Base de dados : LILACS
Pesquisa : D08.811.913.050.134.415.500 [Categoria DeCS]
Referências encontradas : 1 [refinar]
Mostrando: 1 .. 1   no formato [Detalhado]

página 1 de 1

  1 / 1 LILACS  
             
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: lil-606641
Autor: Pierce, Raymond John; Dubois-Abdesselem, Florence; Caby, Stéphanie; Trolet, Jacques; Lancelot, Julien; Oger, Frédérik; Bertheaume, Nicolas; Roger, Emmanuel.
Título: Chromatin regulation in schistosomes and histone modifying enzymes as drug targets
Fonte: Mem. Inst. Oswaldo Cruz;106(7):794-801, Nov. 2011. ilus.
Idioma: en.
Resumo: Only one drug is currently available for the treatment and control of schistosomiasis and the increasing risk of selecting strains of schistosome that are resistant to praziquantel means that the development of new drugs is urgent. With this objective we have chosen to target the enzymes modifying histones and in particular the histone acetyltransferases and histone deacetylases (HDAC). Inhibitors of HDACs (HDACi) are under intense study as potential anti-cancer drugs and act via the induction of cell cycle arrest and/or apoptosis. Schistosomes like other parasites can be considered as similar to tumours in that they maintain an intense metabolic activity and rate of cell division that is outside the control of the host. We have shown that HDACi can induce apoptosis and death of schistosomes maintained in culture and have set up a consortium (Schistosome Epigenetics: Targets, Regulation, New Drugs) funded by the European Commission with the aim of developing inhibitors specific for schistosome histone modifying enzymes as novel lead compounds for drug development.
Descritores: Cromatina/efeitos dos fármacos
Inibidores Enzimáticos/farmacologia
Histona Acetiltransferases/antagonistas & inibidores
Histona Desacetilases/metabolismo
Schistosoma/efeitos dos fármacos
-Cromatina/metabolismo
Desenho de Fármacos
Histona Acetiltransferases/metabolismo
Inibidores de Histona Desacetilases/farmacologia
Schistosoma/enzimologia
Limites: Animais
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME



página 1 de 1
   


Refinar a pesquisa
  Base de dados : Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde