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Id: lil-228498
Autor: Rascón, Ana.
Título: Fosfodiesterasas de nucleótidos cíclicos: diversidad, clasificación, estructura y función / Cyclic nucleotide phosphodiesterases: diversity, classification, structure and function
Fonte: Acta cient. venez;48(3):145-53, 1997.
Idioma: es.
Resumo: During the last years there have been major advances in the knowledge of cyclic nucleotide phosphodiesterases. Particularly, referred to the presence of multiple different isozymes. Seven different phosphodiesterase gene families, have been described in mammalian tissues, containing several distinct genes, most of them expressed in different tissues as functionally unique splice variants. This article includes various aspects of the currently accepted nomenclature, structure and function of each family of phosphodiesterases. Finally, a brief discussion of the presence and role of these enzymes in the cell proliferation and differentiation processes, in parasites of the Trypanosmatidae family, is provided
Descritores: 2',3'-Nucleotídeo Cíclico Fosfodiesterases
AMP Cíclico
GMP Cíclico
-2',3'-Nucleotídeo Cíclico Fosfodiesterases/química
2',3'-Nucleotídeo Cíclico Fosfodiesterases/classificação
2',3'-Nucleotídeo Cíclico Fosfodiesterases/fisiologia
Diferenciação Celular
AMP Cíclico/agonistas
AMP Cíclico/fisiologia
GMP Cíclico/agonistas
GMP Cíclico/fisiologia
Limites: Animais
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME

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Texto completo SciELO Brasil
Texto completo
Id: lil-212574
Autor: Barradas, P. C; Cavalcante, L. A.
Título: Proliferation of differentiated glial cells in the brain stem
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;31(2):257-70, feb. 1998. ilus, tab.
Idioma: en.
Conferência: Apresentado em: International Symposium on Radioautography, 5, Säo Paulo, Aug. 24-26 1997.
Resumo: Classical studies of macroglial proliferation in muride rodents have provided conflicting evidence concerning the proliferating capabilities of oligodendrocytes and microglia. Furthermore, little information has been obtained in other mammalian orders and very little is known about glial cell proliferation and differentiation in the subclass Metatheria although valuable knowledge may be obtained from the protracted period of central nervous system maturation in these forms. Thus, we have studied the proliferative capacity of phenotypically identified brain stem oligodendrocytes by tritiated thymidine radioautography and have compared it with known features of oligodentroglial differentation as well as with proliferation of microglia in the opossum Didelphis marsupialis. We have detected a previously undescribed ephemeral, regionally heterogenous proliferation of oligodendrocytes expressing the actin-binding, ensheathment-related protein 2' 3'- cyclic nucleotide 3' -phosphodiesterase (CNPase), that is not necessarily related to the known regional and temporal heterogeneity of expression of CNPase in cell bodies. On the other hand, proliferation of microglia tagged by the binding of Griffonia simplicifolia B4 isolectin, which recognizes an alpha-D-galactosyl-bearing glycoprotein of the plasma membrane of macrophages/microglia, is known to be long lasting, showing no regional heterogeneity and being found amongst both ameboid and differentiated ramified cells, although at different rates. The functional significance of the proliferative behavior of these differentiated cells is unknown but may provide a lowgrade cell renewal in the normal brain and may be augmented under pathological conditions.
Descritores: Tronco Encefálico/fisiologia
Divisão Celular
-2',3'-Nucleotídeo Cíclico Fosfodiesterases
Limites: Animais
Tipo de Publ: Revisão
Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME

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