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Id: biblio-1039044
Autor: Junqueira, Luis Otávio; Costa, Marcela Oliveira Legramanti da; Rando, Daniela Gonçales Galasse.
Título: N-Myristoyltransferases as antileishmanial targets: a piggyback approach with benzoheterocyclic analogues
Fonte: Braz. J. Pharm. Sci. (Online);55:e18087, 2019. graf.
Idioma: en.
Projeto: FAPESP.
Resumo: Leishmaniasis is one of the neglected diseases that remain in need for pharmacological alternatives. In this context, N-Myristoyltransferases (NMT) arise as interesting targets to explore since they are involved in the co/post-translational processing of peptides which are responsible for host cell invasion. Studies that consider these enzymes as targets point out the potential of benzoheterocyclic compounds as inhibitors of Candida albicans's N-myristoyltransferase. Here we applied a combination of comparative binding site analysis and molecular docking studies based on a Piggyback approach in the search for new Leishmania major NMT ligands. Our results revealed that NMT enzymes from both pathogens present enough structural similarity to allow extrapolation of the knowledge available from C. albicans studies to develop new L. major NMT inhibitors. Molecular docking studies with benzoheterocyclic analogues indicate the potential of benzothiazole derivatives as L. major NMT ligands, giving rise to a completely new class of chemical compounds to be explored in the development of antileishmanial drugs.
Descritores: Benzofuranos/farmacologia
Leishmaniose/tratamento farmacológico
Leishmania major
-Candida albicans
Enzimas/análise
Tipo de Publ: Estudo Comparativo
Responsável: BR40.1 - DBD - Divisão de Biblioteca e Documentacão do Conjunto das Químicas


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Id: biblio-907561
Autor: Martinez, Janio; García, Carlos; Durango, Diego.
Título: Antifungal activity against colletotrichum acutatum and colletotrichum gloeosporioides of the major constituents from wood sawdust of platymiscium gracile benth / Actividad antifúngica contra colletotrichum acutatum y colletotrichum gloeosporioides de los constituyentes mayoritarios del aserrín de madera de platymiscium gracile benth
Fonte: Bol. latinoam. Caribe plantas med. aromát;16(1):14-25, ene. 2017. graf, ilus.
Idioma: en.
Resumo: The tree tomato (Solanum betaceum Cav., Solanaceae) anthracnose, caused by the fungi Colletotrichum acutatum and Colletotrichum gloeosporioides, is the most important disease of this crop in Colombia for its wide distribution and the losses it causes. In the present work, the in vitro antifungal activity of the soluble fractions in n-hexane, dichloromethane, and ethyl acetate, and their major constituents from the sawdust of timber specie Platymiscium gracile Benth. (Fabaceae) against both fungi was evaluated. The n-hexane-soluble fraction exhibited the greatest inhibitory effect. The metabolites homopterocarpin (a pterocarpan, 0.39 percent dry weight), calycosin (an isoflavone, 2.01 percent) and scoparone (a coumarin, 1.48 percent) were isolated for the first time from wood sawdust of P. gracile. The structure of these compounds was determined by 1H and 13C NMR analyses. The three compounds tested showed significant antifungal activity.

La antracnosis del tomate de árbol (Solanum betaceum Cav., Solanaceae), ocasionada por los hongos Colletotrichum acutatum y Colletotrichum gloeosporioides, es la enfermedad más importante de este cultivo en Colombia por su amplia distribución y las pérdidas que ocasiona. En el presente trabajo se evaluó la actividad antifúngica in vitro de las fracciones solubles en n-hexano, diclorometano y acetato de etilo, y sus componentes mayoritarios, del aserrín de la especie maderable Platymiscium gracile Benth. (Fabaceae), contra ambos hongos. La fracción en n-hexano exhibió el mayor efecto inhibitorio. Los metabolitos homopterocarpina (un pterocarpano; 0.39 por ciento del peso seco de aserrín), calicosin (una isoflavona; 2.01 por ciento) y escoparona (una cumarina; 1.48 por ciento) se aislaron por primera vez desde el aserrín de madera de P. gracile empleando técnicas cromatográficas. La estructura de los compuestos se determinó por análisis de RMN de 1H y 13C. Los tres metabolitos mostraron una actividad antifúngica significativa contra ambos hongos.
Descritores: Antifúngicos/farmacologia
Colletotrichum
Fabaceae/química
-Benzofuranos/farmacologia
Benzopiranos/farmacologia
Técnicas In Vitro
Isoflavonas/farmacologia
Testes de Sensibilidade Microbiana
Madeira
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-839306
Autor: Ma, ZG; Xia, HQ; Cui, SL; Yu, J.
Título: Attenuation of renal ischemic reperfusion injury by salvianolic acid B via suppressing oxidative stress and inflammation through PI3K/Akt signaling pathway
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;50(6):e5954, 2017. tab, graf.
Idioma: en.
Projeto: Laiwu Steel Group Hospital.
Resumo: Salvianolic acid B (SAB) is one the major phytocomponents of Radix Salvia miltiorrhiza and exhibit numerous health promoting properties. The objective of the current study was to examine whether SAB exerts a renoprotective effect by attenuating oxidative stress and inflammatory response through activating phosphatidylinositol 3-kinase/serine-threonine kinase B (PI3K/Akt) signaling pathway in a renal ischemic reperfusion rat model. Forty Sprague-Dawley male rats (250–300 g) were obtained and split into four groups with ten rats in each group. The right kidney of all rats was removed (nephrectomy). The rats of the Control group received only saline (occlusion) and served as a sham control group, whereas rats subjected to ischemic reperfusion (IR) insult by clamping the left renal artery served as a postitive control group. The other 2 groups of rats were pretreated with SAB (20 and 40 mg·kg-1·day-1) for 7 days prior IR induction and served as treatment groups (SAB 20+IR; SAB 40+IR). Renal markers creatinine (Cr) and blood urea nitrogen (BUN) were significantly lower in the groups that received SAB. Pretreatment with SAB appears to attenuate oxidative stress by suppressing the production of lipid peroxidation products like malondialdehyde as well as elevating antioxidant activity. The concentration of inflammatory markers and neutrophil infiltration (myeloperoxidase) were significantly decreased. Meanwhile, PI3K protein expression and pAkt/Akt ratio were significantly upregulated upon supplementation with SAB, indicating its renoprotective activity. Taken together, these results indicate that SAB can therapeutically alleviate oxidative stress and inflammatory process via modulating PI3K/Akt signaling pathway and probably ameliorate renal function and thus act as a renoprotective agent.
Descritores: Benzofuranos/farmacologia
Medicamentos de Ervas Chinesas/farmacologia
Estresse Oxidativo/efeitos dos fármacos
Fosfatidilinositol 3-Quinases/metabolismo
Substâncias Protetoras/farmacologia
Proteínas Proto-Oncogênicas c-akt/metabolismo
Traumatismo por Reperfusão/tratamento farmacológico
-Nitrogênio da Ureia Sanguínea
Creatinina/metabolismo
Inflamação/metabolismo
Rim/patologia
Peroxidação de Lipídeos/efeitos dos fármacos
Peroxidase/efeitos dos fármacos
Ratos Sprague-Dawley
Traumatismo por Reperfusão/metabolismo
Transdução de Sinais
Limites: Animais
Masculino
Responsável: BR1.1 - BIREME


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Id: lil-785455
Autor: Modak, Brenda; Torres, Paulina; Mascayano, Carolina; Torres, René; Urzúa, Alejandro; Valenzuela, Beatriz.
Título: Derivatives of 3H-spiro1-benzofuran-2, 1'-cyclohexanes: immunostimulants for veterinary use / Derivados de 3H-espiro1-benzofurano-2, 1'-ciclohexanos: inmunoestimulantes de uso veterinario
Fonte: Bol. latinoam. Caribe plantas med. aromát;13(4):375-380, jul. 2014. ilus, tab.
Idioma: en.
Projeto: Fondecyt.
Resumo: Four 3H-spiro1-benzofuran-2, 1'-cyclohexanes were synthesized from filifolinol, two of which are reported for the first time. Docking molecular studies were carried out to determine in silico whether these derivatives have similar immunostimulant activity to that reported for filifolinol, and its oxidation product, filifolinone. Through of the study of interactions of these compounds with the heterodimer of the protein present in teleost TLR1-TLR2, filifolinol, 3'-filifolinchloride and filifolinyl acetate shows similar interactions between them, allowing to predict that they would have similar immunostimulant activity, but different to filifolinone and filifolinane or that they would act by a different mechanisms.

Cuatro 3H-spiro1-benzofuran-2, 1'-ciclohexanos se sintetizaron a partir de filifolinol, dos de los cuales son reportados por primera vez. Se llevaron a cabo estudios de docking molecular para determinar in silico si estos derivados tienen actividad inmunoestimulante similar a la reportada para filifolinol y su producto de oxidación, filifolinona. A través del estudio de las interacciones de estos compuestos con el heterodímero de la proteína presente en teleósteos TLR1-TLR2 se estableció que el filifolinol, 3'-cloruro de filifolinilo y acetato de filifolinilo tienen interacciones similares con el heterodímero, lo que permite predecir que entre ellos tendrían una actividad simi- lar, pero diferente a la de la filifolinona y filifolinano o que estos últimos actuarían por diferentes mecanismos.
Descritores: Adjuvantes Imunológicos
Benzofuranos/química
Cicloexanos/química
Heliotropium
-Compostos de Espiro/química
Modelos Moleculares
Receptores Toll-Like
Medicina Veterinária
Responsável: CL1.1 - Biblioteca Central


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Id: lil-782055
Autor: Ferraz-Carvalho, Rafaela S; Pereira, Marcela A; Linhares, Leonardo A; Lira-Nogueira, Mariane CB; Cavalcanti, Isabella MF; Santos-Magalhães, Nereide S; Montenegro, Lílian ML.
Título: Effects of the encapsulation of usnic acid into liposomes and interactions with antituberculous agents against multidrug-resistant tuberculosis clinical isolates
Fonte: Mem. Inst. Oswaldo Cruz;111(5):330-334, May 2016. tab.
Idioma: en.
Projeto: FACEPE; . FACEPE; . CNPq.
Resumo: Mycobacterium tuberculosis (Mtb) has acquired resistance and consequently the antibiotic therapeutic options available against this microorganism are limited. In this scenario, the use of usnic acid (UA), a natural compound, encapsulated into liposomes is proposed as a new approach in multidrug-resistant tuberculosis (MDR-TB) therapy. Thus the aim of this study was to evaluate the effect of the encapsulation of UA into liposomes, as well as its combination with antituberculous agents such as rifampicin (RIF) and isoniazid (INH) against MDR-TB clinical isolates. The in vitro antimycobacterial activity of UA-loaded liposomes (UA-Lipo) against MDR-TB was assessed by the microdilution method. The in vitro interaction of UA with antituberculous agents was carried out using checkerboard method. Minimal inhibitory concentration values were 31.25 and 0.98 µg/mL for UA and UA-Lipo, respectively. The results exhibited a synergistic interaction between RIF and UA [fractional inhibitory concentration index (FICI) = 0.31] or UA-Lipo (FICI = 0.28). Regarding INH, the combination of UA or UA-Lipo revealed no marked effect (FICI = 1.30-2.50). The UA-Lipo may be used as a dosage form to improve the antimycobacterial activity of RIF, a first-line drug for the treatment of infections caused by Mtb.
Descritores: Antibióticos Antituberculose/farmacologia
Benzofuranos/farmacologia
Isoniazida/farmacologia
Lipossomos
Mycobacterium tuberculosis/efeitos dos fármacos
Rifampina/farmacologia
-Cápsulas
Farmacorresistência Bacteriana Múltipla/efeitos dos fármacos
Sinergismo Farmacológico
Testes de Sensibilidade Microbiana
Limites: Seres Humanos
Responsável: BR1.1 - BIREME


