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Id: biblio-840825
Autor: Karabakan, Mehmet; Keskin, Ercument; Akdemir, Serkan; Bozkurt, Aliseydi.
Título: Effect of tadalafil 5mg daily treatment on the ejaculatory times, lower urinary tract symptoms and erectile function in patients with erectile dysfunction
Fonte: Int. braz. j. urol;43(2):317-324, Mar.-Apr. 2017. tab.
Idioma: en.
Resumo: ABSTRACT Objective To investigate the effect of a 5mg daily tadalafil treatment on the ejaculation time, erectile function and lower urinary tract symptoms (LUTS) in patients with erectile dysfunction. Materials and Methods A total of 60 patients diagnosed with erectile dysfunction were retrospectively evaluated using the international index of erectile function questionnaire-5 (IIEF-5), intravaginal ejaculatory latency time (IELT) and international prostate symptoms scores (IPSS). After the patients were treated with 5mg tadalafil once a day for three months, their erection, ejaculation and LUTS were assessed again. The fasting levels of blood glucose, total testosterone, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and total cholesterol were measured. The independent-samples t-test was used to compare the pre- and post-treatment scores of the patients. Results The mean age of the 60 participants was 50.4±7.9 and the mean baseline serum total testosterone, total cholesterol, and fasting blood sugar were 444.6±178.6ng dL-1, 188.7±29.6mg/dL-1,104 (80-360) mg dL-1, respectively. The mean baseline scores were 2.2±1.4 min for IELT, 9.5±3.7 for IIEF-5 and 14.1±4.5 for IPSS. Following the three-month daily 5mg tadalafil treatment, the scores were found to be 3.4±1.9 min, 16.1±4.7, and 10.4±3.8 for IELT, IIEF and IPSS, respectively. When the baseline and post-treatment scores were compared, a statistically significant increase was observed in the IELTs and IIEF-5 values whereas there was a significant decrease in IPSS (p<0.01). Conclusion A daily dose of 5mg tadalafil can be safely used in the treatment of erectile dysfunction and LUTS, that prolongs the ejaculatory latency time.
Descritores: Ereção Peniana/efeitos dos fármacos
Ejaculação/efeitos dos fármacos
Inibidores da Fosfodiesterase 5/administração & dosagem
Sintomas do Trato Urinário Inferior/tratamento farmacológico
Ejaculação Precoce/tratamento farmacológico
Tadalafila/administração & dosagem
Disfunção Erétil/tratamento farmacológico
-Testosterona/sangue
Fatores de Tempo
Glicemia/análise
Ereção Peniana/fisiologia
Esquema de Medicação
Colesterol/sangue
Inquéritos e Questionários
Estudos Retrospectivos
Resultado do Tratamento
Estatísticas não Paramétricas
Ejaculação/fisiologia
Sintomas do Trato Urinário Inferior/fisiopatologia
Ejaculação Precoce/fisiopatologia
Disfunção Erétil/fisiopatologia
Pessoa de Meia-Idade
Limites: Humanos
Masculino
Adulto
Idoso
Responsável: BR1.1 - BIREME


  2 / 18 LILACS  
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Id: biblio-840833
Autor: Benli, Erdal; Ayyildiz, Sema Nur; Cirrik, Selma; Koktürk, Sibel; Cirakoglu, Abdullah; Noyan, Tevfik; Ayyildiz, Ali; Germiyanoglu, Cankon.
Título: The effect of tadalafil therapy on kidney damage caused by sepsis in a polymicrobial septic model induced in rats: a biochemical and histopathological study
Fonte: Int. braz. j. urol;43(2):345-355, Mar.-Apr. 2017. tab, graf.
Idioma: en.
Projeto: Ordu University Scientific Research Projects Coordination Department.
Resumo: ABSTRACT Introduction Sepsis is an inflammatory reaction to bacteria involving the whole body and is a significant cause of mortality and economic costs. The purpose of this research was to determine whether tadalafil exhibits a preventive effect on sepsis in a septic model induced in rats with cecal ligation and puncture (CLP). Materials and Methods Rats were randomly separated into groups, 10 rats in each: (i) a sham (control) group, (ii) an untreated sepsis group, (iii) a sepsis group treated with 5mg/kg tadalafil and (iv) a sepsis group treated with 10mg/kg tadalafil. A polymicrobial sepsis model was induced in rats using CLP. Rats were sacrificed after 16h, and blood and kidney tissues were collected for biochemical and histopathological study. Results Levels of the inflammatory parameter IL-6 decreased significantly in the sepsis groups receiving tadalafil in comparison with the untreated sepsis group (p<0.05). In terms of histopathology, inflammation scores investigated in kidney tissues decreased significantly in the sepsis groups receiving tadalafil compared to the untreated sepsis group (p<0.05). In addition, levels of creatinine and cystatin C measured in septic rats receiving tadalafil were lower by a clear degree than in septic rats (p<0.05). Conclusion In this study, tadalafil exhibited a preventive effect for sepsis-related damage by suppressing inflammation in serum and kidney tissue of septic rats in a polymicrobial sepsis model induced with CLP.
Descritores: Sepse/complicações
Sepse/prevenção & controle
Insuficiência Renal/etiologia
Insuficiência Renal/prevenção & controle
Inibidores da Fosfodiesterase 5/uso terapêutico
Tadalafila/uso terapêutico
-Valores de Referência
Espectrofotometria
Superóxido Dismutase/análise
Calcitonina/sangue
Ensaio de Imunoadsorção Enzimática
Imuno-Histoquímica
Catalase/análise
Distribuição Aleatória
Reprodutibilidade dos Testes
Interleucina-6/sangue
Ratos Wistar
Peroxidase/análise
Sepse/patologia
Creatinina/sangue
Modelos Animais de Doenças
Insuficiência Renal/patologia
Cistatina C/sangue
Rim/efeitos dos fármacos
Rim/patologia
Ligadura
Malondialdeído/análise
Limites: Animais
Masculino
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


  3 / 18 LILACS  
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Id: biblio-975634
Autor: Yildirim, Caglar; Yuksel, Ozgur H; Urkmez, Ahmet; Sahin, Aytac; Somay, Adnan; Verit, Ayhan.
Título: Protective effects of Tadalafil and darbepoetin against ischemia - reperfusion injury in a rat testicular torsion model
Fonte: Int. braz. j. urol;44(5):1005-1013, Sept.-Oct. 2018. tab, graf.
Idioma: en.
Resumo: ABSTRACT Objectives: To evaluate protective effects of darbepoetin and tadalafil against ischemia-reperfusion injury in ipsilateral and contralateral testicle. Materials and Methods: Thirty 3-month-old adult male Wistar-Albino rats were randomly divided into 5 groups (A-E). Sham operation was performed in the first group. In Group B, rats did not received any medication after creating 720 degrees torsion of the left testis. The rats in Group C, D and E received darbepoetin, tadalafil, and darbepoetin/tadalafil combination 30 minutes after creating 720 degrees torsion of the left testis, respectively. The testes of rats in these three groups were detorsioned at 90 minutes after drug administration. Both testes were removed at 30 minutes after detorsion. Results: There were significant differences between the groups in terms of the degree of histopathological damage, Johnsen score, fibrosis score and caspase-3 immunoreactivity in the torsioned testes (p: 0.000). The results for each parameter in the left testes were significantly better in the darbepoetin / tadalafil combination group. Similarly, there were also significant differences in the contralateral testes (p: 0.000). Conclusion: The active substances darbepoetin and tadalafil that were used as a combination had protective effects on both testes and produced out better results in preserving testicular histology. Especially in cases where it is not possible to rescue the torsioned testis, this result was more noticeable in the contralateral testis.
Descritores: Torção do Cordão Espermático/tratamento farmacológico
Vasodilatadores/administração & dosagem
Traumatismo por Reperfusão/tratamento farmacológico
Tadalafila/administração & dosagem
Darbepoetina alfa/administração & dosagem
-Torção do Cordão Espermático/patologia
Xilazina/administração & dosagem
Imuno-Histoquímica
Distribuição Aleatória
Ratos Wistar
Modelos Animais de Doenças
Ketamina/administração & dosagem
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


  4 / 18 LILACS  
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Id: biblio-897929
Autor: Oliveira, Granville G de; Oliveira, Samer A H de; Botelho, Paulo Henrique H; Oliveira, Marcos Aurelio Barboza de; Bian, Ka; Murad, Ferid.
Título: Tadalafil: protective action against the development of multiple organ failure syndrome
Fonte: Rev. bras. cir. cardiovasc = Braz. j. cardiovasc. surg. (impr.);32(4):312-317, July-Aug. 2017. tab, graf.
Idioma: en.
Projeto: Brazilian Federal Senate.
Resumo: Abstract Introduction: Multiple organ failure syndrome (MOFS) is a pathology associated to unspecified and severe trauma, characterized by elevated morbidity and mortality. The complex inflammatory MOFS-related reactions generate important ischemia-reperfusion responses in the induction of this syndrome. Nitric oxide elevation, through the activation of cyclic guanosine monophosphate (cGMP), has the potential of counteracting the typical systemic vasoconstriction, and platelet-induced hypercoagulation. Tadalafil would possibly act protectively by reducing cGMP degradation with consequent diffuse vasodilatation, besides reduction of platelet-induced hypercoagulation, thus, preventing multiple organ failure syndrome development. Methods: The experimental protocol was previously approved by an institution animal research committee. Experimental MOFS was induced through the stereotaxic micro-neurosurgical bilateral anterior hypothalamic lesions model. Groups of 10 Wistar rats were divided into: a) Non-operated control; b) Operated control group; c) 2 hours after tadalafil-treated operated group; d) 4 hours after tadalafil-treated operated group; e) 8 hours after post-treated operated group. The animals were sacrificed 24 hours after the neurosurgical procedure and submitted to histopathologic examination of five organs: brain, lungs, stomach, kidneys, and liver. Results: The electrolytic hypothalamic lesions resulted in a full picture of MOFS with disseminated multiple-organs lesions, provoked primarily by diffusely spread micro-thrombi. The treatment with tadalafil 2 hours after the micro-neurosurgical lesions reduced the experimental MOFS lesions development, in a highly significant level (P<0.01) of 58.75%. The treatment with tadalafil, 4 hours after the micro-neurosurgically-induced MOFS lesions, also reduced in 49.71%, in a highly significant level (P<0.01). Finally, the treatment with tadalafil 8 hours after the neurosurgical procedure resulted in a statistically significant reduction of 30.50% (P<0.05) of the experimentally-induced MOFS gravity scores. Conclusion: The phosphodiesterase 5 inhibitor, tadalafil, in the doses and timing utilized, showed to protect against the experimentally-induced MOFS.
Descritores: Substâncias Protetoras/uso terapêutico
Inibidores da Fosfodiesterase 5/uso terapêutico
Tadalafila/uso terapêutico
Insuficiência de Múltiplos Órgãos/prevenção & controle
-Trombose/induzido quimicamente
Trombose/reabilitação
Hipotálamo Anterior/lesões
Técnicas Estereotáxicas
Ratos Wistar
Progressão da Doença
Substâncias Protetoras/administração & dosagem
Modelos Animais de Doenças
Período Pré-Operatório
Inibidores da Fosfodiesterase 5/administração & dosagem
Tadalafila/administração & dosagem
Insuficiência de Múltiplos Órgãos/classificação
Insuficiência de Múltiplos Órgãos/etiologia
Limites: Animais
Masculino
Responsável: BR1.1 - BIREME


  5 / 18 LILACS  
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Id: biblio-910099
Autor: Assunção, Ben-Hur Santiago; Marques, Carolina Ferreira.
Título: Surdez súbita em paciente em uso de tadalafil: um relato de caso clínico / Sudden deafness in a patient with tadalafil use: a clinical case report
Fonte: Rev. Ciênc. Méd. Biol. (Impr.) = J. med. biol. sci;17(1):121-127, jul.17,2018. ilus.
Idioma: pt.
Resumo: Introdução: a Surdez Súbita (SS) é uma emergência médica de baixa prevalência, porém com potencial de perda auditiva irreversível para o paciente. Possui diversos e ainda incertos mecanismos etiopatológicos. Recentemente a literatura vem trazendo a associação da SS com a classe dos inibidores da fosdodiesterase-5 (IPDE-5), a qual inclui medicamentos para tratamento de impotência sexual. Objetivo: relatar caso clínico de paciente idoso que apresentou SS após fazer uso de medicamento da classe dos IPDE-5, pesquisando na literatura qual a provável fisiopatologia. Metodologia: trata-se de estudo qualitativo, descritivo do tipo relato de caso clínico, realizado através da coleta de dados do prontuário médico, que foram comparados com literatura especializada. Resultado: paciente masculino, 72 anos, engenheiro, procurou atendimento referindo hipoacusia e plenitude aural à direita notados subitamente há três dias. Relata ter feito uso de Tadalafil 5mg, anteriormente aos sintomas. Anamnese e exame físico direcionaram para hipótese diagnóstica de SS, de modo que exames complementares foram solicitados. À audiometria evidenciou-se perda auditiva sensorioneural moderada a severa em orelha direita. Após tratamento com prednisolona oral e mesilato de codergocrina, paciente apresentou melhora, com audiometria evidenciando perda sensorioneural leve em orelha direita. Conclusão: a relação entre SS e o uso de IPDE-5 está cada vez mais evidente de acordo com a literatura. É provável que possa haver ativação de vias de estresse celular, contribuindo para patologia
Descritores: Perda Auditiva Súbita/induzido quimicamente
Inibidores da Fosfodiesterase 5/efeitos adversos
Tadalafila/efeitos adversos
Limites: Humanos
Masculino
Idoso
Tipo de Publ: Relatos de Casos
Responsável: BR1826.9 - Universidade Federal da Bahia


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Id: biblio-896388
Autor: Nardozza Junior, Archimedes; Cabrini, Marcelo Rodrigues.
Título: Daily use of phosphodiesterase type 5 inhibitors as prevention for recurrent priapism / Prevenção do priapismo recorrente com a utilização diária de inibidores da fosfodiesterase tipo 5
Fonte: Rev. Assoc. Med. Bras. (1992);63(8):689-692, Aug. 2017. tab.
Idioma: en.
Resumo: Summary Objective: The pathogenesis of recurrent priapism is currently being investigated based on the regulation of the phosphodiesterase 5 (PDE5) enzyme. We explored the daily use of PDE5 inhibitors to treat and prevent priapism recurrences. Method: We administered PDE5 inhibitors using a long-term therapeutic regimen in seven men with recurrent priapism, with a mean age of 29.2 years (range 21 to 35 years). Six men (85.7%) had idiopathic priapism recurrences and one man (24.3%) had sickle cell disease-associated priapism recurrences. Tadalafil 5 mg was administered daily. The mean follow-up was 6.6 months (range 3 to 12 months). Results: Daily long-term oral PDE5 inhibitor therapy alleviated priapism recurrences in all patients. Five (71.4%) had no episodes of priapism and two (28.6%) referred decrease in their episodes of priapism. All patients referred improvement in erectile function. Conclusion: These findings suggest the hypothesis that PDE5 dysregulation exerts a pathogenic role for both sickle cell disease-associated priapism and for idiopathic priapism, and that it offers a molecular target for the therapeutic management of priapism. These preliminary observations suggest that continuous long-term oral PDE5 inhibitor therapy may treat and prevent recurrent priapism.

Resumo Objetivo: Uma das teorias propostas para explicar a etiologia do priapismo recorrente está baseada no mecanismo de regulação da fosfodiesterase tipo 5. Estudamos o uso diário dos inibidores de fosfodiesterase tipo 5 no tratamento e na prevenção do priapismo recorrente. Método: Sete homens com diagnóstico de priapismo recorrente, com idade média de 29,5 anos (21 a 35 anos), utilizaram inibidor de fosfodiesterase tipo 5 em dose diária (tadalafila 5 mg/dia) por período prolongado. Seis homens (85,7%) apresentavam priapismo recorrente de etiologia idiopática, e um homem (24,3%), de etiologia associada à anemia falciforme. O seguimento médio foi de 6,6 meses (3 a 12 meses). Resultados: Todos os pacientes se beneficiaram com a utilização de inibidores de fosfodiesterase tipo 5. Cinco (71,4%) não apresentaram nenhum episódio de priapismo e dois (28,6%) relataram diminuição dos episódios. Todos os pacientes relataram melhora da função erétil. Conclusão: Estes achados sugerem que a hipótese do mecanismo de regulação da fosfodiesterase tipo 5 exerce papel importante na patogenia do priapismo recorrente. O uso contínuo e diário de inibidores da fosfodiesterase tipo 5 pode ser uma opção no tratamento do priapismo recorrente.
Descritores: Priapismo/prevenção & controle
Inibidores da Fosfodiesterase 5/administração & dosagem
Tadalafila/administração & dosagem
-Priapismo/enzimologia
Recidiva
Estudos Prospectivos
Seguimentos
Nucleotídeo Cíclico Fosfodiesterase do Tipo 5/metabolismo
Prevenção Secundária
Limites: Humanos
Masculino
Adulto
Adulto Jovem
Responsável: BR1.1 - BIREME


  7 / 18 LILACS  
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Id: biblio-1003032
Autor: Köktürk, Sibel; Benli, Erdal; Ayyildiz, Ali; Cirrik, Selma; Çetinkol, Yeliz; Ayyildiz, Sema Nur; Noyan, Tevfik.
Título: Positive outcomes of phosphodiesterase type 5 inhibitor on histopathologic and biochemical changes induced by ureteral obstruction
Fonte: Rev. Assoc. Med. Bras. (1992);65(3):388-393, Mar. 2019. graf.
Idioma: en.
Projeto: Education and Research Foundation of Faculty of Medicine, Ordu University.
Resumo: SUMMARY OBJECTIVES: We examined the effects of tadalafil, one of the phosphodiesterase type 5 (PDE5) inhibitors, in a rat model of with partial and complete unilateral ureteral obstruction (UUO). METHODS: The rats were divided into 5 groups: sham (n=6), partial unilateral ureteral obstruction (PUUO, n=6), PUUO with tadalafil treatment (PUUO+T; Cialis, 10 mg/72 h, intragastric; Lilly, Indianapolis, Indiana, USA), complete unilateral ureteral obstruction (CUUO, n=6), and CUUO with tadalafil treatment (CUUO+T). RESULTS: Fifteen days after the UUO, the ureter presented changes in the layers of urothelium and significant infiltration of inflammatory cells in the PUUO and CUUO groups. Compared with the sham, PUUO and CUUO groups had severe increased inflammatory cell infiltration. The urothelial epithelium exhibited cell degeneration and loss because of the swollen, atrophic, and denuded epithelial cells in the PUUO and CUUO groups. In the PUUO+T and CUUO+T groups, the urothelium revealed less epithelial cell degeneration and loss. The expressions of α-smooth muscle actin (α-SMA) and transforming growth factor-β (TGF-β) exhibited up-regulation in the PUUO and CUUO groups. The expression of TGF-β decreased positively correlated with that of α-SMA in the tadalafil therapy groups, PUUO+T and CUUO+T. CONCLUSION: The phosphodiesterase type 5 inhibitor's tadalafil reduced expressions of α-SMA and TGF-β in the obstructed ureters, measured by biochemical examinations. In addition, tadalafil decreased urothelium degeneration due to the decreased epithelial cell loss and inflammatory cell infiltration. Our results show that tadalafil prevents or slows down the onset of ureter inflammation and urothelial degeneration in rats with UUO.

RESUMO OBJETIVOS: Examinamos os efeitos do tadalafil em um dos inibidores da fosfodiesterase tipo 5 (PDE5) em um modelo de rato com obstrução ureteral unilateral parcial e completa (UUO). MÉTODOS: Os ratos foram divididos em cinco grupos: sham (n = 6), obstrução ureteral unilateral parcial (PUUO, n = 6), PUUO com tadalafil (PUUO T; Cialis, 10 mg/72 h, intragástrica; Lilly, Indianapolis, Indiana, EUA), completa obstrução ureteral unilateral (CUUO, n = 6) e CUUO com tratamento com tadalafil (CUUO T). RESULTADOS: Quinze dias após a UUO, o ureter apresentou alterações nas camadas de urotélio e infiltração significativa de células inflamatórias nos grupos PUUO e CUUO. Em comparação com os grupos sham, PUUO e CUUO, houve um aumento grave da infiltração de células inflamatórias. O epitélio urotelial exibiu degeneração e perda celular devido às células epiteliais inchadas, atróficas e desnudas nos grupos PUUO e CUUO. Nos grupos PUUO T e CUUO T, o urotélio revelou menor degeneração e perda de células epiteliais. Nós mostramos que a expressão da actina do músculo liso-α (α-SMA) e do fator de crescimento transformador-β (TGF-β) foram exibidas como sub-regulação nos grupos PUUO e CUUO. A expressão do TGF-β foi diminuída positivamente correlacionada com a da α-SMA nos grupos de terapia com tadalafil, PUUO T e CUUO T. CONCLUSÃO: O tadalafil do inibidor da fosfodiesterase tipo 5 reduziu as expressões α-SMA e TGF-β nos ureteres obstruídos, medidos por exames bioquímicos. Além disso, o tadalafil diminuiu a degeneração do urotélio devido à diminuição da perda de células epiteliais e da infiltração de células inflamatórias. Nossos resultados mostram que o tadalafil previne ou retarda o início da inflamação do ureter e degeneração urotelial em ratos com UUO.
Descritores: Obstrução Ureteral/patologia
Obstrução Ureteral/tratamento farmacológico
Inibidores da Fosfodiesterase 5/farmacologia
Tadalafila/farmacologia
-Valores de Referência
Ureter/efeitos dos fármacos
Ureter/patologia
Ensaio de Imunoadsorção Enzimática
Regulação para Cima
Reprodutibilidade dos Testes
Fator de Crescimento Transformador beta/análise
Actinas/análise
Ratos Sprague-Dawley
Inflamação/patologia
Inflamação/prevenção & controle
Limites: Animais
Masculino
Responsável: BR1.1 - BIREME


  8 / 18 LILACS  
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Amaro, Joäo Luiz
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Id: biblio-1054695
Autor: Toledo, Antônio Carlos de; Kawano, Paulo Roberto; Yamamoto, Hamilto Akihissa; Guerra, Rodrigo; Gomes Filho, Fernando Ferreira; Pajolli, Pedro Ivo Rochetti; Amaro, João Luiz; Cardoso, Luiz Eduardo Macedo; Sampaio, Francisco José.
Título: Effects of tadalafil to prevent injury on corpus cavernosum after vascular or nervous peri-prostatic bundle injury. Experimental model in rats
Fonte: Acta cir. bras;34(9):e201900901, 2019. tab.
Idioma: en.
Resumo: Abstract Purpose: To evaluate the effects of tadalafil (TD) in preventing histological alterations of the corpus cavernosum caused by isolated lesions of cavernous nerve (ILCN) and artery (ILCA) in rats. Methods: Fifty male Wistar rats were randomly assigned in five groups: G1: control; G2: bilateral ILCN; G3: bilateral ILCA; G4: ILCN+TD; G5: ILCA+TD. The cavernous bodies were submitted to histomorphometry, immunohistochemistry and biochemical analysis. Results: Nerve density was significantly higher in G2 and G4 compared to control (22.62±2.84 and 19.53±3.47 vs. 15.72±1.82; respectively, p<0.05). Smooth muscle density was significantly lower in G2 and G3 in comparison to G1 (12.87±1.90 and 18.93±1.51 vs. 21.78±1.81, respectively; p<0.05). A significant decrease in the sinusoidal lumen area was observed in G2 compared to controls (5.01±1.62 vs. 9.88±3.66, respectively; p<0.05) and the blood vessel density was increased in G2 and G3 (29.32±4.13 e 20.80±2.47 vs. 10.13±2.71, p<0.05). Collagen density was higher in G3 compared to G1 (93.76±15.81 vs. 64.59±19.25; p<0.05). Conclusions: Histomorphometric alterations caused by ILCN were more intense than those produced by vascular injury, but the collagen analyses showed more fibrosis in animals with ILCA. TD was effective in preventing the majority of the alterations induced by the periprostatic bundle injury.
Descritores: Pênis/inervação
Pênis/irrigação sanguínea
Substâncias Protetoras/farmacologia
Inibidores da Fosfodiesterase 5/farmacologia
Traumatismos dos Nervos Periféricos/prevenção & controle
Tadalafila/farmacologia
-Pênis/efeitos dos fármacos
Pênis/patologia
Prostatectomia/efeitos adversos
Imuno-Histoquímica
Distribuição Aleatória
Reprodutibilidade dos Testes
Colágeno/análise
Colágeno/efeitos dos fármacos
Ratos Wistar
Tecido Elástico/anatomia & histologia
Tecido Elástico/efeitos dos fármacos
Disfunção Erétil/prevenção & controle
Limites: Animais
Masculino
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


  9 / 18 LILACS  
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Martins, José Luiz
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Id: biblio-1001083
Autor: Teixeira, Luciana Cristina; Fujiki, Renato Toshio Murashita; Souza, Caio Vinicius Coitinho Paiva de; Souza, Camila Mendes de; Mismetti, Maysa Moreira; Artigiane-Neto, Ricardo; Montero, Edna Frasson de Souza; Martins, José Luiz.
Título: Oxidative stress assessment in intestine of newborn rats submitted to hypoxia and reoxygenation with tadalafil
Fonte: Acta cir. bras;34(4):e201900407, 2019. graf.
Idioma: en.
Resumo: Abstract Purpose: To evaluate the functional and structural response of tadalafil effects in the intestinal mucosa, using an experimental model of hypoxia and reoxygenation injury in rats. Methods: The animals were divided into 4 groups: CTL, H/R, H/R+Td and M+Td. The newborn rats allocated in groups H/R, H/R+Td and M+Td were submitted twice a day, to a gas chamber with CO2 at 100% for 10 minutes and afterward reoxygenation with O2 at 98% for 10 minutes, in the three first days of life. Tadalafil dose was given to newborn of group H/R+Td and to the pregnant rat of group M+Td. Histological analysis was made with hematoxylin-eosin technique and oxidative stress through nitrite and nitrate levels and lipid peroxidation. Results: The histological analysis showed a reduction of mucosa alterations in the groups that received tadalafil. In the oxidative stress evaluation, occurred an increase of NO levels and less lipidic peroxidation in the ileum segments that received tadalafil. Conclusion: Tadalafil provides tissue protection when administered independently to both, pregnant or newborns.
Descritores: Oxigênio/metabolismo
Estresse Oxidativo/efeitos dos fármacos
Inibidores da Fosfodiesterase 5/farmacologia
Tadalafila/farmacologia
Mucosa Intestinal/efeitos dos fármacos
Mucosa Intestinal/metabolismo
Hipóxia/metabolismo
-Fatores de Tempo
Peroxidação de Lipídeos
Distribuição Aleatória
Reprodutibilidade dos Testes
Ratos Wistar
Mucosa Intestinal/patologia
Animais Recém-Nascidos
Malondialdeído/análise
Nitratos/análise
Nitritos/análise
Limites: Humanos
Animais
Feminino
Gravidez
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Id: biblio-989052
Autor: Carvalho, Marcos Fiuza de; Pamplona, Thuliermes Lopes; Barreira, Márcio Alencar; Fechine, Francisco Vagnaldo Jacuru; Gonzaga-Silva, Lúcio Flávio; Oliveira, Ricardo Reges Maia de.
Título: Effect of co-administration of BRL-37344 and tadalafil on reduction of overactive bladder symptoms after induction of detrusor overactivity in mice
Fonte: Acta cir. bras;34(2):e201900205, 2019. tab, graf.
Idioma: en.
Resumo: Abstract Purpose: To evaluate the impact of the combination of BRL 37344 and tadalafil (TDF) on the reduction of overactive bladder (OB) symptoms. Methods: Thirty mice were randomized into 5 groups (G) of 6 animals each. L-NAME was used to induce DO. G1: Control; G2: L-NAME; G3: L-NAME + TDF; G4: L-NAME + BRL 37344; G5: L-NAME + TDF + BRL 37344. After 30 days of treatment, the animals were submitted to cystometry to evaluate non-voiding contractions (NVC), threshold pressure (TP), baseline pressure (BP), frequency of micturition (FM) and threshold volume (TV). Differences between the groups were analyzed with ANOVA followed by the Tukey test. Results: NVC increased in G2 (4.33±2.58) in relation to G1 (1.50±0.55). NVC decreased in G3 (2.00±1.10), G4 (1.50±1.52) and G5 (2.00±1.26) compared to G2 (p<0.05). FM decreased in G3 (0.97±0.71), G4 (0.92±0.38) and G5 (1.05±0.44) compared to G2 (p<0.05). However, the combination of TDF and BRL37344 was not more effective at increasing NVC and improving FM than either drug alone. The five groups did not differ significantly with regard to TV. Conclusion: The combination of BRL 37344 and TDF produced no measurable additive effect on reduction of OB symptoms.
Descritores: Etanolaminas/administração & dosagem
Bexiga Urinária Hiperativa/tratamento farmacológico
Agentes Urológicos/administração & dosagem
Tadalafila/administração & dosagem
-Micção/efeitos dos fármacos
Distribuição Aleatória
NG-Nitroarginina Metil Éster/farmacologia
Modelos Animais de Doenças
Quimioterapia Combinada
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME



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