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Texto completo SciELO Chile
Texto completo
Id: biblio-950769
Autor: Matias, Carlos M; Dionísio, Jose C; Saggau, Peter; Quinta-Ferreira, Maria Emilia.
Título: Activation of group II metabotropic glutamate receptors blocks zinc release from hippocampal mossy fibers
Fonte: Biol. Res;47:1-6, 2014. ilus, graf.
Idioma: en.
Resumo: BACKGROUND: The hippocampal CA3 area contains large amounts of vesicular zinc in the mossy fiber terminals which is released during synaptic activity, depending on presynaptic calcium. Another characteristic of these synapses is the presynaptic localization of high concentrations of group II metabotropic glutamate receptors, specifically activated by DCG-IV. Previous work has shown that DCG-IV affects only mossy fiber-evoked responses but not the signals from associational-commissural afferents, blocking mossy fiber synaptic transmission. Since zinc is released from mossy fibers even for single stimuli and it is generally assumed to be co-released with glutamate, the aim of the work was to investigate the effect of DCG-IV on mossy fiber zinc signals. RESULTS: Studies were performed using the membrane-permeant fluorescent zinc probe TSQ, and indicate that DCG-IV almost completely abolishes mossy fiber zinc changes as it does with synaptic transmission. CONCLUSIONS: Zinc signaling is regulated by the activation of type II metabotropic receptors, as it has been previously shown for glutamate, further supporting the corelease of glutamate and zinc from mossy fibers.
Descritores: Zinco/metabolismo
Receptores de Glutamato Metabotrópico/metabolismo
Fibras Musgosas Hipocampais/efeitos dos fármacos
Glicina/análogos & derivados
-Vesículas Sinápticas/efeitos dos fármacos
Vesículas Sinápticas/metabolismo
Transdução de Sinais/efeitos dos fármacos
Ratos Wistar
Terminações Pré-Sinápticas/efeitos dos fármacos
Terminações Pré-Sinápticas/metabolismo
Transmissão Sináptica/efeitos dos fármacos
Estatísticas não Paramétricas
Ácido Glutâmico/metabolismo
Antagonistas de Aminoácidos Excitatórios/farmacologia
Fibras Musgosas Hipocampais/metabolismo
Hipocampo/efeitos dos fármacos
Limites: Animais
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CL1.1 - Biblioteca Central

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Texto completo SciELO Brasil
Quevedo, J
Vianna, M. R. M
Texto completo
Id: lil-230464
Autor: Roesler, R; Quevedo, J; Rodrigues, C; Madruga, M; Vianna, M. R. M; Ferreira, M. B. C.
Título: Increased training prevents the impairing effect of intra-amygdala infusion of the non-NMDA receptor antagonist CNQX on inhibitory avoidance expression
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;32(3):349-53, Mar. 1999. tab.
Idioma: en.
Resumo: Intra-amygdala infusion of the non-N-methyl-D-aspartate (NMDA) receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) prior to testing impairs inhibitory avoidance retention test performance. Increased training attenuates the impairing effects of amygdala lesions and intra-amygdala infusions of CNQX. The objective of the present study was to determine the effects of additional training on the impairing effects of intra-amygdala CNQX on expression of the inhibitory avoidance task. Adult female Wistar rats bilaterally implanted with cannulae into the border between the central and the basolateral nuclei of the amygdala were submitted to a single session or to three training sessions (0.2 mA, 24-h interval between sessions) in a step-down inhibitory avoidance task. A retention test session was held 48 h after the last training. Ten minutes prior to the retention test session, the animals received a 0.5-µl infusion of CNQX (0.5 µg) or its vehicle (25 percent dimethylsulfoxide in saline). The CNQX infusion impaired, but did not block, retention test performance in animals submitted to a single training session. Additional training prevented the impairing effect of CNQX. The results suggest that amygdaloid non-NMDA receptors may not be critical for memory expression in animals given increased training
Descritores: 6-Ciano-7-nitroquinoxalina-2,3-diona/farmacologia
Tonsila do Cerebelo/efeitos dos fármacos
Aprendizagem da Esquiva/efeitos dos fármacos
Reação de Fuga/efeitos dos fármacos
Antagonistas de Aminoácidos Excitatórios/farmacologia
Exercício Físico
Memória/efeitos dos fármacos
-Ratos Wistar
Tempo de Reação
Limites: Ratos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME

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