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Id: biblio-983779
Autor: Gayretli Aydin, Zeynep G; Tanir, Gonul; Genc Sel, Cigdem; Tasci Yıldız, Yasemin; Aydin Teke, Turkan; Kaman, Ayse.
Título: Encefalitis por herpes simple resistente al aciclovir en un niño tratado satisfactoriamente con el agregado de foscarnet: A propósito de un caso / Acyclovir Unresponsive Herpes Simplex Encephalitis in a child successfully treated with the addition of Foscarnet: Case report
Fonte: Arch. argent. pediatr;117(1):47-51, feb. 2019. ilus.
Idioma: en; es.
Resumo: La encefalitis por herpes simple (EHS) es la causa más frecuente de encefalitis focal esporádica en todo el mundo. El aciclovir es el tratamiento preferido para la EHS desde la década de 1980. Después del uso generalizado del aciclovir, se redujo la tasa de mortalidad relacionada con la EHS pero surgieron cepas resistentes. Se ha informado que la incidencia de virus del herpes simple (VHS) resistente al aciclovir es del 0,5 % y del 3,5 %-10 % aproximadamente en los pacientes inmunocompetentes e inmunocomprometidos, respectivamente. En este artículo, describimos el caso de un paciente inmunocompetente de 12 años de edad con encefalitis por VHS-1 tratado satisfactoriamente con aciclovir y foscarnet. En el caso de una condición clínica que desmejora con el tratamiento con aciclovir, incluso si no se demuestra un aumento de la carga viral del VHS en el líquido cefalorraquídeo, se podría considerar la posibilidad de EHS resistente al aciclovir y el agregado de foscarnet al tratamiento con aciclovir.

Herpes simplex encephalitis (HSE) is the most common cause of sporadic focal encephalitis worldwide. Acyclovir is the treatment of choice of HSE since the 1980s. After the widespread use of acyclovir, HSE related mortality rate had reduced but resistant strains emerged. Acyclovir resistant HSV incidence was reported as about 0.5 % and 3.5 %-10 % in immunocompetent and immunocompromised patients, respectively. Herein, a 12-year-old immunocompetent patient with HSV-1 encephalitis who was successfully treated with combined acyclovir and foscarnet therapy is described. In the case of deteriorating clinical condition under acyclovir treatment even if the absence of demonstration of increased CSF HSV viral load, the possibility of acyclovir resistant HSE and the addition of foscarnet to the acyclovir treatment might be considered.
Descritores: Aciclovir
Criança
Foscarnet
Encefalite por Herpes Simples
Limites: Seres Humanos
Masculino
Criança
Tipo de Publ: Relatos de Casos
Responsável: AR94.1 - Centro de Información Pediatrica


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Texto completo SciELO Brasil
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Id: biblio-949961
Autor: Rodriguez-Zuniga, Milton; Torres, Natalie; Garcia-Perdomo, Herney.
Título: Effectiveness of acyclovir in the treatment of pityriasis rosea. A systematic review and meta-analysis
Fonte: An. bras. dermatol;93(5):686-695, Sept.-Oct. 2018. tab, graf.
Idioma: en.
Resumo: Abstract: Background: There is a lack of evidence to support acyclovir administration in pityriasis rosea. Objective: To determine the efficacy of acyclovir in patients with typical pityriasis rosea. Methods: A systematic review and meta-analysis of experimental studies was performed in MEDLINE, SCOPUS, EMBASE and others, from January 1990 to October 2016 on acyclovir for pityriasis rosea. Random effect model was used to find the pooled Risk Ratio. Outcomes, evaluated between weeks 1 to 8, were regression of lesions, cessation of lesions, decrease of symptoms and duration of disease. Comparisons were acyclovir vs. placebo; acyclovir vs. symptomatic treatment; acyclovir vs. antibiotic; acyclovir vs. observation and combined therapy (acyclovir plus symptomatic treatment) vs. symptomatic treatment alone. Results: Seven papers were analyzed with 324 participants, of which 159 received acyclovir and 165 were controls. Acyclovir was superior to placebo for complete regression of lesions at week 1 (Risk Ratio 5.72, CI95% 2.36-13.88). However, combined therapy was not superior to symptomatic treatment at week 4 (Risk Ratio 1.46, CI95% 0.93-2.29). Individual studies showed the superiority of acyclovir for the control of symptoms and pruritus. Study limitations: We faced differences designs of trials and inconsistency between reports. Conclusion: Symptomatic treatment is a reasonable option for pityriasis rosea, and the addition of acyclovir is justified for the control of symptoms and pruritus.
Descritores: Antivirais/uso terapêutico
Aciclovir/uso terapêutico
Pitiríase Rósea/tratamento farmacológico
-Antivirais/administração & dosagem
Placebos
Aciclovir/administração & dosagem
Seguimentos
Administração Tópica
Resultado do Tratamento
Limites: Seres Humanos
Masculino
Feminino
Criança
Adulto
Tipo de Publ: Revisão
Metanálise
57788
Responsável: BR1.1 - BIREME


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Id: lil-781357
Autor: Bittencourt, Maraya de Jesus Semblano; Freitas, Lívia Karlla Marinho; Drago, Marion Guimarães; Carvalho, Alessandra Haber; Nascimento, Bianca Angelina Macêdo do.
Título: Cutaneous neonatal herpes simplex virus infection type 2: a case report
Fonte: An. bras. dermatol;91(2):216-218, Mar.-Apr. 2016. graf.
Idioma: en.
Resumo: Abstract Neonatal herpes is a serious condition. Newborns can be contaminated in utero via transplacental hematogenic transmission, upon delivery (the most frequent route), or during the postnatal period (indirect transmission). Optimal management requires prompt and accurate recognition, particularly in newborns, in order to prevent complications. Acyclovir is the treatment of choice, but its implementation is often delayed while awaiting test results, such as PCR and serology. Cytology for diagnostic purposes is rarely used in dermatology, despite the quick and reliable results. We report a case of neonatal herpes caused by type 2 herpes simplex virus diagnosed by cytology.
Descritores: Complicações Infecciosas na Gravidez/patologia
Herpesvirus Humano 2
Herpes Simples/patologia
-Antivirais/uso terapêutico
Complicações Infecciosas na Gravidez/tratamento farmacológico
Pele/patologia
Aciclovir/uso terapêutico
Técnicas Citológicas
Herpes Simples/tratamento farmacológico
Limites: Seres Humanos
Masculino
Recém-Nascido
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


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Id: biblio-950029
Autor: Lubián López, Simón; Pérez Guerrero, Juan J; Salazar Oliva, Patricia; Benavente Fernández, Isabel.
Título: Parálisis facial neonatal: identificación del virus del herpes simple 1 en el líquido cefalorraquídeo. Caso clínico / Neonatal facial palsy: Identification of herpes simplex virus 1 in cerebrospinal fluid. Case report
Fonte: Arch. argent. pediatr;116(3):468-470, jun. 2018. ilus.
Idioma: es.
Resumo: En los neonatos, la parálisis facial es muy infrecuente y, por lo general, diagnosticada al nacer. Se presenta el primer caso de parálisis facial neonatal con identificación del virus del herpes simple 1 en el líquido cefalorraquídeo. Un varón de 35 días de vida acudió a Urgencias por la desviación de la comisura bucal hacia la izquierda y la ausencia de cierre del ojo derecho, sin sintomatología infecciosa ni antecedentes relevantes. La exploración física fue compatible con parálisis facial periférica. Las exploraciones complementarias de urgencia (hemograma, bioquímica, coagulación y citoquímica de líquido cefalorraquídeo) fueron normales. Fue ingresado con prednisolona oral y aciclovir intravenoso. La resonancia magnética craneal fue normal. A las 48 horas, se recibió el resultado positivo de la reacción en cadena de la polimerasa para el virus del herpes simple 1 en el líquido cefalorraquídeo. Con evolución favorable, completó 7 días de prednisolona oral y fue dado de alta tras 21 días de aciclovir intravenoso, con exploración neurológica previa normal.

Neonatal facial palsy is very uncommon and is generally diagnosed at birth. We present the first published case of neonatal facial palsy with identification of herpes simplex virus 1 in cerebrospinal fluid. A 35-day-old male was presented at the Emergency Department with mouth deviation to the left and impossibility of full closure of the right eye. There were no symptoms of infection or relevant medical history. Physical examination was compatible with peripheral facial palsy. Studies performed at admission were normal (blood count, biochemical analysis and coagulation blood tests and cerebrospinal fluid analysis). The patient was admitted on oral prednisolone and intravenous aciclovir. Cranial magnetic resonance was normal. Polymerase chain reaction test for herpes simplex virus 1 in cerebrospinal fluid was reported positive after 48 hours of admission. Patient followed good evolution and received prednisolone for 7 days and acyclovir for 21 days. At discharge, neurological examination was normal.
Descritores: Herpesvirus Humano 1/isolamento & purificação
Paralisia Facial/diagnóstico
Herpes Simples/diagnóstico
-Antivirais/administração & dosagem
Aciclovir/administração & dosagem
Prednisolona/administração & dosagem
Líquido Cefalorraquidiano/virologia
Resultado do Tratamento
Paralisia Facial/tratamento farmacológico
Paralisia Facial/virologia
Glucocorticoides/administração & dosagem
Herpes Simples/tratamento farmacológico
Limites: Seres Humanos
Masculino
Lactente
Tipo de Publ: Relatos de Casos
Responsável: AR94.1 - Centro de Información Pediatrica


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Id: lil-281705
Autor: Tenembaum, S; Ruggieri, V; Pociecha, J; Fejerman, N.
Título: Compromiso de la sustancia blanca en la encefalitis herpética / White matter compromise in the herpetic encephalitis
Fonte: Med. infant;1(3):167-167, mar. 1994.
Idioma: es.
Conferência: Apresentado em: Congreso Argentino de Neurología Infantil, 13, San Carlos de Bariloche, 25-26 nov. 1993.
Descritores: Aciclovir/uso terapêutico
Doenças Desmielinizantes/etiologia
Simplexvirus
Encefalite Viral/complicações
Encefalite Viral/diagnóstico
Encefalite Viral/terapia
-Argentina
Limites: Seres Humanos
Masculino
Feminino
Lactente
Pré-Escolar
Tipo de Publ: Relatos de Casos
Responsável: AR305.1 - SID - Servicio de Información y Documentación


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Id: lil-750469
Autor: Ruvinsky, Silvina; Taicz, Moira; Pérez, M. Guadalupe; Mónaco, Andrea; García Escudé, Natalia; Inda, Laura; Carbonaro, Mirta; Bologna, Rosa.
Título: Varicela en la Casa Garrahan, 2008-2013: Evaluación de las medidas de profilaxis posexposición / Varicella at "Casa Garrahan", 2008-2013: Assessment of postexposure prophylaxis measures
Fonte: Arch. argent. pediatr;113(3):237-243, jun. 2015. graf, tab.
Idioma: en; es.
Resumo: Introducción. La Casa Garrahan (CG) aloja a niños con patologías complejas de todo el país, atendidos en los hospitales pediátricos de la Ciudad Autónoma de Buenos Aires. La varicela es una enfermedad muy contagiosa, cuya tasa de ataque alcanza el 90% en susceptibles. En comunidades cerradas, es fundamental implementar medidas de prevención ante brotes. Objetivos. Describir las características de los niños expuestos a casos de varicela en la CG, las medidas de profilaxis implementadas y su efectividad. Métodos. Estudio de cohorte prospectivo. Se evaluaron los niños expuestos a varicela en la CG entre 2008 y 2013, sus características demográficas, clínicas y vacunación y/o varicela previa, medidas de profilaxis y tasa de ataque secundaria. Resultados. N: 107. El 53% (n: 57) eran niñas. La mediana de edad fue 84 meses (RIC: 24144). El 95% (n: 102) teman enfermedad de base [oncohematológica: 39% (n: 42); neurológica: 18% (n: 19); cardiopatías congénitas: 9% (n: 10); y posoperatorios: 65 (n: 6)]. Tenían algún grado de inmunosupresión el 50% (n: 54). El 29% (n: 31) referían haber tenido varicela; el 27% (n: 29) referían no haber padecido la enfermedad; y el 41% (n: 44) no recordaban el antecedente. Solo 3% (n: 3) estaban vacunados. Sobre la base del estado inmunológico, edad y antecedentes de varicela previa, se indicó aciclovir como profilaxis en 61% (n: 65); vacuna, en 10% (n: 10); y gammaglobulina, en 1 paciente. No se observaron efectos adversos relacionados con las profilaxis. No se observó ningún caso secundario a los 30 días. Conclusiones. Las medidas implementadas resultaron efectivas en la prevención de casos secundarios. En niños sanos e inmunocomprometidos, la profilaxis con aciclovir fue efectiva y bien tolerada.

Introduction. Casa Garrahan (CG) accommodates children with complex conditions referred nationwide; these children are seen in children's hospitals located in the Autonomous City of Buenos Aires. Varicella is a highly-contagious disease, with attack rates of up to 90% among susceptible individuals. In closed communities, the implementation of outbreak control measures is critical. Objectives. To describe the characteristics of children exposed to varicella at CG, the implemented prophylaxis measures and their effectiveness. Methods. Prospective, cohort study. Children exposed to varicella at CG between2008 and 2013, their demographic and clinical characteristics, immunization and/or history of varicella, prophylaxis measures, and secondary attack rate were assessed. Results. N: 107. Fifty-three percent (n: 57) were girls. Their median age was 84 months old [interquartile range (IQR): 24-144]. Ninety-five percent (n: 102) had an underlying disease [hemato-oncological disease: 39% (n: 42); neurological disease: 18% (n: 19); congenital heart disease: 9% (n: 10); and post-operative period: 65 (n: 6)]. Fifty percent had some degree of immunosuppression (n: 54). Twenty-nine percent (n: 31) referred to have had varicella; 27% (n: 29) indicated that they never had the infection; and 41% (n: 44) did not recall a history of varicella. Only 3% (n: 3) had been vaccinated. Based on their immune status, age and history of varicella, acyclovir was indicated as prophylaxis in 61% (n: 65); immunization in 10% (n: 10); and gamma globulin in 1 patient. No adverse effects were observed in relation to the different prophylaxis measures. No secondary cases were observed at 30 days. Conclusions. Implemented measures were effective to prevent secondary cases. Among healthy and immunocompromised children, prophylaxis with acyclovir was effective and well-tolerated.
Descritores: Aciclovir
Varicela
Profilaxia Pós-Exposição
Limites: Seres Humanos
Criança
Tipo de Publ: Estudo Observacional
Responsável: AR94.1 - Centro de Información Pediatrica


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Lopes, Antonio Carlos
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Id: lil-491529
Autor: Lopes, Antonio Carlos; Souza, Luiz José de; Paravidine, Paulo César Leitão; Lima, Guilherme Alcantara Cunha; Gomes, Maurício Assed Estefan; Araújo, Priscilla Damião.
Título: Encefalite herpética em paciente do sexo feminino de 48 anos previamente hígida / Herpes simplex encephalitis in a forty-eight-year old female-patient
Fonte: Rev. Soc. Bras. Clín. Méd;6(2), mar.-abr. 2008. ilus.
Idioma: pt.
Resumo: A encefalite herpética (EHS) é uma patologia grave, com alto índice de morbidade e letalidade. Esta doença se expressa por um quadro clínico agudo, tendo como principais manifestações:febre, cefaléia e alterações cognitivas e psíquicas. Desta forma, a suspeição clínica, associada a exames laboratoriaise de imagem são de fundamental importância para a detecção precoce e tratamento imediato desta patologia, a fim de impedir sua progressão rapidamente fatal. Neste relato, apresentamos um caso de EHS em uma paciente do sexo feminino, 48 anos, internada no Hospital dos Plantadores de Cana - Campos dos Goytacazes, RJ.(AU)

The herpes simplex encephalitis (HSE) is a serious pathology, with a high rate of morbidly and lethality. This diseasepresents a acute clinical condition, it had like principal symptons: fever, headache and cognitive and psychological alterations. In such a way, the clinical suspicion is associated to laboratorials examinations and of image. This are extremely important to early detect and fast treatment this pathology, on purpose to impede the quickly fatal progression of the illness. In this report, we present a case of Herpes Simplex Encephalitis in a forty-eight-years old female-patient, to taken into thePlantadores de Cana Hospital - Campos dos Goytacazes, RJ.(AU)
Descritores: Herpesvirus Humano 1
Encefalite por Herpes Simples/diagnóstico
Encefalite por Herpes Simples/tratamento farmacológico
-Afasia/etiologia
Convulsões/etiologia
Aciclovir/uso terapêutico
Reação em Cadeia da Polimerase/instrumentação
Febre/etiologia
Cefaleia/etiologia
Náusea/etiologia
Limites: Seres Humanos
Feminino
Meia-Idade
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


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Id: biblio-991333
Autor: O' Relly Noda, Dunia; Miña Oliveros, Lissette; Pérez Delgado, Zurieta; García Hernández, Celso.
Título: Retinitis necrotizante aguda. A propósito de un caso / Acute necrotizing retinitis. Case report
Fonte: Rev. medica electron;41(1):156-162, ene.-feb. 2019. graf.
Idioma: es.
Resumo: RESUMEN La retinitis necrotizante aguda, es una necrosis retinal de todas las capas de la retina. Se caracteriza por necrosis fibrinoides de la pared de los vasos y oclusión vascular. Se presentó un caso de una paciente de 42 años de edad, con pérdida brusca de la visión del ojo derecho, con una semana de evolución. Al examen oftalmológico se observó haze vítreo 2+, edema sucio del disco óptico, con borramiento de todos sus bordes. Presencia de exudación blanca-amarillenta retiniana extensa, en toda la periferia y área ecuatorial asociada a hemorragias intraretinianas. Se realizó además del examen fundoscòpico toma de muestra de humor acuoso para reacción en cadena de la polimerasa y angiografía fluoresceínica. Los signos fundoscópicos de la paciente, así como las anomalías detectadas en la angiografía fluoresceínica sugirieron el diagnóstico clínico de síndrome de necrosis retinal aguda. Se confirmó el diagnóstico etiológico viral, semanas después por el resultado de polimerasa. Se practicó la terapéutica médica y fotocoagulación laser focal retiniano correspondiente, asociado a cirugía del desprendimiento de retina mixto mediante vitrectomía pars plana y se logró la re aplicación de la retina.

ABSTRACT The acute necrotizing retinitis is a retinal necrosis of all the retinal layers. It is characterized by fibrinoid necrosis of the vases' wall and vascular occlusion. The case presented is the case of a female patient aged 42 years, who suffers sudden loss of the left eye vision, with a week of evolution. At the ophthalmologic examination it was observed a 2+ vitreous haze, dirty edema of the optic disk, with effacement of all of its margins. There it was an extended white-yellowish retinal exudation in the entire periphery and the equatorial area, associated to intra-retinal hemorrhages. Besides the funduscopic examination, it was taken a sample of the aqueous humor for a polymerase chain reaction (PCR) and fluorescein angiography. The patient's funduscopic signs, and also the anomalies detected in the fluorescein angiography suggested the clinical diagnosis of acute retinal necrosis syndrome. After several weeks, the viral etiologic diagnosis was confirmed by polymerase chain reaction. It was practiced the correspondent medical therapeutics and focal retinal laser coagulation associated to mixt retinal detachment through pars plana vitrectomy; the retina reapplication was achieved.
Descritores: Descolamento Retiniano/cirurgia
Síndrome de Necrose Retiniana Aguda/complicações
Síndrome de Necrose Retiniana Aguda/diagnóstico
Síndrome de Necrose Retiniana Aguda/etiologia
Síndrome de Necrose Retiniana Aguda/tratamento farmacológico
Uveíte Anterior/complicações
-Vitrectomia/métodos
Descolamento Retiniano/diagnóstico
Aciclovir/uso terapêutico
Ceratite Herpética/tratamento farmacológico
Limites: Seres Humanos
Feminino
Adulto
Tipo de Publ: Relatos de Casos
Responsável: CU424.1 - Centro Provincial de Información de Ciencias Médicas


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Id: biblio-1016288
Autor: Teste, María.
Título: Los antivirales no reducen la incidencia de la neuralgia postherpética / Antivirals do not reduce the incidence of postherpetic neuralgia
Fonte: Evid. actual. práct. ambul;21(2):45-45, jul. 2018. tab..
Idioma: es.
Descritores: Antivirais/uso terapêutico
Aciclovir/uso terapêutico
Neuralgia Pós-Herpética/prevenção & controle
2-Aminopurina/análogos & derivados
-Ensaios Clínicos Controlados Aleatórios como Assunto
FRUCTOSE-BISPHOSPHATE ALDOLASETEMEFOS
2-Aminopurina/uso terapêutico
Limites: Seres Humanos
Tipo de Publ: Comentário
Responsável: AR2.1 - Biblioteca Central


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Id: biblio-996581
Autor: Hernández, Norbelis; Merejildo, Yessenia.
Título: Calcificaciones intracraneales por herpes virus tipo I / Intracranial calcifications for herpes virus type I
Fonte: Rev. ecuat. pediatr;17(2):30-31, 12-2016.
Idioma: es.
Resumo: Las enfermedades intrauterinas representan una carga importante de morbilidad para el recién nacido como es la infección por Herpes simple, al adquirir este tipo de infección puede traer diversas afecciones del sistema nervioso central. El diagnóstico diferencial de las calcificaciones en el cerebro no siempre es fácil, existen múltiples causas que pueden originar calcificaciones intracraneales, dentro de ellas causas fisiológicas congénitas, infecciosas, metabólica, vasculares y por neoplasias. Con alta mortalidad y morbilidad, la incidencia varia de 1/3.000 a 1/20.000 nacimientos. Se requiere de una sospecha clínica precoz para establecer un tratamiento adecuado, presentamos un caso de una recién nacida de 21 días de vida que presenta un cuadro febril cuyo diagnóstico fue confirmado por la técnica de reacción de la polimerasa en cadena, la misma certifico la presencia del virus del herpes simple tipo 1 en liquido céfalo raquídeo, además evidencia de calcificaciones intracraneales en tomografía axial computarizada.

Intrauterina diseases represent an important burden of morbidity for the newborn as is the infection with Herpes simplex, when aquiring this type of infeccion can bring diverse affections of the central nervous system.The differential diagnosis of calcifications in the brain is not always easy, there are multiple causes that can causse intracranial calcifications,within them congenital,infectious,metabolic,vascular and neoplastic,vascular and neoplastic causes,with high mortality and morbidity, the incidence varies from 1/3000 to 1 /20.000 briths,Early clinical suspicion is required to establish an adequate treatment,we present a case of a newborn of 21 days of life that presents a febrile condition whose diagnosis was confirmed by the polymerase chain reaction technique,it certifies the presence of herpes simplex virus type 1 in cerebrospinal fluid,in addition to evidence of intracranial calcifications in computed tomography.
Descritores: Aciclovir
Tomografia Computadorizada por Raios X
Herpesvirus Humano 1
Malformações do Sistema Nervoso
-Anormalidades Congênitas
Líquido Cefalorraquidiano
Herpes Simples
Limites: Seres Humanos
Feminino
Recém-Nascido
Tipo de Publ: Relatos de Casos
Responsável: EC150



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