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| Id: |
lil-308280
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| Autor: |
Chini, E. N. |
| Título: |
Interactions between intracellular Ca2+ stores: Ca2+ released from the NAADP pool potentiates cADPR-induced Ca2+ release |
| Fonte: |
Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;35(5):543-547, May 2002. ilus, graf.
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| Idioma: |
en.
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| Resumo: |
Cells possess multiple intracellular Ca2+-releasing systems. Sea urchin egg homogenates are a well-established model to study intracellular Ca2+ release. In the present study the mechanism of interaction between three intracellular Ca2+ pools, namely the nicotinic acid adenine dinucleotide phosphate (NAADP), the cyclic ADP-ribose (cADPR) and the inositol 1',4',5'-trisphosphate (IP3)-regulated Ca2+ stores, is explored. The data indicate that the NAADP Ca2+ pool could be used to sensitize the cADPR system. In contrast, the IP3 pool was not affected by the Ca2+ released by NAADP. The mechanism of potentiation of the cADPR-induced Ca2+ release, promoted by Ca2+ released from the NAADP pool, is mediated by the mechanism of Ca2+-induced Ca2+ release. These data raise the possibility that the NAADP Ca2+ store may have a role as a regulator of the cellular sensitivity to cADPR
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| Descritores: |
Adenosina Difosfato Ribose
Cálcio
NADP
Óvulo
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-Inositol 1,4,5-Trifosfato
NADP
Ouriços-do-Mar
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| Limites: |
Animais
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| Tipo de Publ: |
Research Support, Non-U.S. Gov't
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| Responsável: |
BR1.1 - BIREME
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