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Id: biblio-951812
Autor: Santos, Alexandra de Andrade; Silveira, Joaquim Albenísio Gomes da; Bonifacio, Aurenivia; Rodrigues, Artenisa Cerqueira; Figueiredo, Márcia do Vale Barreto.
Título: Antioxidant response of cowpea co-inoculated with plant growth-promoting bacteria under salt stress
Fonte: Braz. j. microbiol;49(3):513-521, July-Sept. 2018. tab, graf.
Idioma: en.
Resumo: Abstract Soil salinity is an important abiotic stress worldwide, and salt-induced oxidative stress can have detrimental effects on the biological nitrogen fixation. We hypothesized that co-inoculation of cowpea plants with Bradyrhizobium and plant growth-promoting bacteria would minimize the deleterious effects of salt stress via the induction of enzymatic and non-enzymatic antioxidative protection. To test our hypothesis, cowpea seeds were inoculated with Bradyrhizobium or co-inoculated with Bradyrhizobium and plant growth-promoting bacteria and then submitted to salt stress. Afterward, the cowpea nodules were collected, and the levels of hydrogen peroxide; lipid peroxidation; total, reduced and oxidized forms of ascorbate and glutathione; and superoxide dismutase, catalase and phenol peroxidase activities were evaluated. The sodium and potassium ion concentrations were measured in shoot samples. Cowpea plants did not present significant differences in sodium and potassium levels when grown under non-saline conditions, but sodium content was strongly increased under salt stress conditions. Under non-saline and salt stress conditions, plants co-inoculated with Bradyrhizobium and Actinomadura or co-inoculated with Bradyrhizobium and Paenibacillus graminis showed lower hydrogen peroxide content in their nodules, whereas lipid peroxidation was increased by 31% in plants that were subjected to salt stress. Furthermore, cowpea nodules co-inoculated with Bradyrhizobium and plant growth-promoting bacteria and exposed to salt stress displayed significant alterations in the total, reduced and oxidized forms of ascorbate and glutathione. Inoculation with Bradyrhizobium and plant growth-promoting bacteria induced increased superoxide dismutase, catalase and phenol peroxidase activities in the nodules of cowpea plants exposed to salt stress. The catalase activity in plants co-inoculated with Bradyrhizobium and Streptomyces was 55% greater than in plants inoculated with Bradyrhizobium alone, and this value was remarkably greater than that in the other treatments. These results reinforce the beneficial effects of plant growth-promoting bacteria on the antioxidant system that detoxifies reactive oxygen species. We concluded that the combination of Bradyrhizobium and plant growth-promoting bacteria induces positive responses for coping with salt-induced oxidative stress in cowpea nodules, mainly in plants co-inoculated with Bradyrhizobium and P. graminis or co-inoculated with Bradyrhizobium and Bacillus.
Descritores: Cloreto de Sódio/metabolismo
Bradyrhizobium/fisiologia
Inoculantes Agrícolas/fisiologia
Vigna/microbiologia
Antioxidantes/metabolismo
-Proteínas de Plantas/metabolismo
Estresse Fisiológico
Superóxido Dismutase/metabolismo
Peroxidação de Lipídeos
Catalase/metabolismo
Peroxidase/metabolismo
Estresse Oxidativo
Salinidade
Vigna/crescimento & desenvolvimento
Vigna/metabolismo
Glutationa/metabolismo
Responsável: BR1.1 - BIREME


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Id: biblio-839372
Autor: Mejía-Barajas, Jorge A; Montoya-Pérez, Rocío; Salgado-Garciglia, Rafael; Aguilera-Aguirre, Leopoldo; Cortés-Rojo, Christian; Mejía-Zepeda, Ricardo; Arellano-Plaza, Melchor; Saavedra-Molina, Alfredo.
Título: Oxidative stress and antioxidant response in a thermotolerant yeast
Fonte: Braz. j. microbiol;48(2):326-332, April.-June 2017. tab, graf.
Idioma: en.
Resumo: Abstract Stress tolerance is a key attribute that must be considered when using yeast cells for industrial applications. High temperature is one factor that can cause stress in yeast. High environmental temperature in particular may exert a natural selection pressure to evolve yeasts into thermotolerant strains. In the present study, three yeasts (Saccharomyces cerevisiae, MC4, and Kluyveromyces marxianus, OFF1 and SLP1) isolated from hot environments were exposed to increased temperatures and were then compared with a laboratory yeast strain. Their resistance to high temperature, oxidative stress, and antioxidant response were evaluated, along with the fatty acid composition of their cell membranes. The SLP1 strain showed a higher specific growth rate, biomass yield, and biomass volumetric productivity while also showing lower duplication time, reactive oxygen species (ROS) production, and lipid peroxidation. In addition, the SLP1 strain demonstrated more catalase activity after temperature was increased, and this strain also showed membranes enriched in saturated fatty acids. It is concluded that the SLP1 yeast strain is a thermotolerant yeast with less oxidative stress and a greater antioxidant response. Therefore, this strain could be used for fermentation at high temperatures.
Descritores: Saccharomyces cerevisiae/fisiologia
Estresse Fisiológico
Kluyveromyces/fisiologia
Estresse Oxidativo
Antioxidantes/metabolismo
-Saccharomyces cerevisiae/crescimento & desenvolvimento
Saccharomyces cerevisiae/efeitos da radiação
Saccharomyces cerevisiae/química
Kluyveromyces/crescimento & desenvolvimento
Kluyveromyces/efeitos da radiação
Kluyveromyces/química
Peroxidação de Lipídeos
Catalase/análise
Membrana Celular/química
Espécies Reativas de Oxigênio/metabolismo
Biomassa
Ácidos Graxos/análise
Temperatura Alta
Responsável: BR1.1 - BIREME


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Id: biblio-1048848
Autor: Almeida, Fernando Araújo de; Mann, Renata Silva; Santos, Heloisa Oliveira dos; Pereira, Rucyan Walace; Blank, Arie Fitzgerald.
Título: Germination temperatures affect the physiological quality of seeds of lettuce cultivars / Qualidade fisiológica de sementes de alface sob diferentes temperaturas na germinação
Fonte: Biosci. j. (Online);35(4):1143-1152, july/aug. 2019. tab, ilus.
Idioma: en.
Resumo: The objective of this study was to evaluate the physiological quality allied to biochemical quality of lettuce seeds by germination and enzymes expression at 20, 25, 30, 35, 40 and 42ºC. Germination speed index and percentage of germination were estimated. Isoenzyme expressions were assessed by alcohol dehydrogenase (ADH), malate dehydrogenase (MDH), catalase (CAT), esterase (EST), pyruvate decarboxylase (PDC) and glutamate oxaloacetate transferase (GOT). The experiment consisted of a completely randomized design in a factorial scheme 4x6, with four cultivars and six different temperatures, with four replications. The highest germination and vigor were observed for cv. 'Everglades' at 35°C, which proved that this cultivar is thermotolerant. Catalase can be considered a genetic marker for the identification ofthermotolerant lettuce cultivars. Cultivar 'Everglades' has potential to be used in lettuce breeding programs aimed at cultivars tolerant to high temperatures during germination.

O objetivo deste estudo foi avaliar a qualidade fisiológica e bioquímica de sementes de alface por meio da germinação e expressão de enzimas a 20, 25, 30, 35, 40 e 42ºC. As variáveis velocidade de germinação e o índice de velocidade de germinação foram estimadas. As expressões das enzimas alcool desidrogenase (ADH), malato desidrogenase (MDH), catalase (CAT), esterase (EST), piruvate descarboxilase (PDC) e glutamato oxaloacetato transferase (GOT) foram avaliadas. Para análise dos genótipos foi empregado o delineamento inteiramente casualizado em esquema fatorial 4x6, testando quatro cultivares e seis diferentes temperaturas, com quatro repetições. A maior germinação e vigor foram observadas para a cv. 'Everglades' a 35°C, o que prova que esta cultivar é termotolerante. A catalase pode ser considerada um marcador para a identificação de cultivares de alface termotolerantes. A cultivar 'Everglades' tem potential para uso em programas de melhoramento visando tolerância à alta temperatura durante a germinação.
Descritores: Sementes
Catalase
Alface
Esterases
Termotolerância
Isoenzimas
-Oxirredutases
Responsável: BR396.1 - Biblioteca Central


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Id: lil-792413
Autor: Melekoglu, Rauf; Ciftci, Osman; Cetin, Aslı; Basak, Nese; Celik, Ebru.
Título: The beneficial effects of Montelukast against 2 3 7 8 tetrachlorodibenzo dioxin toxicity in female reproductive system in rats
Fonte: Acta cir. bras;31(8):557-563, Aug. 2016. tab, graf.
Idioma: en.
Resumo: ABSTRACT PURPOSE: To determine the toxic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on reproductive system and the beneficial effects of Montelukast (ML) with histological and biochemical analysis. METHODS: Rats were randomly divided into four equal groups (control, TCDD, ML and TCDD+ML). Tissue samples were collected on day 60 and oxidative status and histological alterations were analyzed. RESULTS: The results showed a significant increase in oxidative and histological damage on uterine and ovarian tissues. Otherwise, the oxidative and histological damages caused by TCDD were prevented with ML treatment. CONCLUSION: The toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on female reproductive system were reversed with Montelukast treatment. Therefore, we claimed that ML treatment might be useful for TCDD toxicity.
Descritores: Ovário/efeitos dos fármacos
Quinolinas/farmacologia
Estresse Oxidativo/efeitos dos fármacos
Dibenzodioxinas Policloradas/toxicidade
Acetatos/farmacologia
Antioxidantes/farmacologia
-Ovário/patologia
Superóxido Dismutase/metabolismo
Útero/patologia
Catalase/metabolismo
Distribuição Aleatória
Ratos Wistar
Glutationa/metabolismo
Folículo Ovariano/efeitos dos fármacos
Limites: Animais
Feminino
Ratos
Responsável: BR1.1 - BIREME


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Id: lil-792407
Autor: Lucas, Márcio Luís; Carraro, Cristina Campos; Belló-Klein, Adriane; Kalil, Antônio Nocchi; Aerts, Newton.
Título: Oxidative stress in carotid arteries of patients submitted to carotid endarterectomy. The role of aging process
Fonte: Acta cir. bras;31(8):564-568, Aug. 2016. tab, graf.
Idioma: en.
Resumo: ABSTRACT PURPOSE: To evaluated the role of oxidative stress on aging process in patients submitted to carotid endarterectomy. METHODS: Twenty patients were divided into two groups: older group (≥ 70 years old); and the younger group (< 70 years old). We evaluated the reactive oxygen species (ROS) concentration, nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase, superoxide dismutase (SOD) and catalase (CAT) activities as so as nitrite levels in fragments of carotid arteries harvested during carotid endarterectomy for treatment of high grade carotid stenosis. RESULTS: We observed a higher levels of ROS and NADPH oxidase activity in the older group (p<0.05). Furthermore, the nitrite concentration was lower in the older group (14.55 ± 5.61 x 10-3 versus 26.42 ± 8.14 x 10-3 µM; p=0.0123). However, the activities of antioxidant enzymes (CAT and SOD) were similar in both the groups. CONCLUSIONS : Arterial aging is associated with increased concentrations of oxygen species and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity as so as nitrite reduction in human carotid artery specimens. Maybe therapies that block NADPH oxidase activity and enhance nitrite stores would be a good strategy to reduce the effect of oxidative stress in arterial aging.
Descritores: Envelhecimento/fisiologia
Artérias Carótidas/fisiologia
Endarterectomia das Carótidas
Estresse Oxidativo/fisiologia
-Superóxido Dismutase/metabolismo
Doença da Artéria Coronariana/cirurgia
Artérias Carótidas/enzimologia
Catalase/metabolismo
Espécies Reativas de Oxigênio/análise
NADP/análise
Limites: Seres Humanos
Masculino
Feminino
Meia-Idade
Idoso
Idoso de 80 Anos ou mais
Responsável: BR1.1 - BIREME


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Id: lil-787264
Autor: Burcu, Gul Baykalir; Osman, Ciftci; Aslı, Cetin; Namik, Oztanir Mustafa; Neşe, Basak Türkmen.
Título: The protective cardiac effects of Β-myrcene after global cerebral ischemia/reperfusion in C57BL/J6 mouse
Fonte: Acta cir. bras;31(7):456-462tab, graf.
Idioma: en.
Resumo: ABSTRACT PURPOSE: To investigate the protective effect of β-myrcene (MYR) on oxidative and histological damage in mice heart tissue caused global cerebral ischemia/reperfusion (IR) in C57BL/J6 mice. METHODS: Animals(n=40) were randomly divided into four groups: (1)control, (2)IR, (3)MYR and (4)MYR+IR. The control group was received 0.1% carboxymethyl cellulose as a vehicle following a medial incision without carotid occlusion. In the IR group, the bilateral carotid arteries were clipped for 15min, and treated with the vehicle intraperitoneally(ip) for 10 days. MYR (200mg/kg) was received dissolved in 0.1%CMC for 10 days. In the MYR+IR group, the IR model was applied exactly as in the IR group, and then they were treated with MYR 10 days. RESULTS: The cerebral IR caused oxidative damage (increase TBARS, decrease antioxidant parameters). Treatment of MYR was increased in GSH,GPx,CAT,SOD activity while TBARS level was decreased. In addition, degenerative changes in I/R group heart tissue were ameliorated by MYR administration. CONCLUSİON: The administration of β-myrcene protects oxidative and histological damage in the heart tissue after global ischemia-reperfusion and may be useful safe alternative treatment for cardiac tissue after ischemic stroke.
Descritores: Cardiotônicos/farmacologia
Traumatismo por Reperfusão/complicações
Isquemia Encefálica/complicações
Monoterpenos/farmacologia
Coração/efeitos dos fármacos
Antioxidantes/farmacologia
-Superóxido Dismutase/metabolismo
Catalase/metabolismo
Distribuição Aleatória
Substâncias Reativas com Ácido Tiobarbitúrico/metabolismo
Estresse Oxidativo/efeitos dos fármacos
Modelos Animais
Glutationa/metabolismo
Glutationa Peroxidase/metabolismo
Camundongos Endogâmicos C57BL
Miocárdio/metabolismo
Miocárdio/patologia
Limites: Animais
Masculino
Responsável: BR1.1 - BIREME


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Id: lil-785013
Autor: Takhtfooladi, Mohammad Ashrafzadeh; Asghari, Ahmad; Hoseinzadeh, Hesam aldin; Mokhtari, Farahnaz.
Título: Effect of Otostegia persica extract on ischemia/reperfusion induced renal damage in diabetic rats. A biochemical study
Fonte: Acta cir. bras;31(6):417-421tab.
Idioma: en.
Resumo: ABSTRACT PURPOSE: To evaluate the effect of Otostegia persica (O. persica) extract on renal damage induced by ischemia/reperfusion (I/R) in diabetic rats. METHODS: Forty-eight rats were subjected to right nephrectomy; then, they were allocated into six groups: Sham; Diabetic sham; I/R; Diabetic I/R; I/R+O. persica; Diabetic I/R+O. persica. Diabetes was induced by streptozotocin (200 mg/kg, i.p.). O. persica (300 mg/kg/day, p.o) was administered for 2 weeks. On the 15th day, ischemia was induced in left kidney for 60 min, followed by reperfusion for 24h. Renal functional and biochemical markers were estimated. RESULTS: I/R in both normal and diabetic rats, induced a significant elevation in serum levels of urea and creatinine (p<0.05). Renal I/R induced a significant increase of malondialdehyde, myeloperoxidase and nitric oxide concentrations associated with significant reduction in superoxide dismutase and catalase activities in comparison with the sham group (p<0.05). Diabetic rats that underwent renal I/R exhibited a significant increase in all the studied parameters with a reduction in the antioxidant enzymes as compared to nondiabetic rats (p<0.05). These deleterious effects associated with renal I/R were improved by the treatment with O. persica (p<0.05). CONCLUSION: Otostegia persica pretreatment protected the renal injury from ischemia-reperfusion in diabetic rats.
