Base de dados : LILACS
Pesquisa : D05.750.078.593.450.300.900 [Categoria DeCS]
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Texto completo SciELO Brasil
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Id: biblio-1012322
Autor: Suyama, Taisuke; Kanbe, Shigeki; Maegawa, Masanobu; Shimizu, Hirofumi; Nakajima, Koichi.
Título: Prognostic significance of inflammation-based prognostic scoring in patients with upper urinary tract urothelial carcinoma
Fonte: Int. braz. j. urol;45(3):541-548, May-June 2019. tab, graf.
Idioma: en.
Resumo: ABSTRACT Objectives: To investigate whether Glasgow Prognostic Score has prognostic significance in patients with upper urinary urothelial carcinoma. Patients and methods: We retrospectively reviewed the clinical records of 74 patients with upper urinary urothelial carcinoma. We set the cut-off value for C-reactive protein as 1.0mg/dL, and 3.5mg/dL for albumin as Glasgow Prognostic Score. Their blood data including albumin and C-reactive protein for Glasgow Prognostic Score and cytokeratin 19 fragment 21-1 as a tumor marker were measured before starting treatment. The patients were stratified into three groups with Glasgow Prognostic Score: The Group-1, albumin ≥3.5g/dL and C-reactive protein < 1.0mg/dL; Group-2, albumin < 3.5g/dL or C-reactive protein ≥1.0mg/dL; Group-3, albumin < 3.5g/dL and C-reactive protein ≥1.0mg/dL. Results: The median follow-up for all patients was 26.9 months (range: 10.9-91.1 months), during which 37 (50%) patients died. There was a significant difference in the estimated survival rate among the 3 groups stratified by Glasgow Prognostic Score. The estimated survival rate in the Group-1 was significantly higher than those in Groups 2 and 3. In the univariate analysis C-reactive protein, serum cytokeratin 19 fragment 21-1 and Glasgow Prognostic Score were significant predictors of overall survival. On the multivariate analysis, serum cytokeratin 19 fragment 21-1 and Glasgow Prognostic Score were independently associated with shorter overall survival. Conclusion: Our review suggests Glasgow Prognostic Score may play as a prognostic predictor for upper urinary urothelial carcinoma.
Descritores: Prognóstico
Carcinoma/sangue
Neoplasias Urológicas/sangue
-Valores de Referência
Proteína C-Reativa/análise
Albumina Sérica/análise
Carcinoma/patologia
Biomarcadores Tumorais/sangue
Modelos de Riscos Proporcionais
Reprodutibilidade dos Testes
Estudos Retrospectivos
Sensibilidade e Especificidade
Neoplasias Urológicas/patologia
Estatísticas não Paramétricas
Urotélio/patologia
Queratina-19/sangue
Estimativa de Kaplan-Meier
Pessoa de Meia-Idade
Antígenos de Neoplasias/sangue
Limites: Humanos
Masculino
Feminino
Idoso
Idoso de 80 Anos ou mais
Responsável: BR1.1 - BIREME


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Texto completo SciELO Chile
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Id: biblio-1100919
Autor: García, Patricia; Bizama, Carolina; Rosa, Lorena; Espinoza, Jaime A; Weber, Helga; Cerda-Infante, Javier; Sánchez, Marianela; Montecinos, Viviana P; Lorenzo-Bermejo, Justo; Boekstegers, Felix; Dávila-López, Marcela; Alfaro, Francisca; Leiva-Acevedo, Claudia; Parra, Zasha; Romero, Diego; Kato, Sumie; Leal, Pamela; Lagos, Marcela; Roa, Juan Carlos.
Título: Functional and genomic characterization of three novel cell lines derived from a metastatic gallbladder cancer tumor
Fonte: Biol. Res;53:13, 2020. tab, graf.
Idioma: en.
Projeto: Fondo Nacional de Desarrollo Científico y Tecnológico, FONDECYT; . Dirección de Investigación Medicina UC-Pontificia Universidad Católica de Chile; . Instituto Milenio IMII; . CONICYT.
Resumo: BACKGROUND: Gallbladder cancer (GBC) is the most common tumor of the biliary tract. The incidence of GBC shows a large geographic variability, being particularly frequent in Native American populations. In Chile, GBC represents the second cause of cancer-related death among women. We describe here the establishment of three novel cell lines derived from the ascitic fluid of a Chilean GBC patient, who presented 46% European, 36% Mapuche, 12% Aymara and 6% African ancestry. RESULTS: After immunocytochemical staining of the primary cell culture, we isolated and comprehensively characterized three independent clones (PUC-GBC1, PUC-GBC2 and PUC-GBC3) by short tandem repeat DNA profiling and RNA sequencing as well as karyotype, doubling time, chemosensitivity, in vitro migration capability and in vivo tumorigenicity assay. Primary culture cells showed high expression of CK7, CK19, CA 19-9, MUC1 and MUC16, and negative expression of mesothelial markers. The three isolated clones displayed an epithelial phenotype and an abnormal structure and number of chromosomes. RNA sequencing confirmed the increased expression of cytokeratin and mucin genes, and also of TP53 and ERBB2 with some differences among the three cells lines, and revealed a novel exonic mutation in NF1. The PUC-GBC3 clone was the most aggressive according to histopathological features and the tumorigenic capacity in NSG mice. CONCLUSIONS: The first cell lines established from a Chilean GBC patient represent a new model for studying GBC in patients of Native American descent.
Descritores: Antígenos Glicosídicos Associados a Tumores/genética
Índios Sul-Americanos/genética
Neoplasias da Vesícula Biliar/genética
-Líquido Ascítico/metabolismo
Células Tumorais Cultivadas
Testes de Carcinogenicidade
Chile
Impressões Digitais de DNA
Proteína Supressora de Tumor p53/genética
Cisplatino/farmacologia
Camundongos Endogâmicos NOD
Células Clonais/efeitos dos fármacos
Células Clonais/metabolismo
Análise de Sequência de RNA
Receptor ErbB-2/genética
Genes erbB-2/genética
Perfilação da Expressão Gênica
Linhagem Celular Tumoral/efeitos dos fármacos
Linhagem Celular Tumoral/metabolismo
Desoxicitidina/análogos & derivados
Desoxicitidina/farmacologia
Células Epiteliais/metabolismo
Queratina-19/genética
Queratina-7/genética
Carcinogênese/genética
Neoplasias da Vesícula Biliar/metabolismo
Antineoplásicos/farmacologia
Limites: Humanos
Animais
Masculino
Pessoa de Meia-Idade
Responsável: CL1.1 - Biblioteca Central



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