Base de dados : LILACS
Pesquisa : D03.633.100.127.125 [Categoria DeCS]
Referências encontradas : 6 [refinar]
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Texto completo SciELO Brasil
Texto completo
Id: lil-618194
Autor: Nikbakhtzadeh, M. R; Vahedi, M; Vatandoost, H; Mehdinia, A.
Título: Origin, transfer and distribution of cantharidin-related compounds in the blister beetle Hycleus scabiosae
Fonte: J. venom. anim. toxins incl. trop. dis;18(1):88-96, 2012. ilus.
Idioma: en.
Projeto: Tarbiat Modares University.
Resumo: Cantharidin provides chemical protection for the coleopteran families Meloidae and Oedemeridae. In the present study, it was observed that cantharidin concentration in Hycleus scabiosae was slightly decreased from mated females (mean = 0.011 mg/mg of dry weight) to males (mean = 0.010 mg/mg) and considerably diminished in relation to virgin females (mean = 0.005 mg/mg). Significant concentrations of palasonin (21.69 ng/mg among virgins and 17.49 ng/mg in mated females) and palasoninimide (14.62 ng/mg in virgins and 9.17 ng/mg in mated females) were found in H. scabiosae. Palasonin, palasoninimide and cantharidinimide content of eggs were measured as 5.61, 7.69 and 7.80 ng/mg respectively. Surprisingly, males showed no trace of cantharidin-related compounds (CRCs); therefore CRCs in H. scabiosae could not be transferred from males to females and based on experiments employing its deuterated form, cantharidin is probably independently synthesized in females from the male nuptial transfer. An inseminated female incorporates about 38.5 ng of cantharidin (0.34 percent of the maternal content), 196.35 ng of palasonin (91.82 percent of maternal content) and 269.15 ng of palasoninimide (96.70 percent maternal content) into each egg mass during oviposition. It seems that eggs of this meloid species exploit a different array of protective chemicals by increasing the ratio of CRCs versus cantharidin. CRCs are less toxic than cantharidin; therefore, such compounds might have been deposited in eggs as a safer substitute for cantharidin to provide effective protection, but does not simultaneously harm the susceptible embryo.(AU)
Descritores: Besouros/fisiologia
Cantaridina/metabolismo
Cantaridina/química
Vesícula
-Cantaridina/toxicidade
Fatores Sexuais
Fatores Etários
Limites: Animais
Masculino
Feminino
Responsável: BR33.1 - Divisão Técnica de Biblioteca e Documentação


  2 / 6 LILACS  
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Texto completo SciELO Chile
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Id: lil-466476
Autor: Ledermann D., Walterá.
Título: Simón Bolívar y las cantáridas / Simon Bolivar and the cantharides
Fonte: Rev. chil. infectol;24(5):409-412, oct. 2007. ilus.
Idioma: es.
Resumo: Simon Bolivar, The Liberator, did not trust medical care and if he ever requested a doctor, it seems to have been mainly politically motivated. Unfortunately his fears seem to have been correct as his death was accelerated by Dr. Revenand, a man whose medical title is yet under discussion, who applied an extract of cantharides, a beetle known as "the Spanish fly", employed generally as an aphrodisiac, over Bolivar's neck region. According to popular belief of the time, cantharidin, the insect's active principle, reduced "the excess of humours", such as cerebrospinal fluid, plasma, "pituita" and others. Cantharidin has severe adverse effects and was for sure the origin of great suffering for many unfortunate patients in the past.
Descritores: Cantaridina/envenenamento
Pessoas Famosas
Militares/história
Limites: História do Século XIX
Tipo de Publ: Biografia
Artigo Histórico
Responsável: BR1.1 - BIREME


  3 / 6 LILACS  
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Id: lil-410842
Autor: Williams, L. A; Mõller, W; Merisor, E; Kraus, W; Rõsner, H.
Título: In vitro anti-proliferation/cytotoxic activity of cantharidin (Spanish Fly) and related derivatives
Fonte: West Indian med. j;52(1):10-13, Mar. 2003.
Idioma: en.
Resumo: The anti-cancer therapeutic promise of cantharidin is limited because of its high mammalian toxicity. In order to find new anti-cancer lead compounds with reduced toxicity of the cantharidin prototype, the following seven derivatives were screened against the human SH-SY5Y neuroblastoma and MCF-7 breast cancer cells in vitro: 2,3-dimethyl-7-oxabicylo-[2.2.1]heptane-2,3-dicarboxylic anhydride (cantharidin) [1], 1-cyclohexen-1,2-dicarboxylic anhydride [2], cis-4-cyclohexen-1,2-dicarboxylic anhydride [3], cis-1, 2-cyclohexanedicarboxylic anhydride [4], exo-7-oxabicyclo[2.2.1]hept-5-ene-2-3 dicarboxylic anhydride [5], exo-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic anhydride (norcantharidin) [6], and (S)-(-)-O-acetylmalic anhydride [7]. Cantharidin, was found to be the most effective anti-proliferative compound on both cell lines. However, on the human neuroblastoma cells cantharidin was of equal toxicity to compound [6]. Mode of action studies revealed that cantharidin inhibited growth factor-mediated activation of mitogen activated protein kinase (MAPkinase) and attenuated the de-phosphorylation of the extracellular regulated kinases 1 and 2 (erk1 and erk2)
Descritores: Anidridos/toxicidade
Cantaridina/toxicidade
Inibidores Enzimáticos/toxicidade
-Ativação Enzimática/efeitos dos fármacos
/farmacologia
FATOR TEMEFOS DE CRESCIMENTO DE FIBROBLASTOS/farmacologia
Matriz Extracelular/efeitos dos fármacos
Matriz Extracelular/enzimologia
Neoplasias da Mama/tratamento farmacológico
Neuroblastoma/tratamento farmacológico
Proteínas Quinases Ativadas por Mitógeno/efeitos dos fármacos
Células Tumorais Cultivadas
Transformação Celular Neoplásica/efeitos dos fármacos
Limites: Humanos
Responsável: BR1.1 - BIREME


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Id: lil-339150
Autor: Rendic, E; Navea, O; Pizarro, M; Marín, E; Rivera, G; Melis, M; Fich, F.
Título: Uso de cantaridina en verrugas comunes y moluscos contagiosos: un estudio abierto / Use of cantaridine in common warts and contagious mollusca: an open study
Fonte: Rev. chil. dermatol;18(2):106-109, 2002. tab.
Idioma: es.
Resumo: Se realiza un estudio abierto, no randomizado, para evaluar la respuesta de cataridina en pacientes con verrugas comunes y pacientes con muluscos contagiosos. Se concluye que la cantaridina es eficaz y segura en el tratamiento de moluscos contagiosos, no así en el caso de verrugas comunes, en que logramos una respuesta pobre
Descritores: Cantaridina
Molusco Contagioso
Verrugas
-Administração Tópica
Limites: Pré-Escolar
Adolescente
Feminino
Pessoa de Meia-Idade
Responsável: CL1.1 - Biblioteca Central


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Fotocópia
Id: lil-157519
Autor: Pellegrino, Juan Carlos.
Título: Venenos animales / Animals poisons
Fonte: Homeopatía (Argent.);57(4):157-8, 1992.
Idioma: es.
Resumo: Esta colaboración trata de explicar lo relativo de los conceptos manejados en relación a los venenos animales y su acción terapéutica homeopática a través de la dinamización hahnemanniana. Las diferencias entre su acción tóxica y patogenética; su justificación a través de los parágrafos 19, 20 y 110 del Organón de Hahnemann. El planteo que otros conceptos son posibles en ciencia y la sugerencia de tender a una epistemología homeopática
Descritores: Venenos/farmacologia
-Apis mellifica/uso terapêutico
Apis mellifica/toxicidade
Aranea diadema/toxicidade
Cantaridina/toxicidade
Venenos Elapídicos/toxicidade
Lachesis muta/efeitos adversos
Lachesis muta/uso terapêutico
Tarentula cubensis/toxicidade
Limites: Humanos
Animais
Responsável: AR144.1 - CIBCHACO - Centro de Información Biomedica del Chaco


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Id: lil-77887
Autor: Méndez, Eustorgio; Sánchez, Rolando E; Johnson, Carl M.
Título: Dermatitis ampollar causada por la Epicauta flagellaria (Erichson) (Coleoptera : Meloidae) / Blister dermatitis caused by Epicauta flagellaria (Erichson) (Coleoptera : Meloidae) species
Fonte: Rev. méd. Panamá;14(3):139-44, sept. 1989. ilus.
Idioma: es.
Resumo: Este trabajo constituye el primer informe de dermatitis ampollar causada por coleópteros de la familia Meloidae en Panamá. Se describe un brote familiar de dermatitis ampollar causado por la especie Epicauta flegallaria (Erichson). En otros casos de dermatitis ampollar diagnosticados anteriormente en el Laboratorio Conmemorativo Gorgas, la especie que la causó fue E. isthmica Werner. Las lesiones ampollares se producen cuando la cantaridina, una toxina vesicante contenida en el cuerpo del coleóptero, es liberada y entra en contacto con la piel, al ser aplastado o frotado en ella. Las medidas terapéuticas y la prevención de esta enfermedad son indicadas
Descritores: Cantaridina
Besouros
Hipersensibilidade/etiologia
Vesícula/etiologia
Limites: Pré-Escolar
Humanos
Masculino
Feminino
Tipo de Publ: Relatos de Casos
Responsável: PA2 - CIDCyT - Centro de Información y Documentación Científica y Tecnologica



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