Base de dados : LILACS
Pesquisa : D08.811.520.300.500 [Categoria DeCS]
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Texto completo SciELO Brasil
Martínez, Denis
Texto completo
Id: biblio-959259
Autor: Carissimi, Alicia; Martinez, Denis; Kim, Lenise J; Fiori, Cintia Z; Vieira, Luciana R; Rosa, Darlan P; Pires, Gabriel N.
Título: Intermittent hypoxia, brain glyoxalase-1 and glutathione reductase-1, and anxiety-like behavior in mice
Fonte: Rev. bras. psiquiatr;40(4):376-381, Oct.-Dec. 2018. tab, graf.
Idioma: en.
Projeto: FAPESP.
Resumo: Objective: Sleep apnea has been associated with anxiety, but the mechanisms of the sleep apnea-anxiety relationship are unresolved. Sleep apnea causes oxidative stress, which might enhance anxiety-like behavior in rodents. To clarify the apnea-anxiety connection, we tested the effect of intermittent hypoxia, a model of sleep apnea, on the anxiety behavior of mice. Methods: The rodents were exposed daily to 480 one-minute cycles of intermittent hypoxia to a nadir of 7±1% inspiratory oxygen fraction or to a sham procedure with room air. After 7 days, the mice from both groups were placed in an elevated plus maze and were video recorded for 10 min to allow analysis of latency, frequency, and duration in open and closed arms. Glyoxalase-1 (Glo1) and glutathione reductase-1 (GR1) were measured in the cerebral cortex, hippocampus, and striatum by Western blotting. Results: Compared to controls, the intermittent hypoxia group displayed less anxiety-like behavior, perceived by a statistically significant increase in the number of entries and total time spent in open arms. A higher expression of GR1 in the cortex was also observed. Conclusion: The lack of a clear anxiety response as an outcome of intermittent hypoxia exposure suggests the existence of additional layers in the anxiety mechanism in sleep apnea, possibly represented by sleepiness and irreversible neuronal damage.
Descritores: Ansiedade/etiologia
Síndromes da Apneia do Sono/complicações
Glutationa Redutase/análise
Lactoilglutationa Liase/análise
Hipóxia/complicações
-Ansiedade/diagnóstico
Ansiedade/fisiopatologia
Síndromes da Apneia do Sono/enzimologia
Síndromes da Apneia do Sono/fisiopatologia
Síndromes da Apneia do Sono/psicologia
Córtex Cerebral/enzimologia
Estresse Oxidativo/fisiologia
Corpo Estriado/enzimologia
Modelos Animais de Doenças
Glutationa Redutase/metabolismo
Lactoilglutationa Liase/metabolismo
Hipóxia/enzimologia
Hipóxia/psicologia
Camundongos Endogâmicos BALB C
Limites: Animais
Masculino
Responsável: BR1.1 - BIREME


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Id: lil-149658
Autor: Ramdath, Dan D; Golden, Michael H. N.
Título: Glyoxalase I activity in erythrocytes from severely malnourished children
Fonte: West Indian med. j;44(1):24-7, Mar. 1995.
Idioma: en.
Resumo: The enzyme glycoxalase I (glyox I) is involved in metabolic detoxification, and requires glutathione (GSH) as a cofactor. Given the low concentration of whole blood GSH in children with oedematous malnutrition, it is possible that the function of this pathway may be compromised in these children. Glyox I activity was therfore assayed in erythocytes taken from 133 severely malnourished children and 21 age-matched controls. The mean values (ñSEM) for the marasmic group (marasmus: 105 ñ 4/u/gm Hb) and the group with kwashiorkor (Kwash: 103 ñ 4/u/gm Hb) were not significantly different from controls (cont: 104 ñ 2u/gm HB)>. In the group with marasmic-kwashiorkor (M-K: 88 ñ 4u/g Hb) Glyox I activity was significantly lower in controls (p < 0.005), as well as in children with marasmus (p < 0.005), and kwashiorkor (p < 0.05). Enzyme activity was lower than normal in 45 per cent of the MK group. Seven children died subsequent to admission; in five cases Glyox I activities were exceedingly low. There was a weak positive correlation between Glyox I activity and whole blood levels of GSH (r=0.215). We conclude that Glyox I activity is relatively unaffected in malnutrition, except in those with M-K and especially those who do not survive the acutely malnourished state
Descritores: Eritrócitos/enzimologia
Lactoilglutationa Liase
Desnutrição Proteico-Calórica/enzimologia
-Kwashiorkor/enzimologia
Marasmo Nutricional/enzimologia
Desnutrição Proteico-Calórica/complicações
Desnutrição Proteico-Calórica/metabolismo
Limites: Humanos
Criança
Responsável: JM3.1 - Médical Library


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Balarin, Marly A. S
Id: lil-141278
Autor: Balarin, Marly A. S; Freire-Maia, Dértia Villalba.
Título: Associaçäo entre glioxalase I e paracoccidioidomicose infecçäo / The association between glyoxalase I and paracoccidioidomycosis infection
Fonte: Rev. Soc. Bras. Med. Trop;26(3):141-3, jul.-set. 1993. tab.
Idioma: pt.
Resumo: Com o objetivo de se estudar a susceptibilidade genética à paracoccidioidomicose infecçäo, procurou-se determinar uma possível associaçäo entre a glixolase I e a reaçäo intradérmica à paracoccidioidina. O fenótipo GLO 1 ocorreu em freqüência significativamente mais alta entre os indivíduos com reaçäo positiva
Descritores: Ensaios Enzimáticos Clínicos
Lactoilglutationa Liase/sangue
Paracoccidioidomicose/diagnóstico
-Suscetibilidade a Doenças
Paracoccidioides
Paracoccidioidomicose/genética
Fenótipo
Proteínas Fúngicas
Testes Cutâneos
Limites: Adolescente
Adulto
Pessoa de Meia-Idade
Humanos
Masculino
Feminino
Responsável: BR1.1 - BIREME



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