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Pesquisa : D08.811.277.656.262.500.096 [Categoria DeCS]
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Id: biblio-966896
Autor: Eslami, Hosein; Yazdani, Javad; Khorshidi-Khiyavi, Reza; Ghavimi, Mohamadali; Ghanizadeh, Milad; Jamlo, Aydin; Mahdinezhad, Aazam.
Título: Effect of Supplementary Administration of Anaheal on Reducing Pain, Swelling and Trismus after Mandibular Third Molar Surgery: A Splitmouth Controlled Randomized Clinical Trial
Fonte: Pesqui. bras. odontopediatria clín. integr;18(1):4131, 15/01/2018. tab.
Idioma: en.
Resumo: Objective: To evaluate the effect of supplementary administration of Anaheal capsule in reducing pain, swelling and trismus after surgical removal of impacted mandibular third molars. Material and Methods: This single-blind controlled randomized clinical trial was conducted on 36 patients referring to Tabriz University of Medical Sciences. Each of the 36 patients had bilateral surgical removal of mandibular third molars in two sessions, with at least a 4-week interval between sessions. In the same individual, one of the sites randomly received a test medication whereas the other site was used as a control. In the test subgroup (test medication side), the first dose of Anaheal capsule was given as a 200-mg dose of bromelain immediately after surgery according to manufacturer's instructions and the subsequent doses were given at 6-hour intervals after the first dose. The medication was administrated for 3 days. In the control subgroup (control side), Anaheal was not administered. The severities of pain, swelling and maximum mouth opening (MMO) were recorded one and three days postoperatively. Paired t-test and t-test for independent samples were used. Statistical significance was defined at p<0.05. Results: A total of 72 surgical extractions were performed; 36 procedures served as control and 36 cases received Anaheal. Pain, swelling and trismus of the patients were at the highest levels one day after surgery, which decreased on day 3. However, independent t-test showed no significant differences in pain, swelling and trismus after surgery between the study subgroups (p>0.05). Conclusion: Supplementary administration of Anaheal (800 mg bromelain daily) had no significant effect on decreasing pain, swelling and trismus at 1- and 3-day intervals after surgical removal of mandibular third molars.
Descritores: Complicações Pós-Operatórias/prevenção & controle
Dente Impactado/cirurgia
Bromelaínas/farmacocinética
Ensaio Clínico Controlado Aleatório
Dente Molar
-Dor Pós-Operatória
Placebos
Cirurgia Bucal/métodos
Método Duplo-Cego
Interpretação Estatística de Dados
Limites: Humanos
Masculino
Feminino
Adolescente
Adulto
Tipo de Publ: Ensaio Clínico Controlado
Estudo de Avaliação
Responsável: BR1822.9 - Associação de Apoio à Pesquisa em Saúde Bucal


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Id: biblio-967099
Autor: Zarandi, Ali; Faramarzi, Masoumeh; Kashefi-Mehr, Atabak; Ataie, Ayda; Rahbar, Mahdi.
Título: Efect of Anaheal (Bromelain) Drug on the Periodontal Clinical Indices in Nonsurgical Periodontal Treatment of Patients with Chronic Periodontitis
Fonte: Pesqui. bras. odontopediatria clín. integr;18(1):4135, 15/01/2018. tab.
Idioma: en.
Resumo: Objective: To evaluate the effect of Anaheal (Bromelain) drug on the periodontal clinical indices in nonsurgical periodontal treatment of patients with chronic periodontitis. Material and Methods: In this double blind clinical trial, 80 patients with chronic moderate periodontitis and a healthy systemic status were chosen, and divided into two 40-subject groups. Thereafter, the standard treatment of periodontitis including scaling and root planning in one session by the unit operator was performed for all patients. Eventually, one group of the patients was administered Bromelain medication (500-mg capsule twice a day) one hour before food, while the other group was given placebo. Four and eight weeks after the treatment, the clinical periodontal indicators were measured and recorded in both groups. The data were assessed using descriptive statistics and analytical test methods (Mann-U-Whitney and Chi-square). P value less than 0.05 was considered statistically significant. Results: Gingival index, probing depth and plaque index before the treatment were similar in both groups (Anaheal and placebo). However, four and eight weeks after the treatment, the three studied indices were significantly lower in the Anaheal group as compared to the placebo (p<0.05). The index of bleeding on probing was also similar before the treatment and four weeks after the treatment in both groups. However, eight weeks after the treatment, this index was significantly lower in the Anaheal group as compared to the placebo group (p<0.05). Conclusion: Administration of oral Anaheal medication after nonsurgical periodontal treatments reduced all the clinical periodontal indices among patients with chronic periodontitis as compared to the control group. Therefore, it can be a suitable substitute for the common oral industrial antibiotics.
Descritores: Bromelaínas/uso terapêutico
Índice Periodontal
Raspagem Dentária/métodos
Periodontite Crônica/diagnóstico
-Distribuição de Qui-Quadrado
Estatísticas não Paramétricas
Ensaio Clínico Controlado
Irã (Geográfico)
Limites: Humanos
Masculino
Feminino
Adulto
Tipo de Publ: Estudo Comparativo
Ensaio Clínico Controlado
Responsável: BR1822.9 - Associação de Apoio à Pesquisa em Saúde Bucal


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Id: biblio-883768
Autor: Kasraei, Shahin; Yarmohammadi, Ebrahim; Farhadian, Maryam; Malek, Mona.
Título: Effect of proteolytic agents on microleakage of etch and rinse adhesive systems
Fonte: Braz. j. oral sci;16:e17048, jan.-dez. 2017. ilus.
Idioma: en.
Resumo: Objective: this study aimed to assess the effect of treatment of phosphoric acid etched dentin surface with 5% bromelain enzyme and Nd:YAG laser prior to the use of etch and rinse adhesive systems on microleakage margins of class V composite restorations. Materials and Methods: sixty sound premolar teeth were selected. Standard class V cavities were prepared in the buccal and lingual surfaces of each teeth. Preparation in that way 1 mm of the cavity was above and 1 mm of it was below the cementoenamel junction. The teeth were then randomly divided into three groups including 20 teeth(40cavities in each gorup). Two ethanol base etch and rinse system (Adper Single Bond and OptiBond Solo) was applied in each group. In the control group, cavities were etched with 37% phosphoric acid. Adper Single Bond was applied to 20 and OptiBond Solo was applied to the remaining 20 cavities and they were restored with Z250 composite (n=40). The same procedures were performed in bromelain and Nd:YAG laser groups with the difference that prior to the application of adhesive, aqueous 5% bromelain was applied in bromelain group while Nd:YAG laser was irradiated in laser group. All teeth were thermocycled and their apices were sealed with sticky wax. The tooth surfaces were coated with nail varnish except for 1 mm around the restoration margins, and the teeth were then immersed in fuchsine and sectioned by a diamond disc into mesial and distal halves. Marginal microleakage at both sides was determined and scored under a stereomicroscope at x40 magnification. Then data were analyzed using the Kruskal Wallis and Mann Whitney tests (α=0.05). Results: according the result of Mann Whitney test, Cervical margins showed significantly higher microleakage than the occlusal margins (P=0.000) but no significant difference was noted in microleakage of occlusal (P=0.362) or gingival (P=0.147) margins among the three groups by Kruskal Wallis test. Conclusion: in conclusion, application of proteolytic agents(5% bromelain solution and Nd:YAG laser) on acid-etched dentin surface prior to the application of adhesive has no significant effect on marginal microleakage of class V composite restorations (AU)
Descritores: Bromelaínas
Infiltração Dentária
Lasers
Limites: Humanos
Responsável: BR218.1 - Biblioteca Carlos Henrique Robertson Liberalli


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Id: biblio-836964
Autor: Novaes, Letícia Célia de Lencastre.
Título: Extração de bromelina dos resíduos de abacaxi ( Ananas comosus ) por sistemas de duas fases aquosas e sua aplicação em hidrogel polimérico / Extraction of bromelain from pineapple waste ( Ananas comosus ) by aqueous two-phase systems and its application in polymeric hydrogels.
Fonte: São Paulo; s.n; nov.2013. 154 p. tab, graf, ilus.
Idioma: pt.
Tese: Apresentada a Universidade de São Paulo. Faculdade de Ciências Farmacêuticas para obtenção do grau de Doutor.
Resumo: Bromelina é um nome coletivo para enzimas proteolíticas encontradas no talo, fruto e folhas do abacaxi (Ananas comosus Merr). A bromelina possui propriedades anti-inflamatórias, de debridamento, entre outras. Para a produção da bromelina deve-se, preferencialmente, usar resíduos do abacaxi, visto que os produtos do fruto têm aplicação comercial. Este trabalho teve como objetivo a extração de bromelina a partir de cascas de abacaxi através de sistema de duas fases aquosas (SDFA), e sua aplicação em hidrogel polimérico. Foram realizados estudos de estabilidade da bromelina comercial, em que se observou maior estabilidade em pH 5,0 com menor perda da atividade relativa em todas as temperaturas estudadas (20, 30, 40 e 50°C). O estudo da extração da bromelina em SDFA formado por polietileno glicol (PEG) e ácido poliacrílico (PAA) (com auxílio da análise de variância de parâmetros como rendimento, fator de purificação e coeficiente de partição) proporcionou rendimento de 335% e fator de purificação de 25,8. Os hidrogéis poliméricos à base de PEG estudados apresentaram-se flexíveis, com pouca elasticidade e taxa de absorção superior a 1000%. Hidrogel carreado de bromelina pelo método de turgescência proporcionou a maior liberação da enzima, assim como a maior atividade (80% da bromelina liberada em 24 h e 278 ± 89 U/mL)

Bromelain is a collective name for the proteolytic enzymes found in the stem, fruit and leaves of pineapple (Ananas comosus Merr.). Bromelain possesses anti-inflammatory properties, debridement, among others. For bromelain production one should preferably use the waste materials, whereas pineapple fruit products have commercial application. This study aimed to extract bromelain from pineapple peels using aqueous two-phase system (ATPS), and its application in polymeric hydrogels. Stability studies of commercial bromelain were performed, which found greater stability at pH 5.0 with minor loss of relative activity at all temperatures studied. The study of bromelain extraction in ATPS composed by polyethylene glycol (PEG) and poly acrylic acid (PAA) (with assistance of variance analysis of parameters such as yield, purification factor and partition coefficient) showed yield 335% and purification factor of 25.8. The PEG-based hydrogels studied presented flexibility, low elasticity and swelling ratio higher than 1000%. Hydrogel containing bromelain, loading by embedding (solvent sorption) method, yielded the highest enzyme release, as well as the highest activity (80% bromelain released over 24 h and 278 ± 89 U / mL)
Descritores: Ananas/anatomia & histologia
Bromelaínas/farmacologia
Hidrogéis/farmacologia
-Biotecnologia
Tecnologia Farmacêutica
Responsável: BR40.1 - DBD - Divisão de Biblioteca e Documentacão do Conjunto das Químicas
BR40.1; T 620.8, N935e. 30100020496


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Texto completo SciELO Brasil
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Id: lil-722178
Autor: Novaes, Letícia Celia de Lencastre; Jozala, Angela Faustino; Mazzola, Priscila Gava; Júnior, Adalberto Pessoa.
Título: The influence of pH, polyethylene glycol and polyacrylic acid on the stability of stem bromelain
Fonte: Braz. j. pharm. sci;50(2):371-380, Apr-Jun/2014. tab, graf.
Idioma: en.
Resumo: Enzyme stability is critical in biotechnology, pharmaceutical and cosmetic industries. Investigations on this subject have drawn attention because of its practical application. Bromelain is a thiol-endopeptidase, obtained from pineapple (Ananas comosus), known for its clinical and therapeutic applications, particularly to selective burn debridement and improvement of antibiotic action and anti-inflammatory activities. To date, the use of bromelain in pharmacological or industrial applications is limited, due to commercial availability, costs, and sensitivity to pH and temperature. Therefore, a better understanding of enzyme stability would be of great interest. The aim of this study was to evaluate bromelain activity and stability in several pH (2.0 to 8.0) and in polyethylene glycol and polyacrylic acid solutions. We observed that bromelain was able to maintain its stability at pH 5.0 for the temperatures studied. PEG solutions increased bromelain stability, but PAA solutions had the opposite effect.

Estabilidade de enzimas é uma questão fundamental em indústrias biotecnológicas, farmacêuticas e cosméticas. As investigações sobre o assunto têm chamado a atenção por sua aplicação prática. A bromelina é uma tiol-endopeptidase, obtida a partir do abacaxi (Ananas comosus). É conhecida por suas aplicações clínicas e terapêuticas, especialmente para desbridamento seletivo de queimaduras, melhoria de ações antibiótica e de atividades anti-inflamatórias. Até o momento, a utilização da bromelina em aplicações farmacológicas industriais é limitada, devido à disponibilidade comercial, os custos, a sensibilidade ao pH e temperatura. Portanto, a maior compreensão da estabilidade desta enzima seria de grande interesse. O objetivo deste estudo foi avaliar a estabilidade da atividade da bromelina em vários pH (2,0 a 8,0) e em soluções de polietilenoglicol e de ácido poliacrílico. Observamos que a bromelina foi capaz de manter a sua estabilidade em pH 5.0, em todas as temperaturas estudadas. Soluções de PEG aumentaram a estabilidade da bromelina, enquanto que soluções de PAA obtiveram efeito oposto.
Descritores: Alcalinização/efeitos adversos
Bromelaínas/análise
-Estabilidade Enzimática
Enzimas
Polietilenoglicóis/análise
Responsável: BR1.1 - BIREME


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Texto completo SciELO Cuba
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Id: lil-585074
Autor: Carvajal, Carol; Márquez, Margarita; Pérez, Aurora T; Chávez, María de los A; Hernández, Martha.
Título: Caracterización cinética de un preparado semipurificado de bromelina para uso antitumoral / Kinetic characterization of a semipurified preparation from bromelain for antitumor use
Fonte: Rev. cuba. plantas med;15(2):27-41, abr.-jun. 2010.
Idioma: es.
Resumo: INTRODUCCIÓN: la mayor parte de la producción mundial de enzimas está destinada a la obtención de proteasas. Las aplicaciones de estas biomoléculas con fines terapéuticos son muy variadas. Algunas se conocen como remedios naturales y otras son fármacos modificadores de la respuesta biológica. Las plantas de piña contienen varias cisteíno-proteasas, el componente mayoritario aislado del tallo es la bromelina de tallo (EC 3.4.22.32). En el campo de la salud se le atribuyen varias acciones entre las que se destaca la de inducir la diferenciación de células tumorales y atenuar el crecimiento del tumor. OBJETIVOS: caracterizar cinéticamente un preparado semipurificado de bromelina obtenida por un procedimiento desarrollado en Cuba para ser evaluado en el campo de la salud. MÉTODOS: el extracto crudo de bromelina, obtenido a partir de tallos de plantas adultas de Ananas comosus (L.) Merr cv Española roja (piña) se purificó por cromatografía de intercambio iónico en carboximetilcelulosa-52 en un sistema semibach. RESULTADOS: la caracterización cinética del extracto purificado permitió comprobar la existencia de un preparado activo y estable con una actividad específica de 0,94 U/mg de proteínas (2,34 veces superior a la del extracto crudo original), con una fracción proteica mayoritaria de masa molar 24 500 Da y un punto isoeléctrico, localizado en la zona de pH básico (9,55). Tiene pH óptimo 6,8 al utilizar hemoglobina 2 por ciento como sustrato a 37 ºC y una estabilidad en función del pH y de la temperatura aceptable. Si se conserva liofilizado a - 20 ºC mantiene 80 por ciento de la actividad durante 1 año. CONCLUSIONES: la cromatografía de intercambio iónico en carboximetilcelulosa-52 posibilitó la obtención de un preparado semipurificado de bromelina, con una actividad específica superior a la del extracto original que puede ser utilizado en la medicina como antitumoral

INTRODUCTION: most of the world production of enzymes is devoted to proteases obtaining. Applications of these biomolecules for therapeutical objectives are very varied. Some are known as natural remedies and other are drugs modifying the biological response. Pineapple plants contain some cysteine-proteases, the majority component isolated from stem is the stem Bromelain (EC 3.4.22.32). In the health field it has attributed some actions including the differentiation induction of tumor cells and attenuation of tumor growth. OBJECTIVES: to characterize kinetically a semipurified preparation from Bromelain obtained by a procedure developed in Cuba to be assessed in the health field. METHODS: the crude extract from Bromelain obtained from the adult plant stems of Ananas comosus (L.) Merr Cv Spanish red (pineapple) was purified by ion-exchange chromatography in carboxylmethylcelulose-52 in semibatch system. RESULTS: kinetic characterization of purified extract allowed us to verify the existence of a stable and active preparation with a specific activity of 0,94 U/mg of proteins (2,34 times superior to that of original crude extract) with a protein fraction in the main of molar mass 24 500 Da and a isoelectric point, located in the basic pH zone (9,55). It has a 6,8optimal pH using the 2 percent hemoglobin as substrate at 37ºC and stability depending on pH and on acceptable temperature. If it is preserved lyophilized at 20 ºC it maintains the 80 percent of activity for a year. CONCLUSIONS: the ion-exchange chromatography in carboxyl methylcellulose-52 allowed the achievement of semipurified preparation from Bromelain with a specific activity higher to that of original extract that may to be used in medicine as antitumor agent
Descritores: Ananas/química
Bromelaínas/uso terapêutico
Neoplasias/tratamento farmacológico
Responsável: CU1.1 - Biblioteca Médica Nacional


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Texto completo SciELO Chile
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Id: lil-522162
Autor: Jung, Yu-Jin; Choi, Chang-Sun; Park, Jin-Heui; Kang, Hee-Wan; Choi, Je-Eul; Nou, Ill-Sup; Lee, Soon Youl; Kang, Kwon-Kyoo.
Título: Overexpression of the pineapple fruit bromelain gene (BAA) in transgenic Chinese cabbage (Brassica rapa) results in enhanced resistance to bacterial soft rot
Fonte: Electron. j. biotechnol;11(1):71-79, Jan. 2008. ilus, graf, tab.
Idioma: en.
Projeto: Agricultural R & D Promotion Center.
Resumo: Bromelain is a crude protein extract obtained from pineapple stems, which comprises a variety of proteolytic enzymes. It exhibits potential therapeutic activities against trauma, inflammation, autoimmune diseases and malignant disorders. In this study, we cloned BAA1 (the gene encoding fruit bromelain) into a plant expression vector that was then used to transform Brassica rapa and overexpress BAA1 under the control of the cauliflower mosaic virus (CaMV) 35S promoter. We demonstrate that constitutive overexpression of BAA1 in B. rapa confers enhanced resistance to the soft rot pathogen Pectobacterium carotovorum ssp. carotovorum. These results suggest that it could be utilized for protecting plants from attack by bacterial pathogens.
Descritores: Ananas
Bromelaínas
Caulimovirus
Pectobacterium
Raízes de Plantas
-Brassica
Plantas Geneticamente Modificadas
Reação em Cadeia da Polimerase
Western Blotting
Responsável: CL1.1 - Biblioteca Central


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Texto completo SciELO Cuba
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Id: lil-324922
Autor: Abreu Payrol, Juan; Miranda Martínez, Migdalia; Toledo Carrabeo, Griset; Castillo García, Osmaida.
Título: Actividad farmacológica preliminar del fruto de Bromelia pinguin L. (piña de ratón) / Preliminary pharmacological activity of the fruit of Bromelia pinguin L. (
Fonte: Rev. cuba. farm;35(1):56-60, ene.-abr. 2001. tab, graf.
Idioma: es.
Resumo: Se presentan los resultados del estudio farmacológico preliminar de un extracto hidroalcohólico concentrado de los frutos de Bromelia pinguin L. (piña de ratón) mediante bioensayos sencillos y confiables. Se determinó la toxicidad frente a Artemia salina Leach, que resultó muy baja. Se probó la actividad antihelmíntica contra Lombricus terrestri, con resultados relevantes. El extracto no mostró actividad contra diversas cepas de hongos y bacterias
Descritores: Anti-Helmínticos
Artemia
Bioensaio
Bromelaínas/farmacologia
Química Farmacêutica
Extratos Vegetais
Plantas Medicinais
Responsável: CU1.1 - Biblioteca Médica Nacional


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Baldini, Vera Lucia Signoreli
Id: lil-147905
Autor: Baldini, Vera Lucia Signoreli; Iaderoza, Marilena; Ferreira, Ercilia A. Henriques; Sales, Arlindo Moreira; Draetta, Iacy dos Santos; Giacomelli, Eloys J.
Título: Ocorrência da bromelina em espécies e cultivares de abacaxizeiro / Occurrence of bromelain in species and cultivars of pineaple plants
Fonte: Colet. Inst. Tecnol. Alimentos;23(1):44-55, jan.-jun. 1993. ilus, tab.
Idioma: pt.
Resumo: Neste trabalho procurou-se caracterizar cultivares de abacaxizeiro pertencentes à coleçäo do Instituto Agronômico de Campinas (IAC) - Säo Paulo, quanto ao teor de bromelina, devido à sua importância para a indústria de alimentos e ao pouco conhecimento acerca de sua atividade nas espécies cultivares de abacaxizeiro. Foram selecionados 16 amostras de diferentes cultivares e dentre essas, a espécie Ananás vermelho-do-mato (Ananas bracteatus, var. typicus). Foi a que se mostrou mais promissora como fonte de bromelina, e o cultivar Roxo-de-tefé (Ananas comosus) praticamente näo apresentou atividade proteolítica, fato este até entäo näo documentado na literatura. Os valores obtidos para a atividade proteolítica variaram de 216,1 a 6617,6 unidades/100g talo
Descritores: Bromelaínas/classificação
Peptídeo Hidrolases/isolamento & purificação
Plantas Comestíveis/química
-Bromelaínas/isolamento & purificação
Citrus
Tipo de Publ: Relatos de Casos
Responsável: BR734.1 - Biblioteca Central Cesar Lattes - BCCL


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Id: lil-141906
Autor: Suárez Batista, Lilia E; Bencomo Hernández, Antonio; González González, Juan Manuel; González Sampedro, Reneé; Rivero Jiménez, René A.
Título: Métodos para el pesquisaje de anticuerpos contra antigenos de grupos sanguineos del sistema ABO humano / Methods for the screeninig antibodies of the human ABO blood group system
Fonte: Rev. cuba. hematol. inmunol. hemoter;9(2):105-8, jul.-dic. 1993.
Idioma: es.
Resumo: Para el pesquisaje inicial de anticuerpos contra antígenos de grupos sanguíneos (tanto en los sueros de ratón como en los sobrenadantes de hibridomas) se utilizó la técnica de aglutinación en microplacas empléandose hematíes A1,A2,Ax, B y O tratados con bromelina. Una vez identificados los clones de hibridomas productores, se estudiaron sus correspondientes líquidos ascíticos por los métodos de aglutinación en microplacas, en tubos por centrifugación y sedimentación y en láminas, lo que permitió demostrar que con el método de pesquisaje inicial se puede procesar un elevado número de muestras y utilizar pequeñas cantidades de sobredonantes, además de que permite seleccionar reactivos adecuados para el fenotipo de grupos sanguíneos en tubos, en láminas y microplacas, que son las 3 técnicas más usadas en el mundo para el inmunofenotipaje de los donantes
Descritores: Anticorpos Monoclonais/análise
Anticorpos Monoclonais/biossíntese
Anticorpos Monoclonais/imunologia
Bromelaínas
Antígenos de Grupos Sanguíneos/imunologia
Hibridomas/imunologia
Técnicas In Vitro
Testes de Hemaglutinação/métodos
Tipagem e Reações Cruzadas Sanguíneas/métodos
Limites: Animais
Camundongos
Responsável: CU1 - INFOMED - Centro Nacional de Información de Ciencias Médicas



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