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Pesquisa : D03.633.100.127 [Categoria DeCS]
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Id: biblio-1011405
Autor: Farooq, Umar; Naz, Sadia; Shams, Afshan; Raza, Yasir; Ahmed, Ayaz; Rashid, Umer; Sadiq, Abdul.
Título: Isolation of dihydrobenzofuran derivatives from ethnomedicinal species Polygonum barbatum as anticancer compounds
Fonte: Biol. Res;52:1, 2019. tab, graf.
Idioma: en.
Projeto: Higher Education Commission (HEC); . Higher Education Commission; . Higher Education Commission.
Resumo: BACKGROUND: Ethnomedicinally, the family Polygonaceae is famous for the management of cancer. Various species of this family have been reported with anticancer potentials. This study was designed to isolate anticancer compounds from ethnomedicinally important species Polygonum barbatum. METHODS: The column chromatography was used for the isolation of compounds from the solvent fraction of P. barbatum. The characterization of isolated compounds was performed by various spectroscopic techniques like UV, IR, mass spectrometry and 1D-2D NMR spectroscopy. Keeping in view the ethnomedicinal importance of the family, genus and species of P barbatum, the isolated compounds (1-3) were screened for anticancer potentials against oral cancer (CAL-27) and lungs cancer (NCI H460) cell lines using MTT assay. Active compound was further investigated for apoptosis by using morphological changes and flow cytometry analysis. In vivo anti-angiogenic study of the isolated compounds was also carried using chorioallantoic membrane assay. Docking studies were carried out to explore the mechanism of anticancer activity. RESULTS: Three dihydrobenzofuran derivatives (1-3) have been isolated from the ethyl acetate fraction of P. barbatum. The structures of isolated compounds were elucidated as methyl (2S,3S)-2-(3,4-dimethoxyphenyl)-4-((E)-3-ethoxy-3-oxoprop-1-en-1-yl)-7-methoxy-2,3-dihydrobenzo-furan-3-carboxylate (1), (E)-3-((2S,3S)-2-(3,4-dimethoxyphenyl)-7-methoxy-3-(methoxy carbonyl)-2,3-dihydrobenzofuran-4-yl)acrylic acid (2) and (2S,3 S)-4-((E)-2-carboxyvinyl)-2-(3,4-dimethoxyphenyl)-7-hydroxy-2,3-dihydrobenzofuran-3-carboxylic acid (3). The compound 1 was found to be more potent with IC50 of 48.52 ± 0.95 and 53.24 ± 1.49 against oral cancer cells as compared to standard drug (IC50 = 97.76 ± 3.44 µM). Both compound also inhibited lung cancer cells but at higher concentrations. Morphological and flow cytometry analysis further confirms that compound 1 induces apoptosis after 24 to 48 h treatment. In antiangiogenesis assay, compounds 1, 2 and 3 exhibited IC50 values of 8.2 ± 1.1,13.4 ± 1.1 and 57.7 ± 0.3 µM respectively. The docking studies revealed that the compounds under study have the potential to target the DNA and thymidylate synthase (TS). CONCLUSION: Based on its overwhelming potency against the tested cell lines and in angiogenesis assay, compound 1 can be further evaluated mechanistically and can be developed as anticancer drug candidate.
Descritores: Benzofuranos/farmacologia
Carcinoma de Células Escamosas/tratamento farmacológico
Apoptose/efeitos dos fármacos
Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico
Polygonum/química
Proliferação de Células/efeitos dos fármacos
Antineoplásicos Fitogênicos/farmacologia
-Benzofuranos/isolamento & purificação
Benzofuranos/química
Carcinoma de Células Escamosas/patologia
Carcinoma Pulmonar de Células não Pequenas/patologia
Polygonum/classificação
Linhagem Celular Tumoral
Antineoplásicos Fitogênicos/isolamento & purificação
Limites: Humanos
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1114696
Autor: Degerli, Elif; Torun, Vildan; Cansaran-Duman, Demet.
Título: miR-185-5p response to usnic acid suppresses proliferation and regulating apoptosis in breast cancer cell by targeting Bcl2
Fonte: Biol. Res;53:19, 2020. graf.
Idioma: en.
Projeto: Ankara University Management of Scientific Research Projects.
Resumo: BACKGROUND: Breast cancer is the most common cancer types among women. Recent researches have focused on determining the efficiency of alternative molecules and miRNAs in breast cancer treatment. The AIMof this study was to determine the effect of usnic acid response-miR-185-5p on proliferation in the breast cancer cell and to determine its relationship with apoptosis pathway. METHODS: The cell proliferation and cell apoptosis rate were significantly increased following the ectopic expression of miR-185-5p in BT-474 cells. Furthermore, the results of cell cycle assay performed by flow cytometry revealed that the transfection with miR-185-5p induced G1/S phase arrest. The apoptosis-related genes expression analysis was performed by qRT-PCR and the direct target of miR-185-5p in BT-474 cells was identified by western blot and luciferase reporter assay. RESULTS: Our data showed that miR-185-5p can cause significant changes in apoptosis-related genes expression levels, suggesting that cell proliferation was suppressed by miR-185-5p via inducing apoptosis in breast cancer cells. According to western blot results, miR-185-5p lead to decrease BCL2 protein level in BT-474 cells and direct target of miR-185-5p was identified as BCL by luciferase reporter assay. CONCLUSION: This study revealed that miR-185-5p may be an effective agent in the treatment of breast cancer.
Descritores: Benzofuranos/metabolismo
Neoplasias da Mama/genética
Proteínas Proto-Oncogênicas c-bcl-2/genética
MicroRNAs/genética
-Neoplasias da Mama/metabolismo
Transfecção
Transdução de Sinais
Regulação para Baixo
Regulação Neoplásica da Expressão Gênica
Apoptose
Proteínas Proto-Oncogênicas c-bcl-2
Reação em Cadeia da Polimerase Via Transcriptase Reversa
MicroRNAs/metabolismo
Linhagem Celular Tumoral
Proliferação de Células
Limites: Humanos
Feminino
Responsável: CL1.1 - Biblioteca Central


  3 / 22 LILACS  
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Id: biblio-886689
Autor: MARINHO, KETSIA S N; ANTONIO, ERIVALDO A; SILVA, CAMILLA V N S; SILVA, KEILA T DA; TEIXEIRA, VALÉRIA W; AGUIAR JUNIOR, FRANCISCO C A DE; SANTOS, KATHARINE R P DOS; SILVA, NICÁCIO H DA; SANTOS, NOEMIA P S.
Título: Hepatic toxicity caused by PLGA-microspheres containing usnic acid from the lichen C ladonia substellata (AHTI) during pregnancy in Wistar rats
Fonte: An. acad. bras. ciênc;89(2):1073-1084, Apr.-June 2017. tab, graf.
Idioma: en.
Resumo: ABSTRACT This study aimed to evaluate the teratogenic and hepatotoxic potential of the usnic acid encapsulated into PLGA-microspheres. In total, 12 female Wistar rats in pregnancy were randomly distributed in the control group (n= 6) that received 1.0 mL of physiological solution and treatment group (n= 6) that received 25 mg/kg of encapsulated usnic acid by oral administration. All females were euthanized at day 20 of pregnancy and their fetuses were removed and analyzed. During the pregnancy was observed a reduction in weight gain. There was no difference in serum transaminases levels analyzed as well as any difference in liver weight in both groups. The histomorphometric analysis of the liver from the treatment group revealed an increase in number of hepatocytes and a decrease in nuclear area of these cells. Moreover, no alteration was observed in cell area of hepatocytes or number of Kupffer cells. The fetuses had an increase in total number of hepatocytes and a reduction in the amount of megakaryocytes. These results show the hepatotoxic potential of usnic acid during pregnancy. However, its toxicity can be minimized by encapsulation in microspheres.
