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Id: biblio-1253101
Autor: Tsai, Wen-Che; Chang, Hung-Chi; Yin, Hsin-Yi; Huang, Meng-Chieh; Chandra Agrawal, Dinesh; Wen, Hsiao-Wei.
Título: The protective ability and cellular mechanism of Koelreuteria henryi Dummer flower extract against hydrogen peroxide-induced cellular oxidative damage
Fonte: Electron. j. biotechnol;47:89-99, sept. 2020. ilus, tab, graf.
Idioma: en.
Resumo: BACKGROUND: Koelreuteria henryi Dummer is an indigenous plant in Taiwan. The species has been used in traditional folk medicine for the promotion of liver functions and for treating malaria and urethritis. The present study investigated the antioxidant activity of the flower extract of Koelreuteria henryi Dummer. The extraction conditions were optimized by the contents of total phenolic acids and total flavonoids, and antioxidant activity assays. Moreover, an in vitro study for investigating antioxidant activity of K. henryi flower extract was demonstrated by hydrogen peroxide (H2O2)-induced apoptosis. RESULTS: K. henryi flower extracted for 150 min showed high contents of total phenolic acids and total flavonoids. In an in vitro model, L929 cells were pretreated with K. henryi flower extract, and then treated with H2O2 to induce oxidative damage. Results demonstrated that H2O2-induced apoptosis was inhibited by the treatment of 200 µg/ml K. henryi flower extract through the mitochondria-mediated pathway and mitogen-activated protein kinase (MAPK) pathway. The caspase 8/9 activity and expression of p-p38 and pERK were repressed by K. henryi flower extract. In addition, the prevention of H2O2-induced apoptosis by K. henryi flower extract activated the nuclear factor-erythroid 2-related factor (Nrf2) stress response pathway to transcript heme oxygenase 1 (HO-1). Also, K. henryi flower extract prevented H2O2-induced apoptosis through HO-1 production, as evident by the use of HO-1 inhibitor. CONCLUSIONS: The present study demonstrated that K. henryi flower extract could inhibit the H2O2-induced apoptosis in L929 cells through the activation of the Nrf2/HO-1 pathway.
Descritores: Extratos Vegetais/farmacologia
Estresse Oxidativo/efeitos dos fármacos
Sapindaceae/química
Antioxidantes/farmacologia
-Flavonoides/análise
Western Blotting
Apoptose
Flores/química
Heme Oxigenase-1
Fator 2 Relacionado a NF-E2
Caspase 8
Peróxido de Hidrogênio
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1054682
Autor: Li, Yanze; Wang, Lei; Chen, Zhiyuan; Liu, Xiuheng.
Título: Picroside II attenuates ischemia/reperfusion testicular injury by alleviating oxidative stress and apoptosis through reducing nitric oxide synthesis
Fonte: Acta cir. bras;34(11):e201901102, Nov. 2019. tab, graf.
Idioma: en.
Projeto: Application and Basic Research Project of Wuhan City; . Wuhan Morning Light Plan of Youth Science and Technology; . Natural Science Foundation of Hubei Province; . Research Project of Wuhan University.
Resumo: Abstract Purpose: To investigate the effect of Picroside II on testicular ischemia and reperfusion (l/R) injury and the underlying mechanism. Methods: Sprague-Dawley rats were randomly divided into 4 groups: sham operated group (Sham), Sham with Picroside II treatment group (Sham+ Pic II), l/R group (l/R) and l/R with Picroside II treatment group (I/R+ Pic II). l/R model was established by rotating the left testis 720° in a clock-wise direction for 4 hours. The histopathologic and spermatogenetic evaluation was performed. The apoptosis changes and the levels of HO-1 (heme oxygenase-1), MPO (myeloperoxidase), NOX (NADPH oxidase), SOD (superoxide dismutase), XO (xanthine oxidase) and NOS (nitric oxide synthase) were measured. Results: The seminiferous tubules were damaged in l/R rats, but Picroside II alleviated the changes induced by l/R. The increased level of apoptosis was decreased by Picroside II (P=0.01, 9.05±0.35 vs. 4.85±0.25). The activities of HO-1, MPO, NOX, XO and MDA content were increased and the SOD activity was decreased in l/R (P<0.05) and could be reversed by Picroside II (P=0.03, 405.5±7.5 vs. 304±17U/mgprot; P=0.02, 0.99±0.05 vs. 0.52±0.04 mgprot; P=0.01, 260+7 vs. 189±2 mgprot; P=0.04, 10.95+0.55 vs. 8.75+0.35 U/mgprot; P=0.045, 6.8+0.7 vs. 3.75+0.35 mgprot; P=0.04, 44.5+3.5 vs. 57.5+3.5 mgprot). Western blot showed that the expression of iNOS, nNOS and eNOS were increased in l/R (P<0.05); however, they were decreased after Picroside II treatment (P<0.05). Conclusion: Picroside II attenuated testicular I/R injury in rats mainly through suppressing apoptosis and oxidative stress through reduction of nitric oxide synthesis.
Descritores: Testículo/irrigação sanguínea
Traumatismo por Reperfusão/prevenção & controle
Cinamatos/farmacologia
Apoptose/efeitos dos fármacos
Estresse Oxidativo/efeitos dos fármacos
Glucosídeos Iridoides/farmacologia
Óxido Nítrico/biossíntese
-Traumatismo por Reperfusão/metabolismo
Traumatismo por Reperfusão/patologia
Distribuição Aleatória
Western Blotting
Ratos Sprague-Dawley
Peroxidase/análise
Marcação In Situ das Extremidades Cortadas
Heme Oxigenase-1/análise
Malondialdeído/análise
NADP/análise
Limites: Animais
Masculino
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


  3 / 18 LILACS  
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Id: biblio-886273
Autor: Tan, Zelong; Wang, Huaizhou; Sun, Jing; Li, Mingsheng.
Título: Effects of propofol pretreatment on lung morphology and heme oxygenase-1 expression in oleic acid-induced acute lung injury in rats
Fonte: Acta cir. bras;33(3):250-258, Mar. 2018. tab, graf.
Idioma: en.
Resumo: Abstract Purpose: To investigate the effects of propofol pretreatment on lung morphology and heme oxygenase-1 expression in oleic acid -induced acute lung injury in rats. Methods: A total of 32 male Sprague-Dawley rats (250-300g) were randomly divided into the following four groups (n=8/group): group C, group OA, group OA+PR, and group OA+IX to compare related parameter changes. Results: PaO2, PCO2, and PaO2/FiO2 were significantly different among the four treatment groups (P<0.05 or P<0.01). Lung wet/dry weight ratio and HO-1 protein expression also significantly differed among the groups (P<0.01). Immunohistochemistry showed that the expression of HO-1 in group OA+PR was stronger than those in groups OA, OA+IX, and C. Light microscopy revealed that pathological changes in lung tissues in group OA+PR were milder than those in group OA and group OA+IX. Electron microscopy showed that alveolar type II epithelial cell ultrastructure in group OA was relatively irregular with cell degeneration and disintegration and cytoplasmic lamellar bodies were vacuolized. Changes in group OA+PR were milder than those in group OA; however, they were more severe in group OA+IX than in group OA. Conclusion: Propofol significantly increases the expression of HO-1 in the lung tissueand prevents changes in lung morphology due to ALI in rats.
Descritores: Propofol/farmacologia
Heme Oxigenase-1/metabolismo
Lesão Pulmonar Aguda/tratamento farmacológico
Pulmão/efeitos dos fármacos
-Imuno-Histoquímica
Distribuição Aleatória
Ratos Sprague-Dawley
Ácido Oleico
Lesão Pulmonar Aguda/induzido quimicamente
Lesão Pulmonar Aguda/metabolismo
Pulmão/enzimologia
Pulmão/ultraestrutura
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


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Id: biblio-1001090
Autor: Li, Hongxia; Liu, Bofeng; Gu, Chunyan; Zeng, Xiao; Liu, Yali; Zhang, Susu; Gong, Haiye; Shao, Yong; Yao, Zhenwei; An, Ruifang.
Título: Relations of neuropeptide Y and heme oxygenase-1 expressions with fetal brain injury in rats with intrahepatic cholestasis of pregnancy
Fonte: Acta cir. bras;34(4):e201900401, 2019. tab, graf.
Idioma: en.
Projeto: Education Department of Shaanxi Provincial Government; . Yan'an Science and Technology People-benefit Project; . Research Project of Postgraduate Education and Teaching Reform Project in Yan'an University.
Resumo: Abstract Purpose: To investigate the relations of neuropeptide Y (NPY) and heme oxygenase-1 (HO-1) expressions with fetal brain injury in rats with intrahepatic cholestasis of pregnancy (ICP). Methods: Sixty rats pregnant for 15 days were randomly divided into experimental and control groups. The ICP model was established in experimental group. On the 21st day, the blood biochemical test, histopathological examination of pregnant rat liver and fetal brain tissues and immunohistochemical analysis of fetal rat brain tissues were performed. Results: On the 21st day, the alanineaminotransferase, aspartate aminotransferase and total bile acid levels in experimental group were significantly higher than control group (P<0.01). Compared with control group, there was obvious vacuolar degeneration in pregnant rat liver tissue and fetal brain tissue in experimental group. NPY expression in fetal brain tissue was negative in control group and positive in experimental group. HO-1 expression in fetal brain tissue was strongly positive in control group and positive in experimental group. There was significant difference of immunohistochemical staining optical density between two groups (P<0.01). Conclusion: In fetal brain of ICP rats, the NPY expression is increased, and the HO-1 expression is decreased, which may be related to the fetal brain injury.
Descritores: Complicações na Gravidez/metabolismo
Neuropeptídeo Y/metabolismo
Lesões Encefálicas/metabolismo
Colestase Intra-Hepática/metabolismo
Heme Oxigenase-1/metabolismo
-Complicações na Gravidez/patologia
Lesões Encefálicas/etiologia
Lesões Encefálicas/patologia
Imuno-Histoquímica
Colestase Intra-Hepática/complicações
Colestase Intra-Hepática/patologia
Ratos Sprague-Dawley
Modelos Animais de Doenças
Limites: Animais
Feminino
Gravidez
Ratos
Responsável: BR1.1 - BIREME


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Id: biblio-971959
Autor: Magalhães, Patrícia Andréa da Fonseca.
Título: Acidose metabólica agrava a lesão renal em modelo experimental de isquemia/reperfusão.
Fonte: Fortaleza; s.n; 2016. 110 p. ilus, tab.
Idioma: pt.
Tese: Apresentada a Universidade Federal do Ceará para obtenção do grau de Doutor.
Resumo: Lesão renal por isquemia/reperfusão (I/R) e acidose metabólica (AM) são duascondições críticas que ocorrem frequentemente na prática clínica. O resultado dessacombinação pode ser prejudicial para os rins, mas esta questão não tem sidoexaustivamente estudada até hoje. O presente estudo avaliou em ratos a influênciado baixo pH sistêmico em vários parâmetros da função renal mediante lesão renalpor I/R. A acidose metabólica foi induzida em ratos Wistar machos através daingestão de cloreto de amônio (NH4CI) dissolvido na água de beber, iniciando 2 diasantes da indução de lesão renal por isquemia/reperfusão e mantida durante todo oestudo. Isquemia/reperfusão renal foi induzida por clampeamento bilateral dasartérias renais durante 45 min, seguido por 48 h de reperfusão. Ao final do estudo,foram obtidas amostras de sangue arterial, urina e tecido renal. Os animais foramdivididos em quatro grupos: controle (submetido à cirurgia sham, n = 8), I/R (n = 8),acidose metabólica (AM; solução de NH4CI 0,28 M + cirurgia sham, n = 6), e AM+I/R(solução de NH4CI 0,28 M + I/R, n = 9). Em comparação com grupo I/R, ratosAM+I/R apresentaram maior mortalidade (50% vs. 11%), redução significativa de pHsanguíneo (7,00 ± 0,04 vs. 7,35 ± 0,03), bicarbonato plasmático (pBic; 9,0 ± 1,4 vs.21,4 ± 0,9 mmol/L), e excesso de base (SBE; -23,8 ± 1,5 vs. -2,7 ± 0,9 mmol/L), comdeclínio no ritmo de filtração glomerular (0,05 ± 0,02 vs. 0,14 ± 0,03 mL/min/100 g) efunção tubular...

