Base de dados : LILACS
Pesquisa : D03.633.300.046 [Categoria DeCS]
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Texto completo SciELO Brasil
Costa, José Oswaldo
Mello, Rômulo Teixeira de
Texto completo
Id: lil-319880
Autor: Pereira, Leogenes Horacio; Coelho, Paulo Marcos; Costa, Jose Oswaldo; Mello, Rômulo Teixeira de.
Título: Activity of 9-acridanone-hydrazone drugs detected at the pre-postural phase, in the experimental schistosomiasis mansoni
Fonte: Mem. Inst. Oswaldo Cruz;90(3):425-428, May-Jun. 1995.
Idioma: en.
Resumo: The compound Ro-15.5458/000, derivative in the class of 9-acridanone-hydrazones, was found to be effective against Schistosoma mansoni in mice, killing almost all the skin schistosomules (24 hr after infection), when administered at the dose of 100 mg/kg. In experiments carried out with Cebus monkeys, the drug was shown to be fully effective at 25 mg/kg, 7 days after infection. These data, associated with the good results obtained earlier at the post-postural phase of schistosomiasis, allow the inference that this promising compound may be important in the set of antischistosomal drugs, depending on further toxicological and clinical tests.
Descritores: Acridinas
Schistosoma mansoni
Esquistossomose mansoni
Esquistossomicidas
-Acridinas
Cebus
Contagem de Ovos de Parasitas
Esquistossomicidas
Limites: Animais
Masculino
Feminino
Camundongos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Fotocópia
Coelho, Paulo Marcos Zech
Mello, Rômulo Teixeira de
Id: lil-163732
Autor: Coelho, Paulo Marcos Zech; Pereira, Leógenes Horácio; Mello, Rômulo Teixeira de.
Título: Antischistosomal activity of acridanone-hydrazones in Cebus monkeys experimentally infected with the SJ strain of Schistosoma mansoni
Fonte: Rev. Soc. Bras. Med. Trop;28(3):179-83, jul.-set. 1995. ilus, tab.
Idioma: en.
Resumo: In this study, four compounds where utilized at the dose of 12.5mg/kg body weight, p.o., to treat Cebus monkeys experimentally infected with about 200 cercariae of Schistosoma mansoni (SJ strain), via transcutaneous route. The oograms performed with rectal snips, as well as stool examinations carried out periodically, showed no viable eggs of the parasite, from day 29 to 226 post-treatment. The perfusion undertaken after killing the animals showed absence of worms in the treated monkeys, whereas 83 worms were recovered from the control, thus corroborating the results obtained by means of oograms and coproscopy. These results confirm the efficacy of 9-acridanonehydrazones previously tested against the LE strain of S. mansoni. The low curative dose and apparent absence of toxicity render these drugs an important therapeutic reserve, taking into consideration the reports on the resistance of S. mansoni to the modern drugs oxamiziquine and praziquantel.
Descritores: Acridinas/uso terapêutico
Hidrazonas/uso terapêutico
Esquistossomose mansoni/tratamento farmacológico
Esquistossomicidas/uso terapêutico
-Cebus
Limites: Animais
Feminino
Masculino
Responsável: BR1.1 - BIREME


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Fotocópia
Id: lil-53180
Autor: Díaz Rodríguez, Enrique; Vázquez Sánchez, Mario; Lugones Botell, Miguel A.
Título: Metodo de rivanol más oxitocina: experiencia de un año / Method of rivanol plus oxytocine: report on one year experience
Fonte: Rev. cuba. obstet. ginecol;13(3):415-21, jul.-sept. 1987. tab.
Idioma: es.
Conferência: Apresentado em: Jornada Nacional de Ginecología y Obstetricia, s.l, mayo 1986.
Resumo: Se analizan las historias clínicas de las pacientes a las que se les realizó la interrupción del embarazo por el método de rivanol más oxitocina durante el año 1985. Se recogen datos referentes a la edad, paridad, uso de contraceptivos, tiempo gestacional, tiempo de expulsión, dosis de oxitocina utilizada, indicaciones del método y complicaciones. Se concluye que la adición de oxitocina abrevia notablemente la expulsión y que el proceder es efectivo después de la 16ta. semana del embarazo
Descritores: Aborto Induzido/métodos
Acridinas
Ocitocina
Limites: Adolescente
Adulto
Seres Humanos
Feminino
Responsável: CU1 - INFOMED - Centro Nacional de Información de Ciencias Médicas



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