Descritores: Ácido Poliglicólico/toxicidade
Ascomicetos/química
Benzofuranos/toxicidade
Ácido Láctico/toxicidade
Feto/efeitos dos fármacos
Líquens/química
Fígado/efeitos dos fármacos
-Ácido Poliglicólico/química
Valores de Referência
Anormalidades Induzidas por Medicamentos
Benzofuranos/química
Distribuição Aleatória
Ratos Wistar
Exposição Materna
Ácido Láctico/química
Peso Fetal/efeitos dos fármacos
Hepatócitos/efeitos dos fármacos
Copolímero de Ácido Poliláctico e Ácido Poliglicólico
Fígado/patologia
Limites: Animais
Feminino
Gravidez
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Id: lil-742966
Autor: Souza, Celso Eduardo de; Pinter, Adriano; Donalisio, Maria Rita.
Título: Risk factors associated with the transmissionof Brazilian spotted fever in the Piracicaba river basin, State of São Paulo, Brazil
Fonte: Rev. Soc. Bras. Med. Trop;48(1):11-17, jan-feb/2015. tab, graf.
Idioma: en.
Resumo: INTRODUCTION : Brazilian spotted fever (BSF) is a disease transmitted by ticks for which the etiological agent is Rickettsia rickettsii. The present essay evaluates the risk factors associated with the transmission of cases of BSF in the time period between 2003 and 2013 in the Piracicaba river basin, state of São Paulo. METHODS : This essay presents a retrospective study to identify the factors associated with the transmission of cases of BSF among all suspected cases identified by the System for Epidemiological Surveillance of São Paulo (CVE). After the description of temporal distribution (onset of symptoms) and the environmental and demographic variations of the confirmed and discarded cases, a multiple logistic regression model was applied. RESULTS : We searched 569 probable locations of infection (PLI) with 210 (37%) confirmed cases of BSF and 359 (63%) discarded cases. The associated variables for the confirmation of BSF in the multiple logistic model using a confidence interval (CI) of 95% were age (OR = 1.025 CI: 1.015-1.035), the presence of Amblyomma sculptum in the environment (OR = 1.629 CI: 1.097-2.439), the collection of ticks from horses (OR = 1.939 CI: 0.999-3.764), the presence of capybaras (OR = 1.467 CI: 1.009-2.138), an urban environment (OR = 1.515 CI: 1.036-2.231), and the existence of a dirty pasture (OR = 1.759 CI: 1.028-3.003). CONCLUSIONS : The factors associated with the confirmation of BSF cases included an urban environment, age, presence of the A. sculptum vector, the collection of ticks from horses, the presence of a capybara population, and a dirty pasture environment. .
Descritores: Apoptose/genética
Benzofuranos/uso terapêutico
-Apoptose/efeitos dos fármacos
Western Blotting
Linhagem Celular
Núcleo Celular/efeitos dos fármacos
Núcleo Celular/metabolismo
Eletroforese em Gel Bidimensional
Hemodinâmica/efeitos dos fármacos
Marcação In Situ das Extremidades Cortadas
Microscopia Eletrônica de Transmissão
Mitocôndrias/efeitos dos fármacos
Mitocôndrias/metabolismo
Infarto do Miocárdio/metabolismo
Miocárdio/citologia
Miocárdio/metabolismo
Miocárdio/ultraestrutura
Miócitos Cardíacos/citologia
Miócitos Cardíacos/metabolismo
NF-kappa B/metabolismo
Poli(ADP-Ribose) Polimerases/metabolismo
Ratos Wistar
Transdução de Sinais/efeitos dos fármacos
Transdução de Sinais/genética
Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz
Espectrometria de Massas em Tandem
Limites: Animais
Masculino
Ratos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: biblio-1039044
Autor: Junqueira, Luis Otávio; Costa, Marcela Oliveira Legramanti da; Rando, Daniela Gonçales Galasse.
Título: N-Myristoyltransferases as antileishmanial targets: a piggyback approach with benzoheterocyclic analogues
Fonte: Braz. J. Pharm. Sci. (Online);55:e18087, 2019. graf.
Idioma: en.
Projeto: FAPESP.
Resumo: Leishmaniasis is one of the neglected diseases that remain in need for pharmacological alternatives. In this context, N-Myristoyltransferases (NMT) arise as interesting targets to explore since they are involved in the co/post-translational processing of peptides which are responsible for host cell invasion. Studies that consider these enzymes as targets point out the potential of benzoheterocyclic compounds as inhibitors of Candida albicans's N-myristoyltransferase. Here we applied a combination of comparative binding site analysis and molecular docking studies based on a Piggyback approach in the search for new Leishmania major NMT ligands. Our results revealed that NMT enzymes from both pathogens present enough structural similarity to allow extrapolation of the knowledge available from C. albicans studies to develop new L. major NMT inhibitors. Molecular docking studies with benzoheterocyclic analogues indicate the potential of benzothiazole derivatives as L. major NMT ligands, giving rise to a completely new class of chemical compounds to be explored in the development of antileishmanial drugs.
Descritores: Benzofuranos/farmacologia
Leishmaniose/tratamento farmacológico
Leishmania major
-Candida albicans
Enzimas/análise
Tipo de Publ: Estudo Comparativo
Responsável: BR40.1 - DBD - Divisão de Biblioteca e Documentacão do Conjunto das Químicas


  6 / 22 LILACS  
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Id: biblio-907561
Autor: Martinez, Janio; García, Carlos; Durango, Diego.
Título: Antifungal activity against colletotrichum acutatum and colletotrichum gloeosporioides of the major constituents from wood sawdust of platymiscium gracile benth / Actividad antifúngica contra colletotrichum acutatum y colletotrichum gloeosporioides de los constituyentes mayoritarios del aserrín de madera de platymiscium gracile benth
Fonte: Bol. latinoam. Caribe plantas med. aromát;16(1):14-25, ene. 2017. graf, ilus.
Idioma: en.
Resumo: The tree tomato (Solanum betaceum Cav., Solanaceae) anthracnose, caused by the fungi Colletotrichum acutatum and Colletotrichum gloeosporioides, is the most important disease of this crop in Colombia for its wide distribution and the losses it causes. In the present work, the in vitro antifungal activity of the soluble fractions in n-hexane, dichloromethane, and ethyl acetate, and their major constituents from the sawdust of timber specie Platymiscium gracile Benth. (Fabaceae) against both fungi was evaluated. The n-hexane-soluble fraction exhibited the greatest inhibitory effect. The metabolites homopterocarpin (a pterocarpan, 0.39 percent dry weight), calycosin (an isoflavone, 2.01 percent) and scoparone (a coumarin, 1.48 percent) were isolated for the first time from wood sawdust of P. gracile. The structure of these compounds was determined by 1H and 13C NMR analyses. The three compounds tested showed significant antifungal activity.

La antracnosis del tomate de árbol (Solanum betaceum Cav., Solanaceae), ocasionada por los hongos Colletotrichum acutatum y Colletotrichum gloeosporioides, es la enfermedad más importante de este cultivo en Colombia por su amplia distribución y las pérdidas que ocasiona. En el presente trabajo se evaluó la actividad antifúngica in vitro de las fracciones solubles en n-hexano, diclorometano y acetato de etilo, y sus componentes mayoritarios, del aserrín de la especie maderable Platymiscium gracile Benth. (Fabaceae), contra ambos hongos. La fracción en n-hexano exhibió el mayor efecto inhibitorio. Los metabolitos homopterocarpina (un pterocarpano; 0.39 por ciento del peso seco de aserrín), calicosin (una isoflavona; 2.01 por ciento) y escoparona (una cumarina; 1.48 por ciento) se aislaron por primera vez desde el aserrín de madera de P. gracile empleando técnicas cromatográficas. La estructura de los compuestos se determinó por análisis de RMN de 1H y 13C. Los tres metabolitos mostraron una actividad antifúngica significativa contra ambos hongos.
Descritores: Antifúngicos/farmacologia
Colletotrichum
Fabaceae/química
-Benzofuranos/farmacologia
Benzopiranos/farmacologia
Técnicas In Vitro
Isoflavonas/farmacologia
Testes de Sensibilidade Microbiana
Madeira
Responsável: CL1.1 - Biblioteca Central


  7 / 22 LILACS  
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Id: biblio-839306
Autor: Ma, ZG; Xia, HQ; Cui, SL; Yu, J.
Título: Attenuation of renal ischemic reperfusion injury by salvianolic acid B via suppressing oxidative stress and inflammation through PI3K/Akt signaling pathway
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;50(6):e5954, 2017. tab, graf.
Idioma: en.
Projeto: Laiwu Steel Group Hospital.
Resumo: Salvianolic acid B (SAB) is one the major phytocomponents of Radix Salvia miltiorrhiza and exhibit numerous health promoting properties. The objective of the current study was to examine whether SAB exerts a renoprotective effect by attenuating oxidative stress and inflammatory response through activating phosphatidylinositol 3-kinase/serine-threonine kinase B (PI3K/Akt) signaling pathway in a renal ischemic reperfusion rat model. Forty Sprague-Dawley male rats (250–300 g) were obtained and split into four groups with ten rats in each group. The right kidney of all rats was removed (nephrectomy). The rats of the Control group received only saline (occlusion) and served as a sham control group, whereas rats subjected to ischemic reperfusion (IR) insult by clamping the left renal artery served as a postitive control group. The other 2 groups of rats were pretreated with SAB (20 and 40 mg·kg-1·day-1) for 7 days prior IR induction and served as treatment groups (SAB 20+IR; SAB 40+IR). Renal markers creatinine (Cr) and blood urea nitrogen (BUN) were significantly lower in the groups that received SAB. Pretreatment with SAB appears to attenuate oxidative stress by suppressing the production of lipid peroxidation products like malondialdehyde as well as elevating antioxidant activity. The concentration of inflammatory markers and neutrophil infiltration (myeloperoxidase) were significantly decreased. Meanwhile, PI3K protein expression and pAkt/Akt ratio were significantly upregulated upon supplementation with SAB, indicating its renoprotective activity. Taken together, these results indicate that SAB can therapeutically alleviate oxidative stress and inflammatory process via modulating PI3K/Akt signaling pathway and probably ameliorate renal function and thus act as a renoprotective agent.
Descritores: Benzofuranos/farmacologia
Medicamentos de Ervas Chinesas/farmacologia
Estresse Oxidativo/efeitos dos fármacos
Fosfatidilinositol 3-Quinases/metabolismo
Substâncias Protetoras/farmacologia
Proteínas Proto-Oncogênicas c-akt/metabolismo
Traumatismo por Reperfusão/tratamento farmacológico
-Nitrogênio da Ureia Sanguínea
Creatinina/metabolismo
Inflamação/metabolismo
Rim/patologia
Peroxidação de Lipídeos/efeitos dos fármacos
Peroxidase/efeitos dos fármacos
Ratos Sprague-Dawley
Traumatismo por Reperfusão/metabolismo
Transdução de Sinais
Limites: Animais
Masculino
Responsável: BR1.1 - BIREME


  8 / 22 LILACS  
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Id: lil-785455
Autor: Modak, Brenda; Torres, Paulina; Mascayano, Carolina; Torres, René; Urzúa, Alejandro; Valenzuela, Beatriz.
Título: Derivatives of 3H-spiro1-benzofuran-2, 1'-cyclohexanes: immunostimulants for veterinary use / Derivados de 3H-espiro1-benzofurano-2, 1'-ciclohexanos: inmunoestimulantes de uso veterinario
Fonte: Bol. latinoam. Caribe plantas med. aromát;13(4):375-380, jul. 2014. ilus, tab.
Idioma: en.
Projeto: Fondecyt.
Resumo: Four 3H-spiro1-benzofuran-2, 1'-cyclohexanes were synthesized from filifolinol, two of which are reported for the first time. Docking molecular studies were carried out to determine in silico whether these derivatives have similar immunostimulant activity to that reported for filifolinol, and its oxidation product, filifolinone. Through of the study of interactions of these compounds with the heterodimer of the protein present in teleost TLR1-TLR2, filifolinol, 3'-filifolinchloride and filifolinyl acetate shows similar interactions between them, allowing to predict that they would have similar immunostimulant activity, but different to filifolinone and filifolinane or that they would act by a different mechanisms.

Cuatro 3H-spiro1-benzofuran-2, 1'-ciclohexanos se sintetizaron a partir de filifolinol, dos de los cuales son reportados por primera vez. Se llevaron a cabo estudios de docking molecular para determinar in silico si estos derivados tienen actividad inmunoestimulante similar a la reportada para filifolinol y su producto de oxidación, filifolinona. A través del estudio de las interacciones de estos compuestos con el heterodímero de la proteína presente en teleósteos TLR1-TLR2 se estableció que el filifolinol, 3'-cloruro de filifolinilo y acetato de filifolinilo tienen interacciones similares con el heterodímero, lo que permite predecir que entre ellos tendrían una actividad simi- lar, pero diferente a la de la filifolinona y filifolinano o que estos últimos actuarían por diferentes mecanismos.
Descritores: Adjuvantes Imunológicos
Benzofuranos/química
Cicloexanos/química
Heliotropium
-Compostos de Espiro/química
Modelos Moleculares
Receptores Toll-Like
Medicina Veterinária
Responsável: CL1.1 - Biblioteca Central


  9 / 22 LILACS  
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Id: lil-782055
Autor: Ferraz-Carvalho, Rafaela S; Pereira, Marcela A; Linhares, Leonardo A; Lira-Nogueira, Mariane CB; Cavalcanti, Isabella MF; Santos-Magalhães, Nereide S; Montenegro, Lílian ML.
Título: Effects of the encapsulation of usnic acid into liposomes and interactions with antituberculous agents against multidrug-resistant tuberculosis clinical isolates
Fonte: Mem. Inst. Oswaldo Cruz;111(5):330-334, May 2016. tab.
Idioma: en.
Projeto: FACEPE; . FACEPE; . CNPq.
Resumo: Mycobacterium tuberculosis (Mtb) has acquired resistance and consequently the antibiotic therapeutic options available against this microorganism are limited. In this scenario, the use of usnic acid (UA), a natural compound, encapsulated into liposomes is proposed as a new approach in multidrug-resistant tuberculosis (MDR-TB) therapy. Thus the aim of this study was to evaluate the effect of the encapsulation of UA into liposomes, as well as its combination with antituberculous agents such as rifampicin (RIF) and isoniazid (INH) against MDR-TB clinical isolates. The in vitro antimycobacterial activity of UA-loaded liposomes (UA-Lipo) against MDR-TB was assessed by the microdilution method. The in vitro interaction of UA with antituberculous agents was carried out using checkerboard method. Minimal inhibitory concentration values were 31.25 and 0.98 µg/mL for UA and UA-Lipo, respectively. The results exhibited a synergistic interaction between RIF and UA [fractional inhibitory concentration index (FICI) = 0.31] or UA-Lipo (FICI = 0.28). Regarding INH, the combination of UA or UA-Lipo revealed no marked effect (FICI = 1.30-2.50). The UA-Lipo may be used as a dosage form to improve the antimycobacterial activity of RIF, a first-line drug for the treatment of infections caused by Mtb.
Descritores: Antibióticos Antituberculose/farmacologia
Benzofuranos/farmacologia
Isoniazida/farmacologia
Lipossomos
Mycobacterium tuberculosis/efeitos dos fármacos
Rifampina/farmacologia
-Cápsulas
Farmacorresistência Bacteriana Múltipla/efeitos dos fármacos
Sinergismo Farmacológico
Testes de Sensibilidade Microbiana
Limites: Humanos
Responsável: BR1.1 - BIREME


  10 / 22 LILACS  
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Id: lil-741617
Autor: Oliveira-Silva, Jaquelline Carla Valamiel de; Machado-de-Assis, Girley Francisco; Oliveira, Maykon Tavares; Paiva, Nívia Carolina Noguieira; Araújo, Márcio Sobreira Silva; Carneiro, Cláudia Martins; Martins-Filho, Olindo Assis; Martins, Helen Rodrigues; Lana, Marta de.
Título: Experimental benznidazole treatment of Trypanosoma cruzi II strains isolated from children of the Jequitinhonha Valley, Minas Gerais, Brazil, with Chagas disease
Fonte: Mem. Inst. Oswaldo Cruz;110(1):86-94, 03/02/2015. tab, graf.
Idioma: en.
Resumo: Trypanosoma cruzi strains from distinct geographic areas show differences in drug resistance and association between parasites genetic and treatment response has been observed. Considering that benznidazole (BZ) can reduce the parasite burden and tissues damage, even in not cured animals and individuals, the goal is to assess the drug response to BZ of T. cruzi II strains isolated from children of the Jequitinhonha Valley, state of Minas Gerais, Brazil, before treatment. Mice infected and treated with BZ in both phases of infection were compared with the untreated and evaluated by fresh blood examination, haemoculture, polymerase chain reaction, conventional (ELISA) and non-conventional (FC-ALTA) serologies. In mice treated in the acute phase, a significant decrease in parasitaemia was observed for all strains. Positive parasitological and/or serological tests in animals treated during the acute and chronic (95.1-100%) phases showed that most of the strains were BZ resistant. However, beneficial effect was demonstrated because significant reduction (p < 0.05%) and/or suppression of parasitaemia was observed in mice infected with all strains (acute phase), associated to reduction/elimination of inflammation and fibrosis for two/eight strains. BZ offered some benefit, even in not cured animals, what suggest that BZ use may be recommended at least for recent chronic infection of the studied region.
Descritores: Descoberta de Drogas
Resíduos Industriais/análise
Nootrópicos/isolamento & purificação
Extratos Vegetais/química
Brotos de Planta/química
Estilbenos/isolamento & purificação
Vitis/química
-Agricultura/economia
Peptídeos beta-Amiloides/antagonistas & inibidores
Peptídeos beta-Amiloides/metabolismo
Benzofuranos/análise
Benzofuranos/química
Benzofuranos/economia
Benzofuranos/isolamento & purificação
Cromatografia Líquida de Alta Pressão
França
Resíduos Industriais/economia
Estrutura Molecular
Fármacos Neuroprotetores/química
Fármacos Neuroprotetores/economia
Fármacos Neuroprotetores/isolamento & purificação
Fármacos Neuroprotetores/farmacologia
Nootrópicos/química
Nootrópicos/economia
Nootrópicos/farmacologia
Agregação Patológica de Proteínas
Fragmentos de Peptídeos/antagonistas & inibidores
Fragmentos de Peptídeos/metabolismo
Fenóis/química
Fenóis/economia
Extratos Vegetais/economia
Agregados Proteicos/efeitos dos fármacos
Espectrometria de Massas por Ionização por Electrospray
Estereoisomerismo
Estilbenos/análise
Estilbenos/química
Estilbenos/economia
Estilbenos/farmacologia
Limites: Humanos
Responsável: BR1.1 - BIREME



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde