Base de dados : LILACS
Pesquisa : D08.811.464.257.050 [Categoria DeCS]
Referências encontradas : 3 [refinar]
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Texto completo SciELO Brasil
Texto completo
Id: lil-797885
Autor: Abreu, P; Vitzel, K F; Monteiro, I C C R; Lima, T I; Queiroz, A N; Leal-Cardoso, J H; Hirabara, S M; Ceccatto, V M.
Título: Effects of endurance training on reduction of plasma glucose during high intensity constant and incremental speed tests in Wistar rats
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;49(11):e5226, 2016. tab, graf.
Idioma: en.
Resumo: The aim of this research was to investigate the effects of endurance training on reduction of plasma glucose during high intensity constant and incremental speed tests in Wistar rats. We hypothesized that plasma glucose might be decreased in the exercised group during heavy (more intense) exercise. Twenty-four 10-week-old male Wistar rats were randomly assigned to sedentary and exercised groups. The prescription of endurance exercise training intensity was determined as 60% of the maximum intensity reached at the incremental speed test. The animals were trained by running on a motorized treadmill, five days/week for a total period of 67 weeks. Plasma glucose during the constant speed test in the exercised group at 20 m/min was reduced at the 14th, 21st and 28th min compared to the sedentary group, as well at 25 m/min at the 21st and 28th min. Plasma glucose during the incremental speed test was decreased in the exercised group at the moment of exhaustion (48th min) compared to the sedentary group (27th min). Endurance training positively modulates the mitochondrial activity and capacity of substrate oxidation in muscle and liver. Thus, in contrast to other studies on high load of exercise, the effects of endurance training on the decrease of plasma glucose during constant and incremental speed tests was significantly higher in exercised than in sedentary rats and associated with improved muscle and hepatic oxidative capacity, constituting an important non-pharmacological intervention tool for the prevention of insulin resistance, including type 2 diabetes mellitus.
Descritores: Glicemia/metabolismo
Fígado/metabolismo
Músculo Esquelético/metabolismo
Condicionamento Físico Animal
Resistência Física/fisiologia
-Acetil-CoA Carboxilase/metabolismo
Citocromos c/metabolismo
Teste de Esforço
Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo/metabolismo
Proteínas Quinases/metabolismo
Ratos Wistar
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


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Texto completo SciELO Costa Rica
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Id: lil-729664
Autor: Reuben-Matamoros, Alejandra; Camacho-Matamoros, Natassia; Quesada-Alvarado, Jonessy; Acosta-Gualandri, Alejandra.
Título: Déficit de 3-metilcrotonil-CoA carboxilasa materna en Costa Rica / Deficit 3-methylcrotonyl breast-CoA carboxylase in Costa Rica
Fonte: Acta méd. costarric;56(4):174-176, oct.-dic. 2014. graf.
Idioma: es.
Resumo: La deficiencia aislada de 3-metilcrotonil-CoA carboxilasa es un desorden autosómico recesivo del catabolismo de leucina con gran variabilidad fenotípica. Es uno de los errores innatos del metabolismo más común, con una incidencia de hasta 1:36.000 neonatos. Mujeres que presentan esta condición han sido identificadas únicamente luego de que las muestras de tamizaje neonatal de sus hijos sanos presentaran resultados anormales. La deficiencia de 3-metilcrotonil-CoA carboxilasa materna debe tomarse en cuenta al evaluar un resultado positivo de 3-OH-isovalerilcarnitina en tamizaje neonatal. Además, se debe valorar si es necesario brindar seguimiento clínico periódico a los niños diagnosticados con déficit de 3-metilcrotonil-CoA carboxilasa en Costa Rica, pues está documentado que la mayoría de estos pacientes permanecen asintomáticos.

Isolated 3-methylcrotonyl-coenzymeA carboxylase deficiency is an autosomal recessive disorder of leucine catabolism with considerable phenotypic heterogeneity. It is one of the most common inborn errors of metabolism with an incidence as high as 1 in 36.000 newborns. Women presenting this deficiency have been identified only by detection of abnormal results in newborn screening samples of their healthy babies. Maternal 3-methylcrotonyl-coenzyme A carboxylase deficiency should be taken into account when assessing a positive newborn screening result for 3-hydroxy-isovaleryl carnitine. The question of whether or not to provide periodic medical examination to children diagnosed with 3-methylcrotonyl-coenzymeA carboxylase deficiency in Costa Rica should also be addressed, since there are clinical studies sustaining that most of these patients remain asymptomatic.
Descritores: Acetil-CoA Carboxilase
Leucina
Programas de Rastreamento
Espectrometria de Massas
Limites: Seres Humanos
Responsável: CR1.1 - BINASSS - Biblioteca Nacional de Salud y Seguridad Social


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Texto completo SciELO Brasil
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Id: lil-722128
Autor: Ebertz, Claudia Emanuelli; Bonfleur, Maria Lúcia; Bertasso, Iala Milene; Mendes, Mariana Carla; Lubaczeuski, Camila; Araujo, Allan Cezar de Freitas; Paes, Antônio Marcus; Amorim, Elaine Manoela Porto de; Balbo, Sandra Lucinei.
Título: Duodenal jejunal bypass attenuates non-alcoholic fatty liver disease in western diet-obese rats
Fonte: Acta cir. bras;29(9):609-614, 09/2014. tab, graf.
Idioma: en.
Resumo: PURPOSE: To evaluate the effects of duodenal-jejunal bypass (DJB) on serum and hepatic profiles of obese rats fed on a western diet (WD). METHODS: Twenty eight male Wistar rats were fed a standard rodent chow diet (CTL group) or WD ad libitum. After 10 weeks, WD rats were submitted to sham (WD SHAM) or duodenal-jejunal bypass (WD DJB). Body weight, fat pad depots, glycemia, insulinemia, HOMA-IR, TyG, lipids profile and hepatic analyses were evaluated two months after surgery. RESULTS: The WD SHAM group presented greater obesity, hyperglycemia, hyperinsulinemia, insulin resistance, hypertriglyceridemia and hepatic steatosis than the CTL group. WD DJB rats presented decreased serum glucose and insulin resistance, when compared to WD SHAM animals, without changes in insulinemia. In addition, DJB surgery normalized serum TG and attenuated TG accumulation and steatosis in the liver of the WD DJB group. Hepatic ACC and FAS protein expressions were similar in all groups. CONCLUSION: Duodenal-jejunal bypass attenuates hepatic parameters of non-alcoholic fatty liver disease in obese rats fed on a western diet. .
Descritores: Dieta Ocidental
Duodeno/cirurgia
Derivação Gástrica/métodos
Jejuno/cirurgia
Hepatopatia Gordurosa não Alcoólica/cirurgia
Obesidade/cirurgia
-Tecido Adiposo
Acetil-CoA Carboxilase/análise
Peso Corporal
Glicemia/análise
Resistência à Insulina
Fígado/metabolismo
Fígado/patologia
Hepatopatia Gordurosa não Alcoólica/metabolismo
Hepatopatia Gordurosa não Alcoólica/patologia
Obesidade/metabolismo
Proteínas Serina-Treonina Quinases/análise
Ratos Wistar
Reprodutibilidade dos Testes
Fatores de Tempo
Triglicerídeos/sangue
Limites: Animais
Masculino
Tipo de Publ: Estudos de Avaliação
Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME



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