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Id: biblio-1138789
Autor: Yurgaky-Sarmiento, James; Otero-Regino, William; Gómez-Zuleta, Martín.
Título: Elevación de las aminotransferasas: una nueva herramienta para el diagnóstico de coledocolitiasis. Un estudio de casos y controles / Elevated transaminases: a new tool for the diagnosis of choledocholithiasis. A case control study
Fonte: Rev. colomb. gastroenterol;35(3):319-328, jul.-set. 2020. tab, graf.
Idioma: es.
Resumo: Resumen Introducción: la coledocolitiasis (CDL) afecta al 10 % de los pacientes con cálculos en la vesícula biliar. La obstrucción del colédoco se asocia a pancreatitis, colangitis y ruptura del colédoco. Clásicamente, la obstrucción biliar es considerada cuando se aumentan la fosfatasa alcalina, la γ-glutamil-transpeptidasa (GGTP) y las bilirrubinas. En la última década, se ha encontrado que hasta un 10 % de los pacientes con CDL presentan elevaciones de las aminotransferasas. En Latinoamérica, no se ha estudiado esta alteración. El objetivo del presente trabajo fue determinar la prevalencia de la elevación de transaminasas y su evolución. Metodología: estudio de casos y controles. Se determinó la alanina aminotransferasa (ALT) al ingreso, a las 48 h y a las 72 h. Si la ecografía era normal, se realizó una colangiorresonancia o una ecoendoscopia, así como una colangiopancreatografía retrógrada endoscópica (CPRE) cuando fue necesario. Resultados: se incluyeron 72 pacientes con CDL (casos) y 128 con colecistitis, sin CDL (controles). En los casos, el 83 % tuvo un aumento de ALT, mientras que el 56,9 % presentó una elevación de 2-9 veces, el 16 %, de 10-20 veces, y el 8,3 % mostró una elevación >20 veces. En contraste, a las 48 h, las ALT descendieron al 30 % y a las 72 h al 56 %. Entre tanto, en los controles hubo un aumento de ALT en el 27,3 %, mientras que en el 15,6 % se observó una elevación de 2-9 veces, en el 7,8 %, de 10-20 veces, y >20 veces en el 2,9 %. La combinación de cólico biliar y la elevación de ALT tuvo un valor predictivo positivo (VPP) para CDL del 72 %, así como un valor predictivo negativo (VPN) del 87,7 %. Conclusión: cuando hay un cólico biliar y una elevación de ALT es imperativo descartar una CDL, y si la ecografía es normal, es necesario realizar una colangiorresonancia o una ecoendoscopia biliopancreática.

Abstract Introduction: Choledocolithiasis (CLD) affects 10% of patients with gallstones. Bile duct obstruction is associated with pancreatitis, cholangitis, and rupture of the common bile duct. This condition usually presents with increased alkaline phosphatase, GGTP and bilirubin levels. In the last decade, it has been found that up to 10% of patients with CLD have elevated aminotransferases levels. In Latin America, this alteration has not been studied. The aim of the present work was to determine the prevalence of transaminase elevation and its evolution. Methodology: Case-control study. ALT was measured on admission, at 48 h and at 72 h. If ultrasound was normal, MRCP and/or echo-endoscopy and ERCP were performed, as appropriate. Results: A total of 72 patients with choledocholithiasis (CLD) (cases) and 128 with cholecystitis without choledocholithiasis (controls) were included. Among the cases, 83% had increased ALT levels, which was 2-9 times higher in 56.9%, 10-20 times higher in 16%, and more than 20 times higher in 8.3%. At 48 hours, those levels decreased by 30% and at 72 hours by 56%. In turn, in 27.3% of the controls, ALT was 2-9 times higher in 15.6%, 10-20 times higher in 7.8% and more than 20 times higher in 2.9%. The combination of biliary colic and ALT elevation had a positive predictive value (PPV) for CLD of 72% and a negative predictive value (NPV) of 87.7%. Conclusion: When biliary colic and ALT elevation are reported, it is imperative to rule out choledocholithiasis. If the ultrasound is normal, MRCP and/or biliopancreatic endoscopy should be performed.
Descritores: Estudos de Casos e Controles
Colangiopancreatografia Retrógrada Endoscópica
Remoção
Coledocolitíase
Diagnóstico
Alanina Transaminase
Transaminases
-Cólica
Endossonografia
Limites: Humanos
Tipo de Publ: Estudo Clínico
Responsável: CO354 - Sociedad Colombiana de Gastroenterología


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Id: biblio-1124988
Autor: Cifuentes Cifuentes, Yolanda; Angel-Müller, Edith; Díaz Moreno, Rosa Cecilia.
Título: Sífilis congénita resultado de una Neurosífilis materna no diagnosticada. Reporte de caso / Congenital syphilis due to undiagnosed maternal neurosyphilis: case report
Fonte: Med. UIS;33(1):73-80, ene.-abr. 2020. tab.
Idioma: es.
Resumo: Resumen En el mundo, se ha evidenciado un aumento de los casos de sífilis, de sífilis gestacional y de sífilis congénita. Se presenta el caso de un recién nacido con sífilis congénita, hijo de una madre con sífilis latente de duración indeterminada (VDRL 1:4 diluciones) diagnosticada y tratada a la semana 12 de gestación, VIH negativa, con compañero seronegativo para sífilis; a pesar del tratamiento con tres dosis de 2'400 000 U de penicilina benzatínica, no modificó los títulos del VDRL ni en el control de la semana 25 de gestación, ni en el momento del parto. En el posparto, la madre fue diagnosticada con neurosífilis y recibió tratamiento con penicilina cristalina durante 14 días. El recién nacido fue diagnosticado con sífilis congénita por presentar VDRL 1:4 diluciones, aumento de aminotransferasas, hematuria y proteinuria, recibiendo tratamiento con penicilina cristalina durante 10 días. La paciente evolucionó favorablemente y el control a los 6 meses fue normal. Deben fomentarse medidas útiles en la prevención de la sífilis gestacional: métodos de barrera, conocimiento de la enfermedad y asistencia a control prenatal. Es fundamental identificar y tratar a las gestantes con sífilis mediante tamizaje serológico para prevenir la sífilis congénita; el seguimiento serológico debe ser estricto para verificar la eficacia del tratamiento e investigar las gestantes que no modifican los títulos después del tratamiento. MÉD.UIS.2020;33(1):73-80.

Abstract In the world, there has been an increase in cases of syphilis, gestational syphilis and congenital syphilis. It's presented the case of a newborn with congenital syphilis, son of a mother with latent syphilis of indeterminate duration (VDRL 1: 4 dilutions) diagnosed and treated at week 12 of gestation, HIV negative, with seronegative partner for syphilis; despite treatment with three doses of 2'400 000 U of benzathine penicillin, the VDRL titres remained unaltered on both the control of the 25th week of gestation and at the time of delivery. The mother, in the postpartum period, was diagnosed with neurosyphilis and was treated with crystalline penicillin for 14 days. The newborn was diagnosed with congenital syphilis by presenting 1:4 VDRL dilutions, increased aminotransferases, hematuria and proteinuria; he was treated with crystalline penicillin for 10 days. Useful measures should be promoted in the prevention of gestational syphilis such as barrier methods, knowledge of the disease and assistance to prenatal control. It is mandatory to identify and treat pregnant women with syphilis by serological screening for the disease in order to prevent congenital syphilis. Serological follow-up should be strict to verify the effectiveness of the treatment and to investigate pregnant women who do not modify the titres after treatment. MÉD.UIS.2020;33(1):73-80.
Descritores: Sífilis Congênita
Sífilis Latente
-Penicilina G Benzatina
Proteinúria
Treponema pallidum
Recém-Nascido
Gravidez
Sífilis
Transaminases
Hematúria
Neurossífilis
Limites: Humanos
Masculino
Recém-Nascido
Tipo de Publ: Relatos de Casos
Responsável: CO48.1 - Biblioteca Médica


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Id: biblio-950745
Autor: Moreira, Priscila R; Maioli, Marcos A; Medeiros, Hyllana CD; Guelfi, Marieli; Pereira, Flávia TV; Mingatto, Fábio E.
Título: Protective effect of bixin on carbon tetrachloride-induced hepatotoxicity in rats
Fonte: Biol. Res;47:1-7, 2014. ilus, graf.
Idioma: en.
Resumo: BACKGROUND: The liver is an important organ for its ability to transform xenobiotics, making the liver tissue a prime target for toxic substances. The carotenoid bixin present in annatto is an antioxidant that can protect cells and tissues against the deleterious effects of free radicals. In this study, we evaluated the protective effect of bixin on liver damage induced by carbon tetrachloride (CCl4) in rats. RESULTS: The animals were divided into four groups with six rats in each group. CCl4 (0.125 mL kg-1 body wt.) was injected intraperitoneally, and bixin (5.0 mg kg-1 body wt.) was given by gavage 7 days before the CCl4 injection. Bixin prevented the liver damage caused by CCl4, as noted by the significant decrease in serum aminotransferases release. Bixin protected the liver against the oxidizing effects of CCl4 by preventing a decrease in glutathione reductase activity and the levels of reduced glutathione and NADPH. The peroxidation of membrane lipids and histopathological damage of the liver was significantly prevented by bixin treatment. CONCLUSION: Therefore, we can conclude that the protective effect of bixin against hepatotoxicity induced by CCl4 is related to the antioxidant activity of the compound.
Descritores: Tetracloreto de Carbono/antagonistas & inibidores
Carotenoides/farmacologia
Espécies Reativas de Oxigênio/análise
Estresse Oxidativo/efeitos dos fármacos
Doença Hepática Induzida por Substâncias e Drogas/prevenção & controle
Antioxidantes/farmacologia
-Extratos Vegetais/química
Peroxidação de Lipídeos/efeitos dos fármacos
Carotenoides/química
Ratos Wistar
Bixaceae/química
Doença Hepática Induzida por Substâncias e Drogas/metabolismo
Doença Hepática Induzida por Substâncias e Drogas/patologia
Glutationa/análise
Glutationa Redutase/efeitos dos fármacos
Transaminases/sangue
Fígado/enzimologia
Malondialdeído/análise
NADP/análise
Limites: Animais
Masculino
Ratos
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1020439
Autor: Carvalho, Letícia Helena de; Teixeira, Leda Fabiélen; Zaqueo, Kayena Delaix; Bastos, Jéssica Felix; Nery, Neriane Monteiro; Setúbal, Sulamita Silva; Pontes, Adriana Silva; Butzke, Diana; Cavalcante, Walter; Gallacci, Marcia; Fernandes, Carla Freire Celedônio; Stabeli, Rodrigo Guerino; Soares, Andreimar Martins; Zuliani, Juliana Pavan.
Título: Local and systemic effects caused by Crotalus durissus terrificus, Crotalus durissus collilineatus, and Crotalus durissus cascavella snake venoms in swiss mice
Fonte: Rev. Soc. Bras. Med. Trop;52:e20180526, 2019. tab, graf.
Idioma: en.
Projeto: Conselho Nacional de Desenvolvimento Científico e Tecnológico.
Resumo: Abstract INTRODUCTION: Crotalus envenomations cause serious complications and can be fatal without appropriate treatment. Venom isoforms present and inter/intraspecific variations in the venom composition can result in different symptoms presented by bites by snakes from the same species but from different geographical regions. We comparatively evaluated the local and systemic effects caused by Crotalus durissus terrificus (Cdt), C.d. collilineatus (Cdcolli), and C.d. cascavella (Cdcasc) envenomation. METHODS: Venom chromatography was performed. Proteolytic, phospholipase, and LAAO activities were analyzed. Edema, myotoxicity, hepatotoxicity, nephrotoxicity, and coagulation alterations were evaluated. RESULTS: The venom SDS-PAGE analyses found the presence of convulxin, gyroxin, crotoxin, and crotamine in Cdt and Cdcolli venoms. Crotamine was not present in the Cdcasc venom. Cdt, Cdcollli, and Cdcasc venoms had no proteolytic activity. Only Cdcasc and Cdt venoms had phospholipase activity. LAAO activity was observed in Cdcolli and Cdcasc venoms. Cdcolli and Cdcasc venoms caused 36.7% and 13.3% edema increases, respectively. Cdt venom caused a 10% edema induction compared to those by other venoms. All venoms increased TOTAL-CK, MB-CK, and LDH levels (indicating muscle injury) and ALT, AST, GGT, and ALP levels (markers of liver damage) and were able to induce a neuromuscular blockade. Urea and creatinine levels were also altered in both plasma and urine, indicating kidney damage. Only Cdcolli and Cdcasc venoms increased TAPP and TAP. CONCLUSIONS: Together, these results allow us to draw a distinction between local and systemic effects caused by Crotalus subspecies, highlighting the clinical and biochemical effects produced by their respective venoms.
Descritores: Crotalus/classificação
Venenos de Crotalídeos/toxicidade
Edema/induzido quimicamente
Rim/efeitos dos fármacos
Fígado/efeitos dos fármacos
-Ureia/sangue
Creatina Quinase/efeitos dos fármacos
Creatina Quinase/sangue
Creatinina/sangue
Modelos Animais
Edema/patologia
Eletroforese em Gel de Poliacrilamida
Fosfatase Alcalina/efeitos dos fármacos
Fosfatase Alcalina/sangue
Transaminases/efeitos dos fármacos
Transaminases/sangue
Rim/patologia
L-Lactato Desidrogenase/efeitos dos fármacos
L-Lactato Desidrogenase/sangue
Fígado/patologia
Camundongos
Limites: Animais
Responsável: BR1.1 - BIREME


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Id: lil-502562
Autor: Anon.
Título: Guías del laboratorio para Screening, diagnóstico y monitoreo de la lesión hepática: Seccion I / Guides laboratory for Screening, Diagnosis and monitoring of liver injury: Section I
Fonte: Acta bioquím. clín. latinoam;39(3):359-376, 2005. tab, graf.
Idioma: es.
Descritores: Testes de Função Hepática/normas
-Albuminas
Amônia/sangue
Bilirrubina
Carcinoma Hepatocelular/diagnóstico
Cirrose Hepática/diagnóstico
Fosfatase Alcalina/sangue
Hepatite Crônica/diagnóstico
Hepatite Viral Humana/diagnóstico
Testes de Função Hepática/métodos
Tempo de Protrombina
Transaminases/sangue
gama-Glutamiltransferase/sangue
Limites: Humanos
Tipo de Publ: Guia
Responsável: AR144.1 - CIBCHACO - Centro de Información Biomedica del Chaco


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Id: biblio-1179095
Autor: Rivera Zelada, Laura Franchesca.
Título: Epidemiologia del hígado graso en niños con obesidad y su relación con niveles de transaminasas, en niños de la consulta externa de endocrinología del Hospital Nacional de Niños Benjamín Bloom, periodo de octubre 2009 ­ octubre 2014 / Fatty liver epidemiology in obese children and its relationship with transaminase levels, in children from the endocrinology outpatient clinic of the Benjamín Bloom National Children's Hospital, period from October 2009 - October 2014.
Fonte: San Salvador; s.n; 2018. 64 p. graf.
Idioma: es.
Tese: Apresentada a Universidad de El Salvador para obtenção do grau de Especialista.
Resumo: El hígado graso no alcohólico es una entidad prevalente que se encuentra frecuentemente asociada al síndrome metabólico en pacientes obesos y está relacionado con alteración de marcadores séricos principalmente transaminasas. Se realizó un estudio descriptivo de corte retrospectivo donde se analizó la base de pacientes con diagnóstico de obesidad de la consulta externa de Endocrinología del Hospital de Niños Benjamín Bloom en el período de octubre de 2009 a octubre de 2014 que constaba de 1040, seleccionando una muestra aleatoria de 281 registros para un intervalo de confianza del 95%. El 53.02%(149) de los pacientes fueron de sexo masculino, el 85.05%(239) se encontraban en los grupos etarios de escolares y adolescentes, que procedían el 70.46% (198) de los departamentos de San Salvador y la Libertad, se determinó estado hepático de hígado Graso en un 54.48%(152/281) basado en hallazgos ultrasonográficos con descripción de hígado graso 30.60%(86/281) o valores elevados de transaminasas altas 41.58% (116/279), de la población con hígado graso se encontró una prevalencia de valores séricos por encima de los rangos normales en triglicéridos 46.36%(70/151, seguido de insulina 20.73%(17/82), colesterol 12.50%(19/152) y glucosa 1.97% (3/152), a diferencia de los que no presentaron hígado graso que evidenciaron valores inferiores. La presencia de hígado graso tomando en cuenta hallazgos ultrasonográficos y valores de transaminasas en los pacientes con obesidad alcanza hasta la mitad de la población en estudio elevando la prevalencia alteraciones en marcadores serológicos siendo los más afectados triglicéridos e insulina
Descritores: Fígado Gorduroso
-Pediatria
Endocrinologia
Obesidade Pediátrica
Transaminases
Responsável: SV2 - Departamento de Gobernanza y Gestión del Conocimiento


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Id: biblio-1091898
Autor: Binicier, Omer Burcak; Tosun, Ferahnaz.
Título: Evaluation of adult celiac disease from a tertiary reference center: a retrospective analysis
Fonte: Rev. Assoc. Med. Bras. (1992);66(1):55-60, Jan. 2020. tab, graf.
Idioma: en.
Resumo: SUMMARY OBJECTIVE It has been observed that celiac disease (CD) is not restricted to a single type characterized by diarrhea but also has atypical, asymptomatic (silent), and latent forms. The prevalence of this autoimmune disease, which affects approximately 1% of the world, is estimated to be around 3%, including atypical and asymptomatic cases. In our study, we aimed to evaluate adult celiac patients. METHODS Between December 2008-2015, patients diagnosed with CD over the age of 18 years old were included in the study. Patients' symptoms at admission, frequency and type of anemia, transaminase levels, and celiac antibody positivity, and autoimmune diseases diagnosed at follow up were evaluated retrospectively. RESULTS Of 195 patients, 151 (77.4%) were female. The mean age of the patients was 35.73 ± 12.19 years (range, 18-71 years). A hundred patients (51.3%) had gastrointestinal symptoms. At the time of admission, 118 patients (60.5%) had anemia, and 52 (26.7%) had hypertransaminasemia. During the mean follow-up period of 58 months (36-120 months), 84 (43.1%) of the patients presented at least one autoimmune disease, and this rate was 96.6% in individuals diagnosed above the age of 50 years. CONCLUSION In adult CD, resistant anemia, dyspepsia, and hypertransaminasemia are very common findings at the time of diagnosis, and the association with other autoimmune diseases, especially Hashimoto's thyroiditis, is high.

RESUMO OBJETIVOS Observou-se que a doença celíaca (DC) não se restringe a um único tipo caracterizado por diarreia, mas também tem formas atípicas, assintomáticas (silenciosas) e latentes. Estima-se que a prevalência desta doença autoimune, que afeta aproximadamente 1% da população do mundo, seja em torno de 3%, incluindo casos atípicos e assintomáticos. Em nosso estudo, objetivou-se avaliar pacientes celíacos adultos. MÉTODOS Entre dezembro de 2008 e 2015, pacientes diagnosticados como DC com idade acima de 18 anos foram incluídos no estudo. Os sintomas dos pacientes na admissão, frequência e tipo de anemia, níveis de transaminases e positividade de anticorpos celíacos e doenças autoimunes diagnosticadas no seguimento foram avaliados retrospectivamente. RESULTADOS Dos 195 pacientes, 151 (77,4%) eram do sexo feminino. A média de idade dos pacientes foi de 35,73±12,19 anos (variação de 18 a 71 anos). Cem pacientes (51,3%) foram encaminhados com sintomas gastrointestinais. No momento da internação, 118 pacientes (60,5%) apresentavam anemia e 52 (26,7%) apresentavam hipertransaminemia. Durante o período médio de acompanhamento de 58 meses (36-120 meses), 84 (43,1%) pacientes estavam acompanhados por pelo menos uma doença autoimune, e essa taxa foi de 96,6% em indivíduos diagnosticados acima dos 50 anos de idade. CONCLUSÃO No adulto DC, anemia resistente, dispepsia e hipertransaminasemia são achados muito comuns no momento do diagnóstico e a associação com outras doenças autoimunes, especialmente tireoidite de Hashimoto, é alta.
Descritores: Doenças Autoimunes/epidemiologia
Doença Celíaca/epidemiologia
Anemia/epidemiologia
-Doenças Autoimunes/complicações
Doenças da Glândula Tireoide/complicações
Doenças da Glândula Tireoide/epidemiologia
Turquia/epidemiologia
Doença Celíaca/complicações
Prevalência
Estudos Retrospectivos
Distribuição por Idade
Estatísticas não Paramétricas
Centros de Atenção Terciária/estatística & dados numéricos
Transaminases/sangue
Anemia/complicações
Pessoa de Meia-Idade
Limites: Humanos
Masculino
Feminino
Adolescente
Adulto
Idoso
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: biblio-1151867
Autor: Soydan, Levent; Akici, Narin; Coskun, Yesim.
Título: Asociación entre el espesor de la grasa subcutánea abdominal y la esteatosis hepática, las enzimas hepáticas y los lípidos séricos en niños obesos / Association of abdominal subcutaneous fat thickness with hepatic steatosis, liver enzymes, and serum lipids in obese children
Fonte: Arch. argent. pediatr;119(2):114-122, abril 2021. tab, ilus.
Idioma: en; es.
Resumo: Introducción. La obesidad infantil puede causar hiperlipidemia y esteatosis hepática y complicaciones crónicas. Nuestro objetivo fue evaluar la relación entre el espesor de la grasa subcutánea abdominal (GSA) y la esteatosis hepática, las transaminasas y los lípidos séricos en niños obesos.Población y métodos. Estudio retrospectivo en niños (4-18 años) que acudieron a los consultorios externos. Se evaluaron las asociaciones entre el espesor de la GSA mediante ecografía y la esteatosis hepática, alanina aminotransferasa (ALT), aspartato aminotransferasa (AST) y el perfil lipídico sérico.Resultados. Se identificaron 95 niños con esteatosis hepática; el grado 1 fue el más frecuente (73,6 %, n: 70), seguido del grado 2 (21,1 %) y del 3 (5,3 %). El espesor medio (en mm) de la GSA de línea media y flancos fue 38,48 ± 11,53 y 20,91 ± 8,00 en grado 1; 41,23 ± 10,03 y 19,84 ± 6,75 en grado 2, y 63,12 ± 12,08 y 23,22 ± 5,92 en grado 3, respectivamente. El espesor de la GSA de línea media y flancos se correlacionó positivamente con triglicéridos en grado 3; el espesor de la GSA de línea media se correlacionó con el índice de masa corporal, colesterol total, colesterol LDL y AST (r: 0,9; p: 0,037; r: 0,648; p: 0,001; r: 0,387; p: 0,001; r: 0,406; p: 0,001; r: 0,463; p: 0,001; respectivamente) en grado 1.Conclusión. El espesor de la GSA mediante ecografía puede predecir hiperlipidemia en niños obesos con esteatosis hepática de grado 3 e hipercolesterolemia en grado 1.

Introduction. Childhood obesity can cause hyperlipidemia and hepatic steatosis at early age and chronic disease complications in adult life. We aimed to evaluate the relationship between abdominal subcutaneous fat thickness (ASFT) and hepatic steatosis, serum lipid and transaminase levels in obese children.Population and methods. A retrospective study was conducted with children (aged 4-18 years) who presented to outpatient clinic due to obesity. Associations between ASFT as assessed by ultrasonography (US) and hepatic steatosis, alanine transaminase (ALT), aspartate transaminase (AST) and serum lipid profile were evaluated.Results. We identified 95 children, all of which were diagnosed as having hepatic steatosis; the most common type was grade 1 (73.6 %, n: 70), followed by grade 2 (21.1 %) and grade 3 (5.3 %). The mean values of midline and flank ASFT were measured as 38.48 ± 11.53 mm and 20.91 ± 8.00 mm in grade 1; 41.23 ± 10.03 and 19.84 ± 6.75 in grade 2 and 63.12 ± 12.08 and 23.22 ± 5.92 in grade 3 hepatic steatosis, respectively. Midline and flank ASFT correlated positively with triglycerides in grade 3 steatosis, while midline ASFT correlated with body mass index, total cholesterol, low-density lipoprotein cholesterol, and AST (r: 0.9; p: 0.037; r: 0.648, p: 0.001; r: 0.387, p: 0.001; r: 0.406, p: 0.001, r: 0.463, p: 0.001; respectively) in grade 1 steatosis.Conclusion. ASFT as assessed by US may be of predictive value for hyperlipidemia in grade 3 and for hypercholesterolemia in grade 1 hepatic steatosis in obese children.
Descritores: Gordura Subcutânea Abdominal/diagnóstico por imagem
Obesidade Pediátrica
-Turquia/epidemiologia
Estudos Retrospectivos
Metabolismo dos Lipídeos
Fígado Gorduroso/diagnóstico por imagem
Transaminases
Limites: Humanos
Masculino
Pré-Escolar
Criança
Adolescente
Responsável: AR94.1 - Centro de Información Pediatrica


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Id: biblio-1011408
Autor: Márquez, Sebastián L; Blamey, Jenny M.
Título: Isolation and partial characterization of a new moderate thermophilic Albidovulum sp. SLM16 with transaminase activity from Deception Island, Antarctica
Fonte: Biol. Res;52:5, 2019. tab, graf.
Idioma: en.
Resumo: BACKGROUND: A moderately thermophilic, slightly halophilic, aerobic, Gram-stain negative, bacterial strain, SLM16, was isolated from a mixed of seawater-sand-sediment sample collected from a coastal fumarole located in Whalers Bay, Deception Island, Antarctica. The aim was to screen for thermophilic microorganisms able to degrade primary amines and search for amine transaminase activity for potential industrial application. RESULTS: Identification and partial characterization of the microorganism SLM16 were carried out by means of morphological, physiological and biochemical tests along with molecular methods. Cells of strain SLM16 were non-motile irregular rods of 1.5-2.5 µm long and 0.3-0.45 µm wide. Growth occurred in the presence of 0.5-5.5% NaCl within temperature range of 35-55 °C and pH range of 5.5-9.5, respectively. The DNA G+C composition, estimated from ftsY gene, was 66% mol. Phylogenetic analysis using de 16S rRNA gene sequence showed that strain SLM16 belongs to the marine bacterial genus Albidovulum. CONCLUSION: Strain SLM16 is a moderate thermophilic Gram negative microorganisms which belongs to the marine bacterial genus Albidovulum and is closely related to Albidovulum inexpectatum species based on phylogenetic analysis. Additionally, amine-transaminase activity towards the arylaliphatic amine α-methylbenzylamine was detected.
Descritores: Água do Mar/microbiologia
DNA Bacteriano/genética
Rhodobacteraceae/isolamento & purificação
Rhodobacteraceae/enzimologia
Transaminases/metabolismo
-Filogenia
RNA Ribossômico 16S/genética
Técnicas de Tipagem Bacteriana
Análise de Sequência de DNA
Rhodobacteraceae/classificação
Regiões Antárticas
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1001219
Autor: Di, Na; Zhou, Xinchuan; Chen, Yaxiao; Zhao, Xiaomiao; Li, Lin; Jiang, Linlin; Luo, Baoming; Chen, Xiaoli; Yang, Dongzi.
Título: Could semiquantitative analysis of real-time ultrasound elastography distinguish more liver parenchyma alterations of nonalcoholic fatty liver disease in patients with polycystic ovary syndrome?
Fonte: Arch. endocrinol. metab. (Online);63(2):128-136, Mar.-Apr. 2019. tab, graf.
Idioma: en.
Projeto: National Natural Science Foundation of China; . National Natural Science Youth Fund of China; . 5010 Programs Fund for clinical medicine research at Sun Yat-sen University; . Science and Technology research project of Guangzhou city; . Science and Technology Project of Guangdong Province.
Resumo: ABSTRACT Objective: Nonalcoholic fatty liver disease is the commonest diffuse liver disease, of which women with polycystic ovary syndrome are at an increased risk. The aim of the present study was to assess the diagnostic value of the semiquantitative strain parameters of real-time ultrasound elastography for nonalcoholic fatty liver disease in patients with polycystic ovary syndrome. Subjects and methods: Thirty-five polycystic ovary syndrome patients with nonalcoholic fatty liver disease, 70 polycystic ovary syndrome patients without nonalcoholic fatty liver disease, and 70 healthy female controls of reproductive age were included. All participants underwent ultrasonic examination and semiquantitative analysis of real-time ultrasound elastography of the liver. Results: Main semi quantitative strain parameters, such as average strain value, differed significantly among groups polycystic ovary syndrome with nonalcoholic fatty liver disease, polycystic ovary syndrome without nonalcoholic fatty liver disease, and control (87.02 ± 10.16 vs. 96.31 ± 11.44 vs. 104.49 ± 7.28, p < 0.001). Clinical and laboratory parameters differed significantly between the two subgroups with low or high average strain value. For diagnostic value of average strain value for elevated aminotransferase, the area under the curve was 0.808 (range 0.721-0.895). In multiple linear regression analysis, polycystic ovary syndrome, waist circumference, and metabolic syndrome were stand-alone independent factors associated with average strain value among subjects without nonalcoholic fatty liver disease. Conclusion: Semiquantitative real-time ultrasound elastography analysis could distinguish liver parenchyma alterations in patients with polycystic ovary syndrome more sensitively. The diagnostic value of the proposed method for nonalcoholic fatty liver disease need further research.
Descritores: Síndrome do Ovário Policístico/diagnóstico por imagem
Técnicas de Imagem por Elasticidade/métodos
Hepatopatia Gordurosa não Alcoólica/diagnóstico por imagem
-Síndrome do Ovário Policístico/fisiopatologia
Pressão Sanguínea
Processamento de Imagem Assistida por Computador
Índice de Massa Corporal
Sensibilidade e Especificidade
Diagnóstico Diferencial
Circunferência da Cintura
Hepatopatia Gordurosa não Alcoólica/fisiopatologia
Tecido Parenquimatoso/fisiopatologia
Tecido Parenquimatoso/diagnóstico por imagem
Transaminases/sangue
Menstruação/fisiologia
Limites: Humanos
Feminino
Adulto
Adulto Jovem
Responsável: BR1.1 - BIREME



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