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Id: biblio-973478
Autor: Lima, Roberta Junqueira de; Schnaider, Taylor Brandão; Francisco, Antônio Marcos Coldibelli; FrancescatoVeiga, Daniela.
Título: Absorbable suture. Best aesthetic outcome in cesarian scar
Fonte: Acta cir. bras;33(11):1027-1036, Nov. 2018. tab, graf.
Idioma: en.
Resumo: Abstract Purpose: To compare two suture threads, poliglecaprone 25 and nylon, used as intradermal suture for skin closure in women undergoing their first cesarean section. Methods: This is a randomized clinical trial. A total of 60 women undergoing their first cesarean section were enrolled and prospectively assessed. They were randomly allocated to group I (n=30), which received an intradermal suture with nylon 4.0 or to group II (n=30), which had an intradermal suture with poliglecaprone 25, 4.0. The main author took standardized photographs of the scar 6 months after the operation. Four independent raters, two senior obstetricians and two senior plastic surgeons (a male and a female physician from each specialty) assessed the photographs.The panelists rated the scar according to Trimbos scale, composed by the subscales hypertrophy, color and width of the scar. Results: At baseline, patients in both groups were similar regarding age and body mass index. Five patients withdraw the study, four from group and one from group II. Scars of patients from group II were significantly less hypertrophic (p=0.001), thinner (p=0.019) and had more acceptable color (p=0.019). Conclusion: The intradermal suture with poliglecaprone 25 for skin closure after cesarean incision provides better aesthetic result.
Descritores: Poliésteres/uso terapêutico
Suturas
Cesárea/métodos
Técnicas de Sutura
Cicatriz
Dioxanos/uso terapêutico
Nylons
-Valores de Referência
Materiais Biocompatíveis
Estudos Prospectivos
Reprodutibilidade dos Testes
Resultado do Tratamento
Estatísticas não Paramétricas
Estética
Limites: Humanos
Feminino
Tipo de Publ: Ensaio Clínico Controlado Aleatório
Responsável: BR1.1 - BIREME


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Torres, Orlando Jorge Martins
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Id: biblio-1019263
Autor: Ribeiro, Waston Gonçalves; Rodrigues, Diego Vinnicyus Santos; Atta, Francisco Felipe Moreira; Ramos, Izabelle Smith Frazão; Frazão, Fabiola Nassar Sousa; Torres, Orlando Jorge Martins; Pitombo, Marcos Bettini.
Título: Comparative study of peritoneal adhesions after intraperitoneal implantation in rats of meshes of polypropylene versus polypropylene/polyglecaprone versus polyester/porcine collagen
Fonte: Acta cir. bras;34(6):e201900603, 2019. tab, graf.
Idioma: en.
Resumo: Abstract Purpose To Compare the extent and intensity of adhesions formed between the intra-abdominal organs and the intraperitoneal implants of polypropylene mesh versus polypropylene/polyglecaprone versus polyester/porcine collagen used for correction of abdominal wall defect in rats. Methods After the defect in the abdominal wall, thirty Wistar rats were placed in three groups (ten animals each) for intraperitoneal mesh implant: polypropylene group, polypropylene/polyglecaprone group, and polyester/porcine collagen group. The macroscopic evaluation of the extent and intensity of adhesions was performed 21 days after the implant. Results The polypropylene group had a higher statistically significant impairment due to visceral adhesions (p value = 0.002) and a higher degree of intense adherence in relation to polypropylene/polyglecaprone and polyester/porcine collagen groups (p value<0.001). The polyester/porcine collagen group showed more intense adhesions than the polypropylene/polyglecaprone group (p value=0.035). Conclusions The intraperitoneal implantation of polypropylene meshes to correct defects of the abdominal wall caused the appearance of extensive and firm adhesions to intra-abdominal structures. The use of polypropylene/polyglecaprone or polyester/porcine collagen tissue-separating meshes reduces the number and degree of adhesions formed.
Descritores: Doenças Peritoneais/etiologia
Poliésteres/administração & dosagem
Polipropilenos/administração & dosagem
Telas Cirúrgicas/efeitos adversos
Aderências Teciduais/etiologia
Colágeno/administração & dosagem
Dioxanos/administração & dosagem
-Poliésteres/efeitos adversos
Polipropilenos/efeitos adversos
Teste de Materiais
Colágeno/efeitos adversos
Ratos Wistar
Parede Abdominal/patologia
Dioxanos/efeitos adversos
Limites: Animais
Masculino
Ratos
Tipo de Publ: Estudo Comparativo
Responsável: BR1.1 - BIREME


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Id: lil-783797
Autor: Biondo-Simões, Maria de Lourdes Pessole; Morais, Camila Gomes de; Tocchio, Anna Flávia Zonato; Miranda, Renata Augusta de; Moura, Paula Almeida Pamponet; Colla, Kelly; Robes, Rogério Ribeiro; Ioshii, Sérgio Ossamu; Tomasich, Flávio Daniel Saavedra.
Título: Characteristics of the fibroplasia and collagen expression in the abdominal wall after implant of the polypropylene mesh and polypropylene/polyglecaprone mesh in rats
Fonte: Acta cir. bras;31(5):294-299, May 2016. graf.
Idioma: en.
Resumo: ABSTRACT PURPOSE: To compare fibroplasia and the resistance of the abdominal wall when polypropylene meshes and polypropylene/poliglecaprone are used. METHODS: Seventy-seven male Wistar rats were divided into three groups: Control Group (for resistance); Group E (polypropylene mesh); and Group U (polypropylene/poliglecaprone mesh). The animals in Groups E and U had a standard muscular and aponeurotic defect, with integral peritoneum, and correction with the mesh. Measurements were taken 4, 7, 14, 28 and 56 days after surgery. The resistance, and collagen density were studied. RESULTS: Resistance on the 56th day was similar in both meshes. The gain in resistance described an ascending curve for the polypropylene mesh and was irregular in the case of the polypropylene/poliglecaprone. Fibroplasia showed a gain in type I and type III collagen in both groups (p<0.001). Collagen III stabilized in the 14th day and collagen I continued to ascend. CONCLUSIONS: The gain in resistance of the polypropylene mesh is regular and ascending, whereas the polypropylene/poliglecaprone is not regular. The final resistance of both meshes is similar; the collagen density increases over time, and show the same inflammatory potential.
Descritores: Poliésteres/uso terapêutico
Polipropilenos/uso terapêutico
Colágeno/metabolismo
Parede Abdominal/cirurgia
Dioxanos/uso terapêutico
Hérnia Incisional/cirurgia
-Período Pós-Operatório
Resistência à Tração/fisiologia
Teste de Materiais/instrumentação
Ratos Wistar
Modelos Animais
Colágeno Tipo I/metabolismo
Colágeno Tipo III/metabolismo
Hérnia Incisional/fisiopatologia
Hérnia Incisional/metabolismo
Limites: Animais
Masculino
Responsável: BR1.1 - BIREME


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Id: lil-749645
Autor: Utiyama, Edivaldo Massazo; Rosa, Maria Beatriz Sartor de Faria; Andres, Marina de Paula; Miranda, Jocielle Santos de; Damous, Sérgio Henrique Bastos; Birolini, Cláudio Augusto Vianna; Damous, Luciana Lamarão; Montero, Edna Frasson de Souza.
Título: Polypropylene and polypropylene/polyglecaprone (Ultrapro(r)) meshes in the repair of incisional hernia in rats
Fonte: Acta cir. bras;30(6):376-381, 06/2015. tab, graf.
Idioma: en.
Projeto: FAPESP.
Resumo: PURPOSE: To compare the inflammatory response of three different meshes on abdominal hernia repair in an experimental model of incisional hernia. METHODS: Median fascial incision and skin synthesis was performed on 30 Wistar rats. After 21 days, abdominal hernia developed was corrected as follows: 1) No mesh; 2) Polypropylene mesh; and, 3) Ultrapro(r) mesh. After 21 days, the mesh and surrounding tissue were submitted to macroscopic (presence of adhesions, mesh retraction), microscopic analysis to identify and quantify the inflammatory and fibrotic response using a score based on a predefined scale of 0-3 degrees, evaluating infiltration of macrophages, giant cells, neutrophils and lymphocytes. RESULTS: No significant difference was seen among groups in adherences, fibrosis, giant cells, macrophages, neutrophils or lymphocytes (p>0.05). Mesh shrinkage was observed in all groups, but also no difference was observed between polypropylene and Ultrapro mesh (7.0±9.9 vs. 7.4±10.1, respectively, p=0.967). Post-operatory complications included fistula, abscess, dehiscence, serohematic collection and reherniation, but with no difference among groups (p=0.363). CONCLUSION: There is no difference between polypropylene (high-density) and Ultrapro(r) (low-density) meshes at 21 days after surgery in extraperitoneal use in rats, comparing inflammatory response, mesh shortening, adhesions or complications. .
Descritores: Dioxanos/uso terapêutico
Hérnia Ventral/cirurgia
Herniorrafia/métodos
Poliésteres/uso terapêutico
Polipropilenos/uso terapêutico
Telas Cirúrgicas
-Hérnia Ventral/patologia
Herniorrafia/efeitos adversos
Teste de Materiais
Ratos Wistar
Reprodutibilidade dos Testes
Fatores de Tempo
Aderências Teciduais
Resultado do Tratamento
Limites: Animais
Masculino
Tipo de Publ: Estudo Comparativo
Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-720404
Autor: Biondo-Simões, Maria de Lourdes Pessole; Moura, Paula Almeida Pamponet; Colla, Kelly; Tocchio, Anna Flávia Zonato; Morais, Camila Gomes de; Miranda, Renata Augusta de; Robes, Rogério Ribeiro; Ioshii, Sérgio Ossamu.
Título: Inflammatory reaction and tensile strength of the abdominal wall after an implant of polypropylene mesh and polypropylene/poliglecaprone mesh for abdominal wall defect treatment in rats
Fonte: Acta cir. bras;29(supl.1):45-51, 2014. tab, graf.
Idioma: en.
Resumo: PURPOSE: To compare the inflammatory reaction and the growing resistance of the abdominal wall with the use of poliglecaprone meshes and polypropylene meshes associated with poliglecaprone in the correction of abdominal defects. METHODS: Seventy-seven Wistar rats were divided into three groups: CG (non-operated animals: EG (polypropylene mesh) and UG (polypropylene and poliglecaprone mesh). A muscular and aponeurotic defect was formed and treated according to the group. Evaluations were made after 4, 7, 14, 28 and 56 days. The resistance and inflammatory pattern were studied. RESULTS: There was a gradual and significant gain in resistance, regularly in the EG and irregularly in the UG, which was lower on the 14th day (p=0.008). The inflammatory reaction was acute and more intense in the UG on the fourth day. At all other times, the inflammatory pattern was acute to chronic, similar in both groups, with minimum intensity on the 56th day. CONCLUSION: The greater resistance offered by the polypropylene mesh was regular and ascending, stabilizing on the 28th day, while that of the polypropylene/poliglecaprone was not even. In the end, the resistances were similar. The inflammatory response was greater in the UG on the fourth day and similar at all other times. .
Descritores: Parede Abdominal/cirurgia
Implantes Absorvíveis/efeitos adversos
Dioxanos/efeitos adversos
Reação a Corpo Estranho/etiologia
Poliésteres/efeitos adversos
Polipropilenos/efeitos adversos
Telas Cirúrgicas/efeitos adversos
-Parede Abdominal/patologia
Materiais Biocompatíveis
Fibrose
Hérnia Ventral/cirurgia
Teste de Materiais
Ratos Wistar
Fatores de Tempo
Resultado do Tratamento
Resistência à Tração/efeitos dos fármacos
Cicatrização
Limites: Animais
Masculino
Responsável: BR1.1 - BIREME


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Wouters, Flademir
Lopes, Luiz Roberto
Andreollo, Nelson Adami
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Id: lil-674136
Autor: Bernis-Filho, Walter Octaviano; Wouters, Flademir; Wouters, Angélica Aparecida Barth; Bernis, Valéria Magro Octaviano; Lopes, Luiz Roberto; Andreollo, Nelson Adami.
Título: Estudo comparativo entre os fios de algodão, poliglactina e poliglecaprone nas anastomoses intestinais de cães / Comparative study of cotton, polyglactin and polyglecaprone sutures in intestinal anastomoses in dogs
Fonte: ABCD arq. bras. cir. dig;26(1):18-26, jan.-mar. 2013. ilus.
Idioma: pt.
Resumo: RACIONAL: Nos últimos anos muitos fios de sutura foram desenvolvidos e depois abandonados. Até hoje não foi encontrado um fio cirúrgico ideal aos intestinos ou a outros tecidos de um modo geral, tornando sua escolha tarefa difícil. OBJETIVO: Avaliar macro e microscopicamente a cicatrização de anastomoses do intestino delgado de cães, utilizando suturas com fios de poliglecaprone 25; poliglactina 910 e algodão. MÉTODOS: Vinte cães machos adultos foram operados e submetidos a três anastomoses no intestino delgado empregando a técnica extramucosa com pontos separados. Foram utilizados os três tipos fios e as anastomoses foram analisadas em diferentes períodos no pós-operatório: grupo I -três dias; grupo II - sete dias; grupo III - 14 dias; grupo IV - 21dias. A análise macroscópica consistiu em avaliar a presença ou não de peritonite, aspecto das anastomoses e aderências. Os estudos histológicos das anastomoses, empregando a hematoxilina e eosina e o tricrômico de Masson analisaram a inflamação exsudativa, inflamação granulomatosa, o revestimento epitelial da mucosa e as fibras colágenas. RESULTADOS: Na avaliação macroscópica os fios apresentaram boa coaptação das bordas com moderado grau de aderência entre alças e omento do 3º ao 21º dia do pós-operatório. A avaliação microscópica mostrou inflamação exsudativa com neutrófilos e fibrina que variou de discreta a moderada até o 14º dia; inflamação granulomatosa com presença de macrófagos, células gigantes multinucleadas e células epitelioides mais evidentes ao 14º dia para o fio algodão; presença de tecido de granulação (fibroblastos) e fibras colágenas, de forma moderada, a partir do 7º dia para os três fios. CONCLUSÃO: Os três tipos de fios de sutura apresentaram comportamento semelhante, com boa cicatrização e podem ser recomendados em anastomoses do intestino delgado.

BACKGROUND: Over the years, many sutures were developed and then abandoned. Until now was not found an ideal suture to the intestinal tract or other tissues in general, making the choice a difficult task. AIM: To evaluate, macroscopically and microscopically, the healing process of intestinal anastomoses in dogs using polyglecaprone 25, polyglactin 910 and cotton sutures. METHODS: Twenty adult male dogs were operated on and underwent to three small bowel anastomosis using the technique with submucosal sutures. Were used three threads and the anastomoses were evaluated at different postoperative periods - group I - three days; group II - seven days; group III - 14 days and group IV - 21days. Macroscopic analysis was to assess the presence or absence of peritonitis, aspect of the anastomosis and adhesions. Histological studies of the anastomoses, using hematoxylin and eosin and Masson's trichrome analyzed the exudative inflammation, granulomatous inflammation, the mucosal epithelial coating and collagen fibers. RESULTS: The macroscopic analysis showed good coaptation of the edges with a moderate degree of adhesion between the intestines and omentum three to 21 days after surgery. The microscopic evaluation revealed exudative inflammation with neutrophils and fibrin, which ranged from mild to moderate until the 14th day; granulomatous inflammation with macrophages, multinucleated giant cells and epithelioid cells were more evident at 14th day for the cotton, presence of granulation tissue (fibroblasts) and collagen fibers, a moderate way, from the 7th for the three threads. CONCLUSION: All three threads showed similar behavior and thus they can be indicated for anastomoses of the small intestine.
Descritores: Fibra de Algodão
Dioxanos
Intestinos/cirurgia
Poliésteres
POLYGLACTIN ACETAZOLAMIDE0
Suturas
Cicatrização
-Anastomose Cirúrgica
Limites: Animais
Cães
Masculino
Tipo de Publ: Estudo Comparativo
Responsável: BR1.1 - BIREME


