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Id: |
lil-722128
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Autor: |
Ebertz, Claudia Emanuelli; Bonfleur, Maria Lúcia; Bertasso, Iala Milene; Mendes, Mariana Carla; Lubaczeuski, Camila; Araujo, Allan Cezar de Freitas; Paes, Antônio Marcus; Amorim, Elaine Manoela Porto de; Balbo, Sandra Lucinei. |
Título: |
Duodenal jejunal bypass attenuates non-alcoholic fatty liver disease in western diet-obese rats |
Fonte: |
Acta cir. bras;29(9):609-614, 09/2014. tab, graf.
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Idioma: |
en.
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Resumo: |
PURPOSE: To evaluate the effects of duodenal-jejunal bypass (DJB) on serum and hepatic profiles of obese rats fed on a western diet (WD). METHODS: Twenty eight male Wistar rats were fed a standard rodent chow diet (CTL group) or WD ad libitum. After 10 weeks, WD rats were submitted to sham (WD SHAM) or duodenal-jejunal bypass (WD DJB). Body weight, fat pad depots, glycemia, insulinemia, HOMA-IR, TyG, lipids profile and hepatic analyses were evaluated two months after surgery. RESULTS: The WD SHAM group presented greater obesity, hyperglycemia, hyperinsulinemia, insulin resistance, hypertriglyceridemia and hepatic steatosis than the CTL group. WD DJB rats presented decreased serum glucose and insulin resistance, when compared to WD SHAM animals, without changes in insulinemia. In addition, DJB surgery normalized serum TG and attenuated TG accumulation and steatosis in the liver of the WD DJB group. Hepatic ACC and FAS protein expressions were similar in all groups. CONCLUSION: Duodenal-jejunal bypass attenuates hepatic parameters of non-alcoholic fatty liver disease in obese rats fed on a western diet. .
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Descritores: |
Dieta Ocidental Duodeno/cirurgia Derivação Gástrica/métodos Jejuno/cirurgia Hepatopatia Gordurosa não Alcoólica/cirurgia Obesidade/cirurgia
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-Tecido Adiposo Acetil-CoA Carboxilase/análise Peso Corporal Glicemia/análise Resistência à Insulina Fígado/metabolismo Fígado/patologia Hepatopatia Gordurosa não Alcoólica/metabolismo Hepatopatia Gordurosa não Alcoólica/patologia Obesidade/metabolismo Proteínas Serina-Treonina Quinases/análise Ratos Wistar Reprodutibilidade dos Testes Fatores de Tempo Triglicerídeos/sangue
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Limites: |
Animais Masculino
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Tipo de Publ: |
Estudo de Avaliação Research Support, Non-U.S. Gov't
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Responsável: |
BR1.1 - BIREME
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