Base de dados : LILACS
Pesquisa : D03.383.129.462.580.693.450 [Categoria DeCS]
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Id: lil-581496
Autor: Gualda, L. B; Martins, G. G; Müller, B; Guimarães, F. S; Oliveira, R. M. W.
Título: 5-HT1A autoreceptor modulation of locomotor activity induced by nitric oxide in the rat dorsal raphe nucleus
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;44(4):332-336, Apr. 2011. ilus.
Idioma: en.
Resumo: The dorsal raphe nucleus (DRN) is the origin of ascending serotonergic projections and is considered to be an important component of the brain circuit that mediates anxiety- and depression-related behaviors. A large fraction of DRN serotonin-positive neurons contain nitric oxide (NO). Disruption of NO-mediated neurotransmission in the DRN by NO synthase inhibitors produces anxiolytic- and antidepressant-like effects in rats and also induces nonspecific interference with locomotor activity. We investigated the involvement of the 5-HT1A autoreceptor in the locomotor effects induced by NO in the DRN of male Wistar rats (280-310 g, N = 9-10 per group). The NO donor 3-morpholinosylnomine hydrochloride (SIN-1, 150, and 300 nmol) and the NO scavenger S-3-carboxy-4-hydroxyphenylglycine (carboxy-PTIO, 0.1-3.0 nmol) were injected into the DRN of rats immediately before they were exposed to the open field for 10 min. To evaluate the involvement of the 5-HT1A receptor and the N-methyl-D-aspartate (NMDA) glutamate receptor in the locomotor effects of NO, animals were pretreated with the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT, 8 nmol), the 5-HT1A receptor antagonist N-(2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl)-N-2-pyridinyl-cyclohexanecarboxamide maleate (WAY-100635, 0.37 nmol), and the NMDA receptor antagonist DL-2-amino-7-phosphonoheptanoic acid (AP7, 1 nmol), followed by microinjection of SIN-1 into the DRN. SIN-1 increased the distance traveled (mean ± SEM) in the open-field test (4431 ± 306.1 cm; F7,63 = 2.44, P = 0.028) and this effect was blocked by previous 8-OH-DPAT (2885 ± 490.4 cm) or AP7 (3335 ± 283.5 cm) administration (P < 0.05, Duncan test). These results indicate that 5-HT1A receptor activation and/or facilitation of glutamate neurotransmission can modulate the locomotor effects induced by NO in the DRN.
Descritores: Molsidomina/análogos & derivados
Atividade Motora/efeitos dos fármacos
Óxido Nítrico/farmacologia
Núcleos da Rafe/efeitos dos fármacos
/efeitos dos fármacos
RECEPTOR, SEROTONIN, ABDOMEN-HT1A/efeitos dos fármacos
/farmacologia
SEROTONIN ABDOMEN-HT1 RECEPTOR ANTAGONISTS/farmacologia
-Relação Dose-Resposta a Droga
Glicina/análogos & derivados
Glicina/farmacologia
Molsidomina/farmacologia
Atividade Motora/fisiologia
Ratos Wistar
Limites: Animais
Masculino
Ratos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-402665
Autor: Gerová, M; Kristek, F; Cacányiová, S; Cebová, M.
Título: Acetylcholine and bradykinin enhance hypotension and affect the function of remodeled conduit arteries in SHR and SHR treated with nitric oxide donors
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;38(6):959-966, June 2005. ilus, tab.
Idioma: en.
Projeto: VEGA.
Resumo: Discrepancy was found between enhanced hypotension and attenuated relaxation of conduit arteries in response to acetylcholine (ACh) and bradykinin (BK) in nitric oxide (NO)-deficient hypertension. The question is whether a similar phenomenon occurs in spontaneously hypertensive rats (SHR) with a different pathogenesis. Wistar rats, SHR, and SHR treated with NO donors [molsidomine (50 mg/kg) or pentaerythritol tetranitrate (100 mg/kg), twice a day, by gavage] were studied. After 6 weeks of treatment systolic blood pressure (BP) was increased significantly in experimental groups. Under anesthesia, the carotid artery was cannulated for BP recording and the jugular vein for drug administration. The iliac artery was used for in vitro studies and determination of geometry. Compared to control, SHR showed a significantly enhanced (P < 0.01) hypotensive response to ACh (1 and 10 æg, 87.9 ± 6.9 and 108.1 ± 5.1 vs 35.9 ± 4.7 and 64.0 ± 3.3 mmHg), and BK (100 æg, 106.7 ± 8.3 vs 53.3 ± 5.2 mmHg). SHR receiving NO donors yielded similar results. In contrast, maximum relaxation of the iliac artery in response to ACh was attenuated in SHR (12.1 ± 3.6 vs 74.2 ± 8.6 percent in controls, P < 0.01). Iliac artery inner diameter also increased (680 ± 46 vs 828 ± 28 æm in controls, P < 0.01). Wall thickness, wall cross-section area, wall thickness/inner diameter ratio increased significantly (P < 0.01). No differences were found in this respect among SHR and SHR treated with NO donors. These findings demonstrated enhanced hypotension and attenuated relaxation of the conduit artery in response to NO activators in SHR and in SHR treated with NO donors, a response similar to that found in NO-deficient hypertension.
Descritores: Acetilcolina/farmacologia
Bradicinina/farmacologia
Hipotensão/metabolismo
Artéria Ilíaca/efeitos dos fármacos
Doadores de Óxido Nítrico/farmacologia
Vasodilatadores/farmacologia
-Pressão Sanguínea/efeitos dos fármacos
Artérias Carótidas/efeitos dos fármacos
Artérias Carótidas/fisiologia
Hipotensão/induzido quimicamente
Artéria Ilíaca/patologia
Artéria Ilíaca/fisiologia
Molsidomina/farmacologia
Óxido Nítrico Sintase/efeitos dos fármacos
Tetranitrato de Pentaeritritol/farmacologia
Ratos Endogâmicos SHR
Ratos Wistar
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


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Id: lil-326430
Autor: Pires, J. G. P; Costa, P. G; Saraiva, F. P; Bonikovski, V; Futuro Neto, H. A.
Título: Gender-related differences in the effects of nitric oxide donors on neuroleptic-induced catalepsy in mice
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;36(2):239-245, Feb. 2003. ilus.
Idioma: en.
Resumo: It has been suggested that nigrostriatal dopaminergic transmission is modulated by nitric oxide (NO). Since there is evidence that gonadal hormones can affect extrapyramidal motor behavior in mammals, we investigated the effects of isosorbide dinitrate (ISD), linsidomine (SIN-1) and S-nitroso-N-acetylpenicillamine (SNAP), three pharmacologically different NO donors, on neuroleptic-induced catalepsy in 60- to 80-day-old male and female albino mice. Catalepsy was induced with haloperidol (1 mg/kg, ip) and measured at 30-min intervals by means of a bar test. Drugs (or appropriate vehicle) were injected ip 30 min before haloperidol, with each animal being used only once. ISD (5, 20 and 50 mg/kg) caused a dose-dependent inhibition of catalepsy in male mice (maximal effect 120 min after haloperidol: 64 percent inhibition). In the females only at the highest dose of ISD was an attenuation of catalepsy observed, which was mild and short lasting. SIN-1 (10 and 50 mg/kg) did not significantly affect catalepsy in female mice, while a significant attenuation was observed in males at the dose of 50 mg/kg (maximal inhibition: 60 percent). SNAP (20 mg/kg) significantly attenuated catalepsy in males 120 min after haloperidol (44 percent inhibition), but had no significant effect on females. These results basically agree with literature data showing that NO facilitates central dopaminergic transmission, although the mechanisms are not fully understood. They also reveal the existence of gender-related differences in this nitrergic modulation in mice, with females being less affected than males
Descritores: Catalepsia
Doadores de Óxido Nítrico
-Análise de Variância
Antipsicóticos
Catalepsia
Haloperidol
Dinitrato de Isossorbida
Molsidomina
S-Nitroso-N-Acetilpenicilamina/farmacologia
Fatores Sexuais
Limites: Animais
Masculino
Feminino
Camundongos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME



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