Base de dados : LILACS
Pesquisa : D08.811.682.047.551 [Categoria DeCS]
Referências encontradas : 8 [refinar]
Mostrando: 1 .. 8   no formato [Detalhado]

página 1 de 1

  1 / 8 LILACS  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
Id: biblio-1129050
Autor: Porcel, José Manuel.
Título: Diagnóstico diferencial del derrame pleural a través de los valores de corte de los parámetros bioquímicos del líquido / Differential diagnosis of pleural effusion assessed by cut off values of biochemical pleural fluid tests
Fonte: Salud(i)ciencia (Impresa) = Salud(i)ciencia (En linea);14(6):392-396, sept. 2006.
Idioma: es.
Resumo: Objective: The aim of biochemical pleural fluid testing is to reach an etiological diagnosis of the pleural effusion. We assessed the utility of considering cut-off points for the wide range of analyses used to investigate pleural fluid. Patients and methods: Among 1 586 patients with pleural effusion, we sought the etiologies of those fluids which showed any of the following characteristics: red blood cell count ≥ 10 x 109 l, leukocytes ≥ 10 x 109 /l, percentage of neutrophils or lymphocytes > 50%, protein ≥ 30 and 50 g/l, glucose ≤ 60 mg/dl, pH ≤ 7.20, lactate dehydrogenase ≥ 1 000 U/l, adenosine deaminase ≥ 40 U/l, amylase ≥ 100 U/l or cholesterol ≥ 40 and 60 mg/dl. Results: Some of the more prominent findings were: 1) 15% and 18% of transudates were blood-tinged or contained predominantly neutrophils respectively, 2) a grossly bloody fluid suggests malignant disease, trauma, pulmonary embolization or pneumonia, 3) nearly 80% of fluids containing > 10 x 109 / leukocytes/l were parapneumonics, 4) 72% of tuberculous pleural fluids had protein > 50 g/l, 5) tuberculosis and parapneumonics explained 90% of fluids with high adenosine deaminase content, 6) one third of amylase-rich pleural effusions were malignant, 7) a low pleural glucose or pH levels indicates a parapneumonic and, less frequently a tuberculous or malignant etiology, 8) the overall diagnostic yield of pleural fluid cytology in malignant effusions was 61%, a percentage which exceeded 80% in those with low pH or glucose fluid levels. Conclusions: Cut-off values of biochemical pleural fluid

Objetivo: Evaluar la utilidad de diversos valores de corte aplicados a una gran variedad de parámetros bioquímicos del líquido pleural para identificar la causa de un derrame pleural. Pacientes y métodos: En 1 586 pacientes con derrame pleural se analizaron las causas de aquellos líquidos que presentaban alguna de las siguientes características: hematíes ≥ 10 x 109/l, leucocitos ≥ 10 x 109/l, porcentaje de neutrófilos o linfocitos > 50%, proteínas ≥ 30 y 50 g/l, glucosa ≤ 60 mg/dl, pH ≤ 7.20, lactato deshidrogenasa ≥ 1 000 U/l, adenosina desaminasa ≥ 40 U/l, amilasa ≥ 100 U/l o colesterol ≥ 45 y 60 mg/dl. Resultados: Algunos de los hallazgos más destacados fueron: 1) 15% y 18% de los trasudados eran sanguinolentos o tenían celularidad de predominio neutrofílico, respectivamente; 2) un derrame francamente hemático sugiere malignidad, traumatismo, embolia pulmonar o neumonía; 3) cerca del 80% de muestras de líquidos con más de 10 x 109 leucocitos/l eran paraneumónicas; 4) el 72% de los líquidos tuberculosos tenían cifras de proteínas ≥ 50 g/l; 5) los derrames tuberculosos y paraneumónicos explican el 90% de los líquidos con concentraciones elevadas de adenosina desaminasa; 6) un tercio de los derrames ricos en amilasa son malignos; 7) cifras bajas de glucosa o pH pleurales indican que el paciente probablemente tiene un derrame paraneumónico o, en menos ocasiones, tuberculoso o maligno; 8) la rentabilidad global de la citología en los derrames malignos fue del 61%, porcentaje que superó el 80% en los líquidos con concentraciones bajas de pH o glucosa. Conclusiones: La consideración de determinados valores de corte de los parámetros bioquímicos del líquido pleural puede apoyar fuertemente algunas etiologías de derrame pleural
Descritores: Derrame Pleural
Adenosina
Adenosina Desaminase
Lactato Desidrogenases
L-Lactato Desidrogenase
Limites: Humanos
Tipo de Publ: Relatório Técnico
Responsável: AR392.1 - Biblioteca


  2 / 8 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: biblio-1054677
Autor: Bai, Yejun; Li, Zhigang; Liu, Weihao; Gao, Dong; Liu, Min; Zhang, Peiying.
Título: Biochanin A attenuates myocardial ischemia/reperfusion injury through the TLR4/NF-κB/NLRP3 signaling pathway
Fonte: Acta cir. bras;34(11):e201901104, Nov. 2019. graf.
Idioma: en.
Resumo: Abstract Purpose: Myocardial ischemia/reperfusion (Ml/R) injury is a leading cause of damage in cardiac tissues, with high rates of mortality and disability. Biochanin A (BCA) is a main constituent of Trifolium pratense L. This study was intended to explore the effect of BCA on Ml/R injury and explore the potential mechanism. Methods: In vivo MI/R injury was established by transient coronary ligation in Sprague-Dawley rats. Triphenyltetrazolium chloride staining (TTC) was used to measure myocardial infarct size. ELISA assay was employed to evaluate the levels of myocardial enzyme and inflammatory cytokines. Western blot assay was conducted to detect related protein levels in myocardial tissues. Results: BCA significantly ameliorated myocardial infarction area, reduced the release of myocardial enzyme levels including aspartate transaminase (AST), creatine kinase (CK-MB) and lactic dehydrogenase (LDH). It also decreased the production of inflammatory cytokines (IL-1β, IL-18, IL-6 and TNF-α) in serum of Ml/R rats. Further mechanism studies demonstrated that BCA inhibited inflammatory reaction through blocking TLR4/NF-kB/NLRP3 signaling pathway. Conclusion: The present study is the first evidence demonstrating that BCA attenuated Ml/R injury through suppressing TLR4/NF-kB/NLRP3 signaling pathway-mediated anti-inflammation pathway.
Descritores: Cardiotônicos/farmacologia
Traumatismo por Reperfusão Miocárdica/prevenção & controle
NF-kappa B/efeitos dos fármacos
Genisteína/farmacologia
Receptor 4 Toll-Like/efeitos dos fármacos
Proteína 3 que Contém Domínio de Pirina da Família NLR/efeitos dos fármacos
-Aspartato Aminotransferases/sangue
Valores de Referência
Traumatismo por Reperfusão Miocárdica/metabolismo
Transdução de Sinais/efeitos dos fármacos
Western Blotting
Reprodutibilidade dos Testes
Citocinas/sangue
NF-kappa B/metabolismo
Ratos Sprague-Dawley
Creatina Quinase/sangue
Lactato Desidrogenases/sangue
Receptor 4 Toll-Like/metabolismo
Anti-Inflamatórios/farmacologia
Limites: Animais
Masculino
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


  3 / 8 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: lil-777096
Autor: Çakır, Tuğrul; Aslaner, Arif; Tekeli, Seçkin Özgür; Güneş, Kasım; Kinaci, Erdem; Doğan, Uğur; Tekeli, Feyza; Akyüz, Cebrail; Koç, Süleyman; Yılmaz, Necat.
Título: Grape seed protects cholestatic rats liver from ischemia/reperfusion injury
Fonte: Acta cir. bras;31(3):183-189, Mar. 2016. tab, graf.
Idioma: en.
Resumo: ABSTRACT PURPOSE: To determine the effect of grape-seed extract against ischemia/reperfusion injury in cholestatic liver. METHODS: Eighteen Wistar albino rats were divided into three groups. In control and study groups, cholestasis was provided by bile duct ligation. Seven days later, the rats were subjected to 30 min hepatic ischemia, followed by 60 min of reperfusion. Oral administration of 50 mg/kg/day grape-seed extract was started 15 days before bile duct ligation and continued to the second operation in the study group. Serum, plasma and liver samples were taken. Laboratory analysis, tissue gluthation, malondialdehyde, myeloperoxidase levels and histopathological examination were performed. RESULTS: Significant decrease in liver gluthation level and significant increase in malondialdehyde level and myeloperoxidase activity were observed after ischemia/reperfusion in cholestatic rats. Serum and plasma levels for laboratory analysis were also significantly higher in cholestatic I/R group. Hepatic necrosis and fibrosis were detected in histopathological examination. Oral grape-seed extract administiration reversed all these parameters and histopathological findings except serum bilirubin levels. CONCLUSION: Oral grape-seed extract treatment can improve liver functions and attenuate the inflammation and oxidative stress in cholestatic ischemia/reperfusion injury.
Descritores: Traumatismo por Reperfusão/prevenção & controle
Colestase/complicações
Extrato de Sementes de Uva/farmacologia
Antioxidantes/farmacologia
-Aspartato Aminotransferases/efeitos dos fármacos
Aspartato Aminotransferases/metabolismo
Bilirrubina/metabolismo
Traumatismo por Reperfusão/metabolismo
Colestase/metabolismo
Colestase/patologia
Ratos Wistar
Estresse Oxidativo/efeitos dos fármacos
Lactato Desidrogenases/efeitos dos fármacos
Lactato Desidrogenases/metabolismo
Alanina Transaminase/efeitos dos fármacos
Alanina Transaminase/metabolismo
Modelos Animais de Doenças
Inflamação/metabolismo
Fígado/efeitos dos fármacos
Fígado/patologia
Limites: Animais
Masculino
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


  4 / 8 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
Id: lil-771294
Autor: Souza, Marina Tessarolo; Medeiros, Wladimir Musetti.
Título: Lesão muscular induzida por eletroestimulação neuromuscular (EENM) com frequências de 30 Hz e 100 Hz / Muscle damage induced by neuromuscular electrical stimulation (NMES) with frequencies of 30 Hz and 100 Hz
Fonte: Acta fisiátrica;22(1), mar. 2015.
Idioma: pt.
Resumo: A eletroestimulação-neuromuscular (EENM) é a ação de estímulos elétricos terapêuticos sobre o tecido muscular, visando a contração muscular e consequentemente a melhora dos status muscular. Objetivo: Avaliar a lesão muscular decorrente da contração muscular isométrica induzida por meio da EENM de baixa frequência (30 Hz) e de alta frequência (100 Hz). Métodos: Estudo experimental tipo Cross-over, randomizado e não cego. Participaram do estudo 10 universitários voluntários, gênero masculino, idade de 24,4 ± 6,0 anos, peso de 77,1 ± 11,8 kg, altura de 176,1 ± 5,6 cm e IMC de 24,8 ± 3,4 kg/m2. Dois protocolos (A) e (B) com intervalo de 7 dias entre eles. (A) - 20 minutos de EENM no quadríceps com frequência de 30 Hz. (B) - 20 minutos de EENM com frequência de 100 Hz. Analisado lactato, creatinafosfoquinase e desidrogenase láctica antes, imediatamente após, 6h e 48h após os protocolos. Resultados: Comparando 30 Hz vs. 100 Hz observou-se: lactato (23,7 ± 6,7 vs. 13,4 ± 3,0 mg/dL, p = 0,001); CPK (195,4 ± 116,1 vs. 262,9 ± 153,6 UI, p = 0,022); DHL (374,3 ± 64 vs. 366,6 ± 84,1 UI, ns). A percepção de eficiência contrátil diminuiu significativamente (p = 0,016) no protocolo com 100 Hz. Conclusão: Tanto a EENM de baixa frequência (30 Hz) quanto de alta frequência (100 Hz) elevam os marcadores sanguíneos de lesão muscular, sendo esta elevação, ainda mais acentuada na alta frequência. Entretanto os valores alcançados refletem uma resposta normal para um exercício de moderada intensidade

Neuromuscular electrical stimulation (NMES) is the action of therapeutic electrical stimulation on muscle tissue in order to contract the muscle and consequently improve the muscle status. Objective: To evaluate the muscle damage stemming from isometric muscle contraction induced by NMES of low frequency (30 Hz) and high frequency (100 Hz). Methods: Experimental crossover study, randomized, unblinded. The study included 10 male college students, age 24.4 ± 6.0 years, weight 77.1 ± 11.8 kg, height 176.1 ± 5.6 cm, and BMI of 24.8 ± 3 4 kg/m2. Two protocols (A) and (B) with an interval of 7 days between them. (A) - 20 minutes of NMES in the quadriceps at a frequency of 30 Hz (B) - 20 minutes of NMES at a frequency of 100 Hz. Measured lactate, creatine phosphokinase and lactate dehydrogenase before, immediately after, and 6 and 48 hours after the protocols. Results: Comparing 30 Hz vs. 100 Hz the following were observed: lactate (23.7 ± 6.7 vs. 13.4 ± 3.0 mg/dl, p = 0.001); CPK (195.4 ± 116.1 vs. 262.9 ± 153.6 IU, p = 0.022); LDH (374.3 ± 64 vs. 366.6 ± 84.1 IU, ns). The perception of contractile efficiency decreased significantly (p = 0.016) in the 100 Hz Protocol. Conclusion: Both the low-frequency NMES (30 Hz) and the high-frequency (100 Hz) elevate blood markers of muscle damage, most strikingly at the higher frequency. However, the achieved values reflect a normal response to a moderate-intensity exercise
Descritores: Músculo Esquelético/lesões
Estimulação Elétrica/instrumentação
Contração Muscular
-Epidemiologia Experimental
Creatina Quinase
Lactato Desidrogenases
Limites: Humanos
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


  5 / 8 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Lopasso, Fábio Pinatel
Texto completo
Id: lil-684438
Autor: Sayão Filho, Rogério Heggendorn; Perini, Marcos Vinicius; Cruz, José Arnaldo; Requena, Juliana; Barbeiro, Hermes Vieira; Molan, Nilza Trindade; Lopasso, Fabio Pinatel; D'Albuquerque, Luiz Augusto Carneiro; Cecconello, Ivan.
Título: Superoxid dismutase activity in portal vein endothelium after partial liver resection
Fonte: Acta cir. bras;28(9):646-651, Sept. 2013. ilus, tab.
Idioma: en.
Resumo: PURPOSE: To investigate superoxide dismutase (SOD) activity in the portal vein endothelium and malondialdehyde acid (MDA) production in liver tissue of rats submitted to 70% hepatectomy. METHODS:Twelve rats were distributed in two groups (hepatectomy and sham). Animals were sacrificed on post operative day 1 and portal vein, liver tissue and blood samples were collected. Portal vein SOD production was measured using lucigenin-amplified chemiluminescence assays. MDA measurement was used as an index of oxidative stress through the formation of TBARS (Thiobarbituric Acid Reactive Species). RESULTS: There was no difference in post operative bilirrubin, AST, ALT levels between groups. DHL level was higher in the hepatectomy group (p=0.01). MDA production in the remnant liver tissue and endothelial portal vein SOD activity were also significantly (p<0.05) elevated in the hepatectomy group when compared to control group. There was no correlation between MDA and SOD activity. SOD activity, on the other hand, showed a positive correlation with LDH level (p=0.038) and MDA levels showed a positive correlation with AST and ALT levels (p<0.001). CONCLUSION: There is an increased production of malondialdehyde acid in liver tissue after partial hepatectomy and increased activity of superoxide dismutase in portal vein endothelium as well.
Descritores: Endotélio Vascular/enzimologia
Hepatectomia/métodos
Fígado/metabolismo
Veia Porta/enzimologia
Superóxido Dismutase/metabolismo
-Alanina Transaminase/sangue
Aspartato Aminotransferases/sangue
Medições Luminescentes
Lactato Desidrogenases/sangue
Malondialdeído/análise
Malondialdeído/metabolismo
Estresse Oxidativo
Ratos Wistar
Superóxido Dismutase/análise
Substâncias Reativas com Ácido Tiobarbitúrico
Fatores de Tempo
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


  6 / 8 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: lil-680720
Autor: la Garza, Francisco Javier Guzman-de; Ibarra-Hernandez, Juan Manuel; Cordero-Perez, Paula; Villegas-Quintero, Pablo; Villarreal-Ovalle, Claudia Ivette; Torres-Gonzalez, Liliana; Oliva-Sosa, Norma Edith; Alarcon-Galvan, Gabriela; Fernandez-Garza, Nancy Esthela; Munoz-Espinosa, Linda Elsa; Camara-Lemarroy, Carlos Rodrigo; Carrillo-Arriaga, Jose Gerardo.
Título: Temporal relationship of serum markers and tissue damage during acute intestinal ischemia/reperfusion
Fonte: Clinics;68(7):1034-1038, jul. 2013. tab, graf.
Idioma: en.
Resumo: OBJECTIVE: It is essential to identify a serological marker of injury in order to study the pathophysiology of intestinal ischemia reperfusion. In this work, we studied the evolution of several serological markers after intestinal ischemia reperfusion injury in rats. The markers of non-specific cell damage were aspartate aminotransferase, alanine aminotransaminase, and lactic dehydrogenase, the markers of inflammation were tumor necrosis factor alpha, interleukin-6, and interleukin-1 beta, and the markers of intestinal mucosal damage were intestinal fatty acid binding protein and D-lactate. We used Chiús classification to grade the histopathological damage. METHODS: We studied 35 Wistar rats divided into groups according to reperfusion time. The superior mesenteric artery was clamped for 30 minutes, and blood and biopsies were collected at 1, 3, 6, 12, 24, and 48 hours after reperfusion. We plotted the mean ± standard deviation and compared the baseline and maximum values for each marker using Student's t-test. RESULTS: The maximum values of interleukin-1 beta and lactic dehydrogenase were present before the maximal histopathological damage. The maximum tumor necrosis factor alpha and D-lactate expressions coincided with histopathological damage. Alanine aminotransaminase and aspartate aminotransferase had a maximum expression level that increased following the histopathological damage. The maximum expressions of interluken-6 and intestinal fatty acid binding protein were not significantly different from the Sham treated group. CONCLUSION: For the evaluation of injury secondary to acute intestinal ischemia reperfusion with a 30 minute ischemia period, we recommend performing histopathological grading, quantification of D-lactate, which is synthesized by intestinal bacteria and is considered an indicator of mucosal injury, and quantification of tumor necrosis ...
Descritores: Biomarcadores/sangue
Intestinos/irrigação sanguínea
Traumatismo por Reperfusão/sangue
-Aspartato Aminotransferases/sangue
Biópsia
Citocinas/sangue
Modelos Animais de Doenças
Proteínas de Ligação a Ácido Graxo/sangue
Intestinos/patologia
Lactato Desidrogenases/sangue
Ratos Wistar
Valores de Referência
Fatores de Tempo
Limites: Animais
Feminino
Ratos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


  7 / 8 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
Id: lil-652540
Autor: Aranda Torrelio, Eduardo.
Título: Educación medica continua: interpretación de la deshidrogenasa láctica / Continuing medical education: interpretation of lactate dehydrogenase
Fonte: Rev. Soc. Boliv. Pediatr;49(2):132-134, 2010.
Idioma: es.
Resumo: Las enzimas generadas durante el metabolismo celular pueden modificar sus concentraciones frente a diversosfenómenos fisiopatológicos, siendo así válida su cuantificación en suero para precisar ciertos diagnósticos.
Descritores: L-Lactato Desidrogenase
Lactato Desidrogenases
Responsável: BO2.1 - Centro de Información y Documentación


  8 / 8 LILACS  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: lil-436887
Autor: Konstantinos, Stamatiou; Alevizos, Alevizos; Anargiros, Mariolis; Constantinos, Mihas; Athanase, Halazonitis; Konstantinos, Bovis; Michail, Eleftherios; Fragiskos, Sofras.
Título: Association between testicular microlithiasis, testicular cancer, cryptorchidism and history of ascending testis
Fonte: Int. braz. j. urol;32(4):434-439, July-Aug. 2006. ilus.
Idioma: en.
Resumo: OBJECTIVE: To prospectively determine the prevalence of testicular microlithiasis in symptomatic patients who were referred for scrotal ultrasound examination and to evaluate the possible association of testicular microlithiasis with testicular cancer and other conditions such as cryptorchidism or history of ascending testis. MATERIALS AND METHODS: 391 men who were referred to our institutions between July 2002 and May 2005 for any type of symptoms from the testicles, underwent physical and scrotal ultrasound examination. The presence of testicular microlithiasis, the number of lesions and the involvement of both testicles in relation to the symptoms as well as the coexistence of other lesions were studied. RESULTS: Eighteen (4.6 percent) of 391 men enrolled into the study had testicular microlithiasis. Two out of the eighteen patients (11 percent) had concomitant testicular cancer, which was confirmed by pathological evaluation of the orchidectomy specimen. One of the patients with testicular microlithiasis presented a rising in biochemical tumor markers (LDH, and HCG) and underwent orchidectomy one year later. Five of the remaining 373 (1.3 percent) patients without microlithiasis were diagnosed with testicular cancer. Thirty six men reported having a history of ascending testis, but none of them was found with testicular cancer. Two cases of testicular torsion in a cryptorchid position had testicular microlithiasis, but the orchidectomy specimen (after surgery) was negative for testicular cancer. The correlation between testicular cancer and testicular microlithiasis found in our study was statistically significant (p < 0.05). CONCLUSION: There seems to be an association between testicular microlithiasis and testicular cancer.
Descritores: Criptorquidismo/complicações
Litíase/complicações
Escroto
Neoplasias Testiculares/complicações
-Gonadotropina Coriônica/análise
Criptorquidismo/epidemiologia
Criptorquidismo
Lactato Desidrogenases/análise
Litíase/epidemiologia
Litíase
Orquiectomia
Prevalência
Estudos Prospectivos
Escroto
Doenças Testiculares/complicações
Doenças Testiculares/epidemiologia
Doenças Testiculares
Neoplasias Testiculares
Biomarcadores Tumorais/análise
Limites: Adulto
Idoso
Humanos
Masculino
Pessoa de Meia-Idade
Responsável: BR1.1 - BIREME



página 1 de 1
   


Refinar a pesquisa
  Base de dados : Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde