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Pesquisa : D03.383.129.708.089 [Categoria DeCS]
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Solé, Dirceu
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Id: lil-744708
Autor: Urrutia-Pereira, Marilyn; Solé, Dirceu.
Título: Vitamin D deficiency in pregnancy and its impact on the fetus, the newborn and in childhood / Deficiência de vitamina D na gravidez e o seu impacto sobre o feto, o recém-nascido e na infância
Fonte: Rev. paul. pediatr;33(1):104-113, Jan-Mar/2015. tab, graf.
Idioma: en.
Resumo: OBJECTIVE: Vitamin D deficiency (VDD) in pregnant women and their children is an important health problem with severe consequences for the health of both. Thus, the objectives of this review were to reassess the magnitude and consequences of VDD during pregnancy, lactation and infancy, associated risk factors, prevention methods, and to explore epigenetic mechanisms in early fetal life capable of explaining many of the non-skeletal benefits of vitamin D (ViD). DATA SOURCE: Original and review articles, and consensus documents with elevated level of evidence for VDD-related clinical decisions on the health of pregnant women and their children, as well as articles on the influence of ViD on epigenetic mechanisms of fetal programming of chronic diseases in adulthood were selected among articles published on PubMed over the last 20 years, using the search term VitD status, in combination with Pregnancy, Offspring health, Child outcomes, and Programming. DATA SYNTHESIS: The following items were analyzed: ViD physiology and metabolism, risk factors for VDD and implications in pregnancy, lactation and infancy, concentration cutoff to define VDD, the variability of methods for VDD detection, recommendations on ViD replacement in pregnant women, the newborn and the child, and the epigenetic influence of ViD. CONCLUSIONS: VDD is a common condition among high-risk pregnant women and their children. The routine monitoring of serum 25(OH)D3 levels in antenatal period is mandatory. Early preventive measures should be taken at the slightest suspicion of VDD in pregnant women, to reduce morbidity during pregnancy and lactation, as well as its subsequent impact on the fetus, the newborn and the child. .

OBJETIVO: Deficiência de vitamina D (DVD) nas gestantes e seus filhos é problema de saúde, com consequências graves à saúde de ambos. Assim, esta revisão visou reavaliar a magnitude e as consequências da DVD na gestação, lactação e infância, fatores de risco associados, métodos de prevenção, além de explorar os mecanismos epigenéticos na vida fetal capazes de explicar benefícios não-esqueléticos da vitamina D (ViD). FONTES DE DADOS: Selecionaram-se artigos originais, de revisão e consensos com nível elevado de evidência para decisões clínicas relacionadas à DVD na saúde das gestantes e seus filhos e artigos sobre sua ação sobre os mecanismos epigenéticos da programação fetal de doenças crônicas na vida adulta, publicados no PubMed nos últimos 20 anos, empregando-se VitD status, e em combinação com Pregnancy, Offspring health, Child outcomes e Programming. SÍNTESE DOS DADOS: Abordou-se fisiologia, metabolismo, fatores de risco para a DVD e implicações na gravidez, lactação e infância, concentração de corte para definir DVD, variabilidade de métodos na sua detecção, recomendações sobre a reposição de ViD nas gestantes, no recém-nascido e na criança, bem como sobre ter as influências epigenéticas da ViD. CONCLUSÕES: DVD é frequente entre gestantes de alto risco e seus filhos. Monitorar rotineiramente os níveis séricos de 25(OH)D3 no período antenatal é imperativo. Medidas preventivas precoces devem ser instituídas à menor suspeita de DVD na gestante, para reduzir morbidades durante a gestação e a lactação, bem como seu posterior impacto sobre o feto, o recém-nascido e na infância. .
Descritores: Antineoplásicos/farmacologia
Benzotiazóis/farmacologia
Neoplasias Experimentais/tratamento farmacológico
Sulfonamidas/farmacologia
-Antineoplásicos/química
Antineoplásicos/síntese química
Benzotiazóis/química
Proliferação de Células/efeitos dos fármacos
Relação Dose-Resposta a Droga
Ensaios de Seleção de Medicamentos Antitumorais
HCTACETYLATION CELLS
MCF-ABDOMINAL INJURIES CELLS
Camundongos Endogâmicos BALB C
Camundongos Nus
Modelos Moleculares
Estrutura Molecular
Neoplasias Experimentais/patologia
Relação Estrutura-Atividade
Sulfonamidas/química
Células Tumorais Cultivadas
Limites: Animais
Humanos
Camundongos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


  2 / 8 LILACS  
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Texto completo SciELO Chile
Texto completo
Id: lil-734621
Autor: Karimi, Ehsan; Jaafar, Hawa ZE; Ghasemzadeh, Ali; Ebrahimi, Mahdi.
Título: Fatty acid composition, antioxidant and antibacterial properties of the microwave aqueous extract of three varieties of Labisia pumila Benth
Fonte: Biol. Res;48:1-6, 2015. graf, tab.
Idioma: en.
Resumo: BACKGROUND: The present study was conducted in order to evaluate the fatty acid profile, anti-oxidant and anti-bacterial activities from the microwave aqueous extract of the leaves of three different varieties of Labisia pumila Benth. RESULTS: The chemical analysis of the extract showed that fatty acids (palmitic, palmitoleic, stearic, oleic, linoleic and α-linolenic) acid as the main components in three varieties of L. pumila leaves. Furthermore, the obtained results of the anti-oxidant revealed that L. pumila var. alata contained higher anti-oxidative activities compared to var. pumila and var. lanceolata. However, these values were lower than the tested anti-oxidant standards. On the other hand, the aqueous leaf extracts in all three varieties of L. pumila were also found to inhibit a variable degree of antibacterial activities against eight bacteria (four Gram-positive and four Gram-negative bacteria). CONCLUSIONS: In this study, it was observed the leaves of three varieties of L. pumila exhibited variable patterns of fatty acids and the microwave aqueous extraction possess anti-oxidant and anti-bacterial activities.
Descritores: Antibacterianos/farmacologia
Antioxidantes/farmacologia
Ácidos Graxos/análise
Micro-Ondas
Primulaceae/química
Extratos Vegetais/química
Extratos Vegetais/farmacologia
-Benzotiazóis/metabolismo
Testes de Sensibilidade a Antimicrobianos por Disco-Difusão
Flavonoides/análise
Depuradores de Radicais Livres/análise
Bactérias Gram-Negativas/efeitos dos fármacos
Bactérias Gram-Positivas/efeitos dos fármacos
INHIBITORY CONCENTRATION ACADEMIES AND INSTITUTES
Primulaceae/classificação
Óxido Nítrico/metabolismo
Fenóis/análise
Folhas de Planta/química
Ácidos Sulfônicos/metabolismo
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CL1.1 - Biblioteca Central


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Texto completo SciELO Chile
Texto completo
Id: lil-700395
Autor: Trejo-Saavedra, D.L; García-Neria, M.A; Rivera-Bustamante, R.F.
Título: Benzothiadiazole (BTH) induces resistance to Pepper golden mosaic virus (PepGMV) in pepper (Capsicum annuum L.)
Fonte: Biol. Res;46(4):333-340, 2013. ilus, graf.
Idioma: en.
Resumo: Pepper is an economically important crop in many countries around the world but it is susceptible to many diseases. In Mexico, diseases caused by bipartite begomoviruses have emerged as important problems in pepper. Several control strategies have been explored wiht little success; most of them are based on the avoidance of virus transmission and the breeding for resistance. Abiotic inducers can act at various points in the signaling pathways involved in disease resistance, providing long-lasting, wide-spectrum resistance. Benzothiadiazole (BTH) shares the property of activating the systemic acquired resistance pathway downstream from the SA signaling. In this work, resistance to PepGMV infection was induced in pepper plants by activating the SA pathway using BTH treatment. The resistance was characterized by evaluating symptom appearance, virus accumulation and viral movement. Our results showed that BTH could be an attractive alternative to induce geminivirus resistance in pepper plants without a significant damage of the fruit quality and productivity.
Descritores: Benzotiazóis/farmacologia
Capsicum/virologia
Resistência à Doença/efeitos dos fármacos
Vírus do Mosaico/efeitos dos fármacos
Doenças das Plantas/virologia
-Vírus do Mosaico/patogenicidade
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CL1.1 - Biblioteca Central


  4 / 8 LILACS  
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Texto completo SciELO Brasil
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Id: lil-675675
Autor: Brazilian Journal of Medical and Biological Research; Serafim, K.R.; Kishi, M.S.; Canto-de-Souza, A.; Mattioli, R..
Título: H1 but not H2 histamine antagonist receptors mediate anxiety-related behaviors and emotional memory deficit in mice subjected to elevated plus-maze testing
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;46(5):440-446, maio 2013. tab, graf.
Idioma: en.
Projeto: FAPESP and CNPq.
Resumo: This study investigated the role of H1 and H2 receptors in anxiety and the retrieval of emotional memory using a Trial 1/Trial 2 (T1/T2) protocol in an elevated plus-maze (EPM). Tests were performed on 2 consecutive days, designated T1 and T2. Before T1, the mice received intraperitoneal injections of saline (SAL), 20 mg/kg zolantidine (ZOL, an H2 receptor antagonist), or 8.0 or 16 mg/kg chlorpheniramine (CPA, an H1 receptor antagonist). After 40 min, they were subjected to the EPM test. In T2 (24 h later), each group was subdivided into two additional groups, and the animals from each group were re-injected with SAL or one of the drugs. In T1, the Student t-test showed no difference between the SAL and ZOL or 8 mg/kg CPA groups with respect to the percentages of open arm entries (%OAE) and open arm time (%OAT). However, administration of CPA at the highest dose of 16 mg/kg decreased %OAE and %OAT, but not locomotor activity, indicating anxiogenic-like behavior. Emotional memory, as revealed by a reduction in open arm exploration between the two trials, was observed in all experimental groups, indicating that ZOL and 8 mg/kg CPA did not affect emotional memory, whereas CPA at the highest dose affected acquisition and consolidation, but not retrieval of memory. Taken together, these results suggest that H1 receptor, but not H2, is implicated in anxiety-like behavior and in emotional memory acquisition and consolidation deficits in mice subjected to EPM testing.
Descritores: Ansiedade/induzido quimicamente
Benzotiazóis/farmacologia
Clorfeniramina/farmacologia
Antagonistas dos Receptores Histamínicos H1/farmacologia
/farmacologia
HISTAMINE HTEMEFOS ANTAGONISTS/farmacologia
Transtornos da Memória/induzido quimicamente
Fenoxipropanolaminas/farmacologia
Piperidinas/farmacologia
Receptores Histamínicos H1/efeitos dos fármacos
-Aprendizagem em Labirinto
Microinjeções
Limites: Animais
Masculino
Camundongos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-605878
Autor: Pereira Júnior, José Carlos; Silva Neto, João Luiz Pereira da; Pradella-Hallinan, Márcia.
Título: Restless legs syndrome in subjects with a knee prosthesis: evidence that symptoms are generated in the periphery
Fonte: Clinics;66(11):1955-1959, 2011.
Idioma: en.
Resumo: OBJECTIVE: There are no data adressing the prevalence of restless legs syndrome in subjects who have knee prosthesis. Therefore, we conducted a cross-sectional survey of subjects who underwent knee prosthesis surgery. METHOD: A total of 107 subjects (30 male, 77 female) were interviewed over the telephone regarding restless legs syndrome symptoms. If the patients exhibited symptoms of the syndrome, we conducted face-to-face interviews. Lastly, a therapeutic test with pramipexole was proposed for each subject. RESULTS: In our cohort, 7 males (23 percent) and 30 females (39 percent) had restless legs syndrome. Of these, 6 males and 23 females were submitted to face-to-face-interview. Of the males, 5 (83 percent) had restless legs after the knee surgeryexclusively in the operated leg- and reported no family restless legs history. One man had a prior case of bilateral restless legs syndrome, a positive family history and claimed exacerbation of symptoms in the operated leg. Among the females, 16 (69 percent) had restless legs prior to surgery. A total of 10 female patients reported bilateral symptoms, with fewer symptoms in the operated leg, while 6 displayed a worse outcome in the operated leg. The 7 females (31 percent) without restless legs prior to surgery and without a family history experienced symptoms only in the operated leg. All subjects responded favorably to the pramipexole therapeutic test. CONCLUSION: Our results suggest that secondary unilateral restless legs syndrome may ensue from knee prosthesis surgery and that the symptoms are generated in the peripheral nervous system.
Descritores: Prótese do Joelho/efeitos adversos
Doenças do Sistema Nervoso Periférico/epidemiologia
Nervo Fibular/lesões
Síndrome das Pernas Inquietas/epidemiologia
-Antidiscinéticos/uso terapêutico
Benzotiazóis/uso terapêutico
Brasil/epidemiologia
Estudos Transversais
Saúde da Família/estatística & dados numéricos
Entrevistas como Assunto
Doenças do Sistema Nervoso Periférico/tratamento farmacológico
Doenças do Sistema Nervoso Periférico/etiologia
Síndrome das Pernas Inquietas/tratamento farmacológico
Síndrome das Pernas Inquietas/etiologia
Distribuição por Sexo
Limites: Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Humanos
Masculino
Pessoa de Meia-Idade
Responsável: BR1.1 - BIREME


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Texto completo SciELO Chile
Texto completo
Id: lil-553228
Autor: Miranda, Marcelo; Slachevsky, Andrea; Bustamante, Leonor; Pérez, Carolina.
Título: Juego patológico como efecto secundario del tratamiento de la enfermedad de Parkinson: [carta al editor] / Pathologic gambling as an adverse effect of the treatment for Parkinson's disease: [letter to the editor]
Fonte: Rev. méd. Chile;138(4):521-522, abr. 2010.
Idioma: es.
Descritores: Antiparkinsonianos/efeitos adversos
Benzotiazóis/efeitos adversos
Jogo de Azar/induzido quimicamente
Doença de Parkinson/tratamento farmacológico
-Jogo de Azar/psicologia
Limites: Humanos
Masculino
Pessoa de Meia-Idade
Tipo de Publ: Relatos de Casos
Carta
Responsável: BR1.1 - BIREME


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Id: lil-485857
Autor: Asghar, M. N; Khan, I. U.
Título: Measurement of antioxidant activity with trifluoperazine dihydrochloride radical cation
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;41(6):455-461, June 2008. graf.
Idioma: en.
Projeto: Higher Education Commission of Pakistan under its Indigenous.
Resumo: A novel, rapid and cost-effective trifluoperazine dihydrochloride (TFPH) decolorization assay is described for the screening of antioxidant activity. A chromogenic reaction between TFPH and potassium persulfate at low pH produces an orange-red radical cation with maximum absorption at 502 nm in its first-order derivative spectrum. TFPH was dissolved in distilled water to give a 100 mM solution. The TFPH radical cation solution was made by reacting 0.5 mL of the solution with K2S2O8 (final concentration: 0.1 mM) and diluting to 100 mL with 4 M H2SO4 solution. A linear inhibition of color production was observed with linearly increasing amounts of antioxidants, with correlation coefficients (R²) ranging from 0.999 to 0.983. The antioxidant capacity of standard solutions of an antioxidant was evaluated by comparing with the inhibition curve using Trolox as the standard. Comparison of antioxidant capacity determined with this newly developed TFPH assay and with the well-known 2,2'-azinobis-[3-ethylbenzthiazoline-6-sulfonic acid] (ABTS)-persulfate decolorization assay indicated the efficacy and sensitivity of the procedure. The proposed assay is less expensive (costs about US$4 per 100 assays) and requires only 20 min for preparation of radical cation solution in comparison with ABTS assay, in which almost 12-16 h are required for preparation of a stable ABTS radical cation solution. The present assay has the advantage over ABTS assay that it can be used to measure the antioxidant activity of the samples, which are naturally found at a pH as low as 1, because the radical cation itself has been stabilized at low pH.
Descritores: Antioxidantes/análise
Benzotiazóis/química
Ácidos Sulfônicos/química
Trifluoperazina/química
-Cátions
Indicadores e Reagentes
Reprodutibilidade dos Testes
Espectrofotometria/métodos
Fatores de Tempo
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Texto completo SciELO Chile
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Id: lil-432425
Autor: Chamy, Verónica M; Lepe, Jaime; Catalán, Álvaro; Retamal, David; Escobar, Jorge A; Madrid, Eva M.
Título: Oxidative stress is closely related to clinical severity of pre-eclampsia
Fonte: Biol. Res;39(2):229-236, 2006. ilus.
Idioma: en.
Resumo: Pre-eclampsia is a hypertensive disorder of pregnancy in which enzymatic antioxidant defenses fail and tissues are injured. This prospective case-control study evaluated whether pre-eclamptic women and their newborns show higher degrees of oxidative stress than normal pregnancies and sought to determine if this stress is related to clinical severity. Forty-four pre-eclamptic and thirty healthy pregnant women attending two hospitals in Valparaíso, Chile, were studied. The following plasmatic variables of antioxidant capacity were evaluated: glutathione peroxidase activity (GPx), total antioxidant capacity measured by oxidation of ABTS substrate (2,2'-azino-bis (3-ethylbenzthiazoline-6-sulfonic acid), and superoxide dismutase activity (SOD). malondialdehide (MDA) was measured to evaluate lipoperoxidation. The evaluation was performed at diagnosis of pre-eclampsia, delivery, 30 days and 120 days post delivery. Newborns were studied at delivery through umbilical cord blood samples. Our analysis shows that antioxidant enzyme activity (SOD, GPx, ABTS) was significantly decreased, while lipoperoxidation (MDA) was increased in both pre-eclamptic groups compared to normal pregnant women (p<0.01). Statistically significant difference was found between mild and severe pre-eclamptic groups (p<0.01), for all biochemical markers studied. Therefore, the clinical severity of this pathology is closely related to the degree of oxidative stress.
Descritores: Peroxidação de Lipídeos
Estresse Oxidativo
Pré-Eclâmpsia/metabolismo
-Benzotiazóis/sangue
Benzotiazóis/metabolismo
Biomarcadores/sangue
Estudos de Casos e Controles
Sangue Fetal/enzimologia
Glutationa Peroxidase/sangue
Glutationa Peroxidase/metabolismo
Estudos Prospectivos
Pré-Eclâmpsia/diagnóstico
Índice de Gravidade de Doença
Ácidos Sulfônicos/sangue
Ácidos Sulfônicos/metabolismo
Superóxido Dismutase/sangue
Superóxido Dismutase/metabolismo
Substâncias Reativas com Ácido Tiobarbitúrico
Limites: Feminino
Humanos
Recém-Nascido
Gravidez
Tipo de Publ: Estudo Multicêntrico
Responsável: BR1.1 - BIREME



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