||WILHELM, ETHEL A; FERREIRA, ANA TERESINHA; PINZ, MIKAELA P; REIS, ANGÉLICA S DOS; VOGT, ANE G; STEIN, ANDRE L; ZENI, GILSON; LUCHESE, CRISTIANE.|
||Antioxidant effect of quinoline derivatives containing or not selenium: Relationship with antinociceptive action quinolines are antioxidant and antinociceptive|
||An. acad. bras. ciênc;89(1,supl):457-467, May. 2017. graf.
||Universidade Federal de Pelotas, Universidade Federal de Santa Maria, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (FAPERGS)/CNPq (PRONEX).
||ABSTRACT The present study investigated the antioxidant effect of a new class of quinoline derivatives (a-d) on assays in vitro. Lipid peroxidation, thiol peroxidase-like and free radical scavenging activities were determined to evaluate antioxidant activity of compounds. Thiol oxidase-like and δ-aminolevulinate dehydratase activities were performed as a toxicological parameter. A second objective of this study was to evaluate the in vivo antinociceptive effect of the compound with better antioxidant effect and without toxic effects in a model of nociception induced by formalin in mice. In liver, at 100 µM, compound a reduced the lipid peroxidation to the control levels, while compounds c and d partially reduced it. In brain, only compound d partially reduced the lipid peroxidation at 50 and 100 µM. Compound b did not have an effect on the lipid peroxidation. Thiol peroxidase-like and free radical scavenging activities are not involved in the antioxidant mechanisms of these compounds. Compounds did not present thiol oxidase-like activity and effect on the δ-aminolevulinate dehydratase. In vivo experiments showed that compound a caused an inhibition of licking time in the first and second phases, and edema formation induced by formalin. In conclusion, quinoline derivative without selenium presented better in vitro antioxidant effect and in vivo antinociceptive activity.|
Estresse Oxidativo/efeitos dos fármacos
Medição da Dor
Sequestradores de Radicais Livres
Modelos Animais de Doenças
Oxirredutases atuantes sobre Doadores de Grupo Enxofre/farmacologia
Sintase do Porfobilinogênio/farmacologia
||BR1.1 - BIREME|