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Id: lil-662361
Autor: Yasojima, Edson Yuzur; Teixeira, Renan Kleber Costa; Houat, Abdallah de Paula; Costa, Felipe Lobato da Silva; Silveira, Edvaldo Lima; Brito, Marcus Vinicius Henriques; Lopes Filho, Gaspar de Jesus.
Título: Effect of copaiba oil on correction of abdominal wall defect treated with the use of polypropylene/polyglecaprone mesh
Fonte: Acta cir. bras;28(2):131-135, Feb. 2013. ilus, tab.
Idioma: en.
Resumo: PURPOSE: To evaluate the effects of copaiba oil on the correction of abdominal defect treated with the use of polypropylene/polyglecaprone mesh in rats. METHODS: A defect in the abdominal wall was created and corrected with polypropylene/polyglecaprone mesh in 36 rats. They were randomly distributed into three groups: control, copaiba by oral administration (gavage) and copaiba oil dip in the mesh. Euthanasia was performed after seven, 14 and 21 post-operative days. The healing process was analyzed regarding the meshes and macroscopic and microscopic aspects. RESULTS: All animals had abdominal adhesions, which were smaller in the copaiba (gavage) group (p<0.05). In microscopy, all animals had an acute inflammation stage and the inflammatory response was best characterized by foreign body-type granulomas around the mesh fragments, which was not found in the mesh fragments within the copaiba dip group. There was a greater area of necrosis and fibrosis in the copaiba dip group compared to the control group (p<0.05). The copaiba (gavage) group had a greater quantity of collagen fibers compared to the control group. CONCLUSION: Copaiba oil administered by gavage decreased the amount of abdominal adhesions, besides accelerating the process of collagen fibers formation, without damages within the early stages of healing. However, when used by dip directly on the mesh, it had corrosive effects compromising the healing process of the abdominal wall.
Descritores: Parede Abdominal/anormalidades
Dioxanos
Fitoterapia
Poliésteres
Polipropilenos
Preparações de Plantas/uso terapêutico
Telas Cirúrgicas
-Músculos Abdominais/anormalidades
Anti-Inflamatórios/uso terapêutico
Colágeno/biossíntese
Avaliação Pré-Clínica de Medicamentos
Fibrose
Granuloma de Corpo Estranho
Necrose
Distribuição Aleatória
Cicatrização/efeitos dos fármacos
Limites: Animais
Ratos
Responsável: BR1.1 - BIREME


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Czeczko, Nicolau Gregori
Malafaia, Osvaldo
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Id: lil-622354
Autor: Utrabo, Carlos Alberto Lima; Czeczko, Nicolau Gregori; Busato, Cesar Roberto; Montemor-Netto, Mario Rodrigues; Malafaia, Osvaldo; Dietz, Ulrich Andreas.
Título: Comparative study between polypropylene and polypropylene/poliglecaprone meshes used in the correction of abdominal wall defect in rats / Estudo comparativo entre as telas de polipropileno e polipropileno/poliglecaprone utilizadas na correção de defeito na parede abdominal ventral de ratos
Fonte: Acta cir. bras;27(4):300-305, Apr. 2012. ilus.
Idioma: en.
Resumo: PURPOSE: To evaluate the healing process of a defect in the ventral abdominal wall of rats, comparing the polypropylene and polypropylene/poliglecaprone meshes on the 30th and 60th postoperative day. METHODS: Thirty two Wistar rats were submitted to a ventral abdominal wall defect, with integrity of the parietal peritoneum. In the repair, were used polypropylene (group A) and polypropylene/poliglecaprone (group B) meshes. The groups were subdivided into four subgroups of eight animals euthanized on the 30th (A30 and B30) and 60th postoperative day (A60 and B60). Fragments of the abdominal wall of the animals were submitted to macroscopic, tensiometric and histological evaluations. RESULTS: The tensiometry on subgroup A30 showed a mean average break point of 0.78 MPa and in A60, 0.66 Mpa. In subgroup B30 it was 0.84 MPa and in B60, 1.27 Mpa. The score of the inflammatory process showed subacute phase on A30 and B30 sub-groups and chronic inflammatory process in subgroups A30 and 60B. CONCLUSIONS: The tensile strength was higher on the wall repaired by polypropylene/poliglecaprone mesh in the 60th post-operative day. Histology showed higher concentration of fibrosis on the surface of the polypropylene mesh with a tendency to encapsulation. In polypropylene/poliglecaprone subgroups the histology showed higher concentration of fibrosis on the surface of mesh filaments.

OBJETIVO: Avaliar a cicatrização de um defeito, na parede abdominal ventral de ratos, comparando-se as telas de polipropileno e polipropileno/poliglecaprone no 30º e 60º dia do pós-operatório. MÉTODOS: Trinta e dois ratos Wistar foram submetidos à produção de defeito na parede abdominal ventral, com integridade do peritônio parietal. Na correção foram utilizadas as telas de polipropileno (grupo A) e polipropileno/poliglecaprone (grupo B). Houve subdivisão em quatro subgrupos (A30, A60, B30 e B60) de oito animais que foram submetidos à eutanásia no 30º e 60º dia do pós-operatório. Fragmentos da parede abdominal foram submetidos à análise macroscópica, tensiométrica e histológica. RESULTADOS: A tensiometria no subgrupo A30 mostrou tensão média de ruptura de 0,78 Mpa e no subgrupo A60 de 0,66 MPa. No subgrupo B30 foi de 0,84 MPa e no B60 de 1,27 MPa. O escore do processo inflamatório mostrou fase subaguda nos subgrupos A30 e B30 e processo inflamatório crônico no subgrupo A60 e B60. CONCLUSÕES: A resistência à tensão foi maior na parede reparada pela tela de polipropileno/poliglecaprone no 60º dia pós-operatório. Na análise histológica houve maior concentração da fibrose na superfície da tela de polipropileno com tendência ao encapsulamento. Nos subgrupos polipropileno/poliglecaprone a análise histológica mostrou maior fibrose entre os filamentos da tela.
Descritores: Parede Abdominal/cirurgia
Materiais Biocompatíveis
Dioxanos
Poliésteres
Polipropilenos
Telas Cirúrgicas
-Parede Abdominal/patologia
Microscopia Eletrônica de Varredura
Ratos Wistar
Fatores de Tempo
Limites: Animais
Masculino
Ratos
Tipo de Publ: Estudo Comparativo
Responsável: BR1.1 - BIREME


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Malafaia, Osvaldo
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Id: lil-617965
Autor: Tabushi, Fernando Issamu; Nomura, Luiz Masakatso; Malafaia, Osvaldo; Ribas-Filho, Jurandir Marcondes; Polonio, Benur; Repka, João Carlos Domingues; Ioshii, Sergio; Costa-Filho, Octavio Antonio Azevedo da.
Título: Cecorraphy in single layer using polypropylene and poliglecaprone 25 threads: comparative study in rats / Cecorrafia em plano único com fios de polipropileno e poliglecaprone 25: estudo comparativo em ratos
Fonte: Acta cir. bras;27(3):251-255, Mar. 2012. ilus, tab.
Idioma: en.
Resumo: PURPOSE: To compare sutures with polypropylene and poliglecaprone 25 after partial cecotomy in rats. METHODS: Thirty six rats divided into two groups, A and B, of 18 animals; each group was also divided into three subgroups of six animals sacrificed at 4th, 7th and 14th days after surgery. Were studied the mortality, morbidity, complications attributable to sutures, macroscopy, optical microscopy and measurement of hydroxyproline at the level of the suture. RESULTS: There were no deaths or wound complications such as hematoma, seroma, abscess, evisceration or eventration. On microscopic evaluation reepithelization, coaptation and inflammation in both groups did not differ significantly. The average rate of tissue hydroxyproline found in the samples on the 4th day after surgery, was 21.38 mg/g tissue for group A and 16.68 mg/g for group B; on day 7 after surgery, the average was 15.64 mg/g tissue for group A and 26.53 mg/g for group B; on day 14, the average was 8.09 mg/g tissue for group A and 25.07 mg/g for group B. CONCLUSION: There were no differences on clinical evolution, macroscopic aspect, microscopic data and hydroxyproline concentration on both sutures.

OBJETIVO: Comparar a sutura com fio de polipropileno e poliglecaprone 25 após cecotomia parcial em ratos. MÉTODOS: Trinta e seis ratos foram distribuídos em dois grupos A e B de 18 animais, e cada grupo foi dividido em três subgrupos de seis, sacrificados no 4º, 7º e 14º dias do pós-operatório. Estudou-se a mortalidade, morbidade, complicações atribuíveis às suturas, macroscopia, microscopia ótica e dosagem de hidroxiprolina no nível da sutura. RESULTADOS: Não houve mortalidade ou complicações da ferida operatória como hematoma, seroma, abscesso, evisceração ou eventração. Na avaliação microscópica os critérios de re-epitelização, coaptação e processo inflamatório ambos os grupos não apresentaram diferença significativa. A taxa tecidual média da hidroxiprolina encontrada nas amostras no 4º dia de pós-operatório foi de 21,38 mg/g de tecido para o grupo A e 16,68 mg/g para o grupo B; no 7º dia a média foi de 15,64 mg/g de tecido para o grupo A e 26,53 mg/g para o grupo B; no 14º dia ela foi de 8,09 mg/g de tecido para o grupo A e 25,07 mg/g para o grupo B. CONCLUSÃO: Não houve diferença estatística entre a evolução clínica, avaliação macroscópica, microscopia e dosagem de hidroxiprolina entre as suturas realizadas com os fios estudados.
Descritores: Ceco/cirurgia
Dioxanos/efeitos adversos
Hidroxiprolina/análise
Polipropilenos
Poliésteres/efeitos adversos
Técnicas de Sutura/instrumentação
-Ceco/ultraestrutura
Modelos Animais
Período Pós-Operatório
Distribuição Aleatória
Ratos Wistar
Suturas/efeitos adversos
Limites: Animais
Masculino
Ratos
Tipo de Publ: Estudo Comparativo
Responsável: BR1.1 - BIREME


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Id: lil-597438
Autor: Ruidiaz, Miller A; Delgado, Daniel R; Martínez, Fleming.
Título: Correlating the solubility of indomethacin in 1.4-dioxane + water mixtures by means of the Jouyban-Acree model / Correlación de la solubilidad de indometacina en mezclas 1.4-dioxano + agua mediante el modelo de Jouyban-Acree
Fonte: Rev. colomb. ciencias quim. farm;39(2):211-226, dic. 2010. tab, graf.
Idioma: en.
Resumo: In this work the validity of the Jouyban-Acree and Yalkowsky-Roseman models is evaluated to correlate the solubility of indomethacin in 1,4-dioxane + water cosolvent mixtures. The solubility correlation is studied as a function of temperature and cosolvent composition. Both models require only the experimental solubility values in the pure solvents at all the temperatures evaluated. The solubility calculated values by using both models deviate notoriously from experimental values in several cases.

En este trabajo se evaluó la utilidad de los modelos Jouyban-Acree y Yalkowsky-Roseman en la correlación de la solubilidad de la indometacina en mezclas cosolventes 1,4-dioxano + agua. La correlación de la solubilidad se estudió en función de la temperatura y la composición cosolvente. Los dos modelos requieren únicamente los valores de solubilidad en los solventes puros a todas las temperaturas de interés. Los valores calculados se desvían significativamente de los experimentales en muchos casos.
Descritores: Dioxanos/química
Indometacina
-Solubilidade
Responsável: CO136.3 - Biblioteca Central



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