Ischemia/reperfusion (I/R) injury and metabolic acidosis (MA) are two criticalconditions that frequently occur in the clinical practice. The result of this combinationcan be harmful to the kidneys, but this issue has not been thoroughly investigatedhitherto. The present study evaluated the influence of low systemic pH on severalkidney function parameters in rats subjected to experimental model of renal I/Rinjury. Metabolic acidosis was induced in male Wistar rats by ingesting ammoniumchloride (NH4Cl) in tap water, beginning 2 days before ischemic insult and maintainedduring the entire study. Ischemia/reperfusion was induced by clamping both renalarteries for 45 min, followed by 48 h of reperfusion. At the end of the study, arterialblood samples and urine were collected and left kidneys were harvested. Fourgroups were studied: control (subjected to sham surgery, n = 8), I/R (n = 8),metabolic acidosis (MA; 0.28 M NH4Cl solution and sham surgery, n = 6), andMA+I/R (0.28 M NH4Cl solution plus I/R, n = 9). Compared with I/R rats, MA+I/R ratsexhibited higher mortality (50% vs. 11%), significant reduction of blood pH (7.00 ±0.04 vs. 7.35 ± 0.03), plasma bicarbonate (pBic; 9.0 ± 1.4 vs. 21.4 ± 0.9 mmol/L), andstandard base excess (SBE; -23.8 ± 1.5 vs. -2.7 ± 0.9 mmol/L), with a severe declinein the glomerular filtration rate (0.05 ± 0.02 vs. 0.14 ± 0.03 mL/min/100 g) and tubularfunction. In addition, tubular changes were more intense determining higher scores oftubular injury...
Descritores: Cetose
Heme Oxigenase-1
NF-kappa B
Injúria Renal Aguda
Limites: Humanos
Responsável: BR6.1 - BCS - Biblioteca de Ciências da Saúde
BR6.1


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Id: biblio-839320
Autor: Gao, XY; Zhou, XF; Wang, H; Lv, N; Liu, Y; Guo, JR.
Título: Effects of heme oxygenase-1 recombinant Lactococcus lactis on the intestinal barrier of hemorrhagic shock rats
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;50(7):e5601, 2017. graf.
Idioma: en.
Projeto: Outstanding Leaders Training Program of Pudong Health Bureau of Shanghai; . Key Disciplines Group Construction Project of Pudong Health Bureau of Shanghai.
Resumo: This study aimed to investigate the effects of heme oxygenase-1 recombinant Lactococcus lactis (LL-HO-1) on the intestinal barrier of rats with hemorrhagic shock. One hundred Sprague-Dawley male rats (280–320 g) were randomly divided into healthy control group (N group) and hemorrhagic shock group (H group). Each group was subdivided into HO1t, HO2t, HO3t, PBS and LL groups in which rats were intragastrically injected with LL-HO-1 once, twice and three times, PBS and L. lactis (LL), respectively. The mortality, intestinal myeloperoxidase (MPO) activity, intestinal contents of TNF-α, IL-10 and HO-1, and intestinal Chiu's score were determined. Results showed that in N group, the HO-1 content increased after LL-HO-1 treatment, and significant difference was observed in HO1t group and HO2t group (P<0.05). In H groups, MPO activity and Chiu's score decreased, but IL-10 content increased in LL-HO-1-treated groups when compared with PBS and LL groups (P<0.05). When compared with N group, the MPO activity reduced dramatically in LL-HO-1-treated groups. Thus, in healthy rats (N group), intragastrical LL-HO-1 treatment may increase the intestinal HO-1 expression, but has no influence on the intestinal barrier. In hemorrhagic shock rats, LL-HO-1 may significantly protect the intestinal barrier, and repeating the intragastrical LL-HO-1 treatments twice has the most obvious protection.
Descritores: Heme Oxigenase-1/uso terapêutico
Lactococcus lactis
Choque Hemorrágico/prevenção & controle
-Modelos Animais de Doenças
Mucosa Intestinal/metabolismo
Mucosa Intestinal/patologia
Distribuição Aleatória
Ratos Sprague-Dawley
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


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Id: lil-769829
Autor: Mendonça, Vitor R de; Barral-Netto, Manoel.
Título: Immunoregulation in human malaria: the challenge of understanding asymptomatic infection
Fonte: Mem. Inst. Oswaldo Cruz;110(8):945-955, Dec. 2015. graf.
Idioma: en.
Projeto: FIOCRUZ; . CNPq.
Resumo: Asymptomatic Plasmodium infection carriers represent a major threat to malaria control worldwide as they are silent natural reservoirs and do not seek medical care. There are no standard criteria for asymptomaticPlasmodium infection; therefore, its diagnosis relies on the presence of the parasite during a specific period of symptomless infection. The antiparasitic immune response can result in reducedPlasmodium sp. load with control of disease manifestations, which leads to asymptomatic infection. Both the innate and adaptive immune responses seem to play major roles in asymptomatic Plasmodiuminfection; T regulatory cell activity (through the production of interleukin-10 and transforming growth factor-β) and B-cells (with a broad antibody response) both play prominent roles. Furthermore, molecules involved in the haem detoxification pathway (such as haptoglobin and haeme oxygenase-1) and iron metabolism (ferritin and activated c-Jun N-terminal kinase) have emerged in recent years as potential biomarkers and thus are helping to unravel the immune response underlying asymptomatic Plasmodium infection. The acquisition of large data sets and the use of robust statistical tools, including network analysis, associated with well-designed malaria studies will likely help elucidate the immune mechanisms responsible for asymptomatic infection.
Descritores: Infecções Assintomáticas
Antígenos de Protozoários/imunologia
Portador Sadio/imunologia
Malária Falciparum/imunologia
Malária Vivax/imunologia
Plasmodium/imunologia
-Imunidade Adaptativa/fisiologia
Biomarcadores
Portador Sadio/parasitologia
Reservatórios de Doenças/parasitologia
Ferritinas/imunologia
Haptoglobinas/imunologia
Heme Oxigenase-1/imunologia
Imunidade Inata/fisiologia
/imunologia
INTERLEUKIN-ABDUCENS NERVE/imunologia
Proteínas Quinases JNK Ativadas por Mitógeno/imunologia
Malária Falciparum/prevenção & controle
Malária Vivax/prevenção & controle
Parasitemia/imunologia
Plasmodium/isolamento & purificação
Fator de Crescimento Transformador beta/imunologia
Limites: Humanos
Tipo de Publ: Research Support, Non-U.S. Gov't
Revisão
Responsável: BR1.1 - BIREME


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Id: lil-756636
Autor: Silva, João Alfredo de Moraes Gomes.
Título: Modulação redox da homeostase de células musculares lisas através de estimuladores do sistema NADPH oxidase / Redox modulation of smooth muscle cells homeostasis via inductors of NADPHoxidase system.
Fonte: Rio de Janeiro; s.n; 2011. 108 f p.
Idioma: pt.
Tese: Apresentada a Universidade do Estado do Rio de Janeiro - Instituto de Biologia Roberto Alcântara Gomes para obtenção do grau de Doutor.
Resumo: As doenças cardiovasculares representam a principal causa de morte nos países ocidentais. Dentre essas doenças, a aterosclerose é que mais se destaca, sendo caracterizada pelo acúmulo de células musculares lisas vasculares (CMLV). O efeito patológico das CMLV em resposta a diferentes estímulos pode acarretar em disfunções nestas células. É notável que a aterosclerose ocorra principalmente em vasos sinuosos onde ocorre um forte turbilhonamento do fluxo sanguíneo, que pode acarretar em hemólise e, consequentemente, acúmulo de heme livre. Além disso, no processo de aterogênese as moléculas de adesão, principalmente integrinas, são de crucial importância durante a resposta de CMLV. Nesse trabalho nosso objetivo inicial foi avaliar o efeito do heme livre nas funções de CMLV, bem como os mecanismos moleculares por trás desses efeitos. Em uma segunda parte, investigamos o envolvimento da integrina α1ß1 no efeito da Angiotensina II (Ang II) em CMLV. Nós observamos que o heme livre é capaz de induzir a proliferação e migração de CMLV via espécies reativas de oxigênio (ERO) provenientes da NADPHoxidase (NADPHox). Adicionalmente vimos que o heme ativa vias de sinalização redox-sensíveis relacionadas à proliferação celular, como MAPKinases e o fator de transcrição NFκB. Também observamos que há uma ligação entre a NADPHox e o sistema heme oxigenase (HO), uma vez que o heme induz a expressão de HO-1 e o pré-tratamento das CMLV com inibidores de HO levam ao aumento tanto o efeito proliferação quanto a indução de ERO promovidas pelo heme. Além disso, vimos que o efeito contra-regulatório promovido pela HO ocorre devido as metabolites do heme: biliverdina, bilirrubina e monóxido de carbono. Por último, quando bloqueamos tanto a NADPHox quanto o sistema HO o heme não teve efeito algum na proliferação de CMLV...

Cardiovascular diseases represent the major mortality reason in western countries. Among these diseases, atherosclerosis is the most prominent one, which is characterized by vascular smooth muscle cell (VSMC) accumulation. The pathological effect of VSMC in response to different stimuli is able to induce VSMC dysfunctions. Notably, this cardiovascular disease occurs mainly in sinuous vessels with turbulent blood flow, which may lead to hemolysis and consequent free heme accumulation. Furthermore, in atherogenesis the adhesion molecule, mainly integrins, were of crucial importance during the VSMC response. In this work our aim was to elucidate the effect of free heme in VSMC, as well the molecular mechanisms underlying this process. In a second part, we investigated the role of α1ß1 integrin in Angiotensin II (Ang II) effect on VSMC. We observed that free heme is able to induce VSMC proliferation in a Reactive Oxygen Species (ROS) derived from NADPHoxidase (NADPHox) dependent manner. Additionally, heme activates proliferation-relationed redox-sensitive signaling routes, such as MAPKinases and the transcription factor NFκB. It was also observed a critical crosstalk between NADPHox and heme oxygenase (HO) system, once heme induces HO-1 expression and VSMC pretreatment with HO inhibitors increased heme proliferative effect and ROS production. Accordingly, we observed that the counter-regulatory effect promoted by HO occurs due heme metabolites: biliverdin, bilirubin and carbon monoxide. Finally, when both NADPHox and HO system were blocked, heme had no effect on VSMC proliferation...
Descritores: Aterosclerose/patologia
Doenças Cardiovasculares/fisiopatologia
Heme
Homeostase
Músculo Liso Vascular/fisiopatologia
NADP
-Modulação Antigênica
Aterosclerose/prevenção & controle
Heme Oxigenase-1
Integrinas/fisiologia
Músculo Liso Vascular/citologia
Limites: Humanos
Responsável: BR1365.1 - Biblioteca Biomédica A - CB/A


  9 / 18 LILACS  
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Id: lil-749647
Autor: Jiang, Guanjun; Liu, Xiuheng; Wang, Min; Chen, Hui; Chen, Zhiyuan; Qiu, Tao.
Título: Oxymatrine ameliorates renal ischemia-reperfusion injury from oxidative stress through Nrf2/HO-1 pathway
Fonte: Acta cir. bras;30(6):422-429, 06/2015. graf.
Idioma: en.
Resumo: PURPOSE: To investigate if oxymatrine pretreatment could ameliorate renal I/R injury induced in rats and explore the possible role of oxymatrine in Nrf2/HO-1 pathway. METHODS: Unilaterally nephrectomized rats were insulted by I/R in their left kidney. Twenty four rats were randomly divided into three groups: sham group, I/R + saline-treated group, I/R + OMT-treated group. Oxymatrine or vehicle solution was administered intraperitoneally injected 60 min before renal ischemia, respectively. Renal function, histology, makers of oxidative stress, cell apoptosis and Nrf2/HO-1 expressions were assessed. RESULTS: Oxymatrine pretreatment exhibited an improved renal functional recovery, alleviated histological injury and oxidative stress, inhibiting tubular apoptosis, and accompanied by upregulated the expression of Nrf2/HO-1 proteins. CONCLUSION: Oxymatrine may attenuate renal ischemia/reperfusion injury, and this renoprotective effect may be through activating the Nrf2/HO-1 pathway. .
Descritores: Alcaloides/farmacologia
Antioxidantes/farmacologia
Heme Oxigenase-1/metabolismo
Rim/irrigação sanguínea
/metabolismo
NF-ETEMEFOS-RELATED FACTOR TEMEFOS/metabolismo
Estresse Oxidativo/efeitos dos fármacos
Quinolizinas/farmacologia
Traumatismo por Reperfusão/prevenção & controle
-Alcaloides/uso terapêutico
Antioxidantes/uso terapêutico
Apoptose/efeitos dos fármacos
Western Blotting
Modelos Animais de Doenças
Heme Oxigenase-1/análise
Imuno-Histoquímica
Marcação In Situ das Extremidades Cortadas
Rim/patologia
/análise
NF-ETEMEFOS-RELATED FACTOR TEMEFOS/análise
Quinolizinas/uso terapêutico
Distribuição Aleatória
Ratos Sprague-Dawley
Reprodutibilidade dos Testes
Traumatismo por Reperfusão/metabolismo
Traumatismo por Reperfusão/patologia
Fatores de Tempo
Resultado do Tratamento
Limites: Animais
Masculino
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Id: lil-744832
Autor: Ventura, Miriam; Simas, Luciana; Larouzé, Bernard.
Título: Maternidade atrás das grades: em busca da cidadania e da saúde. Um estudo sobre a legislação brasileira / Motherhood behind bars: the struggle for citizens' rights and health for women inmates and their children in Brazil / La maternidad entre rejas: en búsqueda de la ciudadanía y de la salud. Un estudio sobre la legislación brasileña
Fonte: Cad. saúde pública = Rep. public health;31(3):607-619, 03/2015. tab.
Idioma: pt.
Resumo: Este estudo analisa as conexões entre saúde, direitos, legislação e políticas públicas a partir da pesquisa documental realizada no âmbito federal e nos estados do Rio Grande do Sul, Mato Grosso, Paraná e São Paulo, acerca das garantias legais das mulheres e seus filhos que vivem no cárcere. Busca instrumentalizar uma atuação garantista dos agentes públicos e dar visibilidade à problemática, diante das extremas vulnerabilidades e invisibilidade jurídica e administrativa da questão. Foram identificadas 33 normas legais, com pontos de tensão, como a possibilidade de prisão domiciliar e as disparidades quanto a prazos e condições de permanência das crianças no sistema penitenciário. A garantia legal constitucional do direito à amamentação é refletida nas regulamentações identificadas. Mas constatam-se ausências de outros aspectos relativos à maternidade na prisão, que se traduzem em dupla penalidade às mulheres, arbitrariamente estendida aos seus filhos. É necessária a ampliação e efetivação da regulamentação existente para prevenir e coibir as violações de direitos apontadas.

This study analyzes the links between health, rights, legislation, and public policies based on document research on legal safeguards for women and their children residing in prison. The research was conducted at the Federal level and in four States of Brazil: Rio Grande do Sul, Mato Grosso, Paraná, and São Paulo. The study aims to back measures by public agencies to guarantee such rights and to raise awareness of the problem, given the extreme vulnerability of women inmates and their children and the issue's legal and administrative invisibility. The authors identified 33 different legal provisions as points of tension, such as the possibility of house arrest and disparities in the terms and conditions for children to remain inside the prison system. Various provisions cite the Constitutional guarantee of women inmates' right to breastfeed in prison. Meanwhile, the study found gaps in other issues pertaining to motherhood in prison, expressed as dual incarceration (imprisonment arbitrarily extended to their children). It is necessary to expand and enforce the existing legislation to prevent such violations of rights.

Este estudio analiza las conexiones entre la salud, derechos humanos, legislación y políticas públicas, partiendo de una investigación documental, realizada a nivel federal y en los estados de Río Grande do Sul, Mato Grosso, Paraná y São Paulo, sobre las garantías jurídicas de las mujeres presas y sus hijos. El estudio pretende instrumentalizar una actuación garantista de los agentes públicos y dar visibilidad a esta problemática, frente a la extrema vulnerabilidad e invisibilidad jurídica y administrativa existente. Se identificaron 33 normas legales, con puntos de tensión, como la posibilidad de arresto domiciliario y disparidades en cuanto a los términos y condiciones de la estancia de los niños en el sistema penitenciario. La garantía constitucional del derecho a la lactancia materna se refleja en las regulaciones identificadas. No obstante, hay ausencias de otros aspectos de la maternidad en la cárcel, que se traduce en una doble pena para las mujeres, extendida arbitrariamente a sus hijos. Es necesaria la ampliación y ejecución efectiva de las regulación existente para prevenir y frenar las violaciones de los derechos.
Descritores: Endotélio Vascular/metabolismo
Heme Oxigenase-1/química
Inibidores de Hidroximetilglutaril-CoA Redutases/farmacologia
-Adenoviridae/metabolismo
Fenômenos Biomecânicos
Endotélio Vascular/citologia
Heme Oxigenase-1/metabolismo
Peróxido de Hidrogênio/química
Inibidores de Hidroximetilglutaril-CoA Redutases/química
MICE, INBRED CABDOMENABDOMINAL INJURIESBL
/metabolismo
NF-ETEMEFOS-RELATED FACTOR TEMEFOS/metabolismo
Estresse Oxidativo
Fosforilação
RNA Interferente Pequeno/metabolismo
Estresse Mecânico
Limites: Animais
Humanos
Camundongos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME



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