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Pesquisa : D08.811.913.050.618 [Categoria DeCS]
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Id: lil-703641
Autor: Silva, Bruna Daniella Souza; Tannus-Silva, Daniela Graner Schuwartz; Rabahi, Marcelo Fouad; Kipnis, Andre; Junqueira-Kipnis, Ana Paula.
Título: The use of Mycobacterium tuberculosis HspX and GlcB proteins to identify latent tuberculosis in rheumatoid arthritis patients
Fonte: Mem. Inst. Oswaldo Cruz;109(1):29-37, 02/2014. tab, graf.
Idioma: en.
Projeto: CNPq; . CNPq; . CNPq.
Resumo: Rheumatoid arthritis (RA) is an autoimmune disease characterised by the destruction of articular cartilage and bone damage. The chronic treatment of RA patients causes a higher susceptibility to infectious diseases such as tuberculosis (TB); one-third of the world’s population is latently infected (LTBI) with Mycobacterium tuberculosis (Mtb). The tuberculin skin test is used to identify individuals LTBI, but many studies have shown that this test is not suitable for RA patients. The goal of this work was to test the specific cellular immune responses to the Mtb malate synthase (GlcB) and heat shock protein X (HspX) antigens of RA patients and to correlate those responses with LTBI status. The T-helper (Th)1, Th17 and Treg-specific immune responses to the GlcB and HspX Mtb antigens were analysed in RA patients candidates for tumour necrosis factor-α blocker treatment. Our results demonstrated that LTBI RA patients had Th1-specific immune responses to GlcB and HspX. Patients were followed up over two years and 14.3% developed active TB. After the development of active TB, RA patients had increased numbers of Th17 and Treg cells, similar to TB patients. These results demonstrate that a GlcB and HspX antigen assay can be used as a diagnostic test to identify LTBI RA patients.
Descritores: Antígenos de Bactérias/imunologia
Artrite Reumatoide/imunologia
Proteínas de Bactérias/imunologia
Tuberculose Latente/diagnóstico
Malato Sintase/imunologia
Mycobacterium tuberculosis/imunologia
Linfócitos T Reguladores/imunologia
-Análise de Variância
Artrite Reumatoide/complicações
Ensaio de Imunoadsorção Enzimática
Citometria de Fluxo
Imunidade Celular/imunologia
/sangue
INTERLEUKIN-ABDOMEN, ACUTE/sangue
Estudos Longitudinais
Tuberculose Latente/complicações
Tuberculose Latente/imunologia
Leucócitos Mononucleares/imunologia
Células Th1/imunologia
/imunologia
THABNORMALITIES, RADIATION-INDUCED CELLS/imunologia
Fator de Crescimento Transformador beta/análise
Fator de Necrose Tumoral alfa/imunologia
Limites: Adulto
Idoso
Feminino
Humanos
Masculino
Pessoa de Meia-Idade
Responsável: BR1.1 - BIREME


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Id: lil-546010
Autor: Reis, Michelle Cristina Guerreiro dos; Rabahi, Marcelo Fouad; Kipnis, André; Junqueira-Kipnis, Ana Paula.
Título: Health care workers humoral immune response against GLcB, MPT51 and HSPX from Mycobacterium tuberculosis
Fonte: Braz. j. infect. dis;13(6):417-421, Dec. 2009. tab, ilus.
Idioma: en.
Resumo: Tuberculosis (TB) is one of the oldest human infectious diseases and one third of the world's population is latently infected. Brazil is an endemic area for TB. One of the most important challenges in TB control is the identification of latently infected individuals. Health Care Workers (HCW) are at high risk of being infected with Mycobacterium tuberculosis and even to become TB latently infected. The aim of this study was to increase knowledge about humoral immune response in TB latently infected individuals. HCW were classified according to their tuberculin skin test (TST), as positive or negative. The antibody response to GLcB, MPT51 and HSPX from Mycobacterium tuberculosis was evaluated. TST negative HCW constituted the majority of those who showed a humoral immune response. Antibody levels varied according to antigen characteristics, TST and BCG status. We suggest that possibly the presence of those antibodies could have a function in the protective immune response against Mycobacterium tuberculosis.
Descritores: Antígenos de Bactérias/imunologia
Proteínas de Bactérias/imunologia
Tuberculose Latente/imunologia
Malato Sintase/imunologia
Mycobacterium tuberculosis/imunologia
Recursos Humanos em Hospital
-Ensaio de Imunoadsorção Enzimática
Imunoglobulina G/imunologia
Imunoglobulina M/imunologia
Tuberculose Latente/microbiologia
Limites: Adulto
Feminino
Humanos
Masculino
Pessoa de Meia-Idade
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME



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