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Id: biblio-1040147
Autor: Castoldi, Robson Chacon; Manganaro, Lincoln José; Ferreira, Soraia Carolline; Alves, Marcelo José; De-Carvalho-Filho, Carlos Augusto; Garcia, Thiago Alves; Ozaki, Guilherme Akio Tamura; Caetano, Heliard Rodrigues dos Santos; Zanuto, Éverton Alex Carvalho; Giometti, Inês Cristina; Camargo-Filho, José Carlos Silva.
Título: Effect of growth hormone (GH) and resistance training on the collagen properties of femoral bone tissue / Efecto de la hormona de crecimiento (HC) y el entrenamiento de fuerza en las propiedades colágenas del tejido óseo femoral
Fonte: Int. j. morphol;37(4):1416-1421, Dec. 2019. tab, graf.
Idioma: en.
Projeto: LabMicro - FAPESP.
Resumo: The indiscriminate use of anabolic steroids in gyms has been growing in a generalized way, among which, the most common is growth hormone (GH). In the short term GH may potentiate muscle growth, especially when taken in combination with resistance training. However, the effects of this hormone are not yet fully understood in the literature, especially in relation to collagen properties. The objective of this study was to evaluate the effect of the application of growth hormone (GH) and resistance training (RT) on the collagen properties of femoral bone tissue using Raman Spectroscopy. In this study 40 male rats were randomly distributed into four groups (n=10): control (C), control and GH application (GH), resistance training (T), and resistance training and GH application (GHT). The training consisted of four series of 10 water jumps, performed three times a week, with an overload corresponding to 50 % of body weight and duration of four weeks. GH was applied at a dosage of 0.2 IU/Kg (0.067 mg/kg) to each animal, three times a week, every other day. The animals were euthanized and the right femurs were collected for analysis of bone structure. Raman spectroscopy (RS) was used to observe the following compounds from their respective bands: type I collagen (662 cm-1), amide III (1243 cm-1), proteins including type I collagen (1278 cm-1), woven collagen (1322 cm-1), association of collagen, phospholipids, nucleic acid, and phosphate (1330 cm-1), and collagen and protein deformation (1448 cm-1). The results demonstrated an increase in the collagen properties in all analyzed variables, however, the T group presented a statistically significant difference (p<0.05). It is possible to conclude that isolated physical training was shown to be more efficient than when combined with the application of GH to increase the collagen properties of the femoral bone tissue.

El uso indiscriminado de anabolizantes en los gimnasios ha aumentado de forma generalizada, entre éstos la hormona de crecimiento (HC) es una de las más utilizadas, y a corto plazo puede potencializar el crecimiento muscular, principalmente cuando es realizado en combinación con el entrenamiento de fuerza. Sin embargo, los efectos de esta hormona aún no están totalmente esclarecidos en la literatura, especialmente en relación a las propiedades colágenas. El objetivo del estudio fue evaluar el efecto de la aplicación del HC y entrenamiento de fuerza (E) en las propiedades colágenas del tejido óseo femoral a partir de la utilización de la espectroscopía Raman. Se usaron 40 ratas Wistar distribuidos en cuatro grupos (n=10): control (C), control y aplicación del HC (HCC), entrenamiento de fuerza (E) y entrenamiento de fuerza y aplicación del HC (THC). El entrenamiento fue compuesto por cuatro series de 10 saltos acuáticos, realizados tres veces por semana, con sobrecarga correspondiente a 50 % del peso corporal y duración de cuatro semanas. El HC fue aplicado en una dosificación de 0,2 UI/Kg (0,067 mg/kg) en cada animal, tres veces por semana, en días no consecutivos. Los animales fueran eutanasiados y se retiró el fémur derecho para realización del análisis de la estructura ósea. La espectroscopía Raman (ER) fue utilizada para observar los siguientes compuestos a partir de las respectivas bandas: colágeno tipo I (662 cm-1), amida III (1243 cm1), proteínas, incluido colágeno tipo I (1278 cm-1), colágeno retorcido (1322 cm-1), asociación de colágeno, fosfolípidos, ácidos nucleicos y fosfato (1330 cm-1), deformación de colágeno y proteína (1448 cm-1). Hubo aumento en las propiedades colágenas en todas las variables analizadas, sin embargo, solamente el grupo E demostró una diferencia estadísticamente significativa (p<0,05). En conclusión, para el aumento de las propiedades colágenas del tejido óseo femoral, el entrenamiento físico aislado es más eficiente que el entrenamiento combinado con el uso de HC.
Descritores: Resistência Física/fisiologia
Hormônio do Crescimento/farmacologia
Fêmur/efeitos dos fármacos
Fêmur/fisiologia
-Hormônio do Crescimento/administração & dosagem
Exercício/fisiologia
Colágeno/efeitos dos fármacos
Ratos Wistar
Microscopia/métodos
Limites: Animais
Masculino
Ratos
Responsável: CL1.1 - Biblioteca Central


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Liberti, Edson Aparecido
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Id: biblio-1040152
Autor: Simões, Mariane Cristina Donato; Agopian, Rafael Gabaret; Cabrita, Henrique Antônio Berwanger de Amorim; Liberti, Edson Aparecido.
Título: Morphofunctional and ultrastructural evaluation of hip joint development in human fetuses / Evaluación morfofuncional y ultraestructural del desarrollo de la articulación de la cadera en fetos humanos
Fonte: Int. j. morphol;37(4):1450-1455, Dec. 2019. tab, graf.
Idioma: en.
Resumo: SUMMARY: The normal sequential development of the hip joint (HJ) was considered for the evaluation of the morphological and ultrastructural aspects of the joint cartilage of the proximal femoral head epiphysis in human fetuses between 16 to 31 weeks of intra uterine life (IUL). Twenty human fetuses were fixed in 10 % formalin solution. Fetuses were divided into 4 groups (n=5): Group 1 (G1): 16-19 weeks IUL; Group 2 (G2): 20-23 weeks IUL; Group 3 (G3): 24-27 weeks IUL and Group 4 (G4): 28-31 weeks IUL. The right moieties of the HJ were subjected to light microscopy to determine the chondrocyte area, volume, and density and the extracellular matrix (ECM) density. The collagen component in ECM was qualitatively evaluated using Safranin-O and picrosirius techniques under polarized light. The left portions were analyzed using scanning electron microscopy (SEM). The advance of age revealed a gradual increase in chondrocyte area and volume and in ECM density, and a decrease in chondrocyte density. The apparent prevalence of type II collagen fibers in G1 and type III collagen fibers in G4, as well as a balance between type I and III collagen fibers in G2 and G3 suggest a process of cartilaginous evolution and repair. The pantographic organization of the collagen fiber meshes from the depth to the cartilage surface of the femoral head suggests that the arcade collagen network architecture starts at the fetal stage, regardless of the compressive forces applied. The morphological data may contribute not only to a better understanding of the maturation and cartilage organization in this area but also to serve as a theoretical basis for aspects related to diseases and joint malformations.

RESUMEN: El desarrollo secuencial normal de la articulación de la cadera (AC) se consideró para la evaluación de los aspectos morfológicos y ultraestructurales del cartílago articular de la epífisis proximal y de la cabeza femoral en fetos humanos entre 16 y 31 semanas de vida intrauterina (SVIU). Veinte fetos humanos fueron fijados en solución de formalina al 10 %. Los fetos se dividieron en 4 grupos (n = 5): Grupo 1 (G1), 1619 semanas de IUL; Grupo 2 (G2), 20-23 semanas SVIU; Grupo 3 (G3), 24-27 semanas SVIU y Grupo 4 (G4), 28-31 semanas SVIU. Las muestras derechas de la AC se sometieron a microscopía óptica para determinar el área, el volumen y la densidad de los condrocitos y la densidad de la matriz extracelular (MEC). El componente de colágeno en la MEC se evaluó cualitativamente utilizando técnicas de safranina-O y picrosirius bajo luz polarizada. Las muestras de la AC izquierda se analizaron utilizando microscopía electrónica de barrido (MEB). El avance de la edad reveló un aumento gradual en el área y el volumen de los condrocitos y en la densidad de la MEB, y una disminución en la densidad de los condrocitos. La aparente prevalencia de las fibras de colágeno tipo II en G1 y tipo III en G4, así como el equilibrio entre las fibras de colágeno tipo I y III en G2 y G3 sugieren un proceso de evolución y reparación cartilaginosa. La organización pantográfica de las mallas de fibra de colágeno desde la profundidad a la superficie del cartílago de la cabeza femoral sugiere que la arquitectura de la red de colágeno comienza en la etapa fetal, independientemente de las fuerzas compresivas aplicadas. Los datos morfológicos pueden contribuir no solo a una mejor comprensión de la organización de la maduración y el cartílago en esta área, sino también servir de base teórica para los aspectos relacionados con enfermedades y malformaciones articulares.
Descritores: Feto
Articulação do Quadril/ultraestrutura
-Microscopia Eletrônica de Varredura
Colágeno/ultraestrutura
Condrócitos/ultraestrutura
Matriz Extracelular
Articulação do Quadril/embriologia
Limites: Seres Humanos
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-949896
Autor: Coelho, Polyana Galvão Bernardes; Souza, Maria Verônica de; Conceição, Lissandro Gonçalves; Viloria, Marlene Isabel Vargas; Bedoya, Sirley Adriana Ortiz.
Título: Evaluation of dermal collagen stained with picrosirius red and examined under polarized light microscopy
Fonte: An. bras. dermatol;93(3):415-418, May-June 2018. graf.
Idioma: en.
Resumo: Abstract: The special picrosirius red staining highlights the natural birefringence of collagen fibers when exposed to polarized light. The results from birefringence allow to evaluate the organization of the collagen fibers in the tissues. The authors intend to elucidate all steps to obtain and capture images of histological sections stained with picrosirius red and evaluated under polarized light microscopy, as well as possible artefacts that may occur.
Descritores: Pele/ultraestrutura
Coloração e Rotulagem/métodos
Compostos Azo/química
Colágeno/ultraestrutura
Microscopia de Polarização/métodos
-Pele/citologia
Birrefringência
Administração Cutânea
Fotomicrografia
Colágeno/análise
Colágenos Fibrilares/ultraestrutura
Cavalos
Limites: Animais
Cães
Responsável: BR1.1 - BIREME


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Almeida Junior, Hiram Larangeira de
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Id: biblio-949950
Autor: Almeida Júnior, Hiram Larangeira de; Bicca, Eduardo de Barros Coelho; Andrade, Mariani Magnus de; Andrade Neto, Pedro da Rocha.
Título: Scanning electron microscopy of granuloma annulare
Fonte: An. bras. dermatol;93(5):740-742, Sept.-Oct. 2018. graf.
Idioma: en.
Resumo: Abstract: Light microscopy of granuloma annulare shows mucin deposition with lympho-histiocytic infiltrate. We describe the ultrastructural three-dimensional aspects of a typical case of granuloma with characteristic histopathological findings. At the ultrastructural level, affected collagen bundles and granular mucin deposition were observed. Round cells corresponding to lymphocytes were identified. Bigger oval cells, corresponding to isolated or palisading histiocytes were also found. The ultrastructural aspects overlap with light microscopy and contribute to its iconographic documentation.
Descritores: Microscopia Eletrônica de Varredura
Colágeno/ultraestrutura
Granuloma Anular/patologia
-Histiócitos/ultraestrutura
Mucinas/metabolismo
Limites: Seres Humanos
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


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Id: biblio-1001169
Autor: de la Fuente-Laso, Pilar; González-García, Javier; Castaño-Rivero, Antón; Gonzalvo-Rodríguez, Pablo; Rodríguez-Díaz, Eloy; Vázquez-Osorio, Igor.
Título: Morfea profunda solitaria: Una forma infrecuente de esclerodermia localizada en la infancia. Caso clínico / Solitary morphea profunda: An unusual form of localized scleroderma in childhood. Case report
Fonte: Arch. argent. pediatr;117(2):137-141, abr. 2019. tab.
Idioma: es.
Resumo: La morfea profunda solitaria es una forma infrecuente de morfea localizada en la infancia. Se caracteriza clínicamente por la presencia de un área indurada, mal delimitada y asintomática, de localización paraespinal, que no tiende a la progresión ni se asocia con manifestaciones sistémicas. Histológicamente, muestra un engrasamiento e hialinización de las fibras de colágeno dérmico, junto con infiltrados de predominio linfohistiocitario en la dermis reticular y la hipodermis. Se presenta a una paciente de 7 años con una lesión solitaria en la región dorsal media izquierda, cuyos hallazgos clínicos, ecográficos e histológicos fueron compatibles con el diagnóstico de una morfea profunda solitaria.

Solitary morphea profunda is an unusual form of localized scleroderma in childhood. It is characterized by a single, poorly defined and indurate plaque often located on the upper trunk near the spine. Solitary morphea profunda is frequently asymptomatic and shows no associated systemic involvement. Histological examination reveals dense sclerosis of collagen and a marked lymphocytic infiltrate in the reticular dermis and subcutis. We report a 7-year-old girl with a solitary asymptomatic and sclerotic plaque on the back. Clinical, ultrasonographic and histological features were consistent with solitary morphea profunda.
Descritores: Pediatria
Esclerodermia Localizada
Ultrassonografia
Colágeno
Limites: Seres Humanos
Feminino
Criança
Tipo de Publ: Relatos de Casos
Responsável: AR94.1 - Centro de Información Pediatrica


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Andrade, Zilton de Araújo
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Id: biblio-827766
Autor: Gonzalez, Ana Cristina de Oliveira; Costa, Tila Fortuna; Andrade, Zilton de Araújo; Medrado, Alena Ribeiro Alves Peixoto.
Título: Wound healing - A literature review
Fonte: An. bras. dermatol;91(5):614-620, Sept.-Oct. 2016. graf.
Idioma: en.
Resumo: Abstract: Regeneration and tissue repair processes consist of a sequence of molecular and cellular events which occur after the onset of a tissue lesion in order to restore the damaged tissue. The exsudative, proliferative, and extracellular matrix remodeling phases are sequential events that occur through the integration of dynamic processes involving soluble mediators, blood cells, and parenchymal cells. Exsudative phenomena that take place after injury contribute to the development of tissue edema. The proliferative stage seeks to reduce the area of tissue injury by contracting myofibroblasts and fibroplasia. At this stage, angiogenesis and reepithelialization processes can still be observed. Endothelial cells are able to differentiate into mesenchymal components, and this difference appears to be finely orchestrated by a set of signaling proteins that have been studied in the literature. This pathway is known as Hedgehog. The purpose of this review is to describe the various cellular and molecular aspects involved in the skin healing process.
Descritores: Cicatrização/fisiologia
-Colágeno/metabolismo
Neovascularização Fisiológica
Proliferação Celular/fisiologia
Proteínas Hedgehog/fisiologia
Transição Epitelial-Mesenquimal
Reepitelização/fisiologia
Limites: Seres Humanos
Tipo de Publ: Revisão
Responsável: BR1.1 - BIREME


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Id: biblio-827757
Autor: Henriques, Águida Cristina Gomes; Freitas, Roseana de Almeida; Pires, Bruno Cunha; Gurgel, Clarissa Araújo; Santos, Jean Nunes dos.
Título: Histochemical and immunohistochemical differences between solitary oral fibroma and fibrous papule of the face
Fonte: An. bras. dermatol;91(5):589-594, Sept.-Oct. 2016. tab, graf.
Idioma: en.
Resumo: Abstract: Background: The morphological similarities between fibrous papules of the face and multiple sporadic oral fibromas were mentioned long ago and a relationship between them has been reported in the literature. Objective: The aim of this study was to evaluate the participation of mast cells, elastin and collagen in a series of oral fibromas and fibrous papules of the face in order to better understand the possible role of these factors in fibrosis and the formation of these lesions. Methods: Thirty cases of oral fibroma involving the buccal mucosa and 30 cases of fibrous papules of the face were selected. Tissue samples were submitted to picrosirius red staining and immunohistochemistry using anti-elastin and anti-tryptase antibodies. Results: The percentage of tryptase-positive mast cells and expression of elastin were higher in cases of fibrous papules of the face (p < 0.05). In contrast, a higher intensity of collagen deposition was observed in oral fibromas. The results showed mast cell accumulation and higher elastin synthesis in fibrous papules of the face, and mast cell accumulation with higher collagen fiber synthesis in oral fibromas. Conclusion: These findings support the hypothesis that mast cells influence the development and growth of these lesions through different mechanisms.
Descritores: Dermatoses Faciais/patologia
Fibroma/patologia
-Fibrose/metabolismo
Imuno-Histoquímica
Colágeno/metabolismo
Elastina/metabolismo
Triptases/metabolismo
Dermatoses Faciais/metabolismo
Fibroblastos/metabolismo
Fibroma/metabolismo
Mastócitos/metabolismo
Mucosa Bucal/metabolismo
Limites: Seres Humanos
Responsável: BR1.1 - BIREME


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Id: biblio-837933
Autor: Fernandes, Karen de Almeida Pinto; Lima, Lourenço de Azevedo; Guedes, Juliana Chaves Ruiz; Lima, Ricardo Barbosa; D'Acri, Antônio Macedo; Martins, Carlos José.
Título: Acquired perforating dermatosis in a patient with chronic renal failure
Fonte: An. bras. dermatol;91(5,supl.1):10-13, Sept.-Oct. 2016. graf.
Idioma: en.
Resumo: Abstract Perforating dermatoses are a group of skin diseases characterized by transepidermal elimination of dermal material. The disease is divided into two groups: the primary group and the secondary group. The classical or primary perforating dermatoses are subdivided into four types according to the eliminated dermal materials: Kyrle disease, perforating reactive collagenosis, elastosis perforans serpiginosa, and perforating folliculitis. The secondary form is known as acquired perforating dermatosis. The term was proposed in 1989 by Rapini to designate the perforating dermatoses affecting adult patients with systemic disease, regardless of the dermal materials eliminated. This report describes a case of the disease with elimination of collagen and elastic fibers in a patient with chronic renal failure.
Descritores: Dermatopatias/etiologia
Dermatopatias/patologia
Doenças do Colágeno/patologia
Epiderme/patologia
Falência Renal Crônica/complicações
-Colágeno
Tecido Elástico/patologia
Limites: Seres Humanos
Masculino
Meia-Idade
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


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Id: lil-787284
Autor: Araújo, Lidiane Advincula de; Addor, Flavia; Campos, Patrícia Maria Berardo Gonçalves Maia.
Título: Use of silicon for skin and hair care: an approach of chemical forms available and efficacy
Fonte: An. bras. dermatol;91(3):331-335
Idioma: en.
Resumo: Abstract Silicon is the second most abundant element on Earth, and the third most abundant trace element in human body. It is present in water, plant and animal sources. On the skin, it is suggested that silicon is important for optimal collagen synthesis and activation of hydroxylating enzymes, improving skin strength and elasticity. Regarding hair benefits, it was suggested that a higher silicon content in the hair results in a lower rate of hair loss and increased brightness. For these beneficial effects, there is growing interest in scientific studies evaluating the efficacy and safety of using dietary supplements containing silicon. Its use aims at increasing blood levels of this element and improving the skin and its annexes appearance. There are different forms of silicon supplements available and the most important consideration to be made in order to select the best option is related to safety and bioavailability. Silicon supplements are widely used, though there is wide variation in silicon bioavailability, ranging from values below 1% up to values close to 50%, depending on the chemical form. Therefore, the aim of this study was to evaluate the scientific literature related to the different chemical forms of silicon supplements available and the limitations and recent progress in this field. According to reported studies, among the different chemical forms available, the orthosilicic acid (OSA) presents the higher bioavailability, whereas the others forms have absorption inversely proportional to the degree of polymerization. However, clinical studies evaluating safety and efficacy are still lacking.
Descritores: Ácido Silícico/farmacocinética
Silício/farmacocinética
Envelhecimento da Pele/efeitos dos fármacos
Doenças do Cabelo
-Ácido Silícico/uso terapêutico
Silício/deficiência
Silício/fisiologia
Silício/uso terapêutico
Disponibilidade Biológica
Envelhecimento da Pele/fisiologia
Colágeno/biossíntese
Compostos de Silício/uso terapêutico
Compostos de Silício/farmacocinética
Suplementos Nutricionais
Doenças do Cabelo/tratamento farmacológico
Doenças da Unha/tratamento farmacológico
Limites: Seres Humanos
Tipo de Publ: Revisão
Responsável: BR1.1 - BIREME


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Id: biblio-1017730
Autor: Herreros, MB; Franco, R; Ascurra, M.
Título: Las Osteogenesis imperfectas: revisión del tema / Osteogenesis imperfecta
Fonte: Pediatr. (Asunción);35(1):33-37, 2008. ilus.
Idioma: es; es.
Resumo: Objetivo: Las osteogénesis imperfectas (OI) son un grupo de patologías genéticas hereditarias del tejido conectivo, que se caracterizan por fragilidad ósea y fracturas. Las osteogénesis imperfectas se clasifican en tipos: I, II, III, IV, V y VI. Las de tipo I y IV se subdividen de acuerdo a la presencia o no, de dentina opalescente y la tipo II se divide en tres subgrupos dependiendo de las características radiológicas. La prevalencia estimada de todos los tipos combinados es de 0,5 en 10.000 nacimientos. Las OI son causadas por mutaciones en los dos genes que codifican las cadenas de colágeno tipo 1, COL1A 1, localizado en el cromosoma 17 y COL1A 2, localizado en el cromosoma 7. El tipo de herencia varia de acuerdo a los tipos y subtipos de OI y la severidad puede ser muy variable, y es diferente hasta en una misma familia, desde individuos sin fracturas, hasta pacientes con múltiples fracturas. Algunas características asociadas incluyen; escleróticas azules, dientes opalescentes, hipoacusia, deformidad de huesos largos y columna vertebral e hiperextensibilidad y luxación articular. Se puede realizar el diagnostico prenatal de las OI por ecografía y si previamente se conoce la mutación, por el estudio de vellosidades coriales o liquido amniótico por biología molecular, que es altamente confiable. Ha habido muchos avances en el diagnostico y el tratamiento de las OI en los últimos años, motivo por el cual, se presenta una revisión de la clínica, clasificación, tipos de herencia, diagnostico, manejo y el tratamiento de la osteogénesis imperfecta
Descritores: Colágeno
Mutação
Osteogênese Imperfeita
Responsável: PY30.1 - Biblioteca



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