||Iannitelli, Patricia; Palacios, M. F; Caballero, C; Maero, E; Sen, Luisa; Estevez, María Elena.|
||Evaluación clínica-inmunológica del tratamiento con Tp-5 en sujetos infectados con HIV / Clinical immunological evaluation of the treatment with tp-5 in subjects infected with HIV
||Bol. Acad. Nac. Med. B.Aires;67(2):369-80, jul.-dic. 1989. tab.
||We studied the effect of Tp-5 treatment on the immune system of 15 HIV+ males. The control groups consisted of 7 asymphtomatic HIV+ homosexual men and 33 health individuals. At the time of admission, the HIV+ subjects showed a significant decrease in the number of CD4+ T-cell and an increase in CD8+ cell when compared to normal controls. During Tp-5 treatment, 4 out of 15 of the HIV infected individuals expressed a transient increase of the CD4+ lymphocyte subpopulation. The number of CD8+ subset was not modified by the pentapepotide. The ability of pokeweed mitogen driven B lymphocytes to differentiate into plasma cell, already significantly low at admission, persisted without change at the end of the treatment. Thus, Tp-5 was not able to restore B-lynphocyte function. The T-lymphocyte PHA proliferative response of T-lymphocytes of HIV infected individuals did not differ from normal controls and no variation was observed after 3 months of the Tp-5 therapy. Nevertheless, the delayed skin reactivity to the 7 antigens tested, increased in 5 out of 9 patients, suggesting a partial restoration of T cell immunity by Tp-5. We conclude that Tp-5 in vivo can induce a transient partial variation at the T lymphocyte level in HIV infected patients|
||Síndrome de Imunodeficiência Adquirida/imunologia|
Infecções por HIV/imunologia
||-Síndrome de Imunodeficiência Adquirida/tratamento farmacológico|
||AR1.1 - Biblioteca Rafael Herrera Vegas|