Base de dados : LILACS
Pesquisa : D03.383.725.620.150 [Categoria DeCS]
Referências encontradas : 43 [refinar]
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Souza, Ivete Pomarico Ribeiro de
Maia, Lucianne Cople
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Id: lil-768253
Autor: ALEXANDRIA, Adílis Kalina; MECKELBURG, Nicolli de Araujo; PUETTER, Ursula Tavares; SALLES, Jordan Trugilho; SOUZA, Ivete Pomarico Ribeiro; MAIA, Lucianne Cople.
Título: Do pediatric medicines induce topographic changes in dental enamel?
Fonte: Braz. oral res. (Online);30(1):e11, 2016. tab, graf.
Idioma: en.
Resumo: Abstract The purpose of the present study was to evaluate the effect of common pediatric liquid medicines on surface roughness and tooth structure loss and to evaluate the pH values of these medicines at room and cold temperatures in vitro. Eighty-four bovine enamel blocks were divided into seven groups (n = 12): G1-Alivium®, G2-Novalgina®, G3-Betamox®, G4-Clavulin®, G5-Claritin®, G6-Polaramine® and G7-Milli-Q water (negative control). The pH was determined and the samples were immersed in each treatment 3x/day for 5 min. 3D non-contact profilometry was used to determine surface roughness (linear Ra, volumetric Sa) and the Gap formed between treated and control areas in each block. Scanning electron microscopy (SEM) and energy dispersive spectrometry (EDS) were also performed. The majority of liquid medicines had pH ≤ 5.50. G1, G4, and G5 showed alterations in Ra when compared with G7 (p < 0.05). According to Sa and Gap results, only G5 was different from G7 (p < 0.05). Alteration in surface was more evident in G5 SEM images. EDS revealed high concentrations of carbon, oxygen, phosphorus, and calcium in all tested groups. Despite the low pH values of all evaluated medicines, only Alivium®, Clavulin®, and Claritin® increased linear surface roughness, and only Claritin® demonstrated the in vitro capacity to produce significant tooth structure loss.
Descritores: Analgésicos/química
Antibacterianos/química
Esmalte Dentário/efeitos dos fármacos
-Combinação Amoxicilina e Clavulanato de Potássio/química
Combinação Amoxicilina e Clavulanato de Potássio/farmacologia
Temperatura Baixa
Clorfeniramina/química
Clorfeniramina/farmacologia
Esmalte Dentário/química
Dipirona/química
Dipirona/farmacologia
Testes de Dureza
Concentração de Íons de Hidrogênio
Loratadina/química
Loratadina/farmacologia
Microscopia Eletrônica de Varredura
Espectrometria por Raios X
Estatísticas não Paramétricas
Propriedades de Superfície/efeitos dos fármacos
Limites: Animais
Bovinos
Tipo de Publ: Estudos de Avaliação
Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-728691
Autor: Maham, Mehdi; Kiarostami, Vahid; Waqif-Husain, Syed; Sharifabadi, Malihe Khoeini.
Título: Analysis of chlorpheniramine in human urine samples using dispersive liquid-liquid microextraction combined with high-performance liquid chromatography
Fonte: Braz. j. pharm. sci;50(3):551-557, Jul-Sep/2014. tab, graf.
Idioma: en.
Resumo: A simple and environmentally friendly microextraction technique was used for determination of chlorpheniramine (CPM), an antihistamine drug, in human urine samples using dispersive liquid-liquid microextraction (DLLME) followed by high performance liquid chromatography with diode array detection (HPLC-DAD). In this extraction technique, an appropriate mixture of acetonitrile (disperser solvent) and carbon tetrachloride (extraction solvent) was rapidly injected into the urine sample containing the target analyte. Tiny droplets of extractant were formed and dispersed into the sample solution and then sedimented at the bottom of the conical test tube by centrifugation. Under optimal conditions, the calibration curve was linear in the range of 0.055-5.5 µg mL-1, with a detection limit of 16.5 ng mL-1. This proposed method was successfully applied to the analysis of real urine samples. Low consumption of toxic organic solvents, simplicity of operation, low cost and acceptable figures of merit are the main advantages of the proposed technique.

Utilizou-se uma técnica de microextração simples e ambientalmente amigável para a determinação de clorfeniramina (CPM), anti-histamínico, em amostras de urina humana, utilizando a microextração dispersiva líquido-líquido (DLLME), seguida por cromatografia líquida de alta eficiência com detecção por arranjo de diodos (HPLC-DAD). Nesse método de extração, mistura apropriada de acetonitrila (solvente dispersor) e tetracloreto de carbono (solvente de extração) foi injetada rapidamente na amostra de urina contendo o analito alvo. As pequenas gotículas de agente de extração foram formadas e dispersas na solução da amostra e, em seguida, sedimentadas no fundo do tubo cônico de ensaio por centrifugação. Em condições ótimas, a curva de calibração foi linear no intervalo entre 0,055 e 5,5 µg mL-1, com limite de detecção de 16,5 ng mL-1. O método proposto foi aplicado com sucesso na análise de amostras de urina reais. Baixo consumo de solventes orgânicos tóxicos, simplicidade de operação, baixo custo e figuras de mérito aceitáveis são as principais vantagens do método sugerido.
Descritores: Clorfeniramina/análise
Cromatografia Líquida/métodos
Microextração em Fase Líquida/métodos
Coleta de Urina/estatística & dados numéricos
-Antagonistas dos Receptores Histamínicos/análise
Análise Quantitativa/análise
Responsável: BR1.1 - BIREME


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Id: lil-699772
Autor: Gianlorenco, A.C.L.; Serafim, K.R.; Canto-de-Souza, A.; Mattioli, R..
Título: Effect of histamine H1 and H2 receptor antagonists, microinjected into cerebellar vermis, on emotional memory consolidation in mice
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;47(2):135-143, 2/2014. tab, graf.
Idioma: en.
Projeto: FAPESP; . FAPESP; . CNPq.
Resumo: This study investigated the effects of histamine H1 or H2 receptor antagonists on emotional memory consolidation in mice submitted to the elevated plus maze (EPM). The cerebellar vermis of male mice (Swiss albino) was implanted using a cannula guide. Three days after recovery, behavioral tests were performed in the EPM on 2 consecutive days (T1 and T2). Immediately after exposure to the EPM (T1), animals received a microinjection of saline (SAL) or the H1 antagonist chlorpheniramine (CPA; 0.016, 0.052, or 0.16 nmol/0.1 µL) in Experiment 1, and SAL or the H2 antagonist ranitidine (RA; 0.57, 2.85, or 5.7 nmol/0.1 µL) in Experiment 2. Twenty-four hours later, mice were reexposed to the EPM (T2) under the same experimental conditions but they did not receive any injection. Data were analyzed using one-way ANOVA and the Duncan test. In Experiment 1, mice microinjected with SAL and with CPA entered the open arms less often (%OAE) and spent less time in the open arms (%OAT) in T2, and there was no difference among groups. The results of Experiment 2 demonstrated that the values of %OAE and %OAT in T2 were lower compared to T1 for the groups that were microinjected with SAL and 2.85 nmol/0.1 µL RA. However, when animals were microinjected with 5.7 nmol/0.1 µL RA, they did not show a reduction in %OAE and %OAT. These results demonstrate that CPA did not affect behavior at the doses used in this study, while 5.7 nmol/0.1 µL RA induced impairment of memory consolidation in the EPM.
Descritores: Vermis Cerebelar/efeitos dos fármacos
Clorfeniramina/farmacologia
Emoções/efeitos dos fármacos
Antagonistas dos Receptores Histamínicos H1/farmacologia
/farmacologia
HISTAMINE HTEMEFOS ANTAGONISTS/farmacologia
Memória/efeitos dos fármacos
Ranitidina/farmacologia
-Microinjeções
Memória/fisiologia
Limites: Animais
Masculino
Camundongos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-675675
Autor: Brazilian Journal of Medical and Biological Research; Serafim, K.R.; Kishi, M.S.; Canto-de-Souza, A.; Mattioli, R..
Título: H1 but not H2 histamine antagonist receptors mediate anxiety-related behaviors and emotional memory deficit in mice subjected to elevated plus-maze testing
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;46(5):440-446, maio 2013. tab, graf.
Idioma: en.
Projeto: FAPESP and CNPq.
Resumo: This study investigated the role of H1 and H2 receptors in anxiety and the retrieval of emotional memory using a Trial 1/Trial 2 (T1/T2) protocol in an elevated plus-maze (EPM). Tests were performed on 2 consecutive days, designated T1 and T2. Before T1, the mice received intraperitoneal injections of saline (SAL), 20 mg/kg zolantidine (ZOL, an H2 receptor antagonist), or 8.0 or 16 mg/kg chlorpheniramine (CPA, an H1 receptor antagonist). After 40 min, they were subjected to the EPM test. In T2 (24 h later), each group was subdivided into two additional groups, and the animals from each group were re-injected with SAL or one of the drugs. In T1, the Student t-test showed no difference between the SAL and ZOL or 8 mg/kg CPA groups with respect to the percentages of open arm entries (%OAE) and open arm time (%OAT). However, administration of CPA at the highest dose of 16 mg/kg decreased %OAE and %OAT, but not locomotor activity, indicating anxiogenic-like behavior. Emotional memory, as revealed by a reduction in open arm exploration between the two trials, was observed in all experimental groups, indicating that ZOL and 8 mg/kg CPA did not affect emotional memory, whereas CPA at the highest dose affected acquisition and consolidation, but not retrieval of memory. Taken together, these results suggest that H1 receptor, but not H2, is implicated in anxiety-like behavior and in emotional memory acquisition and consolidation deficits in mice subjected to EPM testing.
Descritores: Ansiedade/induzido quimicamente
Benzotiazóis/farmacologia
Clorfeniramina/farmacologia
Antagonistas dos Receptores Histamínicos H1/farmacologia
/farmacologia
HISTAMINE HTEMEFOS ANTAGONISTS/farmacologia
Transtornos da Memória/induzido quimicamente
Fenoxipropanolaminas/farmacologia
Piperidinas/farmacologia
Receptores Histamínicos H1/efeitos dos fármacos
-Aprendizagem em Labirinto
Microinjeções
Limites: Animais
Masculino
Camundongos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-511923
Autor: Romaguera, Fernanda; Mattioli, Rosana.
Título: Chlorpheniramine impairs spatial choice learning in telencephalon-ablated fish
Fonte: Biol. Res;41(3):341-348, 2008. ilus, graf.
Idioma: en.
Resumo: This work investigated the effect of the Hj receptor blockade in the forebrain of ablated Carassius auratus in a simple stimulus-response learning task using a T-maze test with positive reinforcement. The goldfish were submitted to surgery for removal of both telencephalic lobes five days before beginning the experiment. A T-shaped glass aquarium was employed, with two feeders located at the extremities of the long arm. One of the two feeders was blocked. The experimental triáis were performed in nine consecutive days. Each fish was individually placed in the short arm and confined there for thirty seconds, then it was allowed to swim through the aquarium to search for food for ten minutes (máximum period). Time to find food was analysed in seconds. Animáis were injected intraperitoneally with chlorpheniramine (CPA) at 16 mg/kg of body weight or saline after every trial, ten minutes after being placed back in the home aquarium. The results show that all the training latencies of the A-SAL group were higher than the latencies of the S-SAL group. The S-SAL group had decreased latencies from the second trial on, while the S-CPA group showed decreased latencies after the fourth trial. The A-SAL group showed reduced latencies after the fifth trial, but the A-CPA group mainteined the latencies throughout the experiment. This suggests that CPA impairs the consolidation of learning both on telencephalon ablated animáis and in sham-operated ones through its action on mesencephalic structures of the brain and/or on the cerebellum in teleost fish.
Descritores: Carpas/fisiologia
Clorfeniramina/farmacologia
Comportamento de Escolha/efeitos dos fármacos
Antagonistas dos Receptores Histamínicos H1/farmacologia
Aprendizagem em Labirinto/efeitos dos fármacos
Telencéfalo/cirurgia
-Carpas/cirurgia
Comportamento de Escolha/fisiologia
Aprendizagem em Labirinto/fisiologia
Tempo de Reação
Limites: Animais
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-509172
Autor: Garção, D. C; Canto-de-Souza, L; Romaguera, F; Mattioli, R.
Título: Chlorpheniramine impairs functional recovery in Carassius auratus after telencephalic ablation
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;42(4):375-379, Apr. 2009. graf, ilus.
Idioma: en.
Projeto: CNPq.
Resumo: We determined the effect of an H1 receptor antagonist on the functional recovery of Carassius auratus submitted to telencephalic ablation. Five days after surgery the fish underwent a spatial-choice learning paradigm test. The fish, weighing 6-12 g, were divided into four groups: telencephalic ablation (A) or sham lesion (S) and saline (SAL) or chlorpheniramine (CPA, ip, 16 mg/kg). For eight consecutive days each animal was trained individually in sessions separated by 24 h (alternate days). Training trials (T1-T8) consisted of finding the food in one of the feeders, which were randomly blocked for each subject. Animals received an intraperitoneal injection of SAL or CPA 10 min after the training trials. The time spent by the animals in each group to find the food (latency) was analyzed separately at T1 and T8 by the Kruskal-Wallis test, followed by the Student Newman-Keuls test. At T1 the latencies (mean ± SEM) of the A-SAL (586.3 ± 13.6) and A-CPA (600 ± 0) groups were significantly longer than those of the S-SAL (226.14 ± 61.15) and S-CPA (356.33 ± 68.8) groups. At T8, the latencies of the A-CPA group (510.11 ± 62.2) remained higher than those of the other groups, all of which showed significantly shorter latencies (A-SAL = 301.91 ± 78.32; S-CPA = 191.58 ± 73.03; S-SAL = 90.28 ± 41) compared with T1. These results support evidence that training can lead to functional recovery of spatial-choice learning in telencephalonless fish and also that the antagonist of the H1 receptor impairs it.
Descritores: Aprendizagem da Esquiva/efeitos dos fármacos
Carpas/fisiologia
Clorfeniramina/farmacologia
Antagonistas dos Receptores Histamínicos H1/farmacologia
Recuperação de Função Fisiológica/efeitos dos fármacos
Telencéfalo/cirurgia
-Aprendizagem da Esquiva/fisiologia
Comportamento de Escolha/efeitos dos fármacos
Comportamento de Escolha/fisiologia
Tempo de Reação/efeitos dos fármacos
Recuperação de Função Fisiológica/fisiologia
Limites: Animais
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Texto completo SciELO Cuba
Texto completo
Id: lil-499413
Autor: Vives Iglesias, Annia Esther; Insua Arregui, Concepción.
Título: Parotiditis crónica recidivante con trastornos inmunológicos asociados / Parotiditis chronic recidivante with immune inconveniences associates
Fonte: Rev. cuba. pediatr;79(4), oct.-dic. 2007. ilus.
Idioma: es.
Resumo: En el departamento de ultrasonido diagnóstico fue atendida una paciente, de tres años de edad, que presentaba inflamación de ambas glándulas parótidas y que había presentado varios episodios de dolor, tumefacción unilateral o bilateral y fiebre. Había sido valorada en varias ocasiones por pediatría y había recibido múltiples tratamientos con antibióticos. Se le indicó ultrasonido de partes blandas y se valoró por inmunología. Se encontró un retardo en la fagocitosis y una disminución de la inmunidad celular. Se puso tratamiento con inmunomoduladores y antihistamínicos.

A 3-year-old female patient with swelling of both parotid glands that had presented various episodes of pain, unilateral or bilateral tumefaction and fever was seen at the diagnostic ultrasound department. She had been evaluated on several occasions by the pediatric department and had received multiple treatments with antibiotics. An ultrasound of soft tissues was indicated and she was assessed at the immunology service. A phagocytosis retardation and a reduction of cellular immunity were found. A treatment with immunomodulators and antihistamines was applied.
Descritores: Clorfeniramina/uso terapêutico
Levamisol/uso terapêutico
Parotidite/tratamento farmacológico
Parotidite
Tiamina/uso terapêutico
/uso terapêutico
VITAMINA B ABDOMEN, ACUTE/uso terapêutico
Limites: Seres Humanos
Feminino
Pré-Escolar
Responsável: CU1.1 - Biblioteca Médica Nacional


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Id: lil-498189
Autor: Yutronic H, Jorge; Saavedra U, Tirza; Bello P, María Piedad.
Título: Loxoscelismo cutáneo necrótico genital / Genital cutaneous loxoscelism with necrosis
Fonte: Rev. chil. dermatol;23(1):73-73, 2007. ilus.
Idioma: es.
Descritores: Picaduras de Aranhas/diagnóstico
Picaduras de Aranhas/tratamento farmacológico
-Clorfeniramina/uso terapêutico
Cloxacilina/uso terapêutico
Necrose
Pênis
Prednisona/uso terapêutico
Limites: Seres Humanos
Masculino
Adulto
Tipo de Publ: Relatos de Casos
Responsável: CL1.1 - Biblioteca Central


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Texto completo
Id: lil-484438
Autor: Faganello, F. R; Mattioli, R.
Título: Chlorpheniramine facilitates inhibitory avoidance in teleosts submitted to telencephalic ablation
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;41(5):398-402, May 2008. graf, ilus.
Idioma: en.
Resumo: The present study investigated the involvement of H(1) histaminegic receptor on the acquisition of inhibitory avoidance in Carassius auratus submitted to telencephalic ablation. The fish were submitted to telencephalic ablation 5 days before the experiment. The inhibitory avoidance procedure included 1 day for habituation, 3 days for training composed of 3 trials each (1st day: T1, T2, T3; 2nd day: 2T1, 2T2, 2T3; 3rd day: 3T1, 3T2, 3T3) and 1 day for test. On training days, the fish were placed in a white compartment, after 30 s the door was opened. When the fish crossed to a black compartment, a weight was dropped (aversive stimuli). Immediately after the third trial, on training days, the fish received, intraperitoneally, one of the pharmacological treatments (saline (N = 20), 8 (N = 12) or 16 (N = 13) µg/g chlorpheniramine, CPA). On the test day, the time to cross to the black compartment was determined. The latency of the saline group increased significantly only on the 3rd trial of the 2nd training day (mean ± SEM, T1 (50.40 ± 11.69), 2T3 (226.05 ± 25.01); ANOVA: P = 0.0249, Dunn test: P < 0.05). The group that received 8 µg/g CPA showed increased latencies from the 2nd training day until the test day (T1 (53.08 ± 17.17), 2T2 (197.75 ± 35.02), test (220.08 ± 30.98); ANOVA: P = 0.0022, Dunn test: P < 0.05)). These results indicate that CPA had a facilitating effect on memory. We suggest that the fish submitted to telencephalic ablation were able to learn due to the local circuits of the mesencephalon and/or diencephalon and that CPA interferes in these circuits, probably due an anxiolytic-like effect.
Descritores: Aprendizagem da Esquiva/efeitos dos fármacos
Clorfeniramina/farmacologia
Carpa Dourada/fisiologia
Antagonistas dos Receptores Histamínicos H1/farmacologia
Telencéfalo/fisiologia
-Análise de Variância
Aprendizagem da Esquiva/fisiologia
Condicionamento Clássico/efeitos dos fármacos
Condicionamento Clássico/fisiologia
Condicionamento Operante/efeitos dos fármacos
Condicionamento Operante/fisiologia
Memória/efeitos dos fármacos
Memória/fisiologia
Retenção (Psicologia)
Telencéfalo/efeitos dos fármacos
Telencéfalo/cirurgia
Limites: Animais
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-478883
Autor: Ogungbamigbe, T. O; Ojurongbe, O; Ogunro, P. S; Okanlawon, B. M; Kolawole, S. O.
Título: Chloroquine resistant Plasmodium falciparum malaria in Osogbo Nigeria: efficacy of amodiaquine + sulfadoxine-pyrimethamine and chloroquine + chlorpheniramine for treatment
Fonte: Mem. Inst. Oswaldo Cruz;103(1):79-84, Feb. 2008. ilus, tab.
Idioma: en.
Resumo: Chloroquine (CQ) resistance in Plasmodium falciparum contributes to increasing malaria-attributable morbidity and mortality in Sub-Saharan Africa. Despite a change in drug policy, continued prescription of CQ did not abate. Therefore the therapeutic efficacy of CQ in uncomplicated falciparum malaria patients was assessed in a standard 28-day protocol in 116 children aged between six and 120 months in Osogbo, Southwest Nigeria. Parasitological and clinical assessments of response to treatment showed that 72 (62.1 percent) of the patients were cured and 44 (37.9 percent) failed the CQ treatment. High initial parasite density and young age were independent predictors for early treatment failure. Out of the 44 patients that failed CQ, 24 received amodiaquine + sulphadoxine/pyrimethamine (AQ+SP) and 20 received chlorpheniramine + chloroquine (CH+CQ) combinations. Mean fever clearance time in those treated with AQ+SP was not significantly different from those treated with CH+CQ (p = 0.05). There was no significant difference in the mean parasite density of the two groups. The cure rate for AQ+SP group was 92 percent while those of CH+CQ was 85 percent. There was a significant difference in parasite clearance time (p = 0.01) between the two groups. The 38 percent treatment failure for CQ reported in this study is higher than the 10 percent recommended by World Health Organization in other to effect change in antimalarial treatment policy. Hence we conclude that CQ can no more be solely relied upon for the treatment of falciparum malaria in Osogbo, Nigeria. AQ+SP and CH+CQ are effective in the treatment of acute uncomplicated malaria and may be considered as useful alternative drugs in the absence of artemisinin-based combination therapies.
Descritores: Antimaláricos/administração & dosagem
Antagonistas dos Receptores Histamínicos H1/administração & dosagem
Malária Falciparum/tratamento farmacológico
Plasmodium falciparum/efeitos dos fármacos
-Amodiaquina/administração & dosagem
Protocolos Clínicos
Cloroquina/administração & dosagem
Clorfeniramina/administração & dosagem
Combinação de Medicamentos
Resistência a Medicamentos
Quimioterapia Combinada
Malária Falciparum/parasitologia
Nigéria
Pirimetamina/administração & dosagem
Sulfadoxina/administração & dosagem
Resultado do Tratamento
Limites: Animais
Criança
Pré-Escolar
Feminino
Seres Humanos
Lactente
Masculino
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME



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