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Pesquisa : D03.633.100.759.160 [Categoria DeCS]
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Id: biblio-831558
Autor: Simões, Marcus Vinicius; Schmidt, André; Tanaka, Denise Mayumi.
Título: Aspectos imunológicos da infecção por Trypanosoma Cruzi - persistência do parasita e autoimunidade / Immunological aspects of Trypanosoma Cruzi infection - persistence of the and autoimmunity
Fonte: Rev. Soc. Cardiol. Estado de Säo Paulo;26(4):240-5, out.-dez.2016.
Idioma: pt.
Resumo: Apesar de a doença de Chagas ter sido intensamente estudada ao longo de mais de um século desde sua descoberta, existem lacunas de conhecimento com relação aos mecanismos fisiopatogênicos que levam ao desenvolvimento tardio da cardiomiopatia chagásica crônica. Um aspecto intrigante da doença é a complexa interação entre o hospedeiro e o parasita e suas repercussões. A ocorrência de documentada inflamação tecidual, presente mais intensamente na fase aguda, mas persistente em baixa intensidade também na fase crônica, pode ser consequência do tropismo cardíaco do parasita ou de alterações autoimunes. Nesta revisão, nós abordaremos as evidências do papel patológico da persistência do parasita e da autoimunidade na patogênese da doença de Chagas

Although Chagas disease has been studied intensely for more than a century since it was first discovered, there are gaps in the knowledge of the physiopathogenic mechanism that lead to the late development of chronic chagasic cardiomyopathy. An intriguing aspect of the disease is the complex interaction between the host and the parasite and its repercussions. The occurrence of documented tissue inflammation, which is more intensely present in the acute phase but also persists with lower intensity in the chronic phase, may be a consequence of cardiac tropism of the parasite or of autoimmune changes. In this review, we address the evidence of the pathological role of persistence of the parasite and autoimmunity in the pathogenesis of Chagas disease
Descritores: Trypanosoma cruzi/imunologia
Cardiomiopatia Chagásica/patologia
Doença de Chagas/etiologia
Doença de Chagas/parasitologia
-Ecocardiografia
Radiografia
Alopurinol/farmacologia
Itraconazol/farmacologia
Eletrocardiografia
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Idoso
Tipo de Publ: Revisão
Responsável: BR44.1 - Serviço de Biblioteca, Documentação Científica e Didática Prof. Dr. Luiz Venere Décourt


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Azevedo, Valderílio Feijó
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Id: biblio-1088617
Autor: Azevedo, Valderilio Feijó; Kos, Igor Age; Vargas-Santos, Ana Beatriz; Pinheiro, Geraldo da Rocha Castelar; Paiva, Eduardo dos Santos.
Título: Benzbromarone in the treatment of gout
Fonte: Adv Rheumatol;59:37, 2019.
Idioma: en.
Resumo: Abstract Background Benzbromarone is a uricosuric drug that has been used in the treatment of gout over the last 30 years. Due to its potent inhibition of the dominant apical (luminal) urate exchanger in the human proximal tubule URAT1, it reduces the urate reabsorption, diminishing serum urate levels and therefore preventing gout flares. Main body of the abstract Through several clinical trials, Benzbromarone has been proved effective and safe, inclusive in patients with chronic kidney disease and as combination therapy with allopurinol. Due to hepatotoxicity reports, it was withdrawn from the European market by the manufacturer, however many authors have questioned the product's withdrawal due to a lack of clinical evidence in order to support its hepatotoxicity. Benzbromarone is still available in several European countries, New Zealand, Brazil and several other countries. Despite the product's marketing over more than 20 years after the first hepatotoxicity reports, we have found only five reports in our literature search, and no prospective or retrospective study correlating hepatotoxicity with benzbromarone use. Short conclusion Benzbromarone is a safe and effective molecule for the treatment of gout. However, due to in vitro and in vivo data related to hepatotoxicity, it is prudent to prescribe it with some caution, especially for patients with an already known liver condition.
Descritores: Benzobromarona/uso terapêutico
Gota/tratamento farmacológico
-Alopurinol/administração & dosagem
Combinação de Medicamentos
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
Limites: Humanos
Responsável: BR1.1 - BIREME


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Id: lil-657002
Autor: Riveros, Efraín; Pérez, Iván; Becerra, Karen; Bustamante, Manuel; Millán, Cristina; Manrique, Fred.
Título: El pretratamiento con alopurinol disminuye la translocación bacteriana y atenúa los cambios morfológicos de la mucosa intestinal en un modelo de isquemia-reperfusión intestinal en ratas / Pretreatment with allopurinol reduces bacterial translocation and ameliorates the morphological changes of the intestinal mucosa in an intestinal ischemia-reperfusion rat model
Fonte: Rev. colomb. cir;27(3):227-234, jul.-set. 2012. ilus, tab.
Idioma: es.
Resumo: Objetivo. Evaluar el efecto protector contra la lesión por isquemia-reperfusión intestinal del pretratamiento con alopurinol en ratas. Materiales y métodos. Se llevó a cabo un experimento controlado en animales. Un grupo de 10 ratas Wistar de características morfométricas comparables se mantuvo en bioterio bajo condiciones controladas por tres días. A cinco animales se les administró 50 mg/kg diarios de alopurinol por vía oral durante los tres días y, una dosis adicional, antes de inducir isquemia intestinal por ligadura quirúrgica durante 60 minutos seguida de 60 minutos de reperfusión. El otro grupo de cinco ratas no recibió el medicamento. Se hizo el análisis histológico de la mucosa intestinal al final del experimento por medio de la clasificación de Chou y se tomaron hemocultivos de la cavidad cardiaca. Resultados. Se encontraron hemocultivos positivos en 20 % de los animales pretratados con alopurinol, en comparación con el 100 % de las ratas control (p<0,0001). Se evidenció lesión profunda en la mucosa intestinal en todos los casos. La administración previa a la injuria de alopurinol redujo significativamente la lesión por isquemia-reperfusión (p<0,001). Conclusiones. La administración de alopurinol antes de la isquemia intestinal, reduce los cambios morfológicos ocasionados por isquemia-reperfusión. El efecto benéfico se demostró con el pretratamiento por tres días.

Objective: To evaluate the protective effect of pretreatment with allopurinol in an intestinal ischemia-reperfusion injury rat model. Materials and methods: A controlled animal trial was conducted; 10 Wistar rats were kept under controlled conditions for three days. One group (n=5) received allopurinol 50 mg/kg per day for the 3-day period and an additional dose immediately prior to surgical mesenteric artery clamping (60 minutes) and reperfusion (60 minutes). The other group (n=5) did not receive the medication. Hystologic analysis of intestinal mucosa by means of Chou grading system was performed, and blood cultures from the heart were withdrawn. Results: Positive blood cultures were found in 20% of the allopurinol group as compared with 100% in the control group (p<0.0001). Deep mucosal lesion was evidence in all cases. Allopurinol pretreatment reduced significantly the ischemia-reperfusion injury (p<0.001). Conclusions: Allopurinol administration prior to intestinal ischemia ameliorated morphologic changes related to the ischemia-reperfusion process. The beneficial effect of allopurinol was demonstrated with pretreatment for three days.
Descritores: Isquemia
-Traumatismo por Reperfusão
Alopurinol
Radicais Livres
Responsável: CO113


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Araujo, E. G
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Id: biblio-1131480
Autor: Brandstetter, L. R. G; Pedroso, A. C. B. R; Oliveira, H. F; Moura, V. M. B. D; Araújo, E. G.
Título: Brief topical and intraluminal use of Carolina rinse solution does not attenuate experimental ischemia and reperfusion injury in rabbit jejunum / [O uso tópico breve e intraluminal da solução de Carolina rinse não atenua a injúria de isquemia e reperfusão experimental no jejuno de coelhos ]
Fonte: Arq. bras. med. vet. zootec. (Online);72(4):1321-1328, July-Aug. 2020. ilus.
Idioma: en.
Resumo: Fifteen New Zealand adult rabbits were randomly allocated into three groups: Sham-operated (group A), Ischemia and Reperfusion (group B) and Carolina Rinse Solution (CRS) (group C). Groups B and C were subjected to one hour of ischemia and two hours of reperfusion. In group C, ten minutes before reperfusion, the bowel lumen was filled with CRS, and the segment immersed in CRS. Necrosis and loss of integrity of the villi were visible in groups B and C. Edema of the submucosa and circular muscle was observed in all groups. Hemorrhage was observed in different layers for groups B and C, but group C showed more severe hemorrhage in different layers during reperfusion. All groups showed polymorphonuclear leukocyte infiltration on the base of the mucosa, submucosa, and longitudinal muscle, in addition to polymorphonuclear leukocytes margination in the mucosal and submucosal vessels. Necrosis of enterocytes, muscles, crypts of Lieberkühn and myenteric plexus was observed in groups B and C during reperfusion. Topical and intraluminal Carolina Rinse Solution did not attenuate the effects of ischemia and reperfusion in the small intestine of rabbits.(AU)

Quinze coelhos da raça Nova Zelândia foram alocados em três grupos: instrumentado (grupo A), isquemia e reperfusão (grupo B) e solução de Carolina rinse (CRS) (grupo C). Os grupos B e C foram submetidos a uma hora de isquemia e a duas horas de reperfusão. No grupo C, 10 minutos antes da reperfusão, o segmento isolado foi imerso e teve seu lúmen preenchido com CRS. Os grupos B e C apresentaram necrose e perda progressiva da integridade das vilosidades. Foi observado edema na submucosa e na camada muscular circular em todos os grupos. Nos grupos B e C, foi observada hemorragia em diferentes camadas, mas, no grupo C, a hemorragia foi mais intensa durante a reperfusão. Todos os grupos apresentaram infiltrado de PMN na base da mucosa, na submucosa e na camada muscular longitudinal e marginação de PMN nos vasos da mucosa e da submucosa. Durante a reperfusão, foi observada necrose dos enterócitos, das camadas musculares, das criptas de Lieberkühn e do plexo mioentérico nos grupos B e C. O uso tópico e intraluminal de CRS não atenuou os efeitos da isquemia e da reperfusão no intestino delgado de coelhos.(AU)
Descritores: Reperfusão/veterinária
Alopurinol/administração & dosagem
Desferroxamina/administração & dosagem
Glutationa/administração & dosagem
Isquemia/veterinária
Jejuno/cirurgia
Limites: Animais
Coelhos
Responsável: BR68.1 - Biblioteca Virginie Buff D'Ápice


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Id: biblio-1125004
Autor: González Escudero, Mabel; Pérez Acosta, Noel David; Roque Pérez, Lázaro.
Título: Síndrome de DRESS secundario a alopurinol / DRESS syndrome secondary to allopurinol
Fonte: Medicentro (Villa Clara);24(2):430-443, abr.-jun. 2020. graf.
Idioma: es.
Resumo: RESUMEN El síndrome de hipersensibilidad por fármacos, también conocido como síndrome de DRESS, es una farmacodermia grave que se caracteriza por una erupción polimorfa diseminada, fiebre y compromiso multiorgánico. Este padecimiento tiene una incidencia que oscila entre el 0,1 % y el 0,01 % de las exposiciones farmacológicas, con una probabilidad de fallecimiento de un 20 % al 30 %. Fue descrito por primera vez en el año 1936, como una reacción adversa a la fenitoína. En la actualidad se reconoce que puede estar asociado a otros fármacos como: abacavir, metronidazol, doxiciclina, isoniazida, carbamacepina, fenobarbital, beta-bloqueadores, dapsona, ranitidina, antiinflamatorios no esteroideos y el alopurinol. Se presenta un paciente de 69 años de edad que desarrolló un síndrome de DRESS secundario a alopurinol. El paciente mostró signos poco frecuentes de esta rara enfermedad: linfocitos atípicos, hepatomegalia y afección renal; falleció poco después debido a un choque séptico por estafilococo áureo.

ABSTRACT Drug hypersensitivity syndrome, also known as DRESS syndrome, is a severe pharmacodermia characterized by a polymorphous disseminated rash, fever, and multi-organ involvement. Its incidence ranges between 0.1 to 0.01% from the pharmacological exposures, with a probability of death ranging from 20 to 30%. It was first described in 1936 as an adverse reaction to phenytoin. Nowadays, it is known that it can also be associated with other drugs such as abacavir, metronidazole, doxycycline, isoniazid, carbamazepine, phenobarbital, beta-blockers, dapsone, ranitidine, nonsteroidal anti-inflammatory drugs and allopurinol. We present a 69-year-old male patient who developed a DRESS syndrome secondary to alupurinol. The patient showed unusual signs of this rare disease such as atypical lymphocytes, hepatomegaly and kidney disease; he dies shortly after from a septic shock due to Staphylococcus aureus.
Descritores: Alopurinol/efeitos adversos
Síndrome de Hipersensibilidade a Medicamentos
Responsável: CU425.1 - Centro Provincial de Información de Ciencias Médicas de Villa Clara


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Id: biblio-886234
Autor: Akahane, Hugo Genki Kagawa; Gomes, Ricardo Zanetti; Paludo, Katia Sabrina; Linhares, Filipe; Lopes, Luana.
Título: The influence of allopurinol and post-conditioning on lung injuries induced by lower-limb ischemia and reperfusion in Wistar rats
Fonte: Acta cir. bras;32(9):746-754, Sept. 2017. tab, graf.
Idioma: en.
Resumo: Abstract Purpose: To analyze the effects of allopurinol and of post-conditioning on lung injuries induced by lower-limb ischemia and reperfusion. Methods: Thirty rats were used. They were divided in 5 groups: (1) group A: abdominal aortic dissection only, (2) group B: ischemia and reperfusion, (3) group C: administered allopurinol (100mg/Kg) a few hours before procedure, (4) group D: post-conditioned and (5) group E: administered allopurinol and post-conditioned. With the exception of group A, all groups were submitted to infrarenal aortic ischemia for 2 hours, and reperfusion for 72 hours. After euthanasia, lungs were removed for histological analysis. They were graded under two scores: pulmonary injury (neutrophil infiltration, interstitial edema, vascular congestion, and destruction of lung architecture) and lymphocytic score (neutrophil infiltration, lymphoid aggregate and secondary follicle). Results: On the pulmonary injury score, the degree of injury was smaller than in groups D and E, when compared to group B, p<0.05. Group C did not obtain the same result (p>0,05). On the lymphocytic score, there was no statistic difference among groups, p>0.05. Conclusion: Both post-conditioning and the combination of allopurinol and post-conditioning were effective in remote lung protection induced by lower-limbs I/R. When used in isolation, allopurinol showed no protective effect.
Descritores: Traumatismo por Reperfusão/complicações
Alopurinol/uso terapêutico
Lesão Pulmonar/prevenção & controle
Pós-Condicionamento Isquêmico
-Ratos Wistar
Modelos Animais de Doenças
Lesão Pulmonar/etiologia
Antimetabólitos/uso terapêutico
Limites: Animais
Masculino
Feminino
Ratos
Responsável: BR1.1 - BIREME


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Id: biblio-886210
Autor: Özer, Nazmi; Bülbüloğlu, Ertan; Yormaz, Serdar; Ece, İlhan.
Título: Evaluation of silybum marinaum efficacy on University of Wisconsin and histidine-tryptophan-ketoglutarate solutions latter the damage of the perfused liver
Fonte: Acta cir. bras;32(6):407-417, June 2017. tab, graf.
Idioma: en.
Resumo: Abstract Purpose: To investigate the hepatoprotective and antioxidant effeicacies of Silybum marianum's (silymarin, S) on University of Wisconsin (UW) and histidinetryptophan-ketoglutarate (HTK) preservation solutions. Methods: Thirty two Wistar albino adult male rats were used. Group 1: UW group, Group 2: UW + Silymarin group(S), Group 3: HTK group, Group 4: HTK + silymarin group (S), respectively. Silymarin was enforced intraperitoneally before the surgery. Biopsies were enforced in 0, 6 and 12.hours to investigate. Results: Biochemical parameters examined in alanine aminotransferase (ALT), furthermore superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA) in rats were also evaluated. Detected histopathological changings were substantially declining in the groups that received silymarin, cellular damage was decreased significantly in HTK + Silymarin group, according to other groups. It has been identified as the most effective group was HTK + silymarin group in evaluation of ALT, electron microscopic results, also decreased MDA and elevated in SOD, and CAT activity. Caspase 3 analysis showed a substantial lower apoptosis ratio in the silymarin groups than in the non-performed groups (p<0.05). Conclusion: Histidinetryptophan-ketoglutarate+silymarin group provides better hepatoprotection than other groups, by decreasing the hepatic pathologic damage, delayed changes that arise under cold ischemic terms.
Descritores: Silimarina/uso terapêutico
Soluções para Preservação de Órgãos
Substâncias Protetoras/uso terapêutico
Doença Hepática Induzida por Substâncias e Drogas/tratamento farmacológico
Antioxidantes/uso terapêutico
-Cloreto de Potássio
Procaína
Rafinose
Imuno-Histoquímica
Adenosina
Alopurinol
Ratos Wistar
Modelos Animais de Doenças
Glucose
Glutationa
Insulina
Manitol
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


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Id: biblio-989063
Autor: Laçin, Nihat; İzol, Bozan Serhat; Özkorkmaz, Ebru Gökalp; Deveci, Buşra; Tuncer, Mehmet Cudi.
Título: The effect of graft application and allopurinol treatment on calvarial bone defect in rats
Fonte: Acta cir. bras;34(3):e201900306, 2019. tab, graf.
Idioma: en.
Resumo: Abstract Purpose: To investigate the effects of allopurinol administration on osteoinductive reaction and bone development with graft material. Methods: Thirty-six Wistar albino rats were divided into 3 groups. In the control group, calvarial bone defect was only created without any treatment. In the Defect + Graft group, allograft treatment was performed by forming 8 mm calvarial bone defect. In the Defect + Graft + Allopurinol group, alloplastic bone graft was placed in the calvarial bone defect and then, allopurinol (50 mg/kg/day) treatment was intraperitoneally applied for 28 days. Results: Histopathological examination revealed inflammation, congestion in the vessels, and an increase in osteoclast cells in the defect area. We also observed that new osteocyte cells, increase in connective tissue fibers, and new bone trabeculae. Osteopontin expression was positive in osteoblast cells and lacunated osteocyte cells were located in the periphery of the new bone trabeculae. Osteopontin expression was also positive in osteoblasts and osteocytes cells of new bone trabeculae in the graft site. Conclusion: It has been shown that allopurinol treatment in rat calvaria defects may induce osteoblastic activity, matrix development, mature bone cell formation and new bone formation when used with autogenous grafts.
Descritores: Osteogênese/efeitos dos fármacos
Crânio/efeitos dos fármacos
Cicatrização/efeitos dos fármacos
Regeneração Óssea/efeitos dos fármacos
Alopurinol/farmacologia
-Crânio/lesões
Ratos Wistar
Modelos Animais de Doenças
Autoenxertos
Limites: Animais
Ratos
Responsável: BR1.1 - BIREME


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Id: lil-777094
Autor: Zhou, Jiang-qiao; Qiu, Tao; Zhang, Lu; Chen, Zhong-bao; Wang, Zhi-shun; Ma, Xiao-xiong; Li, Dongyu.
Título: Allopurinol preconditioning attenuates renal ischemia/reperfusion injury by inhibiting HMGB1 expression in a rat model
Fonte: Acta cir. bras;31(3):176-182, Mar. 2016. graf.
Idioma: en.
Projeto: National Natural Science Foundation of China; . Hubei Natural Science Foundation; . bureau of public health of Hubei Province; . Wuhan Municipal Science and Technology Bureau.
Resumo: ABSTRACT PURPOSE: To investigate the potential effects of pretreatment with allopurinol on renal ischemia/reperfusion injury (IRI) in a rat model. METHODS: Twenty four rats were subjected to right kidney uninephrectomy were randomly distributed into the following three groups (n=8): Group A (sham-operated group); Group B (ischemic group) with 30 min of renal ischemia after surgery; and Group C (allopurinol + ischemia group) pretreated with allopurinol at 50 mg/kg for 14 days. At 72 h after renal reperfusion, the kidney was harvested to assess inflammation and apoptosis. RESULTS: Pretreatment with allopurinol significantly improved renal functional and histological grade scores following I/R injury (p<0.05). Compared with Group B, the expression levels of caspase-3 and Bax were markedly reduced in Group C, meanwhile, whereas expression of bcl-2 was clearly increased (p<0.05). A newly described marker of inflammation, High Mobility Group Box 1(HMGB1), showed reduced expression in Group C (p<0.05). CONCLUSION: Pretreatment with allopurinol had a protective effect on kidney ischemia/reperfusion injury, which might be related to the inhibition of HMGB1 expression.
Descritores: Traumatismo por Reperfusão/prevenção & controle
Alopurinol/farmacologia
Precondicionamento Isquêmico/métodos
Substâncias Protetoras/farmacologia
Proteína HMGB1/efeitos dos fármacos
Rim/irrigação sanguínea
-Superóxido Dismutase/efeitos dos fármacos
Nitrogênio da Ureia Sanguínea
Traumatismo por Reperfusão/metabolismo
Distribuição Aleatória
Ratos Sprague-Dawley
Apoptose/efeitos dos fármacos
Peroxidase/metabolismo
Proteína HMGB1/metabolismo
Modelos Animais de Doenças
Inflamação/metabolismo
Rim/patologia
Limites: Animais
Masculino
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-775566
Autor: Gomes, Ricardo Zanetti; Romanek, Gabriela Moreira Mahle; Przybycien, Michella; Amaral, Danielli Cristina; Akahane, Hugo Genki Kagawa.
Título: Evaluation of the effect of allopurinol as a protective factor in post ischemia and reperfusion inflammation in Wistar rats
Fonte: Acta cir. bras;31(2):126-132, Feb. 2016. tab, graf.
Idioma: en.
Resumo: PURPOSE: To investigate the potential protective effect of allopurinol on reperfusion injury by determining the inflammatory response through the measurement of tumor necrosis factor-alpha (TNF-alpha). METHODS: Sixty rats were distributed into two groups: control and allopurinol and each group was divided into three subgroups, ischemia for two hours, ischemia for three hours and ischemia simulation. Allopurinol group rats received 100mg/kg dose of allopurinol, whereas control group rats received an equivalent dose of saline. Clamping of the infrarenal aorta was performed for two or three hours depending on the subgroup. Ischemia simulation subgroups did not suffer ischemia, just aortic dissection, and maintenance for three hours. After 72 hours of reperfusion, blood was collected by cardiac puncture for TNF-alpha measurement. RESULTS: Allopurinol reduced TNF-alpha significantly (p <0.001) when compared to the matching control subgroups (control X allopurinol in ischemia for two hours and for three hours). CONCLUSION: Allopurinol reduced the concentrations of serum TNF-alpha when used at different times of ischemia followed by reperfusion, which might indicate reduction of the inflammation provoked by the reperfusion injury.
Descritores: Traumatismo por Reperfusão/metabolismo
Alopurinol/farmacologia
Cavidade Abdominal/irrigação sanguínea
Isquemia/cirurgia
Antimetabólitos/farmacologia
-Fatores de Tempo
Traumatismo por Reperfusão/prevenção & controle
Distribuição Aleatória
Fator de Necrose Tumoral alfa/análise
Fator de Necrose Tumoral alfa/efeitos dos fármacos
Espécies Reativas de Oxigênio/metabolismo
Ratos Wistar
Modelos Animais
Inflamação/metabolismo
Limites: Animais
Responsável: BR1.1 - BIREME



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