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Id: biblio-1019970
Autor: Borges, Cristine D Almeida; Ricoldi, Milla Sprone; Messora, Michel Reis; Palioto, Daniela Bazan; Souza, Sérgio Luís Scombatti de; Novaes Júnior, Arthur Belém; Taba Jr, Mario.
Título: Clinical attachment loss and molecular profile of inflamed sites before treatment
Fonte: J. appl. oral sci;27:e20180671, 2019. tab, graf.
Idioma: en.
Projeto: State of São Paulo Foundation (FAPESP); . Coordenação de Nível Superior - Brasil (CAPES).
Resumo: Abstract Objective: To monitor early periodontal disease progression and to investigate clinical and molecular profile of inflamed sites by means of crevicular fluid and gingival biopsy analysis. Methodology: Eighty-one samples of twenty-seven periodontitis subjects and periodontally healthy individuals were collected for the study. Measurements of clinical parameters were recorded at day −15, baseline and 2 months after basic periodontal treatment aiming at monitoring early variations ofthe clinical attachment level. Saliva, crevicular fluid and gingival biopsies were harvested from clinically inflamed and non-inflamed sites from periodontal patients and from control sites of healthy patients for the assessment of IL-10, MMP-8, VEGF, RANKL, OPG and TGF-β1 protein and gene expression levels. Results: Baseline IL-10 protein levels from inflamed sites were higher in comparison to both non-inflamed and control sites (p<0.05). Higher expression of mRNA for IL-10, RANK-L, OPG, e TGF-β1 were also observed in inflamed sites at day −15 prior treatment (p<0.05). After the periodontal treatment and the resolution of inflammation, seventeen percent of evaluated sites still showed clinically detectable attachment loss without significant differences in the molecular profile. Conclusions: Clinical attachment loss is a negative event that may occur even after successful basic periodontal therapy, but it is small and limited to a small percentage of sites. Elevated inflammation markers of inflamed sites from disease patients reduced to the mean levels of those observed in healthy subjects after successful basic periodontal therapy. Significantly elevated both gene and protein levels of IL-10 in inflamed sites prior treatment confirms its modulatory role in the disease status.
Descritores: Perda da Inserção Periodontal/patologia
-Periodontite/terapia
Saliva/química
Fatores de Tempo
Biópsia
Biomarcadores/análise
Estudos de Casos e Controles
Citocinas/análise
Líquido do Sulco Gengival/química
Estatísticas não Paramétricas
Metaloproteinase 8 da Matriz/análise
Fator A de Crescimento do Endotélio Vascular/análise
Osteoprotegerina/análise
Reação em Cadeia da Polimerase em Tempo Real
Gengiva/patologia
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Responsável: BR28.1 - Serviço de Biblioteca e Documentação Professor Doutor Antônio Gabriel Atta


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Id: biblio-841173
Autor: SANTOS, Bianca Fernanda Espósito; SOUZA, Eduardo Quintão Manhanini; BRIGAGÃO, Maísa Ribeiro Pereira Lima; LIMA, Daniela Coelho de; FERNANDES, Leandro Araújo.
Título: Local application of statins in the treatment of experimental periodontal disease in rats
Fonte: J. appl. oral sci;25(2):168-176, Mar.-Apr. 2017. graf.
Idioma: en.
Resumo: Abstract Objective The objective of this study was to evaluate the local effects of statins as adjuvants for treatment by scaling and root planing (SRP) of periodontal disease induced in rats. Material and Methods Ninety rats were used in the present experiment. Periodontal disease was induced in all animals using a cotton thread placed in the left first mandibular molar. After 7 days of induction, the bandage was removed and the animals were divided into three groups: 1) NT group (n=30), no treatment; 2) SRP group (n=30): SRP and irrigation with control gel; 3) S group (n=30) - SRP and irrigation with Simvastatin. Ten animals from each group were euthanized at 7, 15 and 30 days after treatment. Gingival biopsy specimens were processed to analyze the expression of matrix metalloproteinase 8 (MMP-8). The mandibles were removed and submitted to radiographic and laboratory processing for histometric analysis. Results The S group showed a significantly lower expression of MMP-8 compared to NT and SRP groups in all experimental periods. In the radiographic and histometric analyses between the groups, S group showed a significantly lower bone loss (BL) compared to NT and SRP groups in all experimental periods. Conclusions Within the limits of this study, it can be concluded that locally applied statin was effective as an adjuvant treatment for SRP in rats with induced periodontal disease.
Descritores: Conservadores da Densidade Óssea/farmacologia
Periodontite/tratamento farmacológico
Aplainamento Radicular/métodos
Sinvastatina/farmacologia
-Biópsia
Quimioterapia Adjuvante
Gengiva/efeitos dos fármacos
Gengiva/patologia
Mandíbula/diagnóstico por imagem
Mandíbula/patologia
Metaloproteinase 8 da Matriz/análise
Periodontite/patologia
Ratos Wistar
Reprodutibilidade dos Testes
Fatores de Tempo
Limites: Animais
Masculino
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME



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