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Id: lil-692190
Autor: Roth, Alejandro D; Liazoghli, Dalinda; Perez De Arce, Felipe; Colman, David R.
Título: Septin 7: Actin cross-organization is required for axonal association of Schwann cells
Fonte: Biol. Res;46(3):243-249, 2013. ilus, graf.
Idioma: en.
Projeto: DRC; . Fondecyt; . Conicyt, Chile; . Universidad de Chile. Vicerrectoría de Investigación. Myelin Repair Foundation Project.
Resumo: Myelin sheaths present two distinct domains: compacted myelin spirals and flanking non-compacted cytoplasmic channels, where lipid and protein segregation is established by unknown mechanisms. Septins, a conserved family of membrane and cytoskeletal interacting GTPases, form intracellular diffusion barriers during cell division and neurite extension and are expressed in myelinating cells. Septins, particularly septin 7 (Sept7), the central constituent of septin polymers, are associated with the cytoplasmic channels of myelinating cells. Here we show that Schwann cells deprived of Sept7 fail to wrap around axons from dorsal root ganglion neurons and exhibit disorganization of the actin cytoskeleton. Likewise, Sept7 distribution is dependent on microfilament but not microtubule organization.
Descritores: Actinas/metabolismo
Axônios/química
Células de Schwann/química
Septinas/metabolismo
-Axônios/fisiologia
Bainha de Mielina/química
Bainha de Mielina/fisiologia
Neurônios
Células de Schwann/fisiologia
Limites: Animais
Coelhos
Responsável: CL1.1 - Biblioteca Central



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