Descritores: Extratos Vegetais/farmacologia
Traumatismo por Reperfusão/complicações
Lamiaceae
Diabetes Mellitus Experimental/complicações
Antioxidantes/farmacologia
-Superóxido Dismutase/metabolismo
Ureia/sangue
Glicemia/efeitos dos fármacos
Traumatismo por Reperfusão/metabolismo
Catalase/metabolismo
Ratos Wistar
Peroxidase/metabolismo
Estresse Oxidativo/efeitos dos fármacos
Creatinina/sangue
Modelos Animais
Hipoglicemiantes/farmacologia
Rim/efeitos dos fármacos
Peróxidos Lipídicos/metabolismo
Nefrectomia/efeitos adversos
Limites: Animais
Masculino
Responsável: BR1.1 - BIREME


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Id: lil-781326
Autor: Ergün, Yusuf; Üremiş, Muhammed; Kılınç, Metin; Alıcı, Tuğrul.
Título: Antioxidant effect of Legalon(r) SIL in ischemia-reperfusion injury of rat skeletal muscle
Fonte: Acta cir. bras;31(4):264-270, Apr. 2016. tab, graf.
Idioma: en.
Resumo: PURPOSE: To evaluated the potential antioxidant agent Legalon (r) SIL (silibinin-C-2',3-bis(hydrogensuccinat)) in the skeletal muscle of rats. METHODS: IRI was achieved via tourniquet application in Wistar-albino rats. Experimental groups were chosen as (i) sham control, (ii) IRI (3+2 h), (iii) IRI and Legalon (r) SIL-50 (50 mg/kg/i.p.), (iv) IRI and Legalon (r) SIL-100 (100 mg/kg/i.p.), and (v) IRI and Legalon (r) SIL-200 (200 mg/kg/ i.p.). Muscle viability (evaluated by triphenyltetrazolium chloride dye method), malondialdehyde, superoxide dismutase, catalase, and glutathione peroxidase were assessed in muscle samples using a spectrophotometer. RESULTS: Although viability of the injured limb non-significantly declined in the IRI group, administration of Legalon (r) SIL did not prevent injury. However, dramatic increase observed in malondialdehyde levels in the IRI group was prohibited by Legalon (r) SIL in a statistically significant manner. In comparison with the sham-control group, IRI and Legalon (r) SIL administration did not cause any significant alterations in the levels of superoxide dismutase, catalase, and glutathione peroxidase. CONCLUSION: Although Legalon (r) SIL was not sufficient to prevent muscle injury in terms of viability, it is found to be an effective option to reduce reactive oxygen species-induced cell injury.
Descritores: Silimarina/farmacologia
Traumatismo por Reperfusão/prevenção & controle
Músculo Esquelético/irrigação sanguínea
Isquemia/prevenção & controle
Antioxidantes/farmacologia
-Valores de Referência
Superóxido Dismutase/análise
Superóxido Dismutase/efeitos dos fármacos
Sobrevivência de Tecidos/efeitos dos fármacos
Catalase/análise
Catalase/efeitos dos fármacos
Distribuição Aleatória
Reprodutibilidade dos Testes
Espécies Reativas de Oxigênio/análise
Ratos Wistar
Estresse Oxidativo/efeitos dos fármacos
Músculo Esquelético/efeitos dos fármacos
Músculo Esquelético/química
Glutationa Peroxidase/análise
Glutationa Peroxidase/efeitos dos fármacos
Malondialdeído/análise
Limites: Animais
Masculino
Tipo de Publ: Estudos de Avaliação
Responsável: BR1.1 - BIREME


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Id: biblio-1048596
Autor: Martins Filho, Argemiro Pereira; Medeiros, Erika V; Barbosa, Jesimiel Gomes; Barbosa, Jorge Marcos Peniche; Sobral, Júlia Kuklinsky; Motta, Cristina Souza.
Título: Combined effect of pseudomonas sp. and trichoderma aureoviride on lettuce growth promotion / Efeito combinado de Pseudomonas sp. e Trichoderma aureoviride na promoção do crescimento de alface
Fonte: Biosci. j. (Online);35(2):419-430, mar./apr. 2019. graf.
Idioma: en.
Resumo: Plant growth promotion by microorganisms may be a viable alternative to increase lettuce production through pathogens control and nutrients absorption increase. Trichoderma and Pseudomonasgenus are examples of widely studied microorganisms with the capacity to promote plant growth. However, there are still gaps regarding the action of the combined effect of these two microorganisms. Therefore, the objective of this study was to evaluate the combined effect of Pseudomonas sp. UAGF14 and Trichoderma aureoviride URM5158 on the development of lettuce plants. The experimental design was completely randomized, with five treatments: CONT (control), CM (soil with organic fertilization), CMB (soil withorganic fertilization and Pseudomonas sp.), CMF (soil with organic fertilization and T. aureoviride), and CMFB (soil with organic fertilization, Pseudomonas sp. and T. aureoviride), with ten repetitions. At 30, 40 and 60 days after sowing, the following parameters were analyzed: plant and canopy height and number of leaves. At 60 days after emergence, shoot dry matter, leaf area, root dry matter, root length and chlorophyll were analyzed. Catalase, peroxidase and polyphenol oxidase enzymatic activity were determined. The CMFB treatment had the highest means of lettuce growth promotion, confirming the synergistic effect of the combination of the two microorganism types, as it increased height, canopy, shoot and root dry matter, and chlorophyll levels compared to CONT, although did not differ from CM in some variables. Enzymatic activity was also influenced by the action of these microorganisms combined, evidencing by polyphenol oxidase increase. The CMFB or CM were efficient in promoting lettuce growth, showing positive response to the plant morphological and physiological characteristics. However, few responses were observed in lettuce plant growth in the first cycle evaluated after 60 days, compared CM and CMFB treatments, but both treatments showed superiority in lettuce plant growth submitted to CONT treatment. Therefore, further studies are needed to estimate the long-term effects of combined effect of Pseudomonas sp. UAGF14 and T. aureoviride URM5158 on crop productivity in field conditions.

A promoção do crescimento das plantas por micro-organismos pode ser uma alternativa viável para aumentar a produção de alface através de controle de patógenos e aumento da absorção de nutrientes. O gênero fúngico Trichoderma e o gênero bacteriano Pseudomonas são exemplos de micro-organismos amplamente estudados com capacidade para promover o crescimento da planta. No entanto, ainda existem lacunas quanto à ação do efeito combinado desses dois micro-organismos. Portanto, o objetivo deste estudo foi avaliar o efeito combinado de Pseudomonas UAGF14 e Trichoderma aureoviride URM5158 sobre o desenvolvimento de plantas de alface. O delineamento experimental foi completamente casualizados, com cinco tratamentos: CONT (controle, sem fertilização orgânica), CM (solo com fertilização orgânica), CMB (solo com fertilização orgânicae Pseudomonas sp.), CMF (solo com fertilização orgânica e T. aureoviride) e CMFB (solo com fertilização orgânica, Pseudomonas sp. e T. aureoviride), com dez repetições. Aos 30, 40 e 60 dias após a semeadura, foram analisados os seguintes parâmetros: altura da planta e dossel e número de folhas. Aos 60 dias após a emergência, a matéria seca da parte aérea, a área foliar, a massa seca das raízes, o comprimento radicular e a clorofila foram analisados. Catalase, peroxidase e atividade enzimática da polifenol oxidase foram determinadas. O CMFB apresentou o maior crescimento de alface, confirmando o efeito benéfico da combinação dos dois tipos de micro-organismos com a planta, na medida em que aumentou a altura, o dossel, a matéria seca da parte aérea e da raiz, e os níveis de clorofila em relação ao CONT, embora não tenha diferido do CM em algumas variáveis. As atividades enzimáticas também foram influenciadas pela ação desses micro-organismos combinados, evidenciada pelo aumento de polifenol oxidase. O CMFB ou CM foram eficientes na promoção do crescimento da alface, mostrando respostas positivas às características morfológicas e fisiológicas. Entretanto, poucas respostas foram observadas no crescimento da alface noprimeiro ciclo da planta avaliado depois de 60 dias, comparando os tratamentos CM e CMFB, mas ambos tratamentos mostraram superioridade em relação ao crescimento das plantas de alface submetidas ao tratamento controle. Por isso, são necessários futuros estudos para estimar à longo prazo o efeito combinado de Pseudomonas sp. UAGF14 e Trichoderma aureoviride URM5158 na produção de cultura em condições de campo.
Descritores: Catalase
Alface
CHLOROFLUOROCARBONS, METHANEABDOMEN
-Pseudomonas
Trichoderma
Responsável: BR396.1 - Biblioteca Central


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Id: biblio-886223
Autor: Niu, Chengwei; Ma, Man; Han, Xiao; Wang, Zimin; Li, Hangyan.
Título: Hyperin protects against cisplatin-induced liver injury in mice
Fonte: Acta cir. bras;32(8):633-640, Aug. 2017. graf.
Idioma: en.
Projeto: Science and Technology Plan Project of Huai'an; . Practice Innovation Training Projects of Jiangsu College students.
Resumo: Abstract Purpose: To evaluate the effect of hyperin in cisplatin-induced liver injury in mice. Methods: Mice were pretreated with hyperin at doses of 25 mg/kg and 50 mg/kg, respectively, for six days, and intraperitoneal injection of cisplatin (40 mg/kg) was administrated one hour after the final intragastrication of hyperin. Twenty-four hours later, blood and liver were collected for further research. Results: A single injection of cisplatin (40 mg/kg) for 24 h significantly increased serum alanine and aspartate aminotransferases (ALT/AST) and gamma glutamyl transferase (GGT) activities, whileas hyperin reversed cisplatin-induced such increases. Liver histopathological examination further demonstrated the protection of hyperin against cisplatin-induced liver injury. Further results showed hyperin reversed cisplatin-induced the increase in content of malondialdehyde (MDA) and the decrease in level of total antioxidant capacity (T-AOC) in liver. Moreover, hyperin increased the levels of superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), glutathione peroxidase (GPx), glutathione-s transferase (GST) in cisplatin-induced liver. Conclusion: Hyperin inhibits cisplatin-induced hepatic oxidative stress, which contributes greatly to the amelioration of cisplatin-induced liver injury in mice.
Descritores: Quercetina/análogos & derivados
Aspartato Aminotransferases/metabolismo
Cisplatino/efeitos adversos
Doença Hepática Induzida por Substâncias e Drogas/prevenção & controle
Antineoplásicos/efeitos adversos
Antioxidantes/farmacologia
-Quercetina/uso terapêutico
Quercetina/farmacologia
Valores de Referência
Peroxidação de Lipídeos
Catalase/análise
Distribuição Aleatória
Reprodutibilidade dos Testes
Cisplatino/antagonistas & inibidores
Estresse Oxidativo/efeitos dos fármacos
Alanina Transaminase/metabolismo
Doença Hepática Induzida por Substâncias e Drogas/patologia
Glutationa/análise
Glutationa Peroxidase/análise
Glutationa Transferase/análise
Fígado/efeitos dos fármacos
Fígado/enzimologia
Fígado/patologia
Malondialdeído/análise
Camundongos Endogâmicos ICR
Antioxidantes/uso terapêutico
Limites: Animais
Masculino
Tipo de Publ: Estudos de Avaliação
Responsável: BR1.1 - BIREME



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde