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Id: biblio-1145361
Autor: Knoblovits, Pablo; Costanzo, Pablo R.
Título: El hipogonadismo masculino en pacientes con diabetes tipo 2 / Male hypogonadism in patients with type 2 diabetes
Fonte: Rev. Hosp. Ital. B. Aires (2004);36(4):157-159, dic. 2016.
Idioma: es.
Descritores: Diabetes Mellitus Tipo 2/fisiopatologia
Hipogonadismo/complicações
-Resistência à Insulina
Literatura de Revisão como Assunto
Prevalência
Leptina/fisiologia
Diabetes Mellitus Tipo 2/complicações
Estrogênios/fisiologia
Hiperglicemia/complicações
Hiperglicemia/fisiopatologia
Limites: Humanos
Masculino
Tipo de Publ: Comentário
Responsável: AR2.1 - Biblioteca Central


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Id: biblio-1116220
Autor: Durá Travé, Teodoro.
Título: Prevalencia de comorbilidades metabólicas en pacientes con obesidad en la edad escolar y la adolescencia / Prevalence of metabolic comorbidities in school-age and adolescent patients with obesity
Fonte: Salud(i)ciencia (Impresa) = Salud(i)ciencia (En linea);22(1):25-31, jun. 2016. tab..
Idioma: es.
Resumo: Introduction: Although the International Diabetes Federation refers to the impossibility of establishing a diagnosis for metabolic syndrome in school-age patients, epidemiological data seem to suggest that such metabolic syndrome and/or its components are already present at early ages. Objective: To determine the prevalence of metabolic comorbidities and their relationship with leptin plasma levels in school-age and adolescent patients with obesity. Material and methods: Clinical assessment (weight and height, body mass index, blood pressure) and metabolic assessment (serum levels of glucose, insulin, HOMA index, triglycerides, total blood cholesterol and fractions, and leptin) in a group of 106 patients with obesity (47 males and 59 females) of school-age (n = 50) and adolescents (n = 56). Results: The prevalence of insulin resistance, hypertriglyceridemia, low HDL-cholesterol levels and high blood pressure were 51%, 38%, 32% and 21%, respectively. In adolescents, insulin resistance (66% vs. 34%) and hypertriglyceridemia (45% vs. 30%) were significantly higher (p < 0.05) compared to school-age children. There was a positive correlation (p < 0.05) between leptin serum levels and body mass index, and between the HOMA index and serum triglycerides in both age groups. In addition, there was a positive correlation (p < 0.05) between leptin levels and the HOMA index in adolescents. Conclusions: Clinical and metabolic disorders associated with obesity and related to metabolic syndrome are already present in school-age children, and especially in adolescents. Plasma levels of leptin could play an essential role in the pathogenesis of the co-morbidities associated with obesity.

Introducción: El síndrome metabólico asociado con la obesidad tiene un alto valor predictivo de enfermedad cardiovascular y diabetes tipo 2. Aunque la International Diabetes Federation hace referencia a su imposibilidad diagnóstica en la edad escolar, los datos epidemiológicos permiten intuir que el síndrome metabólico, así como sus componentes, parecen estar ya presentes en edades tempranas. Objetivo: Determinar la prevalencia de comorbilidades metabólicas y su relación con los niveles plasmáticos de leptina en un grupo de pacientes en edad escolar y adolescentes con obesidad. Material y métodos: Valoración clínica (peso y talla, índice de masa corporal, tensión arterial) y estudio metabólico (glucosa, insulina, índice HOMA, triglicéridos, colesterol total y fracciones, y leptina) a un grupo de 106 pacientes con obesidad (47 varones y 59 mujeres) en edad prepuberal (n = 56) y puberal (n = 50). Resultados: La prevalencia de resistencia a la insulina, hipertrigliceridemia, cifras bajas de colesterol asociado con lipoproteínas de alta denisdad e hipertensión arterial eran de 51%, 38%, 32% y 21%, respectivamente. En los adolescentes, la resistencia a la insulina (66% vs. 34%) y la hipertrigliceridemia (45% vs. 30%) estaban significativamente más elevados (p < 0.05) respecto de los escolares. Existió una correlación positiva (p < 0.05) entre leptina e índice de masa corporal y entre el índice HOMA y los niveles de triglicéridos en ambos grupos de edad. Además, existe una correlación positiva (p < 0.05) entre leptina e índice HOMA en los adolescentes. Conclusiones: Las alteraciones clínico-metabólicas asociadas con la obesidad y relacionadas con el síndrome metabólico ya se ponen de manifiesto en la edad escolar y, especialmente, en la adolescencia. Los niveles plasmáticos de leptina podrían desempeñar un papel esencial en la etiopatogenia de las comorbilidades asociadas con la obesidad.
Descritores: Doenças Cardiovasculares
Leptina
Síndrome Metabólica
Diabetes Mellitus Tipo 2
-Obesidade
Limites: Humanos
Masculino
Feminino
Criança
Adolescente
Tipo de Publ: Relatório Técnico
Responsável: AR392.1 - Biblioteca


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Id: lil-436743
Autor: Mendivil, Carlos Olimpo.
Título: Obesidad y síndrome metabólico / Obesity and metabolis syndrome
Fonte: Acta méd. colomb;30(3):163-167, jul.-sept. 2005. ilus, tab, graf.
Idioma: es.
Resumo: El síndrome metabólico es un conjunto de alteraciones que se asocian a la resistencia a la insulina. El tejido adiposo, como órgano endocrino activo, produce varios mediadores que afectan directa e indirectamente la sensibilidad a la insulina en varios tejidos. En la presente revisión se examinan los mecanismos fisiológicos de la acción insulínica, y la forma como se pueden ver afectados por la acción de varias hormonas de origen adipocitario, incluyendo leptina, factor de necrosis tumoral alfa y adiponectina.
Descritores: Adipócitos
Hipertensão
Leptina
Obesidade
Resistência à Insulina
Síndrome Metabólica
Tipo de Publ: Revisão
Responsável: CO5.1 - Centro de Información y Conocimiento


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Id: biblio-1121024
Autor: Erdmann, Johannes.
Título: Interacción entre leptina y grelina como parte del control tónico de la ingesta de alimentos / Interaction between leptin and ghrelin as part of tonic control of food intake
Fonte: Salud(i)ciencia (Impresa) = Salud(i)ciencia (En linea);15(6):998-1001, nov. 2007. graf..
Idioma: es.
Resumo: Food intake is regulated by an acute control system that conveys information between the stomach and hypothalamic centres of feeding regulation mainly via neural vagal afferent fibers for satiety and via hormonal signal transmission by ghrelin for recurrence of appetite and hunger. This acute system is under tonic control by adipocyte-derived leptin as an indicator of the nutritional status of the organism. In obese subjects plasma leptin is higher compared to normal weight subjects (NW). This is associated with lower ghrelin levels suggesting that the negative feedback loop to reduce food intake in the case of sufficient energy reserves is intact. A differential analysis of the inverse relationship between leptin and ghrelin, however, suggests an inhibitory effect of leptin is restricted to male normal and overweight subjects. In females and obese subjects of both genders this inverse relationship does exist. These findings indicate that the position of ghrelin within the control system of food intake is somewhat more sophisticated than previously thought and it requires more detailed analysis

La ingesta de alimentos está regulada por un sistema de control inmediato que transmite información entre el estómago y los centros hipotalámicos de regulación de la alimentación, principalmente a través de fibras aferentes vagales nerviosas para la saciedad y mediante la transmisión de señales hormonales de la grelina para la recurrencia del apetito y el hambre. Este sistema inmediato se encuentra bajo control tónico de la leptina derivada de los adipocitos como indicador del estado nutricional del organismo. En los individuos obesos la leptina plasmática es más alta en comparación con los individuos de peso normal. Esto se asocia con concentraciones más bajas de grelina, lo que sugiere que el asa de retroalimentación negativa para reducir la ingesta de alimento en el caso de reservas suficientes de energía está intacta. Sin embargo, el diagnóstico diferencial de la relación inversa entre leptina y grelina sugiere que el efecto inhibidor de la leptina está restringido a hombres normales y con sobrepeso. En las mujeres y en los individuos obesos de ambos sexos existe esta relación inversa. Estos hallazgos indican que la posición de la grelina dentro del sistema de control de la ingesta de alimentos es algo más sofisticada de lo que antes se creía y requiere un análisis más detallado
Descritores: Resistência à Insulina
Estado Nutricional
Leptina
Ingestão de Alimentos
Grelina
Obesidade
Tipo de Publ: Relatório Técnico
Responsável: AR392.1 - Biblioteca


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Id: biblio-996722
Autor: Schmidt, Leucinéia; Soder, Taís Fátima; Benetti, Fábia.
Título: Nutrigenômica como ferramenta preventiva de doenças crônicas não transmissíveis / Nutrigenomics as a preventive tool for chronic non-communicable diseases / NUTRIGENOMICS AS A PREVENTIVE TOOL FOR CHRONIC NON-COMMUNICABLE DISEASES
Fonte: Arq. ciências saúde UNIPAR;23(2):127-138, maio-ago. 2019.
Idioma: pt.
Resumo: A nutrigenômica representa uma ciência emergente que estuda a relação entre os nutrientes e os genes humanos. Dessa forma, as necessidades de alimentos, compostos bioativos e nutrientes variam entre os indivíduos, por conta dos polimorfismos gênicos, principalmente os de nucleotídeo único, podendo resultar no desenvolvimento de diversas doenças crônicas não transmissíveis (DCNTs). Este artigo objetiva conhecer as mais recentes informações sobre a nutrigenômica e os principais polimorfismos genéticos relacionados às DCNTs, bem como o impacto dos nutrientes na modulação da expressão gênica e prevenção destas patologias. Para o levantamento bibliográfico, optou-se pela busca de artigos nas bases de dados PubMed e SciELO, nos idiomas Português e Inglês. Aplicou-se a combinação dos seguintes descritores: "nutrigenômica e necessidades nutricionais", "nutrigenômica e obesidade", "nutrigenômica e diabetes mellitus tipo 2", "nutrigenômica e câncer" e "nutrigenômica e doença inflamatória intestinal". Evidências indicam que diversos tipos de polimorfismos estão associados à incidência, progressão e gravidade de doenças como a obesidade, diabetes mellitus tipo 2 (DM2), câncer e doenças inflamatórias intestinais (DIIs). Os principais polimorfismos encontrados que se relacionam com as DCNTs são: rs9939609 do fat mass and obesity associated (FTO), rs174547 do Fatty acid desaturase 1 (FADS1), Gln27Glu do receptor ß-adrenérgico 2 (ADRB2), Lys656Asn do receptor de leptina (LEPR), -174C/G da interleucina 6 (IL-6), Pro12Ala do receptor ativado por proliferador de peroxissoma gama 2 (PPAR-gama2), rs4315495 da lipina 1 (LPIN1), rs266729 no gene da adiponectina, rs10920533 em adiponectina receptor 1 (AdipoR1), Pro12Ala do receptor ativado por proliferador de peroxissoma γ (PPARγ), rs1440581 da Protein phosphatase, Mg2+/Mn2+ dependent 1K (PPM1K), alelo G para o polimorfismo -11377C>G, alelo A para o polimorfismo 11391 G>A, Cdx2 do receptor de vitamina D (RVD), genes de selenoproteínas sob baixas concentrações de selênio (DIO1, DIO2, GPX-1, GPX-3, SEPHS1, SEPSECS e TXNRD2) e alelo G do rs12212067 do Forkhead box O3 (FOXO3). É fundamental entender as interações gene-nutriente nestas doenças e as diferentes respostas metabólicas envolvidas, para que assim se possa orientar a alimentação de cada indivíduo conforme a sua herança genética. Enfim, os estudos não são conclusivos sobre o papel de cada fator na alteração dos genes, e a nutrigenômica é um fator importante e complexo que precisa avançar com a ciência nutricional.

Nutrigenomics represents an emerging science that studies the relation between nutrients and the human genes. Thus, the need for food, bioactive composts and nutrients vary from person to person due to genic polymorphisms, mainly single nucleotide polymorphism, which can result in the developing of many Chronic Non-Communicable Diseases (NCDs). This article aims at making a scientific literature review regarding the most recent information on nutrigenomics and the main polymorphisms related to the NCDs, as well as the impact of nutrients on the modulation of the genic expression and prevention of those pathologies. For the literature survey, a search was performed in PubMed and SciELO databases, in Portuguese and English using the combination of the following descriptors: "nutrigenomics and nutritional requirements", "nutrigenomics and obesity", "nutrigenomics and diabetes mellitus, type 2", "nutrigenomics and cancer", and "nutrigenomics and inflammatory bowel disease". Evidence has shown that many types of polymorphisms are associated with the incidence, progression and severity of diseases such as obesity, type 2 diabetes mellitus (T2DM), cancer, and inflammatory bowel diseases (IBD). The main polymorphisms found to be related to NCDs are: rs9939609 of the fat mass and obesity associated (FTO), rs174547 of the fatty acid desaturase 1 (FADS1), Gln27Glu of the ß-adrenergic receptor 2 (ADRB2), Lys656Asn of the leptin receptor (LEPR), -174 G/C of the interleukin-6 (IL-6), Pro12Ala of the peroxisome proliferator-activated receptor gamma 2 (PPAR-gama2), rs4315495 of lipin 1 (LPIN1), rs266729 in the adiponectin gene, rs10920533 in adiponectin receptor 1 (AdipoR1), Pro12Ala of Peroxisome proliferator-activated receptor γ (PPARγ), rs1440581 of Protein phosphatase, Mg2+/Mn2+ dependent 1K (PPM1K), G allele of the -11377C>G polymorphism, allele A of the 11391 G>A polymorphism, Cdx2 of the vitamin D receptor (VDR), selenoprotein genes under low selenium concentrations (DIO1, DIO2, GPX-1, GPx-3, SEPHS1, SEPSECS and TXNRD2), and G allele of the Forkhead box O3 (FOXO3) rs12212067. It is fundamental to understand the interaction between gene-nutrients in these diseases and the different metabolic answers involved to guide the eating habits of each person according to their genetic heritage. Finally, the studies are not conclusive on the role of each factor in the alteration of the genes, and nutrigenomics is an important and complex factor that needs to advance with nutritional science.
Descritores: Doença Crônica/prevenção & controle
Nutrigenômica
Doenças não Transmissíveis/prevenção & controle
Obesidade/prevenção & controle
-Polimorfismo Genético
Selênio
Vitamina D
Doenças Inflamatórias Intestinais/prevenção & controle
Expressão Gênica
Nutrientes
Apoptose
Leptina
Diabetes Mellitus Tipo 2
Alelos
Adiponectina
Selenoproteínas
Ciências da Nutrição
Genes
Neoplasias
Tipo de Publ: Revisão
Responsável: BR513.1 - Biblioteca Central


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Lotufo, Paulo A
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Id: biblio-827784
Autor: Almeida-Pititto, Bianca de; Ribeiro-Filho, Fernando Flexa; Barreto, Sandhi; Duncan, Bruce B; Schmidt, Maria Inês; Lotufo, Paulo A; Bensenor, Isabela M; Ferreira, Sandra R G.
Título: Circulating early biomarkers of atherogenesis in participants of the Longitudinal Study of Adult Health (ELSA-Brasil) without diabetes or cardiovascular disease
Fonte: Arch. endocrinol. metab. (Online);60(6):573-581, Nov.-Dec. 2016. tab, graf.
Idioma: en.
Projeto: National Research Council; . National Research Council; . National Research Council; . National Research Council; . National Research Council; . National Research Council.
Resumo: ABSTRACT Objective Our aim was to describe the distribution of selected biomarkers according to age and sex, adjusted for HOMA-IR and adiposity, in a subset of middle-aged individuals of Brazilian Longitudinal Study of Adult Health-ELSA without diabetes mellitus or CVD. Subjects and methods This cross-sectional study was conducted in 998 participants of the ELSA-Brasil without diabetes and/or cardiovascular disease. In addition to the traditional risk factors, several biomarkers concentrations were compared according to sex, age groups (35-44; 45-54 yrs) and HOMA-IR tertiles. Linear regression was used to examine independent associations of sex and age with selected novel biomarkers, adjusted for body adiposity and HOMA-IR. Results Fifty-five percent were women. Men had higher mean values of body mass index, waist circumference, blood pressure, plasma glucose, HOMA-IR, worse lipid profile and higher E-selectin and lower leptin concentrations than women; while women had higher levels of HDL-cholesterol and leptin than men. Mean values of waist circumference, systolic BP, plasma glucose and apolipoprotein B (Apo B) increased with age in both sexes. Leptin and E-selectin concentrations increased across HOMA-IR tertiles. Independent associations of Apo B with age were found only in male sex, while of leptin with body mass index and HOMA-IR, and of E-selectin with HOMA-IR in both sexes. Conclusions In conclusion, our data indicate age, sex, adiposity and, consequently, insulin resistance, influence circulating levels of Apo B, leptin and E-selectin, suggesting that those aspects should be taken into consideration when assessing these parameters for research or clinical purposes in individuals at relatively low cardiometabolic risk.
Descritores: Aterosclerose/sangue
Adiposidade
-Apolipoproteínas B/sangue
Brasil
Resistência à Insulina
Biomarcadores/sangue
Fatores Sexuais
Estudos Transversais
Fatores Etários
Selectina E/sangue
Leptina/sangue
Circunferência da Cintura
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Responsável: BR1.1 - BIREME


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Id: biblio-838409
Autor: Madeira, Isabel; Bordallo, Maria Alice; Rodrigues, Nádia Cristina; Carvalho, Cecilia; Gazolla, Fernanda; Collett-Solberg, Paulo; Medeiros, Clarice; Bordallo, Ana Paula; Borges, Marcos; Monteiro, Claudia; Ribeiro, Rebeca.
Título: Leptin as a predictor of metabolic syndrome in prepubertal children
Fonte: Arch. endocrinol. metab. (Online);61(1):7-13, Jan.-Feb. 2017. tab, graf.
Idioma: en.
Resumo: ABSTRACT Objective Leptin has been suggested as a potential biomarker of cardiovascular risk. This paper aims to ascertain, based on a sample of prepubertal children, which serum leptin value best suited to identify metabolic syndrome (MS). Subjects and methods This observational, cross-sectional study recruited children from the outpatient pediatrics clinic, with the purpose of validating serum leptin level cutoffs to identify MS. All obese and overweight children who met eligibility criteria were included in the study, as was a sample of normal-weight children. The sample underwent clinical assessment and blood fasting glucose, lipid profile, insulin, and leptin were measured. Sensitivity and specificity were estimated for each leptin measurement, using MS as the outcome. These values were used to construct a receiver operating characteristic (ROC) curve. The association between MS and leptin was assessed using logistic models to predict MS. Results A total of 65 normal weight, 46 overweight, and 164 obese children were analyzed (160 boys, 115 girls; age: 93.7 ± 17.8 months). The most appropriate leptin cutoff was 13.4 ng/mL (sensitivity 67.6%; specificity 68.9%; accuracy 72.1%). The logistic model indicated that leptin levels above 13.4 ng/dL were significantly associated with MS and that, for every 1 ng/dL increase in leptin levels, the odds of MS increase by 3% (p = 0.002; OR 1.03; 95% CI 1.01-1.05). Conclusions Leptin may be a useful biomarker of cardiovascular risk in prepubertal children, with an optimal cutoff of 13.4 ng/mL. Identification of potential new risk markers for cardiovascular disease in children could contribute to the development of preventive strategies.
Descritores: Leptina/sangue
Síndrome Metabólica/sangue
-Biomarcadores/sangue
Estudos Transversais
Valor Preditivo dos Testes
Curva ROC
Sensibilidade e Especificidade
Limites: Humanos
Masculino
Feminino
Criança
Tipo de Publ: Estudo Observacional
Responsável: BR1.1 - BIREME


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Id: biblio-838418
Autor: Stroescu, Ramona; Bizerea, Teofana; Doroş, Gabriela; Marazan, Monica; Lesovici, Maria; Mãrginean, Otilia.
Título: Correlation between adipokines and carotid intima media thickness in a group of obese Romanian children: is small for gestational age status an independent factor for cardiovascular risk?
Fonte: Arch. endocrinol. metab. (Online);61(1):14-20, Jan.-Feb. 2017. tab, graf.
Idioma: en.
Projeto: University of Medicine and Pharmacy “Victor Babes” Timisoara.
Resumo: ABSTRACT Objective To investigate the relationship between markers of adiposity and common carotid artery (CIMT) in obese children born small for gestational age (SGA) versus appropriate for gestational age (AGA), to establish cut-off values for CIMT in obese pediatric populations. Subjects and methods A cross-sectional study was carried out over a 1-year period (Jul 2013 – June 2014). We analyzed 122 obese patients aged 4-20 (mean age 14.9 ± 2.28). Twenty-six patients were born SGA. CIMT was measured in all the patients. Using ROC curve, cut-off values were obtained for both groups. Results We demonstrated a correlation between CIMT and adiponectin, leptin and high sensitivity C-reactive protein (hsCRP) (r = -0.25, r = 0.279, r = 0.498) in obese children. CIMT in obese children born SGA were significantly increased as compared with obese children born AGA of similar age, sex and body mass index (BMI) (p = 0.0035). A CIMT cut off value of 0.049 cm has been obtained with a high sensitivity and specificity. Conclusion CIMT is a well-known marker of subclinical atherosclerosis and its measurement is a noninvasive and inexpensive method of detecting subclinical atherosclerosis. Being born SGA increases the atherogenic risk. Obese children with CIMT above 0.049 cm should be screened for metabolic syndrome (MetS).
Descritores: Proteína C-Reativa/análise
Recém-Nascido Pequeno para a Idade Gestacional
Doenças Cardiovasculares/etiologia
Leptina/sangue
Adipocinas/sangue
Obesidade/complicações
-Romênia
Índice de Massa Corporal
Estudos Transversais
Fatores de Risco
Sensibilidade e Especificidade
Espessura Intima-Media Carotídea
Obesidade/sangue
Limites: Humanos
Masculino
Feminino
Pré-Escolar
Criança
Adolescente
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: biblio-838419
Autor: Batista, Gisele Almeida; Souza, Aglécio Luiz de; Marin, Daniela Miguel; Sider, Marina; Melhado, Vaneska Carvalho; Fernandes, Arlete Maria; Alegre, Sarah Monte.
Título: Body composition, resting energy expenditure and inflammatory markers: impact in users of depot medroxyprogesterone acetate after 12 months follow-up
Fonte: Arch. endocrinol. metab. (Online);61(1):70-75, Jan.-Feb. 2017. tab, graf.
Idioma: en.
Resumo: ABSTRACT Objective The aim of this study was to evaluate for 12 months the changes of body weight using Depot Medroxyprogesterone Acetate (DMPA) and if these changes are related to inflammatory markers. Subjects and methods Twenty women of childbearing age who chose the DMPA, without previous use of this method, BMI < 30 kg/m2, and 17 women using IUD TCu 380A, participated in the study. At the baseline and after one year, changes in weight gain, body composition by the bioimpedance electric method, resting energy expenditure (REE) by the indirect calorimetry method, inflammatory markers and HOMA-IR were assessed. Results After 12 months of evaluation, we could observe a significant increase in the DMPA group in weight (3,01 kg) and BMI, while the IUD group’s only significant increase was observed in the BMI. Relative to REE there was an increase of basal metabolic rate (BMR) in both groups after one year. The sub-group DMPA that gained < 3 kg had increased significant weight, BMI and body surface (BS) with respiratory quotient (RQ) reduction, while the sub-group that gained ≥ 3 kg had a significant increase in weight, BMI, BS, fat-free mass, fat mass, BMR, Leptin, HOMA-IR and waist circumference, with RQ significantly reduced. Conclusion Our study found significant changes in weight, body composition and metabolic profile of the population studied in the first 12 months of contraceptive use. These changes mainly increased body weight, leptin levels and HOMA-IR which can contribute to the development of some chronic complications, including obesity, insulin resistance and diabetes mellitus.
Descritores: Composição Corporal/efeitos dos fármacos
Biomarcadores/sangue
Ganho de Peso/efeitos dos fármacos
Acetato de Medroxiprogesterona/farmacologia
Metabolismo Energético/efeitos dos fármacos
-Metabolismo Basal/efeitos dos fármacos
Calorimetria Indireta
Índice de Massa Corporal
Seguimentos
Interleucina-6/sangue
Fator de Necrose Tumoral alfa/sangue
Leptina/sangue
Adiponectina/sangue
Nicotinamida Fosforribosiltransferase/sangue
Glucose/análise
Insulina/sangue
Limites: Humanos
Feminino
Adulto
Responsável: BR1.1 - BIREME


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Boguszewski, Cesar L
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Id: biblio-887553
Autor: Paiva, Eduardo S; Andretta, Aline; Batista, Emmanuelle Dias; Lobo, Márcia Maria Marques Teles; Miranda, Renata Costa de; Nisihara, Renato; Schieferdecker, Maria Eliana Madalozzo; Boguszewski, César L.
Título: Serum levels of leptin and adiponectin and clinical parameters in women with fibromyalgia and overweight/obesity
Fonte: Arch. endocrinol. metab. (Online);61(3):249-256, May-June 2017. tab.
Idioma: en.
Resumo: ABSTRACT Objectives The objectives of this study were to evaluate the serum levels of adipokines in women with fibromyalgia with and without overweight/obesity, and to correlate the adipokines levels with clinical parameters associated with fibromyalgia and adipose tissue mass (body fat). Subjects and methods The study included 100 women divided into four groups: (a) fibromyalgia and overweight/obesity; (b) fibromyalgia and normal weight; (c) controls and overweight/obesity; and (d) controls and normal weight. Patients and controls were evaluated for clinical, anthropometric, and fibromyalgia-related parameters. Assessments included serum levels of leptin, adiponectin, monocyte chemoattractant protein-1 (MCP-1), and C-reactive protein (CRP). Levels of adipokines were further adjusted for fat mass. Results Fibromyalgia patients with overweight/obesity or normal weight had no differences in clinical parameters. Unadjusted leptin levels were lower in fibromyalgia patients than controls, a finding that was more remarkable in fibromyalgia patients with overweight/obesity. Leptin levels had no correlation with clinical parameters of fibromyalgia or inflammation markers (MCP-1 and CRP), and adiponectin levels showed no difference between groups. Conclusions No correlation was observed between adjusted leptin levels and clinical parameters of fibromyalgia. Patients with fibromyalgia and overweight/obesity presented lower levels of leptin than controls with overweight/obesity.
Descritores: Fibromialgia/sangue
Leptina/sangue
Sobrepeso/sangue
Adiponectina/sangue
-Qualidade de Vida
Valores de Referência
Proteína C-Reativa/análise
Biomarcadores/sangue
Fibromialgia/fisiopatologia
Índice de Massa Corporal
Estudos de Casos e Controles
Inquéritos e Questionários
Limiar da Dor
Estatísticas não Paramétricas
Quimiocina CCL2/sangue
Sobrepeso/fisiopatologia
Circunferência da Cintura
Limites: Humanos
Feminino
Adulto
Pessoa de Meia-Idade
Responsável: BR1.1 - BIREME



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