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Pesquisa : D03.383.129.539.850.088 [Categoria DeCS]
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Id: lil-529097
Autor: Vinagre, A. M; Collares, E. F.
Título: Phenylpyrazolone derivatives inhibit gastric emptying in rats by a capsaicin-sensitive afferent pathway
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;42(11):1086-1089, Nov. 2009. ilus.
Idioma: en.
Conferência: Apresentado em: XXI Annual Meeting of Federação de Sociedades de Biologia Experimental (FeSBE), Águas de Lindóia, August 23-26, 2006.
Resumo: Dipyrone (Dp), 4-aminoantipyrine (AA) and antipyrine (At) administered iv and Dp administered icv delay gastric emptying (GE) in rats. The participation of capsaicin (Cps)-sensitive afferent fibers in this phenomenon was evaluated. Male Wistar rats were pretreated sc with Cps (50 mg/kg) or vehicle between the first and second day of life and both groups were submitted to the eye-wiping test. GE was determined in these animals at the age of 8/9 weeks (weight: 200-300 g). Ten minutes before the study, the animals of both groups were treated iv with Dp, AA or At (240 μmol/kg), or saline; or treated icv with Dp (4 μmol/animal) or saline. GE was determined 10 min after treatment by measuring percent gastric retention (GR) of saline labeled with phenol red 10 min after orogastric administration. Percent GR (mean ± SEM, N = 8) in animals pretreated with Cps and treated with Dp, AA or At (35.8 ± 3.2, 35.4 ± 2.2, and 35.6 ± 2 percent, respectively) did not differ from the GR of saline-treated animals pretreated with vehicle (36.8 ± 2.8 percent) and was significantly lower than in animals pretreated with vehicle and treated with the drugs (52.1 ± 2.8, 66.2 ± 4, and 55.8 ± 3 percent, respectively). The effect of icv administration of Dp (N = 6) was not modified by pretreatment with Cps (63.3 ± 5.7 percent) compared to Dp-treated animals pretreated with vehicle (62.3 ± 2.4 percent). The results suggest the participation of capsaicin-sensitive afferent fibers in the delayed GE induced by iv administration of Dp, AA and At, but not of icv Dp.
Descritores: Vias Aferentes/efeitos dos fármacos
Ampirona/farmacologia
Anti-Inflamatórios não Esteroides/farmacologia
Antipirina/farmacologia
Dipirona/farmacologia
-Ampirona/administração & dosagem
Animais Recém-Nascidos
Anti-Inflamatórios não Esteroides/administração & dosagem
Antipirina/administração & dosagem
Capsaicina
Dipirona/administração & dosagem
Relação Dose-Resposta a Droga
Esvaziamento Gástrico/efeitos dos fármacos
Ratos Wistar
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


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Id: lil-771943
Autor: Vinagre, A M; Collares, E F.
Título: Effect of selective beta-adrenoceptor blockade and surgical resection of the celiac-superior mesenteric ganglion complex on delayed liquid gastric emptying induced by dipyrone, 4-aminoantipyrine, and antipyrine in rats
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;49(3):e5011, Mar. 2016. graf.
Idioma: en.
Resumo: There is evidence for participation of peripheral β-adrenoceptors in delayed liquid gastric emptying (GE) induced in rats by dipyrone (Dp), 4-aminoantipyrine (AA), and antipyrine (At). The present study aimed to determine whether β-adrenoceptors are involved in delayed GE induced by phenylpyrazole derivatives and the role of the prevertebral sympathetic nervous system in this condition. Male Wistar rats weighing 220-280 g were used in the study. In the first experiment rats were intravenously pretreated with vehicle (V), atenolol 30 mg/kg (ATE, β1-adrenergic antagonist), or butoxamine 25 mg/kg (BUT, β2-adrenergic antagonist). In the second experiment, rats were pretreated with V or SR59230A 2 mg/kg (SRA, β3-adrenergic antagonist). In the third experiment, rats were subjected to surgical resection of the celiac-superior mesenteric ganglion complex or to sham surgery. The groups were intravenously treated with saline (S), 240 µmol/kg Dp, AA, or At, 15 min after pretreatment with the antagonists or V and nine days after surgery. GE was determined 10 min later by measuring the percentage of gastric retention (%GR) of saline labeled with phenol red 10 min after gavage. The %GR (means±SE, n=6) values indicated that BUT abolished the effect of Dp (BUT+Dp vs V+Dp: 35.0%±5.1% vs 56.4%±2.7%) and At (BUT+At vs V+At: 33.5%±4.7% vs 52.9%±2.6%) on GE, and significantly reduced (P<0.05) the effect of AA (BUT+AA vs V+AA: 48.0%±5.0% vs 65.2%±3.8%). ATE, SRA, and sympathectomy did not modify the effects of treatments. These results suggest that β2-adrenoceptor activation occurred in delayed liquid gastric emptying induced by the phenylpyrazole derivatives dipyrone, 4-aminoantipyrine, and antipyrine. Additionally, the released neurotransmitter did not originate in the celiac-superior mesenteric ganglion complex.
Descritores: Antagonistas Adrenérgicos beta/farmacologia
Anti-Inflamatórios não Esteroides/farmacologia
Antipirina/administração & dosagem
Ganglionectomia
Esvaziamento Gástrico/efeitos dos fármacos
Receptores Adrenérgicos beta/metabolismo
-Antagonistas Adrenérgicos beta/administração & dosagem
Ampirona/farmacologia
Atenolol/farmacologia
Butoxamina/farmacologia
Dipirona/farmacologia
Relação Dose-Resposta a Droga
Gânglios Simpáticos/cirurgia
Modelos Animais
Propanolaminas/farmacologia
Ratos Wistar
Sistema Nervoso Simpático/efeitos dos fármacos
Limites: Animais
Masculino
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


  3 / 16 LILACS  
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Id: lil-704623
Autor: Zong, L.; Yu, Q.H.; Du, Y.X.; Deng, X.M..
Título: Edaravone protects endotoxin-induced liver injury by inhibiting apoptosis and reducing proinflammatory cytokines
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;47(3):231-236, 03/2014. graf.
Idioma: en.
Resumo: Studies have shown that edaravone may prevent liver injury. This study aimed to investigate the effects of edaravone on the liver injury induced by D-galactosamine (GalN) and lipopolysaccharide (LPS) in female BALB/c mice. Edaravone was injected into mice 30 min before and 4 h after GalN/LPS injection. The survival rate was determined within the first 24 h. Animals were killed 8 h after GalN/LPS injection, and liver injury was biochemically and histologically assessed. Hepatocyte apoptosis was measured by TUNEL staining; proinflammatory cytokines [tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6)] in the liver were assayed by ELISA; expression of caspase-8 and caspase-3 proteins was detected by Western blot assay; and caspase-3 activity was also determined. Results showed that GalN/LPS induced marked elevations in serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Edaravone significantly inhibited elevation of serum AST and ALT, accompanied by an improvement in histological findings. Edaravone lowered the levels of TNF-α and IL-6 and reduced the number of TUNEL-positive cells. In addition, 24 h after edaravone treatment, caspase-3 activity and mortality were reduced. Edaravone may effectively ameliorate GalN/LPS-induced liver injury in mice by reducing proinflammatory cytokines and inhibiting apoptosis.
Descritores: Antipirina/análogos & derivados
Apoptose/efeitos dos fármacos
Citocinas/efeitos dos fármacos
Doença Hepática Induzida por Substâncias e Drogas/prevenção & controle
Depuradores de Radicais Livres/farmacologia
-Alanina Transaminase/sangue
Antipirina/farmacologia
Aspartato Aminotransferases/sangue
/análise
CASPASE ABATTOIRS/análise
/metabolismo
CASPASE ABATTOIRS/metabolismo
/análise
CASPASE ABDOMINAL NEOPLASMS/análise
Doença Hepática Induzida por Substâncias e Drogas/fisiopatologia
Ensaio de Imunoadsorção Enzimática
Endotoxinas/toxicidade
Galactosamina/toxicidade
Hepatócitos/efeitos dos fármacos
Marcação In Situ das Extremidades Cortadas
/análise
INTERLEUKIN-ABDOMEN, ACUTE/análise
Lipopolissacarídeos/toxicidade
Camundongos Endogâmicos BALB C
Distribuição Aleatória
Fator de Necrose Tumoral alfa/análise
Limites: Animais
Feminino
Responsável: BR1.1 - BIREME


  4 / 16 LILACS  
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Id: lil-686572
Autor: Vinagre, A.M.; Collares, E.F..
Título: Evidence for the involvement of peripheral -adrenoceptors in delayed liquid gastric emptying induced by dipyrone, 4-aminoantipyrine, and antipyrine in rats
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;46(9):735-738, 19/set. 2013. tab, graf.
Idioma: en.
Resumo: Dipyrone (Dp), 4-aminoantipyrine (AA), and antipyrine (At) delay liquid gastric emptying (GE) in rats. We evaluated adrenergic participation in this phenomenon in a study in male Wistar rats (250-300 g) pretreated subcutaneously with guanethidine (GUA), 100 mg·kg−1·day−1, or vehicle (V) for 2 days before experimental treatments. Other groups of animals were pretreated intravenously (iv) 15 min before treatment with V, prazosin (PRA; 1 mg/kg), yohimbine (YOH; 3 mg/kg), or propranolol (PRO; 4 mg/kg), or with intracerebroventricular (icv) administration of 25 µg PRO or V. The groups were treated iv with saline or with 240 µmol/kg Dp, AA, or At. GE was determined 10 min later by measuring the percentage of gastric retention (%GR) of saline labeled with phenol red 10 min after gavage. %GR (mean±SE, n=8) indicated that GUA abolished the effect of Dp (GUA vs V=31.7±1.6 vs 47.1±2.3%) and of At (33.2±2.3 vs 54.7±3.6%) on GE and significantly reduced the effect of AA (48.1±3.2 vs 67.2±3.1%). PRA and YOH did not modify the effect of the drugs. %GR (mean±SE, n=8) indicated that iv, but not icv, PRO abolished the effect of Dp (PRO vs V=29.1±1.7 vs 46.9±2.7%) and At (30.5±1.7 vs 49±3.2%) and significantly reduced the effect of AA (48.4±2.6 vs 59.5±3.1%). These data suggest activation of peripheral β-adrenoceptors in the delayed GE induced by phenylpyrazolone derivatives.
Descritores: Antagonistas Adrenérgicos/administração & dosagem
Ampirona/administração & dosagem
Anti-Inflamatórios não Esteroides/administração & dosagem
Antipirina/administração & dosagem
Dipirona/administração & dosagem
Esvaziamento Gástrico/efeitos dos fármacos
Receptores Adrenérgicos beta/metabolismo
-Infusões Intraventriculares
Fenolsulfonaftaleína
Prazosina/administração & dosagem
Propranolol/administração & dosagem
Ratos Wistar
Ioimbina/administração & dosagem
Limites: Animais
Masculino
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


  5 / 16 LILACS  
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Id: lil-437825
Autor: Soares, A. C. F; Vinagre, A. M; Collares, E. F.
Título: Effect of antipyrine on the gastric emptying of liquid in rats
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;39(11):1507-1512, Nov. 2006. ilus.
Idioma: en.
Resumo: Antipyrine (At) and dipyrone (Dp) delay gastric emptying (GE) in rats. The objective of the present study was to assess the effects of intravenous (iv) and intracerebroventricular (icv) administration of At and Dp on the GE of liquid by rats. GE was assessed in male Wistar rats (5-10 in each group) 10 min after the icv or iv drug injection by measuring percent gastric retention ( percentGR) of a saline test meal labeled with phenol red 10 min after administration by gavage. The At iv group was significantly higher (64.4 ± 2.6 percent) compared to control (33.4 ± 1.5 percent) but did not differ from the Dp group (54.3 ± 3.8 percent). After icv administration of At, percentGR (34.2 ± 2 percent) did not differ from control (32.6 ± 1.9 percent), but was significantly higher after Dp (54.5 ± 2.3 percent). Subdiaphragmatic vagotomy significantly reduced percentGR in the At group (30.2 ± 0.7 percent) compared to the sham group, but was significantly higher than in the controls (23.0 ± 0.5 percent). In the animals treated with At iv, baclofen significantly reduced percentGR (28.3 ± 2.4 percent) compared to vehicle-treated animals (55.2 ± 3.2 percent). The same occurred in the animals treated iv with vehicle and icv with baclofen. Although vagotomy and baclofen reduced percentGR per se, the reduction was twice more marked in the animals treated with At. The results suggest that At administered iv, but not icv, delays GE of liquid in rats with the participation, at least in part, of the vagus nerve and that this phenomenon is blocked by the activation of GABA B receptors in the central nervous system.
Descritores: Anti-Inflamatórios não Esteroides/farmacologia
Antipirina/farmacologia
Dipirona/farmacologia
Esvaziamento Gástrico/efeitos dos fármacos
-Baclofeno/farmacologia
Relação Dose-Resposta a Droga
Agonistas GABAérgicos/farmacologia
Injeções Intraventriculares
Ratos Wistar
Fatores de Tempo
Nervo Vago/efeitos dos fármacos
Limites: Animais
Masculino
Ratos
Tipo de Publ: Estudo Comparativo
Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


  6 / 16 LILACS  
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Takayanagui, O. M
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Id: lil-303551
Autor: Marques, M. P; Takayanagui, O. M; Lanchote, V. L.
Título: Albendazole metabolism in patients with neurocysticercosis: antipyrine as a multifunctional marker drug of cytochrome P450
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;35(2):261-269, Feb. 2002. ilus, tab, graf.
Idioma: en.
Projeto: FAPESP.
Resumo: The present study investigates the isoform(s) of cytochrome P450 (CYP) involved in the metabolism of albendazole sulfoxide (ASOX) to albendazole sulfone (ASON) in patients with neurocysticercosis using antipyrine as a multifunctional marker drug. The study was conducted on 11 patients with neurocysticercosis treated with a multiple dose regimen of albendazole for 8 days (5 mg/kg every 8 h). On the 5th day of albendazole treatment, 500 mg antipyrine was administered po. Blood and urine samples were collected up to 72 h after antipyrine administration. Plasma concentrations of (+)-ASOX, (-)-ASOX and ASON were determined by HPLC using a chiral phase column and detection by fluorescence. The apparent clearance (CL/f) of ASON and of the (+) and (-)-ASOX enantiomers were calculated and compared to total antipyrine clearance (CL T) and the clearance for the production of the three major antipyrine metabolites (CLm). A correlation (P<=0.05) was obtained only between the CL T of antipyrine and the CL/f of ASON (r = 0.67). The existence of a correlation suggests the involvement of CYP isoforms common to the metabolism of antipyrine and of ASOX to ASON. Since the CL T of antipyrine is a general measure of CYP enzymes but with a slight to moderate weight toward CYP1A2, we suggest the involvement of this enzyme in ASOX to ASON metabolism in man. The study supports the establishment of a specific marker drug of CYP1A2 in the study of the in vivo metabolism of ASOX to ASON
Descritores: Albendazol
Anti-Helmínticos
Anti-Inflamatórios não Esteroides
Antipirina
Sistema Enzimático do Citocromo P-450
Neurocisticercose
-Albendazol
Anti-Helmínticos
Anti-Inflamatórios não Esteroides
Antipirina
Biomarcadores
Sistema Enzimático do Citocromo P-450
Interações Medicamentosas
Isoenzimas
Neurocisticercose
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


  7 / 16 LILACS  
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Id: lil-187720
Autor: Lanchote, V. L; Donzella, H; Chamone, D. A. F; Santos, S. R. C. J.
Título: A simple and sensitive high-performance liquid chromatographic method to measure antipyrine and its metabolites in human urine
Fonte: Rev. farm. bioquim. Univ. Säo Paulo;32(2):71-6, jul.-dez. 1996. ilus, graf.
Idioma: en.
Resumo: A method which permits the simultaneous HPLC analysis of antipyrine (A), 3-hydroxymethylantipyrine (HMA), 4-hydroxyantipyrine (HOA) and norantiopyrine (NORA) using a single extraction step in a five minute chromatographic run is described. Only 500 micraLitro of urine were necessary for the quantitation of all compounds investigated. An analog derivative, 4-aminoantipyrine, was used as internal standard (IS). Urine samples were hydrolyzed with Limpet acetone powder, 37 graus centigrados, pH 5.0 for 2 h. Sodium chloride was added and urine samples were extracted with diclhormethane-isopropyl alcohol (90:10, v/v) in acidic medium. The residue was dissolved with mobile phase, washed with n-hexane and 20 micralitro of the lower phase were injected into a 4-micron Nova-Pak (R) 'C IND. 18' column. Peaks monitored at 254 nm were eluted with 0.75 M sodium acetate buffer, pH 5.0: methanol, (70:30, v/v) as mobile phase. The method, validated on the basis of the confidence limits for antipyrine and its metabolites, presented good stability, sensitivity, linearity, and intra or interassay precisions lower than 5 percente for all commpounds were investigated. This assay was applied for drug metabolism study carried out in ten healthy volunteers: 23 about 5 yr and 63 about 10 kg(mean about SD) after p.o. single dose of antipyrine, 500 mg/capsule. Diuresis of 24 h up to 72 h of drug administration was preserved with sodium metabisulfite, 4 mg/mL. Biological fluids were stored at -20 centigrade degree until assay. The main hydroxy-metabolites (HMA + HOA) and NORA, minor N-demethylated metabolite of antipyrine, were excreted: 60 percent and 20 percente as percentage of the given dose, respectively. Clearances for production of metabolites expressed as mL/min, were: 8.61 about 4.28 (7.24) for HMA, 13.91 about 6.20(12.67) for HOA, and 8.08 about 4.01(5.93) for NORA, mean about SD (median).
Descritores: Antipirina/análise
Antipirina/metabolismo
-Cromatografia
Farmacologia
Limites: Humanos
Pré-Escolar
Criança
Adolescente
Adulto
Responsável: BR40.1 - DBD - Divisão de Biblioteca e Documentacão do Conjunto das Químicas


  8 / 16 LILACS  
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Id: lil-167834
Autor: Santos, Edanir; Oliveira Antonio, Mercedes Peres.
Título: Efeito de antiinflamatórios sobre o conteúdo histamínico pulmonar de ratos submetidos ao edema pulmonar agudo adrenalínico / Effect of antiinflamatory drugs on histamine pulmonary contents of rats submitted to acute adrenaline pulmonary edema
Fonte: Rev. ciênc. farm;10:31-9, 1988. tab.
Idioma: pt.
Resumo: O conteúdo histamínico pulmonar de ratos submetidos ao edema pulmonar agudo adrenalínico näo foi afetado pelos antiinflamatórios tremaril e ácido acetilsalicílico. Porém, os animais previamente tratados com indometacina, na dose única de 50 mg/kg, assim como nas três doses de 25 mg/kg, apresentaram uma variaçäo estatisticamente significativa do conteúdo histamínico pulmonar. O mesmo fato foi observado com os animais pré-tratados com fenazona (10, 40 e 80 mg/kg). Os animais pré-tratados com fenilbutazona, nas doses de 10 e 80 mg/kg e aqueles com oxifenilbutazona (20 mg/kg) apresentaram uma variaçäo estatisticamente significativa do conteúdo histamínico pulmonar
Descritores: Antipirina/farmacologia
Aspirina/farmacologia
Histamina/análise
Indometacina/farmacologia
Oxifenilbutazona/farmacologia
Fenilbutazona/farmacologia
Edema Pulmonar/induzido quimicamente
-Anti-Inflamatórios/farmacologia
Epinefrina
Limites: Animais
Masculino
Ratos
Responsável: BR33.1 - Divisão Técnica de Biblioteca e Documentação


  9 / 16 LILACS  
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Meneghelli, U. G
Id: lil-148773
Autor: Martinelli, A. L; Meneghelli, U. G; Zucoloto, S.
Título: Cytochrome P450 and glutathione in the liver of rats under exclusive sucrose ingestion
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;26(9):989-98, Sept. 1993. tab.
Idioma: en.
Resumo: 1. The objective of the present investigation was to study some of the possible mechanisms involved in the protective effect of sucrose ingestion against liver necrosis induced by acetaminophen. Three groups of male Wistar rats (220-260 g) were submitted to the following experimental conditions for a period of 42 h: free access to a balanced commercial diet (Group I), an exclusive sucrose diet (Group II) and fasting (Group III). At the end of the experiment, hepatic cytochrome P450 levels were measured in 11 rats from each group, plasma antipyrine half-life (t1/2) was determined in 40 rats from each group, and hepatic glutathione (GSH) concentration in 10 rats from each group. GSH consumption elicited by a high dose of acetaminophen (ACP, 1.0 g/kg, by gavage) was also determined in 30 rats each from Groups II and III. 2. The liver of Group II rats presented a significant reduction of cytochrome P450 levels in the microsome fraction (range 0.31-0.46, median, 0.37 nmol/mg vs range 0.60-0.93, median 0.74 for group I, and range 0.63-1.22, median 0.91 for group III, reported as nmol/mg microsome protein; range 23.8-48.4, median 40.4 vs 66.6-130, median 81.8 for group I and range 59.0-117.1, median 77.1 for group III, reported as nmol/100 g body weight), and a prolongation of antipyrine half-life (146.4 vs 83.4 min for group I and 93.6 for group III) when compared with the rats of the two other groups. 3. Since the toxicity of acetaminophen depends on the production of a reactive metabolite by the cytochrome P450 system in the liver, we conclude that changes in this system brought about by exclusive sucrose ingestion for 42 h may explain the liver protection against the toxicity of a high dose of the drug even in the presence of a significant concomitant reduction in liver GSH levels
Descritores: Acetaminofen/toxicidade
Enzima de Clivagem da Cadeia Lateral do Colesterol/metabolismo
Fígado
Glutationa/metabolismo
Sacarose/administração & dosagem
-Antipirina/sangue
Peso Corporal
Jejum
Fígado/metabolismo
Fígado/patologia
Microssomos Hepáticos
Microssomos Hepáticos/metabolismo
Necrose
Ratos Wistar
Fatores de Tempo
Limites: Animais
Masculino
Ratos
Tipo de Publ: Estudo Comparativo
Responsável: BR1.1 - BIREME


  10 / 16 LILACS  
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Lanchote, Vera Lucia
Id: lil-135301
Autor: Lanchote, Vera Lucia.
Título: A influencia da insuficiencia renal na atividade in vivo de formas especificas do citocromo P450. Administracao do "coquetel" antipirina e nifedipina como farmacos marcadores / Influence of renal failure on specific forms of cytochrome P450 activities. After administration of a cocktail antipyrine - nifedipine as marker drugs.
Fonte: Sao Paulo; s.n; 1993. 190 p. ilus, tab.
Idioma: pt.
Tese: Apresentada a Universidade de Sao Paulo. Faculdade de Ciencias Farmaceuticas para obtenção do grau de Doutor.
Resumo: A atividade de formas especificas do citocromo P450 foi caracterizada "in vivo", em pacientes portadores de insuficiencia renal cronica moderada, atraves da administracao dos farmacos marcadores antipirina e nifedipina na forma de "coquetel". Foram investigados nove pacientes portadores de hipertensao arterial e insuficiencia renal cronica moderada e dez pacientes portadores de hipertensao arterial com funcao renal normal. Atraves do "clearance" total da nifedipina e do "clearance" de formacao de cada produto de biotransformacao da antipirina, 3-hidroximetilantipirina (HMA), norantipirina (NORA) e 4-hidroxiantipirina (OHA) foram caracterizadas quatro formas distintas do citocromo P450. Mostraram-se induzidas nos pacientes portadores de insuficiencia renal cronica moderada as formas de citocromo P450 associadas com a formacao da NORA e da desidronifedipina (citocromo P450 III A4). O estudo evidencia seletividade nas formas induzidas justificando o aumento da velocidade de biotransformacao oxidativa de alguns medicamentos na insuficiencia renal cronica
Descritores: Antipirina/farmacocinética
Antipirina/uso terapêutico
Sistema Enzimático do Citocromo P-450/metabolismo
Hipertensão/tratamento farmacológico
Insuficiência Renal Crônica/tratamento farmacológico
Nifedipino/farmacocinética
Nifedipino/uso terapêutico
-Administração Oral
Biotransformação
Limites: Humanos
Masculino
Feminino
Adulto
Responsável: BR40.1 - DBD - Divisão de Biblioteca e Documentacão do Conjunto das Químicas
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