Base de dados : LILACS
Pesquisa : D08.811.913.555.500.100 [Categoria DeCS]
Referências encontradas : 3 [refinar]
Mostrando: 1 .. 3   no formato [Detalhado]

página 1 de 1

  1 / 3 LILACS  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Cavalheiro, Esper Abräo
Amado, Débora
Texto completo
Id: lil-450913
Autor: Lima, Eliângela de; Cabral, Francisco Romero; Cavalheiro, Esper Abrão; Naffah-Mazzacoratti, Maria da Graça; Amado, Débora.
Título: Efeito neuroprotetor da melatonina e N-acetilserotonina na epileptogênese e no controle de crises em animais submetidos ao modelo da pilocarpina / Neuroprotector effect of melatonin and N-acetilserotonin in the epileptogenesis and in the control of seizures in animals submitted to the pilocarpine model
Fonte: J. epilepsy clin. neurophysiol;12(2):75-78, June 2006.
Idioma: pt.
Resumo: PURPOSE: The aim of this research was to study the effects of treatment with melatonin and N-acetilserotonin in the development of pilocarpina model of epilepsy in adult male rats. METHODS: Part I - The animals were divided in 4 groups: SALINE - animals that received only saline; SE - animals submitted to status epilepticus (SE); NAS + SE - animals that received pre-treatment with N-acetylserotonin and were submitted to SE and MEL + SE - animals that received pre-treatment with melatonin and were submitted to SE. Part II - The animals were divided in 6 groups: SALINE - animals that received only saline; SE - animals submitted to status epilepticus (SE); PX + SE - animals submitted to pinealectomy and to SE 7 days later; SH + SE - animals submitted to sham-surgery and to SE 7 days later; SE + NAS - animals submitted to SE and treated with N-acetylserotonin (2,5 mg/kg), 30 min, 1 h, 2 h, 4 h, 6 h, 12 h, 24 h, 36 h and 48 h after the SE and SE + MEL - animals submitted to SE and treated with melatonin (2,5 mg/kg), 30 min, 1 h, 2 h, 4 h, 6 h, 12 h, 24 h, 36 h and 48 h after the SE. Following the treatment the animals were continuously video-recorded for 60 days. The behavioral parameters were observed: latency for the SE in minutes, latency for the first spontaneous seizures (ie, duration of the silent period), number of spontaneous seizures during the chronic period and mortality. Five animals per group were perfused for neo-Timm assay. RESULTS: Part I - The animals treated with melatonin and N-acetylserotonin presented an increased of latency for the status epilepticus and decreased number of spontaneous seizures during the chronic period when compared to SE group. The mortality was reduced 100 percent in animals treated with melatonin and theses animals presented a minor mossy fibers sprouting. Part II - The latency for the first spontaneous seizures and mortality were similar in all groups. The animals treated with melatonin presented...
Descritores: Pilocarpina/administração & dosagem
Acetilserotonina O-Metiltransferasa/farmacocinética
Epilepsia do Lobo Temporal
Melatonina/farmacocinética
-Ratos Wistar
Modelos Animais
Limites: Animais
Ratos
Responsável: BR1.1 - BIREME


  2 / 3 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: lil-348288
Autor: Hotta, C. T; Markus, R. P; Garcia, C. R. S.
Título: Melatonin and N-acetyl-serotonin cross the red blood cell membrane and evoke calcium mobilization in malarial parasites
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;36(11):1583-1587, Nov. 2003. ilus.
Idioma: en.
Resumo: The duration of the intraerythrocytic cycle of Plasmodium is a key factor in the pathogenicity of this parasite. The simultaneous attack of the host red blood cells by the parasites depends on the synchronicity of their development. Unraveling the signals at the basis of this synchronicity represents a challenging biological question and may be very important to develop alternative strategies for therapeutic approaches. Recently, we reported that the synchrony of Plasmodium is modulated by melatonin, a host hormone that is synthesized only during the dark phases. Here we report that N-acetyl-serotonin, a melatonin precursor, also releases Ca2+ from isolated P. chabaudi parasites at micro- and nanomolar concentrations and that the release is blocked by 250 mM luzindole, an antagonist of melatonin receptors, and 20 mM U73122, a phospholipase C inhibitor. On the basis of confocal microscopy, we also report the ability of 0.1 æM melatonin and 0.1 æM N-acetyl-serotonin to cross the red blood cell membrane and to mobilize intracellular calcium in parasites previously loaded with the fluorescent calcium indicator Fluo-3 AM. The present data represent a step forward into the understanding of the signal transduction process in the host-parasite relationship by supporting the idea that the host hormone melatonin and N-acetyl-serotonin generate IP3 and therefore mobilize intracellular Ca2+ in Plasmodium inside red blood cells.
Descritores: Acetilserotonina O-Metiltransferasa
Cálcio
Membrana Eritrocítica
Melatonina
Plasmodium chabaudi
-Sinalização do Cálcio
Permeabilidade da Membrana Celular
Interações Hospedeiro-Parasita
Camundongos Endogâmicos BALB C
Microscopia Confocal
Limites: Animais
Camundongos
Responsável: BR1.1 - BIREME


  3 / 3 LILACS  
              first record previous record
seleciona
para imprimir
Fotocópia
Id: lil-80399
Autor: Pelzer, Lilian E; Guzmán, Jorge A.
Título: Pineal serotonin N - acetyltransferase and hydroxyindole - 0 - methyltransferase activities in vizcacha (Lagostomus maximus maximus) maintained under various photoperiods
Fonte: Acta physiol. pharmacol. latinoam;39(3):299-305, 1989. tab.
Idioma: en.
Resumo: Este trabajo tiene como propósito estudiar las actividades de las enzimas NAT y HIOMT en glándula pineal de vizcacha, bajo distintos regímenes de iluminación. La actividad de NAT presentó marcada variación diaria en los animales mantenidos en condiciones de LD 12:12, permaneciendo descendida durante las horas de iluminación y siendo máxima en oscuridad. En oscuridad permanente aumenta significativamente y se anulan las variaciones diarias de NAT. La actividad de HIOMT en pineal de vizcachas mantenidas en LD 12:12 no presentó ritmos diarios; en iluminación la actividad desciende, no recuperándose en la etapa de oscuridad. En el lote de oscuridad permanente se observó un marcado aumento, mientras que en iluminación permanente descendió a 1/7 de los valores encontrados en oscuridad. En iluminación natural día-noche la HIOMT recuperó su actividad en las horas de oscuridad. Concluimos que en este roedor la actividad de las enzimas estudiadas es afectada por la luz, siendo la HIOMT la más sensible
Descritores: Acetilserotonina O-Metiltransferasa/metabolismo
Arilamina N-Acetiltransferase/metabolismo
Relâmpago
Glândula Pineal/enzimologia
-Escuridão
Roedores/fisiologia
Limites: Animais
Masculino
Feminino
Responsável: BR1.1 - BIREME



página 1 de 1
   


Refinar a pesquisa
  Base de dados : Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde