g, Ur/Crea: 554 mg/g, Crea: 117 mg/dL. A diminishment of excretion with the age was found, regardless the sex, except for Na/Crea and K/Crea. The values obtained were similar to those of others populations with a similar diet.

A detecção de distúrbios metabólicos minerais pode explicar várias anomalias fisiológicas, que exigem a comparação com valores de referência validados para serem interpretados. O objetivo deste estudo foi determinar valores de referência na população infantil uruguaia, dos analitos sódio, potássio, cálcio, magnésio, fósforo e urato relacionados com a creatinina em amostras da segunda micção da manhã em 470 alunos (240 meninas e 230 meninos) com idades entre 7 e 12 anos. As medianas obtidas foram: Na/Crea: 139 mmol/g, K/Crea: 78 mmol/g, Ca/Crea: 77 mg/g, Mg/Crea: 71 mg/g, P/Crea: 500 mg/g, Ur/Crea: 554 mg/g, Crea: 117 mg/dL. Com exceção dos quocientes Na/Crea e K/Crea, foi encontrada uma diminuição na excreção destes analitos com a idade independentemente do sexo. Os valores obtidos foram análogos aos de outras populações com um tipo similar de dieta.
Descritores: Valores de Referência
Urina/química
-Fósforo
Potássio
Sódio
Estudantes
Ácido Úrico
Cálcio
Determinação
Creatinina
Dieta
Magnésio
Minerais
Limites: Humanos
Masculino
Feminino
Criança
Tipo de Publ: Ensaio Clínico
Responsável: AR144.1 - CIBCHACO - Centro de Información Biomedica del Chaco


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Id: biblio-1056356
Autor: Wang, Shu; Zhang, Yitian; Zhang, Xin; Tang, Yuzhe; Li, Jianxing.
Título: Upper urinary tract stone compositions: the role of age and gender
Fonte: Int. braz. j. urol;46(1):70-80, Jan.-Feb. 2020. tab, graf.
Idioma: en.
Projeto: Capital Health Research and Development of Special; . Beijing Municipal Science and Technology Commission.
Resumo: ABSTRACT Objective: To analyze the compositions of upper urinary tract stones and investigate their distributions in different gender and age groups. Materials and Methods: Patients diagnosed with upper urinary tract stone disease between December 2014 and March 2018 were retrospectively reviewed. Patient's age, gender, BMI, comorbidities, stone event characteristics, and compositions were collected, and proportions of stone components in different gender and age groups were analyzed. Results: A total of 1532 stone analyses were performed (992 from males and 540 from females). The mean age was younger in males (p <0.001). Males included more cases with larger BMI, hyperuricemia, and obesity, while females had more urinary tract infections. Multiple components were present in 61.8% of stones. Calcium oxalate (CaOx) (67.0%) was the most common component, followed by uric acid (UA) (11.8%), infection stone (11.4%), calcium phosphate (CaP) (8.0%), cystine (1.1%), brushite (0.4%), and 2, 8-dihydroxyadenine (0.2%). Men contributed with more CaOx stones than women at age 30-49 years (all p <0.01) and more UA stones at 30-59 years (all p <0.05). Women contributed with more infection stones than men in age groups 30-49 and 60-69 years (all p <0.05), and more CaP stones at 30-49 years. The prevalence peak was 50-59 years in men and 60-69 years in women. Both genders had the lowest prevalence in adolescence. Prevalence of UA stones increased while that of infection stones decreased with aging in both genders. Conclusions: Age and sex had a strong association with distribution of stone compositions in this Chinese cohort.
Descritores: Cálculos Urinários/epidemiologia
Cálculos Urinários/química
Fatores de Risco
-Ácido Úrico/análise
Oxalato de Cálcio/análise
Fosfatos de Cálcio/análise
Adenina/análise
Adenina/análogos & derivados
Cálculos Urinários/etiologia
Modelos Logísticos
China/epidemiologia
Fatores Sexuais
Prevalência
Estudos Retrospectivos
Fatores Etários
Distribuição por Sexo
Distribuição por Idade
Pessoa de Meia-Idade
Limites: Humanos
Masculino
Feminino
Adulto
Responsável: BR1.1 - BIREME


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Id: biblio-1017224
Autor: Ruta, Santiago Oscar.
Título: Recomendaciones de la Liga Europea contra el Reumatismopara el manejo de la gota / European League Against Rheumatism recommendations for the management of gout
Fonte: Evid. actual. práct. ambul;21(1):24-28, 2018. tab..
Idioma: es.
Descritores: Supressores da Gota/uso terapêutico
Gota/tratamento farmacológico
-Ácido Úrico/sangue
Literatura de Revisão como Assunto
Anti-Inflamatórios não Esteroides/uso terapêutico
Educação de Pacientes como Assunto
Técnica Delfos
Interleucina-1/antagonistas & inibidores
Guias de Prática Clínica como Assunto
Corticosteroides/uso terapêutico
Medicina Baseada em Evidências
Aconselhamento Diretivo
Exacerbação dos Sintomas
Revisões Sistemáticas como Assunto
Gota/sangue
Gota/terapia
Estilo de Vida
Limites: Humanos
Tipo de Publ: Comentário
Responsável: AR2.1 - Biblioteca Central


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Id: biblio-1247386
Autor: Wagbara, Chisom Clara; Alikor, Chizindu Akubudike.
Título: Alterations in serum uric acid values in a sample of Nigerian pregnant women
Fonte: Int. j. med. surg. sci. (Print);6(4):111-114, dic. 2019. tab.
Idioma: en.
Resumo: Introduction: Serum uric acid level is an important prognostic variable in pregnancy as subjects with preeclampsia have elevated serum uric acid levels. Methods: The concentrations of serum uric acid were investigated in 100 women of which 75 were pregnant women and categorized into 3 groups of 25 each, based on their trimesters of pregnancy and 25 non-pregnant women, which served as control. Results: In the first trimester, the mean values of uric acid were 122 µmol/L with a decrease in the levels of uric acid when compared with the control levels of 308 µmol/L (p<0.05). In the second trimester, the values of uric acid were 199umol/l with a significant (p<0.05) decrease in the levels of uric acid when compared with the controls. In the third trimester of pregnancy, the values of uric acid were 360 µmol/L. There was a significant (p<0.05) increase in the level of uric acid when compared with the controls. Conclusion: The progressive increase in the levels of uric acid through the trimesters of pregnancy suggests an impairment in uric acid excretion, may be with concomitant increase in renal tubular re-absorp-tion of uric acid, thereby leading to hyperuricaemia.
Descritores: Ácido Úrico/sangue
Gravidez/sangue
-Sorologia
Biomarcadores
Nigéria
Limites: Humanos
Feminino
Tipo de Publ: Estudo Clínico
Responsável: CL61.1 - Biblioteca Central Campus Sur


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Id: biblio-1041539
Autor: Gomes, Luciano Teixeira; Bellei, Ananda Karla; Andrade, Denise Inácio de; Gotardo, Priscila Zanini; Nery, Andreia Ferreira; Fontes, Cor Jesus Fernandes.
Título: Decreased uric acid levels in the acute phase of Plasmodium vivax malaria
Fonte: Rev. Soc. Bras. Med. Trop;52:e20170412, 2019. tab, graf.
Idioma: en.
Resumo: Abstract INTRODUCTION Uric acid is one of the compounds associated with the inflammatory process in malaria. It acts as an indicator of cellular damage by activating the immune response and inflammatory process. METHODS: We measured serum concentrations of uric acid in 60 symptomatic patients before and after treatment for malarial infections caused by Plasmodium vivax. RESULTS: Lower serum concentrations of uric acid were found during the acute phase of P. vivax malaria compared to those in its convalescent phase (p < 0.0001). CONCLUSIONS: Patients in the acute phase of malaria had lower uric acid levels than those in its convalescent phase.
Descritores: Ácido Úrico/sangue
Malária Vivax/sangue
Antimaláricos/uso terapêutico
-Biomarcadores/sangue
Doença Aguda
Malária Vivax/tratamento farmacológico
Pessoa de Meia-Idade
Limites: Humanos
Masculino
Feminino
Pré-Escolar
Criança
Adolescente
Adulto
Idoso
Adulto Jovem
Responsável: BR1.1 - BIREME



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