Base de dados : LILACS
Pesquisa : D03.383.621.808 [Categoria DeCS]
Referências encontradas : 2 [refinar]
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Texto completo SciELO Brasil
Cicarelli, Regina Maria Barreto
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Id: biblio-974208
Autor: Vieira, Gabriela Alves Licursi; Silva, Marco Túlio Alves da; Regasini, Luis Octávio; Cotinguiba, Fernando; Laure, Helen Julie; Rosa, José César; Furlan, Maysa; Cicarelli, Regina Maria Barretto.
Título: Trypanosoma cruzi: analysis of two different strains after piplartine treatment
Fonte: Braz. j. infect. dis;22(3):208-218, May-June 2018. tab, graf.
Idioma: en.
Projeto: FAPESP; . CAPES and PADC.
Resumo: ABSTRACT The hemoflagellate protozoan, Trypanosoma cruzi, mainly transmitted by triatomine insects through blood transfusion or from mother-to-child, causes Chagas' disease. This is a serious parasitic disease that occurs in Latin America, with considerable social and economic impact. Nifurtimox and benznidazole, drugs indicated for treating infected persons, are effective in the acute phase, but poorly effective during the chronic phase. Therefore, it is extremely urgent to find innovative chemotherapeutic agents and/or effective vaccines. Since piplartine has several biological activities, including trypanocidal activity, the present study aimed to evaluate it on two T. cruzi strains proteome. Considerable changes in the expression of some important enzymes involved in parasite protection against oxidative stress, such as tryparedoxin peroxidase (TXNPx) and methionine sulfoxide reductase (MSR) was observed in both strains. These findings suggest that blocking the expression of the two enzymes could be potential targets for therapeutic studies.
Descritores: Piperidonas/farmacologia
Tripanossomicidas/farmacologia
Trypanosoma cruzi/efeitos dos fármacos
Trypanosoma cruzi/química
Extratos Vegetais/farmacologia
Proteínas/análise
-Valores de Referência
Espectrometria de Massas
Trypanosoma cruzi/metabolismo
Eletroforese em Gel Bidimensional
Reprodutibilidade dos Testes
Estresse Oxidativo
Proteômica
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Id: lil-428281
Autor: Bezerra, D. P; Castro, F. O; Alves, A. P. N. N; Pessoa, C; Moraes, M. O; Silveira, E. R; Lima, M. A. S; Elmiro, F. J. M; Costa-Lotufo, L. V.
Título: In vivo growth-inhibition of Sarcoma 180 by piplartine and piperine, two alkaloid amides from Piper
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;39(6):801-807, June 2006. ilus, tab.
Idioma: en.
Resumo: Piplartine {5,6-dihydro-1-[1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl]-2(1H)pyridinone} and piperine {1-5-(1,3)-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]piperidine} are alkaloid amides isolated from Piper. Both have been reported to show cytotoxic activity towards several tumor cell lines. In the present study, the in vivo antitumor activity of these compounds was evaluated in 60 female Swiss mice (N = 10 per group) transplanted with Sarcoma 180. Histopathological and morphological analyses of the tumor and the organs, including liver, spleen, and kidney, were performed in order to evaluate the toxicological aspects of the treatment with these amides. Administration of piplartine or piperine (50 or 100 mg kg-1 day-1 intraperitoneally for 7 days starting 1 day after inoculation) inhibited solid tumor development in mice transplanted with Sarcoma 180 cells. The inhibition rates were 28.7 and 52.3 percent for piplartine and 55.1 and 56.8 percent for piperine, after 7 days of treatment, at the lower and higher doses, respectively. The antitumor activity of piplartine was related to inhibition of the tumor proliferation rate, as observed by reduction of Ki67 staining, a nuclear antigen associated with G1, S, G2, and M cell cycle phases, in tumors from treated animals. However, piperine did not inhibit cell proliferation as observed in Ki67 immunohistochemical analysis. Histopathological analysis of liver and kidney showed that both organs were reversibly affected by piplartine and piperine treatment, but in a different way. Piperine was more toxic to the liver, leading to ballooning degeneration of hepatocytes, accompanied by microvesicular steatosis in some areas, than piplartine which, in turn, was more toxic to the kidney, leading to discrete hydropic changes of the proximal tubular and glomerular epithelium and tubular hemorrhage in treated animals.
Descritores: Alcaloides/uso terapêutico
Antineoplásicos Fitogênicos/uso terapêutico
Benzodioxóis/uso terapêutico
Piper/química
Piperidinas/uso terapêutico
Piperidonas/uso terapêutico
Alcamidas Poli-Insaturadas/uso terapêutico
/tratamento farmacológico
SARCOMA ACROMION/tratamento farmacológico
-Alcaloides/isolamento & purificação
Alcaloides/toxicidade
Antineoplásicos Fitogênicos/isolamento & purificação
Antineoplásicos Fitogênicos/toxicidade
Benzodioxóis/isolamento & purificação
Benzodioxóis/toxicidade
Proliferação de Células/efeitos dos fármacos
Modelos Animais de Doenças
Rim/efeitos dos fármacos
Rim/patologia
Fígado/efeitos dos fármacos
Fígado/patologia
Transplante de Neoplasias
Piperidinas/isolamento & purificação
Piperidinas/toxicidade
Piperidonas/isolamento & purificação
Piperidonas/toxicidade
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/uso terapêutico
Extratos Vegetais/toxicidade
Raízes de Plantas/química
Alcamidas Poli-Insaturadas/isolamento & purificação
Alcamidas Poli-Insaturadas/toxicidade
/patologia
SARCOMA ACROMION/patologia
Baço/efeitos dos fármacos
Baço/patologia
Limites: Animais
Feminino
Camundongos
Responsável: BR1.1 - BIREME



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