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Texto completo SciELO Cuba
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Id: lil-731964
Autor: Al-Shaghdari, Ahmed; Bello Alarcón, Adonis; Cuesta-Rubio, Osmany.
Título: Determinación de biflavonoides en diferentes partes de la especie Garcinia bakeriana (Urb) Borhidi / Determination of biflavonoids in different parts of Garcinia bakeriana (Urb) Borhidi
Fonte: Rev. cuba. farm;48(2), abr.-jun. 2014. Ilus, tab.
Idioma: es.
Resumo: INTRODUCCIÓN: el género Garcinia produce una gran variedad de metabolitos secundarios representados por xantonas, acilfloroglucinoles y biflavonoides fundamentalmente. Sin embargo, existe muy poca información sobre la composición química de las especies cubanas pertenecientes a este género. OBJETIVO: determinar la presencia de 11 biflavonoides en las hojas, la corteza del tallo y el látex de Garcinia bakeriana (Urb) Borhidi. MÉTODOS : los extractos de las hojas, látex y la corteza del tallo de G. bakeriana fueron comparados empleando un método de cromatografía líquida de ultra alta eficacia (CLUAE) y 11 biflavonoides como sustancias de referencia. RESULTADOS: los biflavonoides GB-1A, GB-2A, glicósido de GB-2A, glicósido de morelloflavona, 4´´´metoxi- I3,II8-biapigenina, I3,II8-biapigenina, amentoflavona y 4´´´-metoxiamentoflavona fueron detectados como constituyentes de las hojas y la corteza del tallo de G. bakeriana. CONCLUSIONES: la especie G. bakeriana presenta biflavonoides como constituyentes de las hojas y la corteza del tallo. Además, la metodología de trabajo desarrollada contribuye al conocimiento de la composición química de la flora cubana y podría constituir una alternativa, rápida y de bajo consumo de disolventes, para el estudio comparativo de especies endémicas cubanas de escasa distribución y abundancia(AU)

INTRODUCTION: previous studies have revealed genus Garcinia to be a rich source of secondary metabolites, namely xanthones, acylphloroglucinols and bioflavonoids. However, the chemical composition of Cuban species in this genus is almost unknown. OBJECTIVE: to determine the presence of 11 biflavonoids in Garcinia bakeriana leaves, latex and stem bark. METHODS: leaves, latex and stem bark extracts of G. bakeriana were compared by using an ultra high performance liquid chromatography method (UPLC) and 11 biflavonoid standards. RESULTS: biflavonoids GB-1A, GB-2A, GB-2A glycoside, morelloflavone glycoside, 4´´´methoxy- I3,II8-biapigenin, I3,II8-biapigenin, amentoflavone y 4´´´-methoxyamentoflavone were detected as components in G. bakeriana leaves and stem bark. CONCLUSIONS: G. Bakeriana species has biflavonoids as components of its leaves and stem bark. The work methodology described in this paper helps to expand the knowledge about the chemical composition of the Cuban flora and may represent a rapid method with low dissolver consumption for the comparative study of poorly distributed and non abundant Cuban endemic species(AU)
Descritores: Garcinia
Biflavonoides/química
Fitoterapia
-Cromatografia Líquida de Alta Pressão/métodos
Limites: Humanos
Responsável: CU1.1 - Biblioteca Médica Nacional


  2 / 9 LILACS  
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Texto completo SciELO Brasil
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Id: biblio-889471
Autor: Passos, Vanara Florêncio; Melo, Mary Anne Sampaio de; Lima, Juliana Paiva Marques; Marçal, Felipe Franco; Costa, Cecília Atem Gonçalves de Araújo; Rodrigues, Lidiany Karla Azevedo; Santiago, Sérgio Lima.
Título: Active compounds and derivatives of camellia sinensis responding to erosive attacks on dentin
Fonte: Braz. oral res. (Online);32:e40, 2018. tab, graf.
Idioma: en.
Resumo: Abstract This research explored the potential of Camellia sinensis-derived teas and active compounds to be used as treatments to prevent dentin wear. Human root dentin slabs were randomly assigned to 5 groups (n = 10) as follows: distilled water (DW, control), epigallocatechin-3-gallate (EGCG), theaflavin gallate derivatives (TF), commercial green tea (GT), and commercial black tea (BT). The samples were submitted to a pellicle formation and an erosive cycling model (5x/day, demineralization using 0.01 M hydrochloric acid/60 s) followed by remineralization (human stimulated saliva/60 min) for three days. The samples were treated for 5 min using the test group solutions between the erosive cycles. Dentin changes were assessed with profilometry analysis and FT-Raman spectroscopy. The data regarding wear were analyzed by ANOVA followed by Tukey's test (p < 0.05). EGCG, TF derivatives, and both regular teas significantly suppressed erosive dentin loss (38-47%, p < 0.05). No obvious changes in the Raman spectra were detected in the specimens; however, the DW group had a minor relationship of 2880/2940 cm−1. The phenolic contents in both green and black tea and the important catechins appear to have protective effects on dentin loss.
Descritores: Biflavonoides/farmacologia
Camellia sinensis/química
Catequina/análogos & derivados
Dentina/efeitos dos fármacos
Ácido Gálico/análogos & derivados
Chá/química
Erosão Dentária/prevenção & controle
-Catequina/farmacologia
Fluoretos/análise
Fluoretos/farmacologia
Ácido Gálico/farmacologia
Água/química
Limites: Humanos
Responsável: BR1.1 - BIREME


  3 / 9 LILACS  
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Texto completo SciELO Chile
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Id: lil-780482
Autor: Ajayi, S. A; Azu, O. O; Chuturgoon, A; Phulukdaree, A; Komolafe, O. A; Ofusori, D. A.
Título: Comparison of antioxidant effects of kolaviron and vitamin C interventions on testicular structures following nevirapine administration in Sprague-Dawley rats / Comparación de los efectos antioxidantes en la intervención con kolaviron y vitamina C sobre las estructuras testiculares después de la administración de nevirapina en ratas Sprague-Dawley
Fonte: Int. j. morphol;34(1):102-109, Mar. 2016. ilus.
Idioma: en.
Resumo: Testicular toxicity has been implicated in highly active anti-retroviral therapy (HAART) treatment. Hence there is need to identify an effective antioxidant product that can alleviate testicular necrosis due to HAART administration. Forty eight adult male Sprague-Dawley rats were used in this study. The animals were divided into eight (8) groups: A-H (n= 6). Group A animals received normal saline as the control; Group B was given Nevirapine (Nv); Group C was given Kolaviron (Kv); Group D was given vitamin C; Group E was given Nv and Kv; Group F was given Nv and Vitamin C; Group G was given Nv for 56 d and Kv for 28 d serving as a withdrawal group; Group H was given corn oil. Nv, Kv and Vit. C were given at 1.54, 200 and 250 (mg·kg)/bw respectively while all administrations were through oral gavage. The body weights were taken every other day. Thereafter, they were anaesthetized with halothane. The testes were excised, weighed, fixed in Bouin's fluid and stained with H&E while the epididymes removed for semen fluid analyses. The results showed a significant (P<0.05) decrease in sperm motility in group E (Nevirapine + kolaviron) when compared with group F (Nevirapine + Vitamin C) while Sperm count was not significantly different (P>0.05) across the groups. The testicular histoarchitectural studies revealed indistinct spermatogonia, necrotic interstititial endocrine cells in the altered interstitial space, fragmented spermatids, atrophy of mature spermatocytes, degenerated germ cells, obliterated seminiferous tubules lumen, undifferentiated spermatogonia and cellular debris in the somniferous tubules lumen of nevirapine administered group but normal across the other groups. In the testis, there were no significant reduction in SOD, Catalase and GPx activities but a significant decrease in GST activity (P<0.001) when group E was compared with group F. In conclusion, vitamin C presents a better remediation in nevirapine induced spermiotoxicity compared to kolaviron in Sprague-Dawley rats.

La toxicidad testicular ha sido implicada en la terapia antirretroviral altamente activa (TARAA). Por lo tanto existe la necesidad de identificar un producto antioxidante eficaz que pueda aliviar la necrosis testicular en la administración de la TARAA. Cuarenta y ocho ratas macho Sprague-Dawley adultas fueron utilizadas. Los animales se dividieron en ocho (8) grupos: AH (n= 6). Grupo A, animales recibieron solución salina normal como el control; Grupo B, recibió Nevirapina (Nv); Grupo C, recibió Kolaviron (Kv); Grupo D, recibió vitamina C; Grupo E, recibió Nv y Kv; Grupo F, recibió Nv y vitamina C; Grupo G, recibió Nv durante 56 d y Kv por 28 d como un grupo de retirada; Grupo H, recibió aceite de maíz. Nv, Kv y Vit. C se administraron en dosis de 1, 54, 200 y 250 (mg · kg) de peso corporal respectivamente; todas las administraciones fueron por sonda oral. Los pesos corporales se tomaron cada dos días. A partir de ese momento los animales fueron anestesiados con halotano. Los testículos fueron extirpados, pesados y fijados en solución de Bouin y teñidos con H&E, mientras que el epidídimo se retiró para analizar el semen. Los resultados mostraron un descenso (p<0,05) en la motilidad de los espermatozoides en el grupo E (Nevirapina + Kolaviron) en comparación con el grupo F (Nevirapina + vitamina C), mientras que el recuento espermático no mostró diferencias significativas (P>0,05) entre los grupos. El estudio de la histoarquitectura testicular reveló espermatogonias indiferenciadas, con células intersticiales necróticas en el espacio intersticial y espermátidas fragmentadas. Además, en el grupo que recibió Nevirapina mostró espermatocitos maduros atrofiados, degeneración de células germinales, lumen de los túbulos seminíferos obliterados, espermatogonias indiferenciadas y restos celulares en el lumen de los tubulos seminíferos. En el resto de los grupos los resultados fueron normales. En el testículo hubo una reducción significativa en las actividades de la superóxido dismutasa, catalasa y glutatión peroxidasa, pero una disminución significativa en la actividad glutatión S-transferasa (P <0,001) al comparar los grupo E y F.
Descritores: Antioxidantes/farmacologia
Garcinia kola/química
Nevirapina/toxicidade
Extratos Vegetais/farmacologia
Superóxido Dismutase/antagonistas & inibidores
Testículo/efeitos dos fármacos
-Fármacos Anti-HIV/toxicidade
Ácido Ascórbico/farmacologia
Biflavonoides/farmacologia
Peso Corporal
Catalase/antagonistas & inibidores
Glutationa Peroxidase/antagonistas & inibidores
Ratos Sprague-Dawley
Sementes
Contagem de Espermatozoides
Motilidade Espermática/efeitos dos fármacos
Testículo/enzimologia
Testículo/patologia
Limites: Animais
Masculino
Ratos
Responsável: CL1.1 - Biblioteca Central


  4 / 9 LILACS  
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Texto completo SciELO Brasil
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Id: lil-777370
Autor: Queiroz, Dayane Priscilla de Souza; Carollo, Carlos Alexandre; Kadri, Mônica Cristina Toffoli; Rizk, Yasmin Silva; Araujo, Vanessa Carneiro Pereira de; Monteiro, Paulo Eduardo de Oliveira; Rodrigues, Patrik Oening; Oshiro, Elisa Teruya; Matos, Maria de Fátima Cepa; Arruda, Carla Cardozo Pinto de.
Título: In vivo antileishmanial activity and chemical profile of polar extract from Selaginella sellowii
Fonte: Mem. Inst. Oswaldo Cruz;111(3):147-154, Mar. 2016. tab, graf.
Idioma: en.
Resumo: The polar hydroethanolic extract from Selaginella sellowii(SSPHE) has been previously proven active on intracellular amastigotes (in vitro test) and now was tested on hamsters infected with Leishmania (Leishmania) amazonensis (in vivo test). SSPHE suppressed a 100% of the parasite load in the infection site and draining lymph nodes at an intralesional dose of 50 mg/kg/day × 5, which was similar to the results observed in hamsters treated with N-methylglucamine antimonate (Sb) (28 mg/Kg/day × 5). When orally administered, SSPHE (50 mg/kg/day × 20) suppressed 99.2% of the parasite load in infected footpads, while Sb suppressed 98.5%. SSPHE also enhanced the release of nitric oxide through the intralesional route in comparison to Sb. The chemical fingerprint of SSPHE by high-performance liquid chromatography with diode-array detection and tandem mass spectrometry showed the presence of biflavonoids and high molecular weight phenylpropanoid glycosides. These compounds may have a synergistic action in vivo. Histopathological study revealed that the intralesional treatment with SSPHE induced an intense inflammatory infiltrate, composed mainly of mononuclear cells. The present findings reinforce the potential of this natural product as a source of future drug candidates for American cutaneous leishmaniasis.
Descritores: Antiprotozoários/farmacologia
Leishmania/efeitos dos fármacos
Extratos Vegetais/química
Selaginellaceae/química
-Administração Oral
Antiprotozoários/isolamento & purificação
Biflavonoides/análise
Cromatografia Líquida de Alta Pressão
Drenagem
/parasitologia
Glicosídeos/química
Infusões Intralesionais
Leucócitos Mononucleares/parasitologia
Macrófagos/parasitologia
Meglumina/administração & dosagem
Óxido Nítrico/análise
Compostos Organometálicos/administração & dosagem
Carga Parasitária
Extratos Vegetais/administração & dosagem
Solventes
Espectrometria de Massas em Tandem
Limites: Animais
Cricetinae
Masculino
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


  5 / 9 LILACS  
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Id: lil-732611
Autor: Rizk, Yasmin Silva; Fischer, Alice; Cunha, Marillin de Castro; Rodrigues, Patrik Oening; Marques, Maria Carolina Silva; Matos, Maria de Fátima Cepa; Kadri, Mônica Cristina Toffoli; Carollo, Carlos Alexandre; Arruda, Carla Cardozo Pinto de.
Título: In vitro activity of the hydroethanolic extract and biflavonoids isolated from Selaginella sellowii on Leishmania (Leishmania) amazonensis
Fonte: Mem. Inst. Oswaldo Cruz;109(8):1050-1056, 12/2014. tab, graf.
Idioma: en.
Resumo: This study is the first phytochemical investigation of Selaginella sellowii and demonstrates the antileishmanial activity of the hydroethanolic extract from this plant (SSHE), as well as of the biflavonoids amentoflavone and robustaflavone, isolated from this species. The effects of these substances were evaluated on intracellular amastigotes of Leishmania (Leishmania) amazonensis, an aetiological agent of American cutaneous leishmaniasis. SSHE was highly active against intracellular amastigotes [the half maximum inhibitory concentration (IC50) = 20.2 &#181;g/mL]. Fractionation of the extract led to the isolation of the two bioflavonoids with the highest activity: amentoflavone, which was about 200 times more active (IC50 = 0.1 &#956;g/mL) and less cytotoxic than SSHE (IC50 = 2.2 and 3 &#956;g/mL, respectively on NIH/3T3 and J774.A1 cells), with a high selectivity index (SI) (22 and 30), robustaflavone, which was also active against L. amazonensis (IC50 = 2.8 &#181;g/mL), but more cytotoxic, with IC50 = 25.5 &#181;g/mL (SI = 9.1) on NIH/3T3 cells and IC50 = 3.1 &#181;g/mL (SI = 1.1) on J774.A1 cells. The production of nitric oxide (NO) was lower in cells treated with amentoflavone (suggesting that NO does not contribute to the leishmanicidal mechanism in this case), while NO release was higher after treatment with robustaflavone. S. sellowii may be a potential source of biflavonoids that could provide promising compounds for the treatment of cutaneous leishmaniasis.
Descritores: Antiprotozoários/uso terapêutico
Biflavonoides/uso terapêutico
Leishmania/efeitos dos fármacos
Leishmaniose Cutânea/tratamento farmacológico
Fitoterapia
Extratos Vegetais/uso terapêutico
Selaginellaceae/química
-Biflavonoides/isolamento & purificação
Leishmania/metabolismo
Camundongos Endogâmicos BALB C
Testes de Sensibilidade Microbiana
Macrófagos/efeitos dos fármacos
NIH ABATTOIRSTABATTOIRS CELLS
Óxido Nítrico/análise
Cultura Primária de Células
Limites: Animais
Feminino
Camundongos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


