||Coura, Renata dos Santos; Marques, Christiane de Fátima Silva; Koifman, Rosalina J; Koifman, Sergio; Cabello, Pedro Hernan; Hatagima, Ana.|
||CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population|
||Genet. mol. biol;30(1):1-5, 2007. tab.
||The enzymes encoded by the polymorphic genes CYP1A1 and CYP2E1 play an important role in the activation and inactivation of xenobiotics. These enzymes have been associated with xenobiotic-induced diseases, such as cancer, therapeutic failure and adverse effects of drugs. The aim of the present study was to determine the allelic and genotypic frequencies of these polymorphisms in a large, ethnically mixed Brazilian population sample from Rio de Janeiro. Polymorphisms CYP1A1 and CYP2E1 were determined in 870 unrelated individuals by PCR-RFLP analysis in peripheral blood DNA. The observed allelic frequencies were 0.90 for CYP1A1*1A and 0.95 for CYP2E1*1A, in the total sample. The allelic frequency of CYP1A1*2C in "pardos" (0.13) and Brazilian whites (0.11) was higher than in Caucasians (0.05), which may be a result of the Amerindian genetic component, that presents the highest frequency of this allele observed up to now. The genotype distributions for both polymorphisms were in Hardy-Weinberg equilibrium and were statistically different between males and females, and among ethnic groups.|
||Citocromo P-450 CYP1A1|
Citocromo P-450 CYP2E1
||BR1.1 - BIREME|