Base de dados : LILACS
Pesquisa : D05.500.562.750.500 [Categoria DeCS]
Referências encontradas : 3 [refinar]
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Texto completo SciELO Brasil
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Id: biblio-841780
Autor: Sodero, Ana Carolina Rennó; Abrahim-Vieira, Bárbara; Torres, Pedro Henrique Monteiro; Pascutti, Pedro Geraldo; Garcia, Célia RS; Ferreira, Vitor Francisco; Rocha, David Rodrigues da; Ferreira, Sabrina Baptista; Silva Jr, Floriano Paes.
Título: Insights into cytochrome bc1 complex binding mode of antimalarial 2-hydroxy-1, 4-naphthoquinones through molecular modelling
Fonte: Mem. Inst. Oswaldo Cruz;112(4):299-308, Apr. 2017. tab, graf.
Idioma: en.
Projeto: FAPESP.
Resumo: BACKGROUND Malaria persists as a major public health problem. Atovaquone is a drug that inhibits the respiratory chain of Plasmodium falciparum, but with serious limitations like known resistance, low bioavailability and high plasma protein binding. OBJECTIVES The aim of this work was to perform molecular modelling studies of 2-hydroxy-1,4-naphthoquinones analogues of atovaquone on the Qo site of P. falciparum cytochrome bc1 complex (Pfbc1) to suggest structural modifications that could improve their antimalarial activity. METHODS We have built the homology model of the cytochrome b (CYB) and Rieske iron-sulfur protein (ISP) subunits from Pfbc1 and performed the molecular docking of 41 2-hydroxy-1,4-naphthoquinones with known in vitro antimalarial activity and predicted to act on this target. FINDINGS Results suggest that large hydrophobic R2 substituents may be important for filling the deep hydrophobic Qo site pocket. Moreover, our analysis indicates that the H-donor 2-hydroxyl group may not be crucial for efficient binding and inhibition of Pfbc1 by these atovaquone analogues. The C1 carbonyl group (H-acceptor) is more frequently involved in the important hydrogen bonding interaction with His152 of the Rieske ISP subunit. MAIN CONCLUSIONS Additional interactions involving residues such as Ile258 and residues required for efficient catalysis (e.g., Glu261) could be explored in drug design to avoid development of drug resistance by the parasite.
Descritores: Plasmodium falciparum/efeitos dos fármacos
Complexo III da Cadeia de Transporte de Elétrons/química
Antimaláricos/farmacologia
Antimaláricos/química
-Naftoquinonas/química
Análise de Sequência de Proteína
Responsável: BR1.1 - BIREME


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Texto completo SciELO Saúde Pública
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Id: lil-733306
Autor: Rivera-Ávila, Roberto Carlos.
Título: Fiebre chikungunya en México: caso confirmado y apuntes para la respuesta epidemiológica / Chikungunya fever in Mexico: confirmed case and notes on the epidemiologic response
Fonte: Salud pública Méx;56(4):402-404, jul.-ago. 2014. tab.
Idioma: es.
Resumo: La fiebre chikungunya (CHIK) es una enfermedad viral transmitida al ser humano por el mismo vector del dengue, el mosquito Aedes. Además de fiebre y fuertes dolores articulares, produce otros síntomas como mialgias, cefalea, náuseas, cansancio y exantema. No tiene tratamiento específico; el manejo terapéutico de los pacientes se enfoca en el alivio de los síntomas. Históricamente se han reportado brotes de grandes proporciones; incluso desde 2010 se llegó a considerar como una potencial epidemia emergente. En 2013 se introdujo a las islas del Caribe y recientemente se ha reportado en el continente americano. En este trabajo se describe el primer caso confirmado de chikungunya en México, en el municipio de Tlajomulco de Zúñiga, Jalisco, en mayo de 2014, importado de la isla Antigua y Barbuda, en el Caribe, por una mujer de 39 años de edad.

Chikungunya fever (CHIK) is a viral disease transmitted to human beings by the same vector as dengue -the Aedes mosquito. Besides fever and severe pain in the joints, it produces other symptoms such as myalgias, headache, nausea, fatigue and exanthema. There is no specific treatment for it; the therapeutic management of patients focuses on symptom relief. Historically, outbreaks of large proportions have been reported; even since 2010 it was considered to be a potential emerging epidemic. In 2013 it was introduced into the islands of the Caribbean, and it has recently been reported in the American continent. This paper describes the first confirmed case of chikungunya in Mexico -in the municipality of Tlajomulco de Zúñiga, Jalisco, in May, 2014-, which was imported from the Caribbean island of Antigua and Barbuda by a 39 year-old woman.
Descritores: Antídotos/farmacologia
Temperatura Alta
Imidazóis/toxicidade
Carne
Mitocôndrias/metabolismo
Mutagênicos/toxicidade
Consumo de Oxigênio/efeitos dos fármacos
Ubiquinona/farmacologia
-Antídotos/administração & dosagem
Culinária
Dieta
Complexo II de Transporte de Elétrons
Complexo III da Cadeia de Transporte de Elétrons/metabolismo
Complexo IV da Cadeia de Transporte de Elétrons/metabolismo
Transporte de Elétrons/efeitos dos fármacos
Alimentos Fortificados
Mitocôndrias Cardíacas/efeitos dos fármacos
Mitocôndrias Cardíacas/metabolismo
Mitocôndrias Hepáticas/efeitos dos fármacos
Mitocôndrias Hepáticas/metabolismo
Mitocôndrias Musculares/efeitos dos fármacos
Mitocôndrias Musculares/metabolismo
Complexos Multienzimáticos/metabolismo
NAD(P)H Desidrogenase (Quinona)/metabolismo
Oxirredutases/metabolismo
Ratos Wistar
Succinato Desidrogenase/metabolismo
Ubiquinona/administração & dosagem
Limites: Animais
Bovinos
Masculino
Ratos
Responsável: BR1.1 - BIREME


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Id: lil-537183
Autor: Lubes, Vito; Mendoza, Marla; Araujo, Mary Lorena; Brito, Felipe.
Título: Complejos de vanadio (III) con glutatión en disolución acuosa / Vanadium (III) complexes with glutathione in aqueous solution
Fonte: Acta cient. venez;56(2):65-68, 2005. tab, graf.
Idioma: es.
Resumo: Se presentan los resultados del estudio de los complejos de vanadio(III) con glutatión (GSH, H3L) a 25 °C y en KCl3,0 M mediante medidas de fuerzas electromotrices, emf(H). El análisis de los datos mediante el programa de mínimos cuadrados generalizados LETAGROP indica la formación de cantidades significativas de los complejos VH4l4+, VH3L3+, V(H3L)23+ yv(L)(3L)2+, cuyas constantes de estabilidad fueron determinadas.

The formation of the vanadium(III) complexes with glutathione (GSH, H3L) was studied in 3.0 M KCl at 25 °C by means of electromotive forces measurements, emf (H). The analysis of the potentiometric data by means of the least-squares program LETAGROP indicates the formation of significant quantities of the complexes VH4l4+, VH3L3+, V(H3L)23+ yv(L)(3L)2+, whose stability constants were determined.
Descritores: Complexo III da Cadeia de Transporte de Elétrons/análise
Complexo III da Cadeia de Transporte de Elétrons/química
Dissolução/análise
Glutationa/análise
Glutationa/química
-Química
Tipo de Publ: Estudo Comparativo
Responsável: VE1.1 - Biblioteca Humberto Garcia Arocha



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