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Cedenho, Agnaldo Pereira
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Id: biblio-892875
Autor: Sposito, Camila; Camargo, Mariana; Tibaldi, Danielle Spinola; Barradas, Valéria; Cedenho, Agnaldo Pereira; Nichi, Marcílio; Bertolla, Ricardo Pimenta; Spaine, Deborah Montagnini.
Título: Antioxidant enzyme profile and lipid peroxidation products in semen samples of testicular germ cell tumor patients submitted to orchiectomy
Fonte: Int. braz. j. urol;43(4):644-651, July-Aug. 2017. tab.
Idioma: en.
Resumo: ABSTRACT Purpose To determine enzymatic antioxidant and lipid peroxidation levels in seminal plasma of patients orchiectomized for testicular tumors. Materials and Methods The study included 52 patients: 26 control men and 26 orchiectomized patients for testicular tumor, of which 12 men had seminoma tumor and 14 men non-seminoma tumor. After semen analysis performed according to the WHO guidelines, an aliquot of semen was centrifuged and the seminal plasma was collected. Lipid peroxidation was performed by thiobarbituric acid reactive substances (TBARS) assay and antioxidant profile was assessed by analyzing catalase, glutathione peroxidase (GPx) and superoxide anion (SOD) activities using colorimetric assays with a standard spectrophotometer. Data were tested for normality and compared using one-way ANOVA (p<0.05). Results Seminoma and non-seminoma groups presented lower sperm concentration and morphology when compared to control group (p=0.0001). Both study groups (seminoma and non-seminoma) presented higher TBARS levels when compared to control group (p=0.0000013). No differences were observed for SOD (p=0.646) andGPx (p=0.328). It was not possible to access the enzymatic activity of catalase in any group. Conclusion Patients with testicular tumor present increased semen oxidative stress, but no differences were observed in antioxidant levels, even after orchiectomy. This indicates that most likely an increased generation of oxidative products takes place in these patients.
Descritores: Sêmen/enzimologia
Neoplasias Testiculares/metabolismo
Peroxidação de Lipídeos/fisiologia
Seminoma/metabolismo
Antioxidantes/metabolismo
-Oligospermia
Contagem de Espermatozoides
Superóxido Dismutase/metabolismo
Neoplasias Testiculares/cirurgia
Orquiectomia
Catalase/metabolismo
Estudos de Casos e Controles
Estudos Transversais
Estresse Oxidativo/fisiologia
Análise do Sêmen
Glutationa Peroxidase/metabolismo
Pessoa de Meia-Idade
Limites: Humanos
Masculino
Adolescente
Adulto
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: biblio-840833
Autor: Benli, Erdal; Ayyildiz, Sema Nur; Cirrik, Selma; Koktürk, Sibel; Cirakoglu, Abdullah; Noyan, Tevfik; Ayyildiz, Ali; Germiyanoglu, Cankon.
Título: The effect of tadalafil therapy on kidney damage caused by sepsis in a polymicrobial septic model induced in rats: a biochemical and histopathological study
Fonte: Int. braz. j. urol;43(2):345-355, Mar.-Apr. 2017. tab, graf.
Idioma: en.
Projeto: Ordu University Scientific Research Projects Coordination Department.
Resumo: ABSTRACT Introduction Sepsis is an inflammatory reaction to bacteria involving the whole body and is a significant cause of mortality and economic costs. The purpose of this research was to determine whether tadalafil exhibits a preventive effect on sepsis in a septic model induced in rats with cecal ligation and puncture (CLP). Materials and Methods Rats were randomly separated into groups, 10 rats in each: (i) a sham (control) group, (ii) an untreated sepsis group, (iii) a sepsis group treated with 5mg/kg tadalafil and (iv) a sepsis group treated with 10mg/kg tadalafil. A polymicrobial sepsis model was induced in rats using CLP. Rats were sacrificed after 16h, and blood and kidney tissues were collected for biochemical and histopathological study. Results Levels of the inflammatory parameter IL-6 decreased significantly in the sepsis groups receiving tadalafil in comparison with the untreated sepsis group (p<0.05). In terms of histopathology, inflammation scores investigated in kidney tissues decreased significantly in the sepsis groups receiving tadalafil compared to the untreated sepsis group (p<0.05). In addition, levels of creatinine and cystatin C measured in septic rats receiving tadalafil were lower by a clear degree than in septic rats (p<0.05). Conclusion In this study, tadalafil exhibited a preventive effect for sepsis-related damage by suppressing inflammation in serum and kidney tissue of septic rats in a polymicrobial sepsis model induced with CLP.
Descritores: Sepse/complicações
Sepse/prevenção & controle
Insuficiência Renal/etiologia
Insuficiência Renal/prevenção & controle
Inibidores da Fosfodiesterase 5/uso terapêutico
Tadalafila/uso terapêutico
-Valores de Referência
Espectrofotometria
Superóxido Dismutase/análise
Calcitonina/sangue
Ensaio de Imunoadsorção Enzimática
Imuno-Histoquímica
Catalase/análise
Distribuição Aleatória
Reprodutibilidade dos Testes
Interleucina-6/sangue
Ratos Wistar
Peroxidase/análise
Sepse/patologia
Creatinina/sangue
Modelos Animais de Doenças
Insuficiência Renal/patologia
Cistatina C/sangue
Rim/efeitos dos fármacos
Rim/patologia
Ligadura
Malondialdeído/análise
Limites: Animais
Masculino
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Id: biblio-989637
Autor: Kandemir, Yasemin Behram; Konuk, Esma; Katırcı, Ertan; Xxx, Feride; Behram, Mustafa.
Título: Is the effect of melatonin on vascular endothelial growth factor receptor-2 associated with angiogenesis in the rat ovary?
Fonte: Clinics;74:e658, 2019. tab, graf.
Idioma: en.
Resumo: OBJECTIVES Vascular endothelial growth factor (VEGF) and its receptors play important roles in angiogenesis. Melatonin plays an important role in gonadal development; thus, its effect on the reproductive system is evident. We investigated the influence of melatonin on the expression of VEGF, vascular endothelial growth factor receptor-1 (VEGFR1) and vascular endothelial growth factor receptor-2 (VEGFR2), as well as on changes in oxidative stress markers and follicle numbers in rat ovaries. METHODS For this purpose, 45 Wistar rats were separated into the following groups: Group 1, control; Group 2, vehicle; and Group 3, melatonin. Rats in Group 3 were treated with melatonin at 50 mg/kg/day for 30 days. The effects of melatonin on the expression of VEGF, VEGFR1 and VEGFR2 were established by immunohistochemistry analysis. The effects of melatonin on antioxidant enzyme activities were demonstrated by spectrophotometric analysis. RESULTS Based on immunohistochemistry analysis, VEGFR2 was predominantly localized to theca cells in the ovary. Our data indicate that melatonin treatment can significantly increase VEGF and VEGFR1 expression in the ovary ( p <0.05). Additionally, the number of degenerated follicles significantly decreased with melatonin treatment ( p <0.05). Melatonin administration also led to significant increases in antioxidant enzyme levels in the ovary. CONCLUSION Melatonin treatment exerts protective effects on follicles against increased lipid peroxidation through modulating tissue antioxidant enzyme levels. These effects may be related to angiogenesis and antioxidant activities.
Descritores: Ovário/efeitos dos fármacos
Neovascularização Fisiológica/efeitos dos fármacos
Receptor 2 de Fatores de Crescimento do Endotélio Vascular/efeitos dos fármacos
Fator A de Crescimento do Endotélio Vascular/efeitos dos fármacos
Melatonina/farmacologia
Antioxidantes/farmacologia
-Ovário/enzimologia
Ovário/irrigação sanguínea
Superóxido Dismutase/metabolismo
Peroxidação de Lipídeos
Catalase/metabolismo
Ratos Wistar
Modelos Animais
Malondialdeído/metabolismo
Melatonina/metabolismo
Antioxidantes/metabolismo
Limites: Animais
Feminino
Responsável: BR1.1 - BIREME


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Id: biblio-843447
Autor: Lucas, Márcio Luís; Carraro, Cristina Campos; Belló-Klein, Adriane; Kalil, Antonio Nocchi; Aerts, Newton.
Título: Oxidative stress in human aorta of patients with advanced aortoiliac occlusive disease
Fonte: Rev. bras. cir. cardiovasc = Braz. j. cardiovasc. surg. (impr.);31(6):428-433, Nov.-Dec. 2016. tab, graf.
Idioma: en.
Resumo: Abstract Introduction: Oxidative stress seems to be a role in the atherosclerosis process, but research in human beings is scarce. Objective: To evaluate the role of oxidative stress on human aortas of patients submitted to surgical treatment for advanced aortoiliac occlusive disease. Methods: Twenty-six patients were divided into three groups: control group (n=10) formed by cadaveric organ donors; severe aortoiliac stenosis group (patients with severe aortoiliac stenosis; n=9); and total aortoiliac occlusion group (patients with chronic total aortoiliac occlusion; n=7). We evaluated the reactive oxygen species concentration, nicotinamide adenine dinucleotide phosphate-oxidase, superoxide dismutase and catalase activities as well as nitrite levels in samples of aortas harvested during aortofemoral bypass for treatment of advanced aortoiliac occlusive disease. Results: We observed a higher level of reactive oxygen species in total aortoiliac occlusion group (48.3±9.56 pmol/mg protein) when compared to severe aortoiliac stenosis (33.5±7.4 pmol/mg protein) and control (4.91±0.8 pmol/mg protein) groups (P<0.05). Nicotinamide adenine dinucleotide phosphate oxidase activity was also higher in total aortoiliac occlusion group when compared to the control group (3.81±1.7 versus 1.05±0.31 µmol/min.mg protein; P<0.05). Furthermore, superoxide dismutase and catalase activities were significantly higher in the severe aortoiliac stenosis and total aortoiliac occlusion groups when compared to the control cases (P<0.05). Nitrite concentration was smaller in the severe aortoiliac stenosis group in comparing to the other groups. Conclusion: Our results indicated an increase of reactive oxygen species levels and nicotinamide adenine dinucleotide phosphate-oxidase activity in human aortic samples of patients with advanced aortoiliac occlusive disease. The increase of antioxidant enzymes activities may be due to a compensative phenomenon to reactive oxygen species production mediated by nicotinamide adenine dinucleotide phosphate oxidase. This preliminary study offers us a more comprehensive knowledge about the role of oxidative stress in advanced aortoiliac occlusive disease in human beings.
Descritores: Doenças da Aorta/cirurgia
Arteriopatias Oclusivas/cirurgia
Estresse Oxidativo
Artéria Ilíaca/cirurgia
-Doenças da Aorta/enzimologia
Arteriopatias Oclusivas/enzimologia
Superóxido Dismutase/análise
Índice de Gravidade de Doença
Catalase/análise
Estudos de Casos e Controles
NADP/análise
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Adulto Jovem
Tipo de Publ: Estudo Comparativo
Responsável: BR1.1 - BIREME


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Id: biblio-950775
Autor: Muradoglu, Ferhad; Gundogdu, Muttalip; Ercisli, Sezai; Encu, Tarik; Balta, Fikri; Jaafar, Hawa ZE; Zia-Ul-Haq, Muhammad.
Título: Cadmium toxicity affects chlorophyll a and b content, antioxidant enzyme activities and mineral nutrient accumulation in strawberry
Fonte: Biol. Res;48:1-7, 2015. graf, tab.
Idioma: en.
Projeto: Yuzuncu Yil Universty of the head of scientific research.
Resumo: BACKGROUND: Cadmium (Cd) is well known as one of the most toxic metals affecting the environment and can severely restrict plant growth and development. In this study, Cd toxicities were studied in strawberry cv. Camarosa using pot experiment. Chlorophyll and malondialdehyde (MDA) contents, catalase (CAT), superoxide dismutase (SOD), ascorbate peroxidase (APX) activities and mineral nutrient concentrations were investigated in both roots and leaves of strawberry plant after exposure Cd. RESULTS: Cd content in both roots and leaves was increased with the application of increasing concentrations of Cd. We found higher Cd concentration in roots rather than in leaves. Chlorophyll a and b was decreased in leaves but MDA significantly increased under increased Cd concentration treatments in both roots and leaves. SOD and CAT activities was also increased with the increase Cd concentrations. K, Mn and Mg concentrations were found higher in leaves than roots under Cd stress. In general, increased Cd treatments increased K, Mg, Fe, Ca, Cu and Zn concentration in both roots and leaves. Excessive Cd treatments reduced chlorophyll contents, increased antioxidant enzyme activities and changes in plant nutrition concentrations in both roots and leaves. CONCLUSION: The results presented in this work suggested that Cd treatments have negative effect on chlorophyll content and nearly decreased 30% of plant growth in strawberry. Strawberry roots accumulated higher Cd than leaves. We found that MDA and antioxidant enzyme (CAT, SOD and APX) contents may have considered a good indicator in determining Cd tolerance in strawberry plant.
Descritores: Cádmio/toxicidade
Clorofila/metabolismo
Micronutrientes/metabolismo
Fragaria/efeitos dos fármacos
Antioxidantes/metabolismo
-Potássio/análise
Superóxido Dismutase/análise
Extratos Vegetais/química
Peroxidação de Lipídeos/efeitos dos fármacos
Catalase/análise
Clorofila/análise
Raízes de Plantas/efeitos dos fármacos
Raízes de Plantas/química
Folhas de Planta/efeitos dos fármacos
Folhas de Planta/química
Fragaria/metabolismo
Ascorbato Peroxidases/análise
Clorofila A
Magnésio/análise
Malondialdeído/análise
Manganês/análise
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-950779
Autor: Moukette, Bruno Moukette; Pieme, Constant Anatole; Njimou, Jacques Romain; Biapa, Cabral Prosper Nya; Marco, Bravi; Ngogang, Jeanne Yonkeu.
Título: In vitro antioxidant properties, free radicals scavenging activities of extracts and polyphenol composition of a non-timber forest product used as spice: Monodora myristica
Fonte: Biol. Res;48:1-17, 2015. graf, tab.
Idioma: en.
Resumo: BACKGROUND: Excessive production of free radicals causes direct damage to biological molecules such as DNA, proteins, lipids, carbohydrates leading to tumor development and progression. Natural antioxidant molecules from phytochemicals of plant origin may directly inhibit either their production or limit their propagation or destroy them to protect the system. In the present study, Monodora myristica a non-timber forest product consumed in Cameroon as spice was screened for its free radical scavenging properties, antioxidant and enzymes protective activities. Its phenolic compound profile was also realized by HPLC. RESULTS: This study demonstrated that M. myristica has scavenging properties against DPPH',OH',NO', and ABTS'radicals which vary in a dose depending manner. It also showed an antioxidant potential that was comparable with that of Butylated Hydroxytoluene (BHT) and vitamin C used as standard. The aqueous ethanol extract of M. myristica barks (AEH); showed a significantly higher content in polyphenolic compounds (21.44 ± 0.24 mg caffeic acid/g dried extract) and flavonoid (5.69 ± 0.07 quercetin equivalent mg/g of dried weight) as compared to the other studied extracts. The HPLC analysis of the barks and leaves revealed the presence of several polyphenols. The acids (3,4-OH-benzoic, caffeic, gallic, O- and P- coumaric, syringic, vanillic), alcohols (tyrosol and OH-tyrosol), theobromine, quercetin, rutin, catechine and apigenin were the identified and quantified polyphenols. All the tested extracts demonstrated a high protective potential on the superoxide dismutase (SOD), catalase and peroxidase activities. CONCLUSION: Finally, the different extracts from M. myristica and specifically the aqueous ethanol extract reveal several properties such as higher free radical scavenging properties, significant antioxidant capacities and protective potential effects on liver enzymes.
Descritores: Extratos Vegetais/farmacologia
Sequestradores de Radicais Livres/farmacologia
Especiarias
Annonaceae/química
Polifenóis/química
Antioxidantes/farmacologia
-Peroxidases/efeitos dos fármacos
Picratos/metabolismo
Ácidos Sulfônicos/metabolismo
Superóxido Dismutase/efeitos dos fármacos
Flavonoides/análise
Compostos de Bifenilo/metabolismo
Técnicas In Vitro
Camarões
Extratos Vegetais/química
Catalase/efeitos dos fármacos
Florestas
Cromatografia Líquida de Alta Pressão
Radical Hidroxila/metabolismo
Folhas de Planta/química
Casca de Planta/química
Benzotiazóis/metabolismo
Óxido Nítrico/metabolismo
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-950783
Autor: NK, Asha Tukappa; Londonkar, Ramesh L; Nayaka, Hanumantappa B; CB, Sanjeev Kumar.
Título: Cytotoxicity and hepatoprotective attributes of methanolic extract of Rumex vesicarius L
Fonte: Biol. Res;48:1-9, 2015. ilus, graf, tab.
Idioma: en.
Resumo: BACKGROUND: To evaluate the hepatoprotective potential and invitro cytotoxicity studies of whole plant methanol extract of Rumex vesicarius L. Methanol extract at a dose of 100 mg/kg bw and 200 mg/kg bw were assessed for its hepatoprotective potential against CCl4-induced hepatotoxicity by monitoring activity levels of SGOT (Serum glutamic oxaloacetic transaminase), SGPT (Serum glutamic pyruvic transaminase), ALP (Alkaline phosphatase), TP (Total protein), TB (Total bilirubin) and SOD (Superoxide dismutase), CAT (Catalase), MDA (Malondialdehyde). The cytotoxicity of the same extract on HepG2 cell lines were also assessed using MTT assay method at the concentration of 62.5, 125, 250, 500 µg/ml. RESULTS: Pretreatment of animals with whole plant methanol extracts of Rumex vesicarius L. significantly reduced the liver damage and the symptoms of liver injury by restoration of architecture of liver. The biochemical parameters in serum also improved in treated groups compared to the control and standard (silymarin) groups. Histopathological investigation further corroborated these biochemical observations. The cytotoxicity results indicated that the plant extract which were inhibitory to the proliferation of HepG2 cell line with IC50 value of 563.33 ± 0.8 Mg/ml were not cytotoxic and appears to be safe. CONCLUSIONS: Rumex vesicarius L. whole plant methanol extract exhibit hepatoprotective activity. However the cytotoxicity in HepG2 is inexplicable and warrants further study.
Descritores: Extratos Vegetais/farmacologia
Citotoxinas/farmacologia
Rumex/química
Proliferação de Células/efeitos dos fármacos
Doença Hepática Induzida por Substâncias e Drogas/tratamento farmacológico
Fitoterapia/métodos
-Aspartato Aminotransferases/metabolismo
Silimarina/farmacologia
Superóxido Dismutase/metabolismo
Sais de Tetrazólio
Bilirrubina/metabolismo
Tetracloreto de Carbono
Catalase/metabolismo
Anticarcinógenos/farmacologia
Ratos Wistar
Alanina Transaminase/metabolismo
Metanol
Ingestão de Líquidos/efeitos dos fármacos
Ingestão de Alimentos/efeitos dos fármacos
Fosfatase Alcalina/metabolismo
Células Hep G2
Doença Hepática Induzida por Substâncias e Drogas/metabolismo
Doença Hepática Induzida por Substâncias e Drogas/patologia
Formazans
Fígado/efeitos dos fármacos
Fígado/metabolismo
Malondialdeído/metabolismo
Antioxidantes/metabolismo
Antioxidantes/farmacologia
Limites: Humanos
Animais
Masculino
Ratos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1134512
Autor: Zaki, Mohamed Samir Ahmed; Haidara, Mohamed A; Heitham, Mohammed; Asim, Abdalla; Massoud, Ehab El Sayed; Eid, Refaat A.
Título: Antioxidant activity of selenium on bisphenol-induced apoptosis and testicular toxicity of Albino rats / Actividad antioxidante el selenio sobre la apoptosis inducid por bisfenol y toxicidad testicular en ratas albinas
Fonte: Int. j. morphol;38(6):1786-1796, Dec. 2020. graf.
Idioma: en.
Projeto: King Khalid University.
Resumo: SUMMARY: Bisphenol A (BPA) is an industrial chemical widely used to make polycarbonate plastics for packaging and epoxy resins. This study sought to examine how selenium (Se) affects BPA toxicity in terms of albino rats' histological structure, antioxidant enzymes and reproductive organs (seminiferous tubules). Twenty-four adult male rats were divided into four experimental groups: Group 1: Control; Group 2: Orally administered BPA; Group 3: Orally administered sodium selenite; Group 4: Treated daily with BPA followed by selenium (Se). All experiment done for 4 weeks. BPA exposure caused changes in the testicular histological structure, which consists apoptosis, and led to changes in several biochemical markers: Malondialdehyde, catalase, superoxide dismutase, and glutathione peroxidase. However, these BPA side effects may be ameliorated in rats treated with BPA-plus-Se. These protective effects of Se may attributable to its ability to remove potentially damaging oxidizing agents in living organisms. The results may confirm that Se countered the oxidant effects and increased the BPA-induced stress response in rats. So, Se promotes the healthy growth and development of mammals by protecting them from oxidative stress. As human are greatly exposed to BPA and it can accumulate in tissues, there is concern about human reproductive functions particularly for occupational workers exposed usually to greater levels of BPA. Thus, the use of BPA in multiple industries must be restricted and the inaccurate usage of plastic containers should be avoided to decrease the health hazards. Administration of Se may protect against the adverse effects of BPA on reproductive functions and structures.

RESUMEN: El bisfenol A (BPA) es un químico industrial ampliamente utilizado para fabricar plásticos de policarbonato para envases y resinas epoxi. Este estudio examinó el efecto de selenio (Se) en la toxicidad del BPA en términos de la estructura histológica, enzimas antioxidantes y los órganos reproductivos (túbulos seminíferos) de ratas albinas. Se dividieron veinticuatro ratas macho adultas en cuatro grupos experimentales: Grupo 1: control; Grupo 2: BPA administrado por vía oral; Grupo 3: BPA administrado por vía oral para; Grupo 4: tratado diariamente con BPA seguido de selenio (Se). El experimento se realizó durante cuatro semanas y se observó que la exposición al BPA provocó cambios en la estructura histológica testicular, incluyendo apoptosis, y alteraciones en varios marcadores bioquímicos:malondialdehído, catalasa, superóxido dismutasa y glutatión peroxidasa. Sin embargo, estos efectos secundarios del BPA pueden mejorar en ratas tratadas con BPA-plus-Se. Estos efectos protectores del Se pueden ser atribuidos a la capacidad de eliminar agentes oxidantes potencialmente dañinos en organismos vivos. Los resultados indicaron que se contrarrestaron los efectos oxidantes y aumentó la respuesta al estrés inducido por BPA en ratas, y favorece el crecimiento y desarrollo en los mamíferos al protegerlos del estrés oxidativo. Debido a la exposición al BPA en el ser humano, se puede acumular en los tejidos, por lo que existe una preocupación por el daño a las funciones reproductivas en particular de los trabajadores que generalmente están expuestos a niveles más altos de BPA. Por lo tanto, se debe restringir el uso de BPA en las industrias y evitar el uso incorrecto de envases de plástico para así disminuir los riesgos para la salud. La administración correcta de Se puede proteger contra los efectos adversos del BPA en las funciones y estructuras reproductivas.
Descritores: Fenóis/toxicidade
Selênio/farmacologia
Testículo/efeitos dos fármacos
Compostos Benzidrílicos/toxicidade
Antioxidantes/farmacologia
-Fenóis/administração & dosagem
Superóxido Dismutase/efeitos dos fármacos
Testículo/patologia
Compostos Benzidrílicos/administração & dosagem
Microscopia Eletrônica
Biomarcadores
Catalase/efeitos dos fármacos
Administração Oral
Apoptose/efeitos dos fármacos
Estresse Oxidativo
Glutationa Peroxidase/efeitos dos fármacos
Limites: Animais
Masculino
Ratos
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-976782
Autor: Coutinho, Fábio Gonçalves; Diniz, Edna Maria de Albuquerque; Kandler, Ingrid; Cianciarullo, Marco Antônio; Santos, Natália Rodrigues dos.
Título: Assessment of oxidative damage and enzymatic antioxidant system activity on the umbilical cord blood and saliva from preterm newborns with risk factors for early-onset neonatal sepsis
Fonte: Rev. Assoc. Med. Bras. (1992);64(10):888-895, Oct. 2018. tab, graf.
Idioma: en.
Resumo: SUMMARY BACKGROUND: To determine the concentration of the Lipid Peroxidation Marker: Malondialdehyde (MDA), and Antioxidant Markers: Superoxide Dismutase (SOD), Glutathione Peroxidase (GPX), Catalase (CAL) in umbilical cord blood and in unstimulated saliva in the first 24 and 48 hours of life in the PTNB of mothers with and without risk factors for early-onset neonatal sepsis. METHODS: Cross-sectional study with the signing of informed consent by the pregnant women and application of a standard questionnaire classifying the PTNB in Group 1 or 2. RESULTS: Twenty-one PTNB were studied. Regarding gender, birth weight, need for oxygen, use of phototherapy, diagnosis of assumed sepsis, presence of fetal distress, number of pregnancies, type of delivery, use of corticosteroids, premature rupture of membranes, maternal fever, chorioamnionitis, APGAR at the 5th and 10th minute of life. Statistical analysis was performed with the Mann-Whitney test (p = 0.019) on the GPX variable of umbilical cord blood in the group of mothers with risk factors for early-onset neonatal sepsis. There was no statistical difference in the MDA, SOD, and CAT variables of the group with risk factors and in any variable of the group without risk factors. CONCLUSION: There was an increase of the GPX concentration in the blood from the umbilical vein in the group with risk factors for early-onset neonatal sepsis. There was no statistical significance in the comparison of saliva and umbilical cord blood. There was no statistically significant difference in MDA, SOD, CAT.

RESUMO OBJETIVOS: Determinar a concentração do marcador de peroxidação lipídica: Malondialdeído (MDA) e dos marcadores antioxidantes: Superóxido Dismutase (SOD), Glutationa Peroxidase (GPX), Catalase (CAL) no sangue do cordão umbilical e na saliva não estimulada nas primeiras 24 e 48 horas de vida nos RNPT de mães com e sem fatores de risco para sepse neonatal precoce. METODOLOGIA: Estudo transversal com a assinatura do termo de consentimento livre esclarecido pela gestante e aplicação de um questionário padrão classificando o RNPT no Grupo 1 ou 2. RESULTADOS: Foram estudados 21 RNPT. Quanto ao gênero, peso ao nascimento, necessidade de oxigênio, uso de fototerapia, diagnóstico de sepse presumida, presença de sofrimento fetal, número de gestações, tipo de parto, uso de corticoide, rotura prematura de membranas, a presença de febre materna, a presença de corioamnionite, Apgar no 50 e 100 minuto de vida, a análise estatística foi feita com o teste de Mann-Whitney (p=0,019) na váriável GPX do sangue do cordão umbilical no grupo das mães com fatores de risco para sepse neonatal precoce. Não houve diferença estatística nas outras variáveis MDA, SOD, CAT do grupo com fatores de risco e em nenhuma variável do grupo sem fatores de risco. CONCLUSÃO: O aumento de duas vezes a concentração da GPX no sangue da veia umbilical dos RNPT do grupo das mães com fatores de risco para sepse neonatal precoce. Sem significância estatística na comparação entre a saliva e o sangue do cordão umbilical. Não houve diferença estatisticamente significante nas variáveis MDA, SOD e CAT.
Descritores: Biomarcadores/análise
Sangue Fetal/química
Sepse Neonatal/diagnóstico
-Saliva/química
Superóxido Dismutase/análise
Ruptura Prematura de Membranas Fetais
Recém-Nascido Prematuro
Catalase/análise
Estudos Transversais
Fatores de Risco
Sepse Neonatal/metabolismo
Glutationa Peroxidase/análise
Malondialdeído/análise
Antioxidantes/análise
Antioxidantes/metabolismo
Limites: Humanos
Masculino
Feminino
Gravidez
Recém-Nascido
Responsável: BR1.1 - BIREME


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Id: biblio-888340
Autor: Baghcheghi, Yousef; Hosseini, Mahmoud; Beheshti, Farimah; Salmani, Hossein; Anaeigoudari, Akbar.
Título: Thymoquinone reverses learning and memory impairments and brain tissue oxidative damage in hypothyroid juvenile rats / Timoquinona protegeu contra deficiências de aprendizagem e memória e danos nos tecidos cerebrais em ratos hipotireoidais juvenis
Fonte: Arq. neuropsiquiatr;76(1):32-40, Jan. 2018. graf.
Idioma: en.
Resumo: ABSTRACT In this study, the effect of thymoquinone (TQ) on propylthiouracil (PTU)-induced memory impairment was investigated in juvenile rats. The rats were grouped into control, Hypo, Hypo-TQ5 and Hypo-TQ10. Propylthiouracil increased latency time in the Morris water maze test and decreased delay in entering the dark compartment in the passive avoidance test. Both 5 mg/kg and 10 mg/kg doses of TQ decreased latency time in the Morris water maze test and increased delay in entering the dark compartment in a passive avoidance test. The PTU also increased malondialdehyde and nitric oxide metabolites in the brain while reduced the thiol content and superoxide dismutase and catalase activities and serum T4 level. Both doses of TQ decreased malondialdehyde and nitric oxide metabolites in the brain while enhanced the thiol content and superoxide dismutase and catalase activities and serum T4 level. The results of the present study showed that TQ protected against PTU-induced memory impairments in rats.

RESUMO Neste estudo, foi investigado o efeito da timoquinona (TQ) contra deficiências de memória induzidas por propiltiouracilo (PTU) em ratos juvenis. Os ratos foram agrupados em grupos: controle, Hypo, Hypo-TQ5, e Hypo-TQ10. O PTU aumentou o tempo de latência no teste do labirinto aquático de Morris (MWM) e diminuiu o atraso para entrar no compartimento escuro no teste de evasão passiva (PA). Ambas as doses de TQ diminuíram o tempo de latência no teste de MWM e aumentaram o atraso para entrar no compartimento escuro no teste de PA. O PTU também aumentou os metabolitos de malondialdeído (MDA) e óxido nítrico (NO) no cérebro, enquanto reduziu o teor de tiol e as atividades de superóxido dismutasa (SOD) e catalasa (CAT) e o nível sérico de T4. Ambas as doses de TQ diminuíram os metabolitos de MDA e de NO no cérebro, aumentaram o conteúdo de tiol e as atividades de SOD e CAT e o nível de T4 no soro. Os resultados do presente estudo mostraram que a TQ protegeu contra deficiências de memória induzidas por PTU em ratos.
Descritores: Benzoquinonas/farmacologia
Estresse Oxidativo/efeitos dos fármacos
Hipotireoidismo/complicações
Deficiências da Aprendizagem/tratamento farmacológico
Transtornos da Memória/tratamento farmacológico
Antioxidantes/farmacologia
-Propiltiouracila
Aprendizagem da Esquiva/efeitos dos fármacos
Superóxido Dismutase/análise
Antitireóideos
Lesões Encefálicas/metabolismo
Catalase/análise
Ratos Wistar
Aprendizagem em Labirinto/efeitos dos fármacos
Modelos Animais de Doenças
Hipocampo/efeitos dos fármacos
Hipotireoidismo/induzido quimicamente
Deficiências da Aprendizagem/induzido quimicamente
Malondialdeído/análise
Transtornos da Memória/induzido quimicamente
Óxido Nítrico/análise
Limites: Animais
Masculino
Responsável: BR1.1 - BIREME



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