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Id: biblio-949918
Autor: Liu, Jian-Jun; Lu, Shi-Chao; Liu, Jun-Lian; Yang, He-Ming.
Título: Toxic epidermal necrosis induced by carbamazepine embedded in the subcutis
Fonte: An. bras. dermatol;93(4):620-621, July-Aug. 2018. graf.
Idioma: en.
Descritores: Carbamazepina/efeitos adversos
Síndrome de Stevens-Johnson/etiologia
Absorção Subcutânea/efeitos dos fármacos
Anticonvulsivantes/efeitos adversos
-Braço
Biópsia
Carbamazepina/administração & dosagem
Síndrome de Stevens-Johnson/cirurgia
Tela Subcutânea/cirurgia
Tela Subcutânea/patologia
Anticonvulsivantes/administração & dosagem
Limites: Seres Humanos
Feminino
Adulto
Tipo de Publ: Relatos de Casos
Carta
Responsável: BR1.1 - BIREME


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Id: biblio-950021
Autor: Pereira-Ospina, Rocío del P; Bejarano-Quintero, Ana M; Suescún-Vargas, José M; Pinzón-Salamanca, Javier Y.
Título: Síndrome de sensibilidad a fármacos con eosinofilia y síntomas sistémicos debido a la carbamazepina: Caso pediátrico / Drug reaction with eosinophilia and systemic symptoms due to carbamazepine: Pediatric case
Fonte: Arch. argent. pediatr;116(3):433-436, jun. 2018. tab.
Idioma: es.
Resumo: Entre las reacciones medicamentosas graves en la piel, se encuentran el síndrome de Stevens-Johnson, la necrólisis epidérmica tóxica y el síndrome de sensibilidad a fármacos con eosinofilia y síntomas sistémicos (drug reaction with eosinophilia and systemic symptoms; DRESS, por sus siglas en inglés), que son poco comunes en la población pediátrica (incidencia: 1/1000-10 000 niños), sin embargo, tienen mal pronóstico. El síndrome de sensibilidad a fármacos con eosinofilia y síntomas sistémicos consiste en erupciones cutáneas, alteraciones hematológicas, linfadenopatía y afectación de órganos. Se presenta el caso de un paciente masculino de 12 años que desarrolló esta patología después de iniciar el tratamiento anticonvulsivo con carbamazepina. Se considera que es importante que el personal de la salud tenga conocimiento de esta enfermedad para que sea incluida entre los diagnósticos diferenciales de pacientes con afecciones similares, ya que este síndrome es potencialmente mortal.

Severe skin reactions include Stevens-Johnson Syndrome, toxic epidermal necrolysis and Drug reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome, which are uncommon in the pediatric population (incidence 1/1000-10 000 children), but they have bad prognosis. Drug-sensitive Syndrome with eosinophilia and systemic symptoms consists in rash, hematological abnormalities, lymphadenopathy and organ involvement. We report the case of a 12-year-old male patient who developed this pathology after initiating anticonvulsant therapy with carbamazepine. We consider that it is important to be aware of this disease and to include it among the differential diagnoses in patients with similar conditions because this syndrome is life-threatening.
Descritores: Carbamazepina/efeitos adversos
Síndrome de Hipersensibilidade a Medicamentos/etiologia
Anticonvulsivantes/efeitos adversos
-Carbamazepina/administração & dosagem
Epilepsias Parciais/tratamento farmacológico
Diagnóstico Diferencial
Síndrome de Hipersensibilidade a Medicamentos/diagnóstico
Anticonvulsivantes/administração & dosagem
Limites: Seres Humanos
Masculino
Criança
Tipo de Publ: Relatos de Casos
Responsável: AR94.1 - Centro de Información Pediatrica


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Id: lil-704849
Autor: Simioni, Caio Grava.
Título: Discussão sobre o Estudo SANAD* (Standard And News Antiepileptic Drugs) / Talk about SANAD Study * (Standard Antiepileptic Drugs And News)
Fonte: RBM rev. bras. med;70(4,n.esp), set. 2013.
Idioma: pt.
Descritores: Carbamazepina/análise
Carbamazepina/classificação
Carbamazepina/efeitos adversos
Epilepsia
Responsável: BR12.1 - Biblioteca Setorial da Ciências da Saúde


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Battistella, Linamara Rizzo
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Id: lil-704981
Autor: Tuacek, Tatiana Amadeo; Tsukimoto, Gracinda Rodrigues; Figliolia, Carmen Silvia; Cardoso, Maiara Celina de Carvalho; Tsukimoto, Denise Rodrigues; Rosa, Chennyfer Dobbins Paes; Imamura, Marta; Battistella, Linamara Rizzo.
Título: Neuropatias: Síndrome de Guillain-Barré: reabilitação / Neuropathies: Guillain-Barré syndrome: rehabilitation
Fonte: Acta fisiátrica;20(2), jun. 2013.
Idioma: pt.
Resumo: A estratégia de busca utilizada baseou-se em perguntas estruturadas na forma P.I.C.O. (das iniciais "Paciente", "Intervenção", "Controle", "Outcome"). Foram utilizados como descritores: Exercise, Physical OR Physical Exercise OR Physical Exercises OR prevention and control OR preventive therapy OR preventive measures OR prophylaxis OR preventions OR control OR Guillain-Barre Syndrome OR Syndrome, Guillain-Barre OR Guillaine-Barre Syndrome OR Guillaine Barre Syndrome OR Syndrome, Guillain Barre OR Polyneuropathy, Acute Inflammatory OR Acute Autoimmune Neuropathy OR Acute Autoimmune Neuropathies OR Plasmaphereses OR Plasmapheresis OR Plasma Exchange OR Immunoglobulins/therapeutic use OR Immunoglobulins/administration and dosage OR Exercise Therapy OR Physical Therapy OR Physical Therapies OR Exercise therapies OR Resistant Training OR Strength Training OR rehabilitation OR Splints OR Splint OR Orthopedic Fixation Devices OR Orthotic Devices OR device orthotic OR devices orthotic OR Orthoses OR Orthosis OR Upper Extremity OR Upper Extremities OR Upper Limb OR Upper limbs OR Membrum Superius OR Extremities, Upper OR Limb, Upper OR Limbs, Upper OR hand deformities OR Hand Deformities, acquired OR Rehabilitation OR Lower Extremity OR Extremities, Lower OR Lower Extremities OR Lower Limb OR Limb, Lower OR Lower Limbs OR Membrum Inferius OR Walking OR Ambulation OR dependent ambulation OR Ambulation, Dependent OR gait OR gaits OR Functional Electrical Stimulation OR Electrical Stimulation, Functional OR Fes OR Electric Stimulation Therapy OR Stimulation Therapy, Electric OR Therapeutic Electrical Stimulation OR Electrical Stimulation, Therapeutic OR Stimulation, Therapeutic Electrical OR Therapy, Electric Stimulation OR Therapeutic Electric Stimulation OR Electric Stimulation, Therapeutic OR Stimulation, Therapeutic Electric OR Electrical Stimulation Therapy OR Stimulation Therapy, Electrical OR Therapy, Electrical Stimulation OR Self-help devices OR Self-help device OR Device, Self-Help device OR Assistive Technology OR Assistive Technologies OR Technologies, Assistive OR Technology, Assistive OR Assistive Devices OR Assistive Device OR Device, Assistive OR Devices, Assistive OR daily activities OR daily activity OR activity of daily living OR activities of daily living OR activities of self care OR activity of self care OR usual activities OR usual activity OR usual activity of daily living OR usual activities of daily living OR Patient Positioning OR Patient Positionings OR Positioning, Patient OR Positionings, Patient OR pressure ulcer OR pressure ulcer/prevention & control OR Guillain-Barre OR Guillain-Barre Syndrome/therapy* OR Guillain-Barre Syndrome/rehabilitation* OR Nursing care OR Pressure Ulcer OR Pressure Ulcers OR Pressure Sore OR Pressure Sores OR Decubitus ulcer OR Bed sore OR Bedsore OR Weaning Mechanical Ventilation OR Extubation OR Mechanical Ventilation Predictors OR Weaning Mechanical Ventilator Predictors OR Extubation Predictors.

The search strategy used was based on structured questions in the P.I.C.O. format (from the initials: Patient, Intervention, Control and Outcome). The descriptors used were: Exercise, Physical OR Physical Exercise OR Physical Exercises OR prevention and control OR preventive therapy OR preventive measures OR prophylaxis OR preventions OR control OR Guillain-Barre Syndrome OR Syndrome, Guillain-Barre OR Guillaine-Barre Syndrome OR GuillaineBarre Syndrome OR Syndrome, GuillainBarre OR Polyneuropathy, Acute Inflammatory OR Acute Autoimmune Neuropathy OR Acute Autoimmune Neuropathies OR Plasmaphereses OR Plasmapheresis OR Plasma Exchange OR Immunoglobulins/therapeutic use OR Immunoglobulins/administration and dosage OR Exercise Therapy OR Physical Therapy OR Physical Therapies OR Exercise therapies OR Resistant Training OR Strength Training OR rehabilitation OR Splints OR Splint OR Orthopedic Fixation Devices OR Orthotic Devices OR device orthotic OR devices orthotic OR Orthoses OR Orthosis OR Upper Extremity OR Upper Extremities OR Upper Limb OR Upper limbs OR Membrum Superius OR Extremities, Upper OR Limb, Upper OR Limbs, Upper OR hand deformities OR Hand Deformities, acquired OR Rehabilitation OR Lower Extremity OR Extremities, Lower OR Lower Extremities OR Lower Limb OR Limb, Lower OR Lower Limbs OR Membrum Inferius OR Walking OR Ambulation OR dependent ambulation OR Ambulation, Dependent OR gait OR gaits OR Functional Electrical Stimulation OR Electrical Stimulation, Functional OR Fes OR Electric Stimulation Therapy OR Stimulation Therapy, Electric OR Therapeutic Electrical Stimulation OR Electrical Stimulation, Therapeutic OR Stimulation, Therapeutic Electrical OR Therapy, Electric Stimulation OR Therapeutic Electric Stimulation OR Electric Stimulation, Therapeutic OR Stimulation, Therapeutic Electric OR Electrical Stimulation Therapy OR Stimulation Therapy, Electrical OR Therapy, Electrical Stimulation OR Self-help devices OR Self-help device OR Device, Self-Help device OR Assistive Technology OR Assistive Technologies OR Technologies, Assistive OR Technology, Assistive OR Assistive Devices OR Assistive Device OR Device, Assistive OR Devices, Assistive OR daily activities OR daily activity OR activity of daily living OR activities of daily living OR activities of self care OR activity of self care OR usual activities OR usual activity OR usual activity of daily living OR usual activities of daily living OR Patient Positioning OR Patient Positionings OR Positioning, Patient OR Positionings, Patient OR pressure ulcer OR pressure ulcer/prevention & control OR Guillain-Barre OR Guillain-Barre Syndrome/therapy* OR Guillain-Barre Syndrome/rehabilitation* OR Nursing care OR Pressure Ulcer OR Pressure Ulcers OR Pressure Sore OR Pressure Sores OR Decubitus ulcer OR Bed sore OR Bedsore OR Weaning Mechanical Ventilation OR Extubation OR Mechanical Ventilation Predictors OR Weaning Mechanical Ventilator Predictors OR Extubation Predictors.
Descritores: Síndrome de Guillain-Barré/reabilitação
Distonia/terapia
-Aparelhos Ortopédicos
Respiração Artificial/instrumentação
Equipamentos de Autoajuda
Imunoglobulinas/uso terapêutico
Carbamazepina/uso terapêutico
Modalidades de Fisioterapia/instrumentação
Plasmaferese/instrumentação
Estimulação Elétrica/instrumentação
/uso terapêutico
FRESH WATER1/uso terapêutico
Limites: Seres Humanos
Tipo de Publ: Revisão
Responsável: BR1.1 - BIREME


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ANDRADE FILHO, ANTONIO DE SOUZA
Rodrigues, Luis Erlon Araujo
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Id: lil-434909
Autor: Santos, Helder Jacobina; Andrade Filho, Antonio de Souza; Sanches, Olivia Lordelo; Spolador, Tiago; Rodrigues, Luís Erlon Araújo.
Título: As fosfatases alcalinas, transaminases e gama-glutamil-transferase séricas em pacientes epilépticos tratados com carbamazepina / The serum alkaline phosphatases, transaminases, and gamma-glutamil transferases in epileptic patients treated with carbamazepine
Fonte: J. epilepsy clin. neurophysiol;12(1):17-23, Mar. 2006. tab.
Idioma: en; pt.
Resumo: Carbamazepine is the drug of choice used in the treatment of patients with partial (or focal) epilepsy with secondary generalization. Despite its therapeutical use, this drug has been implicated in the increase of serum activities in some enzymes. Some authors have described prevalence values of 7.7 percent, 13 percent, and 22 percent for the increase of activity of serum alkaline phosphatases (AF or EC 3.1.3.1). A divergence in the results was also found for the activities of the serum g-glutamil transferase (gamma-glutamil transferase or GGT, or EC 2.3.2.2). OBJECTIVE: Hence, among other objectives, the aim of this research is to determine the frequency of sample alterations in serum enzymatic activities of AF, GGT and transaminases (AST, aspartate amino-transferase, EC 2.6.1.1; and ALT, alanine-amino-transferase, EC 2.6.1.2) in epilepsy ward patients in Salvador, Bahia. MATERIAL AND METHODS: The design of the study is descriptive and it is a case series type. It has been approved by the local Ethics Committee. In this study, a convenience sample of 52 epileptic patients who receive ambulatory care was obtained without interference by the researchers. These patients were divided according to age groups of 12 to 30 years and 31 to 90 years, which were then subdivided according to the period of monotherapy with carbamazepine. The serum activities of the enzymes GGT, AF, AST and ALT were determined. RESULTS: The ratios of alterations per variables were described: 42 percent for the FA, 18 percent for the GGT, 2 percent for the ALT, and 12 percent for the AST respectively. The age group of 12 to 30 years presented 56 percent of alterations in the AF while the group of 31 to 90 years presented only 18 percent of alterations. CONCLUSION: We conclude that the enzymes AF, GGT, AST, and ALT presented higher frequencies of alterations of their activities in those patients with age equal to or below 30 years, while the AF presented higher values.

INTRODUÇÃO: A carbamazepina é a droga utilizada no tratamento de pacientes com epilepsia parcial (ou focal) secundariamente generalizada. Apesar do uso terapêutico, este fármaco tem sido implicado no aumento das atividades séricas de algumas enzimas. Alguns autores descreveram valores de prevalência de 7,7 por cento, 13 por cento e 22 por cento para aumento de atividade das fosfatases alcalinas séricas (FA ou EC 3.1.3.1). A divergência de resultados também foi encontrada para as atividades da gama-glutamil-transferase sérica (gama-glutamil transferase ou GGT ou EC 2.3.2.2). OBJETIVO: Assim, a meta desta pesquisa é determinar, dentre outros objetivos, a freqüência de alterações nas atividades das FA, GGT e transaminases (AST, aspartato-amino-transferase, EC 2.6.1.1; e ALT, alanina-amino-transferase, EC 2.6.1.2) de uma amostra de pacientes do ambulatório de epilepsia em Salvador, Bahia. MATERIAL E MÉTODOS: O desenho do estudo é descritivo do tipo série de casos, aprovado pelo Comitê de Ética local, no qual uma amostra de conveniência de 52 pacientes epilépticos de acompanhamento ambulatorial foi obtida sem interferência dos pesquisadores. Estes pacientes foram organizados por faixa etária de 12 a 30 e de 31 a 90 anos e, subdivididos por tempo de monoterapia com carbamazepina. As atividades séricas das enzimas GGT, FA, AST e ALT foram determinadas. RESULTADOS: As proporções de alterações por variáveis foram descritas: 42 por cento para as FA, 18 por cento para as GGT, 2 por cento para as ALT e 12 por cento para as AST, respectivamente. A faixa etária de 12 a 30 anos apresentou 56 por cento de alterações nas FA enquanto que aquela de 31 a 90 anos, apenas 18 por cento. CONCLUSÃO: Nós concluímos que as enzimas FA, GGT, AST e ALT apresentaram maiores freqüências de alterações de suas atividades naqueles pacientes com idade igual ou inferior a 30 anos, sendo que as FA apresentaram maiores valores.
Descritores: Carbamazepina/uso terapêutico
Fosfatase Alcalina/sangue
Epilepsia
gama-Glutamilciclotransferase/sangue
Transaminases/sangue
-Epidemiologia Descritiva
Limites: Seres Humanos
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


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Id: lil-434908
Autor: Fagiolino, Pietro; Vázquez, Marta; Olano, Ivette; Delfino, Aurora.
Título: Systemic and presystemic conversion of carbamazepine to carbamazepine-10, 11-epoxide during long term treatment / Conversão da carbamazepina para 10, 11-epóxido-carbamazepina no tratamento prolongado
Fonte: J. epilepsy clin. neurophysiol;12(1):13-16, Mar. 2006. ilus.
Idioma: en; pt.
Resumo: INTRODUCTION: Carbamazepine (CBZ) undergoes biotransformation, being CYP3A4 the major cytocrome P450 (CYP) enzyme catalyzing the carbamazepine-10,11-epoxide (EPOX) formation, which is quantitatively the most important pathway in CBZ metabolism. There is evidence of dose-dependent elimination of this drug due to its autoinduction capacity. Moreover, published data showed an incomplete bioavailability of CBZ since its absorption increases when grapefruit juice was administered. Both CYP3A4 and MRP2 (located in the enterocyte) are autoinduced during long term use of CBZ. As the other enzymes involved in CBZ metabolism are negligible in the gut, presystemic biotransformation through CYP3A4 could be responsible for the bioavailability of the drug as well as EPOX formation. OBJECTIVE: The purpose of our study was to assess the importance of presystemic formation of EPOX during the autoinduction of CBZ versus the daily administered dose. PATIENTS AND METHODS: 40 adults (average age: 28 years) and 29 children (average age: 9 years) receiving CBZ as monotherapy were included in the study. CBZ and EPOX plasma concentrations were analyzed by a previous validated HPLC method. RESULTS AND CONCLUSION: The results obtained confirmed the metabolic induction after chronic administration and provided new elements to suggest a strong contribution of dose-dependent bioavailability in the non linear kinetics of CBZ.
Descritores: Carbamazepina/sangue
Biotransformação
Epilepsia
-Disponibilidade Biológica
Citocromo P-450 CYP3A
Limites: Seres Humanos
Responsável: BR1.1 - BIREME


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Id: lil-471127
Autor: Oliveira, Bruno Lucio Marques Barbosa de; Parreiras, Mariane Santos; Doretto, Maria Carolina.
Título: Epilepsia e depressão: falta diálogo entre a neurologia e a psiquiatria? / Epilepsy and depression: is lacking dialogue between neurology and psychiatry?
Fonte: J. epilepsy clin. neurophysiol;13(3):109-113, Sept. 2007.
Idioma: pt.
Resumo: INTRODUÇÃO: Epilepsia e depressão são duas das mais freqüentes morbidades que acometem o sistema nervoso central. Vários estudos mostram que muitas pessoas com epilepsia são também acometidas de depressão. OBJETIVO: Alertar quanto à prevalência da comorbidade depressão/epilepsia e a importância do tratamento concomitante das duas entidades, bem como auxiliar na escolha da melhor abordagem terapêutica. MÉTODO: Foi realizada uma pesquisa no HighWire Press no período de 1996-2007, utilizando-se os descritores: depression, epilepsy, seizures, treatment, além de referências cruzadas dos artigos selecionados e análise adicional de referências na literatura específica do tema. RESULTADOS: Apesar da grande influência negativa dos transtornos de humor na qualidade de vida de pessoas com epilepsia, existe uma injustificada resistência dos clínicos em tratar concomitantemente ambas as enfermidades. CONCLUSÃO: Apesar das evidências, existe ainda uma demora em iniciar o tratamento da depressão em pacientes com epilepsia, com prejuízo da qualidade de vida. É necessário que neurologistas e psiquiatras estejam preparados para conduzir satisfatoriamente esses casos.

INTRODUCTION: Epilepsy and depression are two of the most frequent central nervous system disorders. Some studies have shown that many individuals with epilepsy also suffer of depression. OBJECTIVE: To warning about the prevalence of co-morbidity of depression/epilepsy and the importance of the concomitant treatment of the two entities, as well as to assist in the choice of the best therapeutic approach. METHOD: A searching in the HighWire Press in the period of 1996-2007 was carried out, using the describers: depression, epilepsy, seizures, treatment, crossed references of selected articles and additional analysis of references in the specific literature. RESULTS: Despite the negative influence of the mood disorders in the quality of life of patients with epilepsy, there is an unjustified resistance of physicians in treating both diseases. CONCLUSIONS: Neurologists and psychiatrists should be prepared to treat these patients successfully and thus improve the quality of life of patients with epilepsy.
Descritores: Depressão/tratamento farmacológico
Epilepsia/tratamento farmacológico
-Qualidade de Vida
Convulsões
Carbamazepina/uso terapêutico
Ácido Valproico/uso terapêutico
Transtornos do Humor
/uso terapêutico
FRESH WATERABDOMINAL NEOPLASMS/uso terapêutico
/uso terapêutico
FREUDIAN THEORYABDOMINAL NEOPLASMS/uso terapêutico
/uso terapêutico
FUCOSIDOSISABDOMEN, ACUTE/uso terapêutico
Limites: Seres Humanos
Responsável: BR1.1 - BIREME


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Stavale, Joäo N
Yacubian, Elza Márcia T
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Id: lil-458777
Autor: Melo, Julieta G. S. P; Centeno, Ricardo S; Malheiros, Suzana M. F; Ferraz, Fernando A. P; Stávale, João N; Carrete, Henrique H; Sakamoto, Américo C; Yacubian, Elza Márcia T.
Título: Clinical features and surgical outcome of patients with indolent brain tumors and epilepsy
Fonte: J. epilepsy clin. neurophysiol;13(2):65-69, June 2007. ilus.
Idioma: en.
Resumo: INTRODUCTION: In this study the authors review the outcomes of 22 patients with medically refractory epilepsy and slow growth brain tumors. OBJECTIVES: Evaluate the clinical, electrophysiological, operative, and histopathological features. PATIENTS AND RESULTS: The majority of the tumors were located in the temporal lobe (n = 20) and involved the cortical gray matter. The most frequent tumors were gangliogliomas (n = 9), astrocytomas grade I and II (n = 6), dysembryoplastic neuroepithelial tumors (n = 5) and ganglioneuroma (n = 2). The biological behavior of the tumors was strikingly indolent, as indicated by a long preoperative history of chronic seizures (mean, 14 years). Mean follow-up time after resection was 27 months, and according to EngelÆs classification, 85 percent were seizure-free, 10 percent showed a reduction of seizure frequency of at least 90 percent, and 5 percent had reduction in seizure frequency at least 75 percent. CONCLUSION: The data indicate that neoplasms associated with pharmacoresistent epilepsy constitute a distinct clinicopathological group of tumors that arise in young patients, involve the cortex, and exhibit indolent biological behavior for many years. Complete surgical removal of these tumors, including the epileptogenic area, can achieve excellent seizure control.

INTRODUÇÃO: Neste estudo os autores avaliaram retrospectivamente 22 pacientes tratados cirurgicamente com diagnóstico de epilepsia refratária e tumor cerebral de crescimento lento. OBJETIVOS: Avaliar os aspectos clínicos, eletrofisiológicos, cirúrgicos e histopatológicos. PACIENTES E RESULTADOS: A maioria dos tumores estava localizada no lobo temporal (n = 20) com envolvimento da substância cinzenta. Ganglioglioma foi o tumor mais frequente (n = 9), seguido do astrocitoma grau I e II OMS (n = 6), tumor neuroepitelial disembrioplástico (DNET) (n = 5) e ganglioneuroma (n = 2). O comportamento biológico dos tumores foi estritamente indolente como indicado pela longa história pré-operatória de (média, 14 anos). O tempo de acompanhamento pós-operatório médio foi de 27 meses e de acordo com a Classificacão de Engel, 85 por cento ficaram sem crises (Classe I), 10 por cento obtiveram redução maior de 90 por cento das crises (Classe II), e 5 por cento tiveram redução menor que 75 por cento (Classe III). CONCLUSÃO: Os dados indicam que neoplasias associadas à epilepsia crônica refratária constituem um grupo de tumores com características clinico-patológicas distintas que se iniciam em pacientes jovens, envolvem o córtex e apresentam comportamento biológico indolente. A ressecção cirúrgica completa destes tumores, incluindo a zona epileptogênica, levou ao controle total das crises na maior parte dos casos estudados.
Descritores: Neoplasias Encefálicas/cirurgia
Epilepsia/cirurgia
-Fenobarbital/efeitos adversos
Fenitoína/efeitos adversos
Carbamazepina/efeitos adversos
Estudos Retrospectivos
Responsável: BR1.1 - BIREME


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Id: biblio-998194
Autor: Rojas Torres, Paula Fernanda; Stevens Cortés, Paula Rosario; Geraldo Von Bennewitz, Alfredo Eduardo; Araya Navarrete, José Roberto.
Título: Síndrome de sensibilidad a drogas con eosinofilia y síntomas sistémicos (DRESS) atípico por carbamazepina, a propósito de un caso pediátrico / Drug sensitivity syndrome with eosinophilia and atypical symptoms (DRESS) by carbamazepine: a case report
Fonte: Rev. pediatr. electrón;15(3):13-22, oct. 2018. ilus.
Idioma: es.
Resumo: Introducción: El síndrome de sensibilidad a drogas con eosinofilia y síntomas sistémicos (DRESS) generalmente es acompañado por eosinofilia. Es una enfermedad que pone en peligro la vida del paciente. Se presenta como reacción adversa a infecciones y a medicamentos, usualmente asociada al uso de antiepilépticos. Caso clínico: Paciente de 6 años, masculino, con antecedente de Epilepsia de reciente diagnóstico, que consultó en Servicio de Urgencias dos semanas después de iniciar tratamiento con Carbamazepina, por cuadro caracterizado por eritema de predominio facial, exacerbado con la exposición al sol. Posteriormente presentó fiebre con episodios hasta 40 °C, que se asoció a convulsiones. Después de un exhaustivo estudio se concluyó DRESS atípico (sin eosinofilia), iniciando tratamiento corticoideo con favorable respuesta clínica. Discusión: El síndrome de DRESS, es una enfermedad de difícil diagnóstico por sus múltiples diagnósticos diferenciales y falta de criterios diagnósticos. Es esencial la suspensión inmediata del fármaco causante, para evitar progresión de la enfermedad e iniciar tratamiento precoz.

Background: The drug sensitivity syndrome with eosinophilia and systemic symptoms (DRESS) is usually accompanied by eosinophilia. It is a disease that endangers the life of the patient. It occurs as an adverse reaction to infections and medications, usually associated with the use of antiepileptics. Case report: A 6-year-old patient, male, with a recent diagnosis of epilepsy, who consulted the Emergency Department two weeks after initiating treatment with Carbamazepine because of a condition characterized by facial predominance erythema, exacerbated by sun exposition. Subsequently presented fever with episodes up to 40 ° C, which was associated with seizures. After an exhaustive study, atypical DRESS syndrome (without eosinophilia) was made, initiating corticoid treatment with favorable clinical response. Discussion: DRESS syndrome is a disease difficult to diagnose because of its multiple differential diagnoses and lack of diagnostic criteria. Immediate suspension of the causative drug is essential to prevent progression of the disease and initiate early treatment Keywords: Drug Hypersensitivity Syndrome, Carbamazepine, Corticoid.
Descritores: Carbamazepina/efeitos adversos
Síndrome de Hipersensibilidade a Medicamentos
Anticonvulsivantes/efeitos adversos
Limites: Seres Humanos
Masculino
Criança
Tipo de Publ: Relatos de Casos
Responsável: CL126.3 - Biblioteca Campus Oriente Peñalolén


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Id: biblio-986418
Autor: López Naranjo, Dennis Fabricio; Barragán Pérez, Eduardo.
Título: Factores de riesgo en la aparición del trastorno por déficit de atención e hiperactividad en pacientes con epilepsia infantil de reciente diagnóstico / Risk factors in the emergence of attention deficit hyperactivity disorder in patients with diagnosis child recent epilepsy
Fonte: Metro cienc;24(1):5-8, JUN.2016.
Idioma: es.
Resumo: Resumen: Antecedentes: la epilepsia y el trastorno por déficit de atención e hiperactividad (TDAH) son frecuentes de la infancia; se han reportado como comorbilidades. Se estima que aproximadamente 40% de los pacientes con epilepsia pueden presentar TDAH; sin embargo, hay pocas evidencias de si es acompañante o producto de la actividad epiléptica anormal, efectos secundarios de los fármacos o un proceso multigenético asociado. Objetivos: describir qué factores neurobiológicos tiene mayor relevancia en la aparición del trastorno por déficit de atención e hiperactividad en pacientes con epilepsia infantil de reciente diagnóstico. Materiales y métodos: se evaluó pacientes con epilepsia recién diagnosticada, entre los 4 y 16 años de edad durante el período comprendido entre octubre de 2011 y abril de 2012 con un seguimiento prospectivo de 6 meses, estableciendo desde el inicio si existían criterios de TDAH y midiendo factores tanto biológicos como asociados para el desarrollo de TDAH. Se completó los estudios para el abordaje de epilepsia. Resultados: se evaluaron 32 pacientes en los que se observó que el 40% tenía criterios de TDAH del subtipo inatento; además, se determinó que en el sexo masculino las epilepsias parciales representan el 63.2%, y en el femenino las epilepsias generalizadas el 53.8%. Los fármacos utilizados más frecuentes fueron el AVP (72%) y CBZ (28%). Conclusiones: consideramos que es muy frecuente el subtipo de TDAH inatento, lo que sustenta la idea de que sus síntomas son una disfunción neurológica causada por la epilepsia que por un trastorno biológico asociado. Esto realza la importancia de diagnosticar y tratar la epilepsia en sí, y evaluar después de un tiempo, la necesidad de complementar los tratamientos que controlen el TDAH. Palabras claves: factores neurobiológicos, epilepsia infantil de reciente diagnóstico, trastorno de déficit de atención e hiperactividad (TDAH).

Background: Epilepsy and ADHD are neurological disorders frequently seen in childhood, and have been reported as comorbidities. It is estimated that about 40% of patients with epilepsy may have ADHD, however, there is little evidence that if this disorder is or companion product of the abnormal epileptic activity, drug side effects or process associated multigenic. Objective: Describe which of the neurobiological factors have greater relevance in the development of attention deficit disorder and hyperactivity in patients with newly diagnosed childhood epilepsy. Materials and methods: We evaluated patients with newly diagnosed epilepsy, between 4 and 16 years of age in the period between October 2011 and April 2012 with a prospective monitoring six months from start setting if were no criteria for ADHD and measuring both biological factors associated with development of ADHD. Were completed relevant studies for addressing epilepsy. Results: We evaluated more than 32 patients, where it was observed that 40% of the sample had ADHD criteria for inattentive subtype, also was determined that in males partial epilepsies represent 63.2% and in women the epilepsy represents 53,8% overall. Among the most common drugs used were VPA by 72% and 28% CBZ. Conclusions: We believe it is very common subtype of ADHD is found the inattentive, so supports the idea that many of the symptoms of ADHD represent a more neurological dysfunction that epilepsy associated with a biological disorder, This enhances the importance of a diagnosis and treatment of epilepsy itself and to assess after a while, the need to supplement with control treatments for ADHD.
Descritores: Transtorno do Deficit de Atenção com Hiperatividade
Epilepsia Generalizada
Anticonvulsivantes
-Carbamazepina
Limites: Seres Humanos
Pré-Escolar
Criança
Adolescente
Tipo de Publ: Artigo Clássico
Responsável: EC110.1 - Biblioteca



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