  6 / 9 LILACS  
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Cortez, Díogenes Aparício Garcia
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Id: lil-711741
Autor: Pires, Claudia Terencio Agostinho; Brenzan, Mislaine Adriana; Scodro, Regiane Bertin de Lima; Cortez, Diógenes Aparício Garcia; Lopes, Luciana Dias Ghiraldi; Siqueira, Vera Lucia Dias; Cardoso, Rosilene Fressatti.
Título: Anti-Mycobacterium tuberculosis activity and cytotoxicity of Calophyllum brasiliense Cambess (Clusiaceae)
Fonte: Mem. Inst. Oswaldo Cruz;109(3):324-329, 06/2014. tab, graf.
Idioma: en.
Resumo: We evaluated the in vitro anti-Mycobacterium tuberculosis activity and the cytotoxicity of dichloromethane extract and pure compounds from the leaves of Calophyllum brasiliense. Purification of the dichloromethane extract yielded the pure compounds (-) mammea A/BB (1), (-) mammea B/BB (2) and amentoflavone (3). The compound structures were elucidated on the basis of spectroscopic and spectrometric data. The contents of bioactive compounds in the extracts were quantified using high performance liquid chromatography coupled to an ultraviolet detector. The anti-M. tuberculosis activity of the extracts and the pure compounds was evaluated using a resazurin microtitre assay plate. The cytotoxicity assay was performed in J774G.8 macrophages using the 3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyl tetrazolium bromide colourimetric method. The quantification of the dichloromethane extract showed (1) and (2) at concentrations of 31.86 ± 2.6 and 8.24 ± 1.1 µg/mg of extract, respectively. The dichloromethane and aqueous extracts showed anti-M. tuberculosis H37Rv activity of 62.5 and 125 µg/mL, respectively. Coumarins (1) and (2) showed minimal inhibitory concentration ranges of 31.2 and 62.5 µg/mL against M. tuberculosis H37Rv and clinical isolates. Compound (3) showed no activity against M. tuberculosis H37Rv. The selectivity index ranged from 0.59-1.06. We report the activity of the extracts and coumarins from the leaves of C. brasiliense against M. tuberculosis.
Descritores: Antibacterianos/farmacologia
Biflavonoides/farmacologia
Calophyllum/química
Macrófagos/efeitos dos fármacos
Cloreto de Metileno/farmacologia
Mycobacterium tuberculosis/efeitos dos fármacos
Extratos Vegetais/farmacologia
-Antibacterianos/toxicidade
Biflavonoides/isolamento & purificação
Biflavonoides/toxicidade
Testes de Sensibilidade Microbiana
Cloreto de Metileno/isolamento & purificação
Cloreto de Metileno/toxicidade
Extratos Vegetais/toxicidade
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


  7 / 9 LILACS  
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Id: lil-537231
Autor: Osorio D., Edison; Montoya P., Guillermo; Bastida., Jaume.
Título: Caracterización fitoquímica de una fracción de biflavonoides de Garcinia madruno: Su inhibición de la oxidación de LDL humana y su mecanismo de estabilización de especies radicalarias / Phytochemycal characterization of a biflavonoid fraction from Garcinia madruno: Inhibition of human LDL oxidation and its free radical scavenging mechanism
Fonte: Vitae (Medellín);16(3):369-377, sept.-dec. 2009.
Idioma: es.
Resumo: A una fracción biflavonoide (FB) caracterizada fitoquímicamente de Garcinia madruno (Clusiaceae),se le evalúa su potencial inhibitorio de la oxidación de LDL y su capacidad estabilizadora de especies radicalarias, correlacionando dichas actividades con su contenido en biflavonoides. Los biflavonoides morelloflavona, volkensiflavona y amentoflavona se identifican a partir de la FB. El extracto que contiene la FB (extracto AcOEt) se determina como el principal factor involucrado en la actividad estabilizadora de radicales libres de esta especie vegetal, obteniendo la actividad estabilizadora del radical DPPH• a una concentración de 4,50 μg/mL. La peroxidación inducida con CuSO4 de las lipoproteínas de baja densidad, se reduce significativamente en presencia de FB (CE50 = 11,85 μg/mL). El biflavonoide morelloflavona se determina como el principal responsable de la protección ejercida por la FB frente a la actividad estabilizadora de radicales libres y la peroxidación lipídica, aunque posiblemente existan procesos de sinergismo. Estas propiedades sugieren que la FB de G. madruno es un excelente candidato para ser utilizado como antioxidante.
Descritores: Biflavonoides
Clusiaceae
Responsável: CO56.3 - Biblioteca


  8 / 9 LILACS  
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Texto completo SciELO Brasil
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Id: lil-491963
Autor: Reyes-Chilpa, Ricardo; Estrada-Muñiz, Elizabeth; Vega-Avila, Elisa; Abe, Fumiko; Kinjo, Junei; Hernández-Ortega, Simón.
Título: Trypanocidal constituents in plants: 7. Mammea-type coumarins
Fonte: Mem. Inst. Oswaldo Cruz;103(5):431-436, Aug. 2008. ilus, tab.
Idioma: en.
Resumo: Calophyllum brasiliense and Mammea americana (Clusiaceae) are two trees from the tropical rain forests of the American continent. A previous screening showed high trypanocidal activity in the extracts of these species. Several mammea-type coumarins, triterpenoids and biflavonoids were isolated from the leaves of C. brasiliense. Mammea A/AA was obtained from the fruit peels of M. americana. These compounds were tested in vitro against epimastigotes and trypomastigotes of Trypanosoma cruzi, the etiologic agent of Chagas disease. The most potent compounds were mammea A/BA, A/BB, A/AA, A/BD and B/BA, with MC100 values in the range of 15 to 90 g/ml. Coumarins with a cyclized ,-dimethylallyl substituent on C-6, such as mammea B/BA, cyclo F + B/BB cyclo F, and isomammeigin, showed MC100 values > 200 g/ml. Several active coumarins were also tested against normal human lymphocytes in vitro, which showed that mammea A/AA and A/BA were not toxic. Other compounds from C. brasiliense, such as the triterpenoids, friedelin, canophyllol, the biflavonoid amentoflavone, and protocatechuic and shikimic acids, were inactive against the epimastigotes. The isopropylidenedioxy derivative of shikimic acid was inactive, and its structure was confirmed by X-ray diffraction. Our results suggest that mammea-type coumarins could be a valuable source of trypanocidal compounds.
Descritores: Biflavonoides/farmacologia
Cumarínicos/farmacologia
Mammea/química
Triterpenos/farmacologia
Tripanossomicidas/farmacologia
Trypanosoma cruzi/efeitos dos fármacos
-Biflavonoides/química
Biflavonoides/isolamento & purificação
Cumarínicos/química
Cumarínicos/isolamento & purificação
Dimetil Sulfóxido/farmacologia
LETHAL DOSE ACADEMIES AND INSTITUTES
Linfócitos/efeitos dos fármacos
Extratos Vegetais/farmacologia
Triterpenos/química
Triterpenos/isolamento & purificação
Tripanossomicidas/química
Tripanossomicidas/isolamento & purificação
Limites: Adulto
Animais
Humanos
Masculino
Responsável: BR1.1 - BIREME


  9 / 9 LILACS  
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Texto completo SciELO Brasil
Young, Maria Claudia Marx
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Id: lil-465468
Autor: Carbonezi, Carlos Alberto; Hamerski, Lidilhone; Gunatilaka, A. A. Leslie; Cavalheiro, Alberto; Castro-Gamboa, Ian; Silva, Dulce Helena Siqueira; Furlan, Maysa; Young, Maria Claudia Marx; Lopes, Marcia Nasser; Bolzani, Vanderlan da Silva.
Título: Bioactive flavone dimers from Ouratea multiflora (Ochnaceae)
Fonte: Rev. bras. farmacogn = Braz. j. pharmacogn.;17(3):319-324, jul.-set. 2007. ilus, tab.
Idioma: en.
Resumo: Chromatographic fractionation of the organic extract from leaves of Ouratea multiflora afforded the flavone dimers heveaflavone, amentoflavone-7'',4''''-dimethyl eter, podocarpusflavone-A and amentoflavone. Their structures were elucidated from spectral data, including 2D-NMR experiments of the natural substances. Biological activities of all isolates were evaluated, using antimicrobial assay against Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis, cytotoxicity assay against mouse lymphoma (L5178) and KB cell lines, TLC screening for acetylcholinesterase inhibitors and antioxidant activity measured by DPPH test.

O fracionamento cromatográfico do extrato orgânico das folhas de Ouratea multiflora forneceu os flavonóides diméricos, heveaflavona, 7'',4''''-dimetilamentoflavona, podocarpusflavona-A e amentoflavona. Suas estruturas foram elucidadas com base nos dados espectrais, incluindo experimentos bidimensionais de RMN, das substâncias naturais. A atividade antibiótica de todos os isolados foi avaliada, usando-se as bacterias Gram-positivas Staphylococcus aureus and Bacillus subtilis. Teste de citotoxicidade nas linhagens de linfoma de ratos (L5178) e KB também foram conduzidos para avaliar os extratos e os flavonóides isolados. a triagem biológica para a avaliação de atividade antioxidante e inibidora de acetil colinesterase foram conduzidas pela técnica da bioautografia com DPPH e teste pelo teste de Ellman respectivamente.
Descritores: Biflavonoides/farmacologia
Biflavonoides/isolamento & purificação
Técnicas In Vitro
Ochnaceae
Ochnaceae/química
Responsável: BR8.1 - Biblioteca Central



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde