Base de dados : LILACS
Pesquisa : D08.811.797 [Categoria DeCS]
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Id: lil-602394
Autor: Cavagnari, Brian M.
Título: Terapia génica: los ácidos nucleicos como fármacos: mecanismos de acción y vías de entrega a la célula / Gene therapy: nucleic acids as drugs: action mechanisms and delivery into the cell
Fonte: Arch. argent. pediatr;109(3):237-244, jun. 2011.
Idioma: es.
Resumo: La terapia génica involucra la transferencia de material genético a una célula para conseguir un beneficio terapéutico, por lo que ofrece una nueva opción para el tratamiento de muchas patologías. En este artículo se presentan algunos de los nuevos fármacos a base de ácidos nucleicos, como plásmidos, aptámeros, oligonucleótidos, ribozimas y pequeños ácidos ribonucleicos de interferencia. Se comenta el mecanismo y nivel de acción de estos agentes terapéuticos y se discuten sus varias vías de administración, como liposomas, polímeros catiónicos, transferencia directa de ácidos nucleicos y vectores virales.

Gene therapy involves the transference of new genetic material to the cell in order to obtain a therapeutic benefit, offering a new option for the treatment of various diseases. In this article, some of these nucleic acid-based drugs, such asplasmids, aptamers, oligonucleotides, ribozymes and small interfering ribonucleic acid, are presented. Their mechanism and level of action iscommented and several delivery systems, such as liposomes, cationic polymers, direct nucleic acid transfer and viral vectors, are also discussed.
Descritores: RNA Catalítico/uso terapêutico
Aptâmeros de Nucleotídeos
Biologia Molecular
Ácidos Nucleicos
Oligonucleotídeos
Limites: Seres Humanos
Masculino
Feminino
Responsável: AR94.1 - Centro de Información Pediatrica


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Id: lil-334867
Autor: Spangenberg, H. C; Wands, Jack R.
Título: Perspectivas futuras: imunização baseada em DNA, estratégias antipolaridade, ribozimas, mutantes negativos dominantes e anticorpos intracelulares / Future perspectives: DNA-based vaccination, antisense strategies and other molecular approaches
Fonte: In: Focaccia, Roberto. Tratado de hepatites virais. São Paulo, Atheneu, 2002. p.629-640, ilus.
Idioma: pt.
Descritores: Anticorpos
Hepatite Viral Humana
RNA Catalítico
Vacinas de DNA
Responsável: BR31.1 - SIDC - Serviço de Informação e Documentação Científica
BR31.1; WC536, F681t, 2002


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Id: lil-326425
Autor: Gallo, M; Montserrat, J. M; Iribarren, A. M.
Título: Design and applications of modified oligonucleotides
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;36(2):143-151, Feb. 2003. ilus.
Idioma: en.
Conferência: Apresentado em: Annual Meeting of the Brazilian Society of Biochemistry and Molecular Biology, 30, Caxambu, May 19-22, 2001.
Resumo: Oligonucleotides have a wide range of applications in fields such as biotechnology, molecular biology, diagnosis and therapy. However, the spectrum of uses can be broadened by introducing chemical modifications into their structures. The most prolific field in the search for new oligonucleotide analogs is the antisense strategy, where chemical modifications confer appropriate characteristics such as hybridization, resistance to nucleases, cellular uptake, selectivity and, basically, good pharmacokinetic and pharmacodynamic properties. Combinatorial technology is another research area where oligonucleotides and their analogs are extensively employed. Aptamers, new catalytic ribozymes and deoxyribozymes are RNA or DNA molecules individualized from a randomly synthesized library on the basis of a particular property. They are identified by repeated cycles of selection and amplification, using PCR technologies. Modified nucleotides can be introduced either during the amplification procedure or after selection
Descritores: Desenho de Drogas
Oligonucleotídeos
-Biblioteca Gênica
Terapia Genética
Oligonucleotídeos
Oligonucleotídeos Antissenso
RNA Catalítico
Limites: Seres Humanos
Tipo de Publ: Revisão
Responsável: BR1.1 - BIREME


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Id: lil-234893
Autor: Flatschart, R. B; Sogayar, M. C.
Título: Functional analysis of newly discovered growth control genes: experimental approaches
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;32(7):867-75, July 1999.
Idioma: en.
Conferência: Apresentado em: International Symposium on \"Signal Transduction and Gene Expression in Cell Proliferation and Differentiation\", 1, Säo Paulo, Aug. 31-Sept. 2, 1998.
Resumo: A large number of DNA sequences corresponding to human and animal transcripts have been filed in data banks, as cDNAs or ESTs (expression sequence tags). However, the actual function of their corresponding gene products is still largely unknown. Several of these genes may play a role in regulation of important biological processes such as cell division, differentiation, malignant transformation and oncogenesis. Elucidation of gene function is based on 2 main approaches, namely, overexpression and expression interference, which respectively mimick or suppress a given phenotype. The currently available tools and experimental approaches to gene functional analysis and the most recent advances in mass cDNA screening by functional analysis are discussed
Descritores: Elementos Antissenso (Genética)
Expressão Gênica
RNA Catalítico
Transgenes
-DNA Recombinante
Limites: Animais
Seres Humanos
Tipo de Publ: Revisão
Responsável: BR1.1 - BIREME



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