  6 / 20 LILACS  
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Id: lil-742966
Autor: Souza, Celso Eduardo de; Pinter, Adriano; Donalisio, Maria Rita.
Título: Risk factors associated with the transmissionof Brazilian spotted fever in the Piracicaba river basin, State of São Paulo, Brazil
Fonte: Rev. Soc. Bras. Med. Trop;48(1):11-17, jan-feb/2015. tab, graf.
Idioma: en.
Resumo: INTRODUCTION : Brazilian spotted fever (BSF) is a disease transmitted by ticks for which the etiological agent is Rickettsia rickettsii. The present essay evaluates the risk factors associated with the transmission of cases of BSF in the time period between 2003 and 2013 in the Piracicaba river basin, state of São Paulo. METHODS : This essay presents a retrospective study to identify the factors associated with the transmission of cases of BSF among all suspected cases identified by the System for Epidemiological Surveillance of São Paulo (CVE). After the description of temporal distribution (onset of symptoms) and the environmental and demographic variations of the confirmed and discarded cases, a multiple logistic regression model was applied. RESULTS : We searched 569 probable locations of infection (PLI) with 210 (37%) confirmed cases of BSF and 359 (63%) discarded cases. The associated variables for the confirmation of BSF in the multiple logistic model using a confidence interval (CI) of 95% were age (OR = 1.025 CI: 1.015-1.035), the presence of Amblyomma sculptum in the environment (OR = 1.629 CI: 1.097-2.439), the collection of ticks from horses (OR = 1.939 CI: 0.999-3.764), the presence of capybaras (OR = 1.467 CI: 1.009-2.138), an urban environment (OR = 1.515 CI: 1.036-2.231), and the existence of a dirty pasture (OR = 1.759 CI: 1.028-3.003). CONCLUSIONS : The factors associated with the confirmation of BSF cases included an urban environment, age, presence of the A. sculptum vector, the collection of ticks from horses, the presence of a capybara population, and a dirty pasture environment. .
Descritores: Apoptose/genética
Benzofuranos/uso terapêutico
-Apoptose/efeitos dos fármacos
Western Blotting
Linhagem Celular
Núcleo Celular/efeitos dos fármacos
Núcleo Celular/metabolismo
Eletroforese em Gel Bidimensional
Hemodinâmica/efeitos dos fármacos
Marcação In Situ das Extremidades Cortadas
Microscopia Eletrônica de Transmissão
Mitocôndrias/efeitos dos fármacos
Mitocôndrias/metabolismo
Infarto do Miocárdio/metabolismo
Miocárdio/citologia
Miocárdio/metabolismo
Miocárdio/ultraestrutura
Miócitos Cardíacos/citologia
Miócitos Cardíacos/metabolismo
NF-kappa B/metabolismo
Poli(ADP-Ribose) Polimerases/metabolismo
Ratos Wistar
Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz
Transdução de Sinais/efeitos dos fármacos
Transdução de Sinais/genética
Espectrometria de Massas em Tandem
Limites: Animais
Masculino
Ratos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


  7 / 20 LILACS  
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Id: lil-741617
Autor: Oliveira-Silva, Jaquelline Carla Valamiel de; Machado-de-Assis, Girley Francisco; Oliveira, Maykon Tavares; Paiva, Nívia Carolina Noguieira; Araújo, Márcio Sobreira Silva; Carneiro, Cláudia Martins; Martins-Filho, Olindo Assis; Martins, Helen Rodrigues; Lana, Marta de.
Título: Experimental benznidazole treatment of Trypanosoma cruzi II strains isolated from children of the Jequitinhonha Valley, Minas Gerais, Brazil, with Chagas disease
Fonte: Mem. Inst. Oswaldo Cruz;110(1):86-94, 03/02/2015. tab, graf.
Idioma: en.
Resumo: Trypanosoma cruzi strains from distinct geographic areas show differences in drug resistance and association between parasites genetic and treatment response has been observed. Considering that benznidazole (BZ) can reduce the parasite burden and tissues damage, even in not cured animals and individuals, the goal is to assess the drug response to BZ of T. cruzi II strains isolated from children of the Jequitinhonha Valley, state of Minas Gerais, Brazil, before treatment. Mice infected and treated with BZ in both phases of infection were compared with the untreated and evaluated by fresh blood examination, haemoculture, polymerase chain reaction, conventional (ELISA) and non-conventional (FC-ALTA) serologies. In mice treated in the acute phase, a significant decrease in parasitaemia was observed for all strains. Positive parasitological and/or serological tests in animals treated during the acute and chronic (95.1-100%) phases showed that most of the strains were BZ resistant. However, beneficial effect was demonstrated because significant reduction (p < 0.05%) and/or suppression of parasitaemia was observed in mice infected with all strains (acute phase), associated to reduction/elimination of inflammation and fibrosis for two/eight strains. BZ offered some benefit, even in not cured animals, what suggest that BZ use may be recommended at least for recent chronic infection of the studied region.
Descritores: Descoberta de Drogas
Resíduos Industriais/análise
Nootrópicos/isolamento & purificação
Extratos Vegetais/química
Brotos de Planta/química
Estilbenos/isolamento & purificação
Vitis/química
-Agricultura/economia
Peptídeos beta-Amiloides/antagonistas & inibidores
Peptídeos beta-Amiloides/metabolismo
Benzofuranos/análise
Benzofuranos/química
Benzofuranos/economia
Benzofuranos/isolamento & purificação
Cromatografia Líquida de Alta Pressão
França
Resíduos Industriais/economia
Estrutura Molecular
Fármacos Neuroprotetores/química
Fármacos Neuroprotetores/economia
Fármacos Neuroprotetores/isolamento & purificação
Fármacos Neuroprotetores/farmacologia
Nootrópicos/química
Nootrópicos/economia
Nootrópicos/farmacologia
Agregação Patológica de Proteínas
Fragmentos de Peptídeos/antagonistas & inibidores
Fragmentos de Peptídeos/metabolismo
Fenóis/química
Fenóis/economia
Extratos Vegetais/economia
Agregados Proteicos/efeitos dos fármacos
Espectrometria de Massas por Ionização por Electrospray
Estereoisomerismo
Estilbenos/análise
Estilbenos/química
Estilbenos/economia
Estilbenos/farmacologia
Limites: Seres Humanos
Responsável: BR1.1 - BIREME


  8 / 20 LILACS  
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Id: lil-687017
Autor: Modak, Brenda; Torres, René; De Saint Pierre, Michelle; Saud, Katherine; Armijo, Adriana; Caviedes, Raúl; Caviedes, Pablo.
Título: In vitro antiproliferative activity of 3 H-spiro [1-benzofuran-2,1'-cyclohexane] derivatives / Actividad antiproliferativa in vitro de derivados de 3 H-spiro [1-benzofuran-2, 1'-cyclohexano]
Fonte: Bol. latinoam. Caribe plantas med. aromát;10(3):281-288, mayo 2011. ilus, tab.
Idioma: en.
Projeto: FONDECYT; . Enlaces.
Resumo: The in vitro effect of the resinous exudate of Heliotropium filifolium, of the 3 H-spiro[1-benzofuran-2,1 '-cyclohexane] derivative called filifolinol 1, isolated from the resin and the semi-synthetic compounds filifolinone 2 and filifolinoic acid 3, obtained from filifolinol 1, were evaluated on the proliferation of an immortalized cell line, UCHT1, derived from rat thyroid. We evaluated the effect of these compounds on UCHT1 cell growth parameters by calculating doubling time; and toxicity using the LIVE/DEAD™ in vitro test. The results showed that the resin is not active, while filifolinone 2, filifolinoic acid 3 and filifolinol 1 produced a significant inhibition of cell doubling time, in concentrations equal or greater than 50, 25 and 75 uM, respectively. The LIVE/DEAD test showed no significant toxicity at these concentrations, compared to cultures kept in absence of compounds. These results suggest a possible cytostatic effect of these compounds, and could therefore constitute potential alternatives for antineoplasic therapy.

Se evaluó el efecto in vitro de la resina aislada desde Heliotropium filifolium y del derivado 3 H-spiro[1-benzofuran-2,1'-cyclohexano] llamado filifolinol 1, obtenido desde este exudado resinoso y los compuestos semi-sintéticos filifolinona 2 y ácido filifolinoico 3, obtenidos a partir de filifolinol 1, sobre la proliferación de la línea celular inmortal, UCHT1, derivada de tumor de tiroide de rata. Evaluamos el efecto de estos compuestos en el desarrollo celular de UCHT1 a través de los parámetros tiempo de doblaje y citotoxicidad usando el test LIVE/DEAD™ in vitro. Los resultados mostraron que la resina no presentó actividad y que filifolinona, ácido filifolinoico y filifolinol producen una inhibición significativa del tiempo de doblaje celular, en concentraciones iguales o superiores a 50, 25 y 75 uM, respectivamente. El test LIVE/DEAD no mostró toxicidad significativa en comparación con los cultivos mantenidos en ausencia de compuestos. Estos resultados sugieren un posible efecto citostático de estos compuestos y por lo tanto, constituirían alternativas potenciales para terapia antineoplásica.
Descritores: Antineoplásicos/farmacologia
Extratos Vegetais/farmacologia
Heliotropium/química
Neoplasias da Glândula Tireoide/tratamento farmacológico
Proliferação Celular
-Benzofuranos
Cicloexanos
Exsudatos de Plantas/farmacologia
Resinas Vegetais
Compostos de Espiro
Sobrevivência Celular
Técnicas de Cultura de Tecidos
Limites: Animais
Ratos
Responsável: CL1.1 - Biblioteca Central


  9 / 20 LILACS  
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Id: lil-684525
Autor: Brazilian Journal of Medical and Biological Research; Chen, C.; Yang, R.L..
Título: A phthalide derivative isolated from endophytic fungi Pestalotiopsis photiniae induces G1 cell cycle arrest and apoptosis in human HeLa cells
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;46(8):643-649, ago. 2013. graf.
Idioma: en.
Projeto: National Natural Science Foundation of China; . Scientific Research Program of HeBei Provincial Education Bureau.
Resumo: MP [4-(3′,3′-dimethylallyloxy)-5-methyl-6-methoxyphthalide] was obtained from liquid culture of Pestalotiopsis photiniae isolated from the Chinese Podocarpaceae plant Podocarpus macrophyllus. MP significantly inhibited the proliferation of HeLa tumor cell lines. After treatment with MP, characteristic apoptotic features such as DNA fragmentation and chromatin condensation were observed in DAPI-stained HeLa cells. Flow cytometry showed that MP induced G1 cell cycle arrest and apoptosis in a dose-dependent manner. Western blotting and real-time reverse transcription-polymerase chain reaction were used to investigate protein and mRNA expression. MP caused significant cell cycle arrest by upregulating the cyclin-dependent kinase inhibitor p27KIP1 protein and p21CIP1 mRNA levels in HeLa cells. The expression of p73 protein was increased after treatment with various MP concentrations. mRNA expression of the cell cycle-related genes, p21CIP1 , p16INK4a and Gadd45α, was significantly upregulated and mRNA levels demonstrated significantly increased translation of p73, JunB, FKHR, and Bim. The results indicate that MP may be a potential treatment for cervical cancer.
Descritores: Apoptose/efeitos dos fármacos
Benzofuranos/administração & dosagem
Endófitos/química
Pontos de Checagem da Fase G1 do Ciclo Celular/efeitos dos fármacos
Xylariales/química
-Proteínas Reguladoras de Apoptose/genética
Benzofuranos/isolamento & purificação
Proteínas de Ciclo Celular/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
/efeitos dos fármacos
CYCLIN-DEPENDENT KINASE INHIBITOR PABORTION APPLICANTS/efeitos dos fármacos
/efeitos dos fármacos
CYCLIN-DEPENDENT KINASE INHIBITOR PABORTION, EUGENIC/efeitos dos fármacos
Proteínas de Ligação a DNA/efeitos dos fármacos
Citometria de Fluxo
Fatores de Transcrição Forkhead/efeitos dos fármacos
Cycadopsida
/efeitos dos fármacos
GENES, PABNORMALITIES, MULTIPLE/efeitos dos fármacos
Células HeLa
Proteínas Nucleares/efeitos dos fármacos
Reação em Cadeia da Polimerase em Tempo Real
Transcrição Genética
Fatores de Transcrição/efeitos dos fármacos
Proteínas Supressoras de Tumor/efeitos dos fármacos
Limites: Seres Humanos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


  10 / 20 LILACS  
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Id: lil-647667
Autor: Modak, Brenda; Valenzuela, Beatriz; Imarai, Mónica; Torres, René.
Título: In vitro immunostimulant activity of the aromatic geranyl derivative Filifolinone / Actividad inmunoestimulante in vitro del derivado aromático geranilado Filifolinona
Fonte: Bol. latinoam. Caribe plantas med. aromát;11(3):285-290, mayo 2012. ilus.
Idioma: en.
Projeto: FONDECYT.
Resumo: The in vitro effect of the 3 H-spiro [1-benzofuran-2,1'-ciclohexane] derivative (Filifolinone), was evaluated on mouse dendritic cells through the level of expression of MHC molecules class II by flow cytometry. The results show that Filifolinone increases the expression of MHC promoting maturation of dendritic cells. The results suggest that Filifolinone is a potential immunomodulator for veterinary use.

La actividad in vitro del derivado 3H-espiro [1-benzofurano-2,1'-ciclohexano] (Filifolinona), fue evaluado en células dendríticas de ratón a través del nivel de expresión de moléculas MHC clase II utilizando citometría de flujo. Los resultados muestran que Filifolinona incrementa la expresión de MHC promoviendo la maduración de las células dendríticas. Estos resultados permiten sugerir que Filifolinona es un potencial inmunomodulador de uso veterinario.
Descritores: Benzofuranos
Células Dendríticas
Heliotropium/química
Fatores Imunológicos
Compostos de Espiro
-Citometria de Fluxo
Camundongos Endogâmicos BALB C
Limites: Animais
Feminino
Camundongos
Responsável: CL1.1 - Biblioteca Central



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