Base de dados : LILACS
Pesquisa : D08.811.277.352.897.387.100 [Categoria DeCS]
Referências encontradas : 3 [refinar]
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Id: biblio-839295
Autor: Cantelli, KR; Soares, GM; Ribeiro, RA; Balbo, SL; Lubaczeuski, C; Boschero, AC; Araújo, ACF; Bonfleur, ML.
Título: Duodenal-jejunal bypass normalizes pancreatic islet proliferation rate and function but not hepatic steatosis in hypothalamic obese rats
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;50(5):e5858, 2017. tab, graf.
Idioma: en.
Projeto: Fundação Araucária; . FAPESP.
Resumo: Modifications in life-style and/or pharmacotherapies contribute to weight loss and ameliorate the metabolic profile of diet-induced obese humans and rodents. Since these strategies fail to treat hypothalamic obesity, we have assessed the possible mechanisms by which duodenal-jejunal bypass (DJB) surgery regulates hepatic lipid metabolism and the morphophysiology of pancreatic islets, in hypothalamic obese (HyO) rats. During the first 5 days of life, male Wistar rats received subcutaneous injections of monosodium glutamate (4 g/kg body weight, HyO group), or saline (CTL). At 90 days of age, HyO rats were randomly subjected to DJB (HyO DJB group) or sham surgery (HyO Sham group). HyO Sham rats were morbidly obese, insulin resistant, hypertriglyceridemic and displayed higher serum concentrations of non-esterified fatty acids (NEFA) and hepatic triglyceride (TG). These effects were associated with higher expressions of the lipogenic genes and fatty acid synthase (FASN) protein content in the liver. Furthermore, hepatic genes involved in β-oxidation and TG export were down-regulated in HyO rats. In addition, these rats exhibited hyperinsulinemia, β-cell hypersecretion, a higher percentage of islets and β-cell area/pancreas section, and enhanced nuclear content of Ki67 protein in islet-cells. At 2 months after DJB surgery, serum concentrations of TG and NEFA, but not hepatic TG accumulation and gene and protein expressions, were normalized in HyO rats. Insulin release and Ki67 positive cells were also normalized in HyO DJB islets. In conclusion, DJB decreased islet-cell proliferation, normalized insulinemia, and ameliorated insulin sensitivity and plasma lipid profile, independently of changes in hepatic metabolism.
Descritores: Duodeno/cirurgia
Fígado Gorduroso/metabolismo
Derivação Gástrica/métodos
Doenças Hipotalâmicas/metabolismo
Ilhotas Pancreáticas/citologia
Ilhotas Pancreáticas/metabolismo
Jejuno/cirurgia
Obesidade/metabolismo
-Animais Recém-Nascidos
Glicemia/metabolismo
Proliferação de Células
Colesterol/sangue
Ácido Graxo Sintase Tipo I/metabolismo
Ácidos Graxos/sangue
Fígado Gorduroso/fisiopatologia
Doenças Hipotalâmicas/fisiopatologia
Doenças Hipotalâmicas/cirurgia
Resistência à Insulina
Insulina/metabolismo
Ilhotas Pancreáticas/fisiopatologia
Lipogênese/genética
Fígado/metabolismo
Fígado/patologia
Obesidade/fisiopatologia
Obesidade/cirurgia
Pâncreas/metabolismo
Pâncreas/patologia
Distribuição Aleatória
Ratos Wistar
Reprodutibilidade dos Testes
Fatores de Tempo
Triglicerídeos/sangue
Limites: Animais
Masculino
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Almeida, Oslei Paes de
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Id: lil-704194
Autor: FALCI, Saulo Gabriel Moreira; MESQUITA, Ana Terezinha Marques; ANDRADE, Bruno Augusto Benevenuto de; MIRANDA, Joao Luiz de; LEON, Jorge Esquiche; ALMEIDA, Oslei Paes de; SANTOS, Cassio Roberto Rocha dos.
Título: FASN expression, angiogenesis and lymphangiogenesis in central and peripheral giant cell lesions
Fonte: J. appl. oral sci;22(2):131-137, Mar-Apr/2014. tab, graf.
Idioma: en.
Projeto: Sao Paulo Research Foundation.
Resumo: Central giant cell lesion (CGCL) and peripheral giant cell lesion (PGCL) are non-neoplastic proliferative processes of the jaws. PGCL is a reactive process induced by irritant local factors and CGCL is an intra-osseous lesion of unknown etiology. Both lesions exhibit similar histologic features showing abundant mononuclear cells, admixed with a large number of multinucleated giant cells and a rich vascularized stroma with extravasated erythrocytes, hemosiderin deposition, and blood-filled pools. Recent studies have linked fatty acid synthase (FASN) with angiogenesis. Objective: To evaluate angiogenesis and lymphangiogenesis and their relationship with FASN expression in CGCL and PGCL. Material and Methods: Thirteen CGCL and 14 PGCL of the jaws were selected for immunoexpression of FASN; CD34 and CD105 (to assess blood microvessel density [MVD] and microvessel area [MVA]); and D2-40 (to assess lymphatic MVD and MVA). Results: Within PGCL and CGCL, MVD-CD34 was signifcantly higher than MVD-CD10S, followed by MVD-D2-40. Moreover, a signifcantly higher number of FASN-positive multinucleated giant cells than mononuclear cells were observed. Between PGCL and CGCL, only MVD-CD34 and all MVA were signifcantly higher in PGCL. Positive correlation between MVA-CD10S with FASNpositive mononuclear cells in both lesions was observed. Conclusions: Our results show both lesions exhibiting similar levels of FASN expression and neoangiogenesis, suggesting constitutive processes that regulate tissue maintenance. .
Descritores: Ácido Graxo Sintase Tipo I/análise
Células Gigantes/patologia
Doenças Maxilomandibulares/patologia
Linfangiogênese/fisiologia
Neovascularização Patológica/patologia
-Antígenos CD/análise
/análise
ANTIGENS, CDABORTION, THERAPEUTIC/análise
Biópsia
Imuno-Histoquímica
Microvasos/patologia
Estudos Retrospectivos
Receptores de Superfície Celular/análise
Estatísticas não Paramétricas
Limites: Adolescente
Adulto
Feminino
Humanos
Masculino
Adulto Jovem
Tipo de Publ: Estudo de Avaliação
Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-681865
Autor: Brazilian Dental Journal; Pontes, Helder Antonio Rebelo; Pontes, Flavia Sirotheau Correa; Silva, Brunno Santos de Freitas; Fonseca, Felipe Paiva; Andrade, Bruno Augusto Benevenuto de; Rizo, Victor Hugo Toral; Romanach, Mario Jose; Leon, Jorge Esquiche; Almeida, Oslei Paes de.
Título: Extranodal Nasal NK/T-Cell Lymphoma: A Rare Oral Presentation and FASN, CD44 and GLUT-1 Expression
Fonte: Braz. dent. j;24(3):284-288, May-Jun/2013. tab, graf.
Idioma: en.
Resumo: Extranodal natural killer (NK)/T-cell lymphoma is an aggressive malignant tumor with distinctive clinicopathological features, characterized by vascular invasion and destruction, prominent necrosis, cytotoxic lymphocyte phenotype and a strong association with Epstein-Barr virus. Here is reported an extranodal nasal NK/T-cell lymphoma case, involving the maxillary sinus, floor of the orbit, and interestingly extending to the oral cavity through the alveolar bone and buccal mucosa, preserving the palate, leading to a primary misdiagnosis of aggressive periodontal disease. Moreover, this work investigated for the first time the immunohistochemical expression of fatty acid synthase (FASN) and glucose transporter 1 (GLUT-1) proteins in this neoplasia. FASN showed strong cytoplasmatic expression in the neoplastic cells, whereas GLUT-1 and CD44 were negative. These findings suggest that the expression of FASN and the loss of CD44 might be involved in the pathogenesis of the extranodal nasal NK/T-cell lymphoma, and that GLUT-1 may not participate in the survival adaptation of the tumor cells to the hypoxic environment. Further studies with larger series are required to confirm these initial results.

O linfoma de células natural killers (NK)/T extranodal é um tumor maligno agressivo com características clinicopatológicas distintas, caracterizadas por invasão e destruição vasculares, necrose proeminente, fenótipo linfocítico citotóxico e uma forte associação com o vírus Epstein-Barr. Relatamos aqui um caso de linfoma de células NK/T nasal extranodal, envolvendo o seio maxilar, assoalho de órbita, e interessantemente estendendo-se para a cavidade oral através do osso alveolar e mucosa vestibular, preservando o palato, levando a um diagnóstico inicial equivocado de doença periodontal agressiva. Ainda, nós investigamos pela primeira vez a expressão imunoistoquímica das proteínas Fatty acid sinthase (FASN) e glucose transporter 1 (GLUT-1) nesta neoplasia. FASN revelou uma forte expressão citoplasmática nas células neoplásicas, enquanto GLUT-1 e CD44 foram negativas. Estes achados sugerem que a expressão de FASN e a perda de CD44 podem estar envolvidas na patogênese do linfoma de células NK/T nasal extranodal, e que GLUT-1 não deve participar da adaptação das células tumorais ao ambiente de hipóxia. Estudos adicionais com séries maiores são necessários para confirmar nossos resultados iniciais.
Descritores: /análise
ANTIGENS, CDABSENTEEISM/análise
Ácido Graxo Sintase Tipo I/análise
Neoplasias Gengivais/diagnóstico
Transportador de Glucose Tipo 1/análise
Linfoma Extranodal de Células T-NK/diagnóstico
Neoplasias do Seio Maxilar/diagnóstico
Neoplasias Orbitárias/diagnóstico
-Erros de Diagnóstico
Evolução Fatal
Gengivite Ulcerativa Necrosante/diagnóstico
Limites: Adulto
Feminino
Humanos
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME



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