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  1 / 15 LILACS  
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Id: lil-735868
Autor: You, Jie; Yue, YaJun; Xing, Feng; Xia, Wei; Lai, ShaoYang; Zhang, FengLei.
Título: Tetrodotoxin poisoning caused by Goby fish consumption in southeast China: a retrospective case series analysis
Fonte: Clinics;70(1):24-29, 1/2015. graf.
Idioma: en.
Resumo: OBJECTIVES: To investigate an unusual outbreak of tetrodotoxin poisoning in Leizhou, southeast China, a case series analysis was conducted to identify the source of illness. METHODS: A total of 22 individuals experienced symptoms of poisoning, including tongue numbness, dizziness, nausea and limb numbness and weakness. Two toxic species, Amoya caninus and Yongeichthys nebulosus, were morphologically identified from the batches of gobies consumed by the patients. Tetrodotoxin levels in the blood and Goby fish samples were detected using liquid chromatography-tandem mass spectrometry. RESULTS: The tetrodotoxin levels in the remaining cooked Goby fish were determined to be 2090.12 µg/kg. For Amoya caninus, the toxicity levels were 1858.29 µg/kg in the muscle and 1997.19 µg/kg in the viscera and for Yongeichthys nebulosus, they were 2783.00 µg/kg in the muscle and 2966.21 µg/kg in the viscera. CONCLUSION: This outbreak demonstrates an underestimation of the risk of Goby fish poisoning. Furthermore, the relationships among the toxic species, climates and marine algae present should be clarified in the future. .
Descritores: Peixes Venenosos
Doenças Transmitidas por Alimentos/etiologia
Perciformes
Tetrodotoxina/envenenamento
-Cromatografia Líquida
China/epidemiologia
Surtos de Doenças
Doenças Transmitidas por Alimentos/epidemiologia
Estudos Retrospectivos
Espectrometria de Massas em Tandem
Tetrodotoxina/sangue
Limites: Adulto
Idoso
Animais
Feminino
Humanos
Masculino
Pessoa de Meia-Idade
Responsável: BR1.1 - BIREME


  2 / 15 LILACS  
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Id: lil-727656
Autor: Yao, Q.Y.; Chen, D.P.; Ye, D.M.; Diao, Y.P.; Lin, Y..
Título: Modulatory effects of taurine on jejunal contractility
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;47(12):1068-1074, 12/2014. graf.
Idioma: en.
Projeto: the National Natural Science Foundation of China.
Resumo: Taurine (2-aminoethanesulfonic acid) is widely distributed in animal tissues and has diverse pharmacological effects. However, the role of taurine in modulating smooth muscle contractility is still controversial. We propose that taurine (5-80 mM) can exert bidirectional modulation on the contractility of isolated rat jejunal segments. Different low and high contractile states were induced in isolated jejunal segments of rats to observe the effects of taurine and the associated mechanisms. Taurine induced stimulatory effects on the contractility of isolated rat jejunal segments at 3 different low contractile states, and inhibitory effects at 3 different high contractile states. Bidirectional modulation was not observed in the presence of verapamil or tetrodotoxin, suggesting that taurine-induced bidirectional modulation is Ca2+ dependent and requires the presence of the enteric nervous system. The stimulatory effects of taurine on the contractility of isolated jejunal segments was blocked by atropine but not by diphenhydramine or by cimetidine, suggesting that muscarinic-linked activation was involved in the stimulatory effects when isolated jejunal segments were in a low contractile state. The inhibitory effects of taurine on the contractility of isolated jejunal segments were blocked by propranolol and L-NG-nitroarginine but not by phentolamine, suggesting that adrenergic β receptors and a nitric oxide relaxing mechanism were involved when isolated jejunal segments were in high contractile states. No bidirectional effects of taurine on myosin phosphorylation were observed. The contractile states of jejunal segments determine taurine-induced stimulatory or inhibitory effects, which are associated with muscarinic receptors and adrenergic β receptors, and a nitric oxide associated relaxing mechanism.
Descritores: Jejuno/efeitos dos fármacos
Contração Muscular/efeitos dos fármacos
Músculo Liso/efeitos dos fármacos
Miosinas/metabolismo
Taurina/farmacologia
-Antagonistas Adrenérgicos alfa/farmacologia
Antagonistas Adrenérgicos beta/farmacologia
Atropina/farmacologia
Bloqueadores dos Canais de Cálcio/farmacologia
Cimetidina/farmacologia
Difenidramina/farmacologia
Sistema Nervoso Entérico/efeitos dos fármacos
Antagonistas dos Receptores Histamínicos H1/farmacologia
/farmacologia
HISTAMINE HTEMEFOS ANTAGONISTS/farmacologia
Jejuno/fisiologia
Antagonistas Muscarínicos/farmacologia
Quinase de Cadeia Leve de Miosina/metabolismo
Óxido Nítrico Sintase/antagonistas & inibidores
Óxido Nítrico/metabolismo
Fosforilação
Fentolamina/farmacologia
Propranolol/farmacologia
Ratos Sprague-Dawley
Taurina/antagonistas & inibidores
Tetrodotoxina/farmacologia
Verapamil/farmacologia
Limites: Animais
Masculino
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


  3 / 15 LILACS  
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Id: lil-540521
Autor: Santana Neto, Pedro de Lima; Aquino, Elisabeth Cristina Moreira de; Silva, José Afrânio da; Amorim, Maria Lucineide Porto; Oliveira Júnior, Américo Ernesto de; Haddad Júnior, Vidal.
Título: Envenenamento fatal por baiacu (Tetrodontidae): relato de um caso em criança / Fatal poisoning caused by puffer fish (Tetrodontidae): report of a case involving a child
Fonte: Rev. Soc. Bras. Med. Trop;43(1):92-94, Jan.-Feb. 2010. ilus.
Idioma: pt.
Resumo: É descrito um envenenamento pela ingestão de vísceras de um baiacu-pintado (Sphoeroides testudineus) por uma criança de dois anos, que apresentou sudorese fria, fraqueza muscular progressiva, parada cardiorrespiratória e morte. São discutidos os riscos do consumo da carne e vísceras de baiacus, fato comum em certas regiões do Brasil.

A case of poisoning resulting from ingestion of viscera from a spotted puffer fish (Sphoeroides testudineus) by a two-year-old child is described. The child presented cold sweating, progressive muscle weakness, cardiorespiratory arrest and death. The risks of consuming the meat and viscera of puffer fish, which is a common occurrence in certain regions of Brazil, are discussed.
Descritores: Doenças Transmitidas por Alimentos
Tetraodontiformes
Tetrodotoxina/envenenamento
-Evolução Fatal
Limites: Animais
Humanos
Lactente
Masculino
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


  4 / 15 LILACS  
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Id: lil-510146
Autor: Cardoso, R. S; Caetano, C. H. S; Cabrini, T. M. B.
Título: Biphallia in imposexed females of marine gastropods: new record for Nassarius vibex from Brazil
Fonte: Braz. j. biol;69(1):223-224, Feb. 2009. ilus.
Idioma: en.
Descritores: Transtornos do Desenvolvimento Sexual
Disruptores Endócrinos/toxicidade
Gastrópodes/efeitos dos fármacos
Tetrodotoxina/toxicidade
Poluentes Químicos da Água/toxicidade
-Brasil
Monitoramento Ambiental
Gastrópodes/anatomia & histologia
Pênis/anatomia & histologia
Limites: Animais
Feminino
Humanos
Masculino
Responsável: BR1.1 - BIREME


  5 / 15 LILACS  
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Id: lil-360966
Autor: Al-Balool, Fawzia Yaqoub.
Título: Effects of tetrodotoxin and ion replacements on the short-circuit current induced by Escherichiacoli heat stable enterotoxin across small intestine of the gerbil (Gerbillus cheesmani)
Fonte: Mem. Inst. Oswaldo Cruz;99(2):141-145, Mar. 2004. tab.
Idioma: en.
Projeto: Kuwait University. Research Administration.
Resumo: The effects of mucosally added Escherichia coli heat stable enterotoxin (STa 30 ng ml-1) on the basal short-circuit current (Isc in µA cm-2) across stripped and unstripped sheets of jejuna and ilea taken from fed, starved (4 days, water ad lib) and undernourished (50 percent control food intake for 21 days) gerbil (Gerbillus cheesmani) were investigated. The effect of neurotoxin tetrodotoxin (TTX 10 µM) and the effects of replacing chloride by gluconate or the effects of removing bicarbonate from bathing buffers on the maximum increase in Isc induced by STa were also investigated. The maximum increase in Isc which resulted from the addition of STa were significantly higher in jejuna and ilea taken from starved and undernourished gerbils when compared with the fed control both using stripped and unstripped sheets. In the two regions of the small intestine taken from fed and starved animals TTX reduced the maximum increase in Isc induced by STa across unstripped sheets only. Moreover in jejuna and ilea taken from undernourished gerbils TTX reduced significantly the maximum increase in Isc induced by STa across stripped and unstripped sheets. Replacing chloride by gluconate decreased the maximum increase in Isc induced by STa across jejuna and ilea taken from undernourished gerbils only. Removing bicarbonates from bathing buffer decreased the maximum increase in Isc across the jejuna and ilea taken from starved and undernourished gerbils.
Descritores: Anestésicos Locais
Cloretos
Íleo
Jejuno
Tetrodotoxina
-Condutividade Elétrica
Gerbillinae
Potenciais da Membrana
Limites: Animais
Feminino
Masculino
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


  6 / 15 LILACS  
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Id: lil-320013
Autor: Kotsias, Basilio A.
Título: Tapones del canal de sodio y un crimen casi perfecto / Sodium channel plugs and an almost perfect crime
Fonte: Medicina (B.Aires);55(5/2):621-624, set.-oct. 1995.
Idioma: es.
Descritores: Crime
Toxinas Marinhas
Saxitoxina
Bloqueadores dos Canais de Sódio
Tetrodotoxina
-Canais de Sódio/efeitos dos fármacos
Toxinas Marinhas
Saxitoxina
Tetrodotoxina
Limites: Animais
Humanos
Responsável: BR1.1 - BIREME


  7 / 15 LILACS  
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Id: lil-249054
Autor: Santos, Cláudia Regina dos; Neves, Fabiana Ferreira; Lima, Luiz de; Grando, Margaret; Benato, Vanira Silva; França, Francisco Oscar Siqueira; Zannin, Marlene(edt).
Título: Ocorrência de intoxicação por ingestão de baicu / Occurrence of Intoxication from eating globfish
Fonte: Rev. ciênc. saúde;15(1/2):253-63, jan.-dez. 1996. tab, graf.
Idioma: pt.
Resumo: Os peixes considerados venenosos ou sarcotóxicos possuem toxinas na pele, músculos, víceras e gônodas. Dentre as 80 espécies existentes no Brasil, em Santa Catarina destaca-se o baiacu, cuja toxina (tetrodotoxina) apresenta propriedades neurotôxicas. Os acidentes causados pela ingestão de baiacu tem sido descrita ocasionalmente no estado de Santa Catarina....
Descritores: Peixes Venenosos/microbiologia
Tetrodotoxina/envenenamento
-Epidemiologia/classificação
Limites: Humanos
Feminino
Criança
Tipo de Publ: Relatos de Casos
Responsável: BR17.1 - Biblioteca Setorial Centro de Ciências da Saúde (BSCCSM)


  8 / 15 LILACS  
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Id: lil-241340
Autor: Wacyk, Jurij; Fuenzalida, Marcela; Morales, Miguel; Acuña, Olga; Lemus, David.
Título: Effect of cholinergic agonists on muscular tonus of the lizard small intestine and esophagus
Fonte: Biol. Res;32(1):29-33, 1999. tab, graf.
Idioma: en.
Resumo: The underlying mechanisms of acetycholine-induced intestinal relaxation in the lizard Liolaemus tenuis tenuis are still unknows. By using a classical model of intestinal recording of isometric contraction and relaxation in conjunction with specific pharmacological tools, this article studies the possible influence of EDRF/NO and nicotinic ganglionar receptors on the Ach-induced relaxation in an effort to elucidate the probable mechanisms involved in ACh effect. It was observed that the relaxation of the lizard intestine elicited by ACh (10(-7) - 4 x 10(-4) M) was not affected by hexametonium (5 x 10(4) M) or tetrodotoxin (10(-6) M). Nicotine (10(-7) to 10(-4) M) induced relaxation was significantly antagonized by hexametonium; however, it was not influenced by tetrodotoxin. These results allow us to discard a neuronal pathway in cholinergic-induced relaxation, suggesting a more direct cholinergic effect on the smooth muscle, perhaps mediated by an unknown substance released by some specialized tissue. N-nitro-L-arginine, used to block NO-synthase and NO production, induced no changes in ACh-induced relaxation. Methylene blue, a soluble guanylate cyclase inhibitor, induced no changes in ACh-induced relaxation. These results allow us to dicard a probable role of EDRF/nitric oxide in the ACh-induced relaxation of lizard small intestine, providing evidence that this mechanism could be different from reported on other species.
Descritores: Agonistas Colinérgicos/farmacologia
Esôfago/efeitos dos fármacos
Intestino Delgado/efeitos dos fármacos
Relaxamento Muscular/efeitos dos fármacos
Tono Muscular/efeitos dos fármacos
-Inibidores Enzimáticos/farmacologia
Hexametônio/farmacologia
Lagartos
Azul de Metileno/farmacologia
Nicotina/farmacologia
Agonistas Nicotínicos/farmacologia
Antagonistas Nicotínicos/farmacologia
Óxido Nítrico Sintase
Nitroarginina/farmacologia
Tetrodotoxina/farmacologia
Limites: Animais
Masculino
Feminino
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


  9 / 15 LILACS  
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Id: lil-196659
Autor: Saldeña, T. A; Saraví, F. D; Cincunegui, Liliana M; Carra, Graciela E.
Título: Rat colon epithelium response to hypoxia is modified by intrinsic innervation blockade
Fonte: Acta gastroenterol. latinoam;27(1):19-25, mar. 1997. tab, graf, ilus.
Idioma: en.
Resumo: Background/Aim: Short-circuit current (Isc) and transepithelial potential difference (PD) of rat distal colon decrease during acute hypoxia and overshoot on reoxygenation. It is not known whether tonic intrinsic nervous activity may influence these responses. Methods: Preparations lacking the submucosal plexus (isolet mucosa) and preparations retaining it (mucosa-submucosa) were mounted in Ussing chambers at 37 degrees Celsius and gassed with 95 percent O2 -5 percent CO2; Isc and PD were monitored. A 5-min hypoxia with 95 percent N2-5 percent CO2 was followed by reoxygenation. The procedure was repeated in the presence of the nervous blocking agent, tetrodotoxin (10(-6)M) in the serosal side of the chamber. Results: In the isolated mucosa (n=10) hypoxia reduced Isc by -55 + 5 percent and PD by -54 + 6 percent below baseline; reoxygenatory overschoots were, respectively, + 60 + 17 percent and + 16 percent. Tetrodotoxin slightly and transiently reduced baseline Isc (-16 + 2 percent) and PD (-14 + 3 percent), with a small resistivity increase. It did not significatively modify the responses to responses to either hypoxia or reoxygenation. In mucosa-submucosa preparations (n=9) hypoxia reduced Isc (-54 + 8 percent) and PD (-61 + 4 percent). On reoxygenation Isc and PD were increased, respectively, +30 + 5 percent and +19 + 6 percent over baseline. Tetrodotoxin reduced baseline Isc (-59,6 + 5 percent) and PD (61,3 + 6 percent). It enhanced hypoxic Isc and PD decreases (-80 + 5 percent), but not the reoxygenatory overschoots. Conclusions: 1) Tetrodotoxin affects baseline Isc and PD more intensely in submucosal plexus innervated preparations than in the isolated mucosa. 2) The epithelial electrical response to acute hypoxia appears to be modulated by tonic neural activity.
Descritores: Colo/inervação
Hipóxia/metabolismo
Plexo Submucoso/metabolismo
Tetrodotoxina/farmacologia
-Doença Aguda
Colo/efeitos dos fármacos
Colo/metabolismo
Eletrofisiologia
Epitélio/inervação
Mucosa Intestinal/efeitos dos fármacos
Mucosa Intestinal/inervação
Mucosa Intestinal/metabolismo
Ratos Wistar
Limites: Ratos
Animais
Masculino
Tipo de Publ: Estudo Comparativo
Responsável: BR1.1 - BIREME


  10 / 15 LILACS  
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Id: lil-194269
Autor: Freitas, J. C; Ogata, T; Veit, C. H; Kodama, M.
Título: Occurrence of tetrodotoxin and paralytic shellfish toxins in Phallusia nigra (Tunicata, Ascidiacea) from the brazilian coast
Fonte: J. venom. anim. toxins;2(1):28-38, 1996. tab, ilus.
Idioma: en.
Resumo: We have already shown the presence of guanidine neurotoxins in calcareous red algae and mussels collected in the Säo Sebastiäo channel State of Säo Paulo,Brazil). It is known that these neurotoxins comprise more than 25 analogues such as tetrodotoxin (TTX) and derivatives plus the paralytic shellfish toxins (PST) found in a variety of marine, freshwater and amphibious species. Filter feeding animals generally possess large amounts of these neurotoxins. The tunicates are sessil marine animals with a high rate of sea water filtration. The tunics and siphons of 50 specimens of Phallusia nigra were dissected and the visceral organs were immersed in methanol containing acetic acid 0.02 N ph 5.0. The extract was prepared by homogenization, filtration and the methanolic phase was concentrated under reduced pressure and defatted with chloroform. The polar phase was evaporated and the residue dissolved in deionized water for further purification in ionic-exchange resin column (Bio-Gel P-2) and HPLC analysis. The extract showed paralytic effects on mouse assay (26.9 MU/100mg) and on crustacean isolated nerve preparations. The chemical analysis for TTX and PST revealed toxins with retention times similar to gonyautoxins, saxitoxins and TTX. These findings are important to explain future toxin envenoming outbreaks on the Brazilian coast.
Descritores: Água do Mar/química
Braquiúros/efeitos dos fármacos
Dinoflagelados/patogenicidade
Moluscos
Neurotoxinas/envenenamento
Paralisia
Saxitoxina/farmacologia
Tetrodotoxina/farmacologia
Urocordados/patogenicidade
Microbiologia da Água
Limites: Animais
Responsável: BR33.1 - Divisão Técnica de Biblioteca e Documentação



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