Base de dados : LILACS
Pesquisa : D08.811.913.696.445.735.270.750 [Categoria DeCS]
Referências encontradas : 5 [refinar]
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Id: lil-732512
Autor: Carrion, Carla Torres Pereira; Margotto, Lilian Rose; Aragão, Elizabeth Maria Andrade.
Título: As causas das internações no Hospital Adauto Botelho (Cariacica, ES) na segunda metade do século XX / The motives for hospitalization at Adauto Botelho Hospital (Cariacica, ES) in the second half of the twentieth century
Fonte: Hist. ciênc. saúde-Manguinhos;21(4):1323-1340, Oct-Dec/2014. tab.
Idioma: pt.
Resumo: Discutem-se aqui as formas de encaminhamento de pacientes ao Hospital Adauto Botelho, localizado em Cariacica, Espírito Santo. A pesquisa se deu por meio de prontuários médicos datados desde a inauguração em 1954 e de depoimentos de pessoas que trabalharam lá durante a segunda metade do século XX. Foram analisados 102 prontuários e entrevistadas quatro pessoas. A pesquisa dos prontuários mostra forte inserção da Chefatura de Polícia no processo de internação. As falas dos entrevistados reiteram esse ponto, mostrando também a longa duração das internações. São as histórias de vida dos internos que dão o tom deste trabalho. Conclui-se, a partir delas, que o Hospital Adauto Botelho, mais que uma instituição de tratamento, era um espaço de confinamento.

This paper discusses the procedures for referring patients to Adauto Botelho Hospital, in Cariacica, Espírito Santo state, Brazil. The research is based on the medical records since its inauguration in 1954 and statements by people who worked there in the second half of the twentieth century. One hundred and two records were analyzed and four people were interviewed. The records revealed the active involvement of the Chief of Police in hospitalizations. The interviews corroborate this, while also showing the long duration of the hospitalizations. The tone of the paper is set by the life stories of the people hospitalized there. The conclusion is that this hospital served not so much for treatment as for confinement.
Descritores: Proteínas de Neoplasias/metabolismo
Elongação Traducional da Cadeia Peptídica
RNA Polimerase I/metabolismo
Fatores Genéricos de Transcrição
Transcrição Genética
Fatores de Elongação da Transcrição
Fatores de Transcrição/metabolismo
-Sequência de Aminoácidos
DNA Polimerase II/metabolismo
Detergentes/metabolismo
Eletroforese em Gel de Poliacrilamida
Dados de Sequência Molecular
Sarcosina/análogos & derivados
Sarcosina/metabolismo
Xenopus
Limites: Animais
Tipo de Publ: Research Support, U.S. Gov't, P.H.S.
Responsável: BR1.1 - BIREME


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Id: lil-470361
Autor: Orlando, Tereza Cristina; Mayer, Mário Gustavo; Campbell, David A; Sturm, Nancy R; Floeter-Winter, Lucile Maria.
Título: RNA polymerase I promoter and splice acceptor site recognition affect gene expression in non-pathogenic Leishmania species
Fonte: Mem. Inst. Oswaldo Cruz;102(7):891-894, Nov. 2007. ilus.
Idioma: en.
Projeto: FAPESP; . CNPq; . NIH.
Resumo: Leishmania (Sauroleishmania) tarentolae has biotechnological potential for use as live vaccine against visceral leishmaniasis and as a system for the over expression of eukaryotic proteins that possess accurate post-translational modifications. For both purposes, new systems for protein expression in this non-pathogenic protozoan are necessary. The ribosomal RNA promoter proved to be a stronger transcription driver since its use yielded increased levels of recombinant protein in organisms of both genera Trypanosoma or Leishmania. We have evaluated heterologous expression systems using vectors with two different polypyrimidine tracts in the splice acceptor site by measuring a reporter gene transcribed from L. tarentolae RNA polymerase I promoter. Our data indicate that the efficiency of chloramphenicol acetyl transferase expression changed drastically with homologous or heterologous sequences, depending on the polypyrimidine tract used in the construct and differences in size and/or distance from the AG dinucleotide. In relation to the promoter sequence the reporter expression was higher in heterologous lizard-infecting species than in the homologous L. tarentolae or in the mammalian-infecting L. (Leishmania) amazonensis.
Descritores: Leishmania/genética
Regiões Promotoras Genéticas
RNA Polimerase I/genética
Sítios de Splice de RNA/genética
-Expressão Gênica
Leishmania/classificação
Limites: Animais
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Mortara, R. A
Andrade, L. E. C
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Id: lil-360932
Autor: Silva, N. P; Christofolini, D. M; Mortara, R. A; Andrade, L. E. C.
Título: Colocalization of coilin and nucleolar proteins in Cajal body-like structures of micronucleated PtK2 cells
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;37(7):997-1003, July 2004. ilus.
Idioma: en.
Resumo: Cajal bodies (CB) are ubiquitous nuclear structures involved in the biogenesis of small nuclear ribonucleoproteins and show narrow association with the nucleolus. To identify possible relationships between CB and the nucleolus, the localization of coilin, a marker of CB, and of a set of nucleolar proteins was investigated in cultured PtK2 cells undergoing micronucleation. Nocodazol-induced micronucleated cells were examined by double indirect immunofluorescence with antibodies against coilin, fibrillarin, NOR-90/hUBF, RNA polymerase I, PM/Scl, and To/Th. Cells were imaged on a BioRad 1024-UV confocal system attached to a Zeiss Axiovert 100 microscope. Since PtK2 cells possess only one nucleolus organizer region, micronucleated cells presented only one or two micronuclei containing nucleolus. By confocal microscopy we showed that in most micronuclei lacking a typical nucleolus a variable number of round structures were stained by antibodies against fibrillarin, NOR-90/hUBF protein, and coilin. These bodies were regarded as CB-like structures and were not stained by anti-PM/Scl and anti-To/Th antibodies. Anti-RNA polymerase I antibodies also reacted with CB-like structures in some micronuclei lacking nucleolus. The demonstration that a set of proteins involved in RNA/RNP biogenesis, namely coilin, fibrillarin, NOR-90/hUBF, and RNA polymerase I gather in CB-like structures present in nucleoli-devoid micronuclei may contribute to shed some light into the understanding of CB function.
Descritores: Corpos Enovelados
Proteínas Nucleares
Região Organizadora do Nucléolo
-Autoanticorpos
Biomarcadores
Técnica Indireta de Fluorescência para Anticorpo
Microscopia Confocal
RNA Polimerase I
Limites: Seres Humanos
Responsável: BR1.1 - BIREME


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Id: lil-22062
Autor: Iapalucci Espinoza, S; Haim Muchnik, L; Robetto, E; Franze Fernandez, M. T.
Título: Lack of correlation between liver RNA polymerase I and ornithine decarboxylase activities after re-feeding of protein-depleted mice.
Fonte: Acta physiol. pharmacol. latinoam;34(2):157-62, 1984.
Idioma: en.
Descritores: Dieta
Fígado
Ornitina Descarboxilase
RNA Polimerase I
Limites: Masculino
Animais
Camundongos
Responsável: BR1.1 - BIREME


  5 / 5 LILACS  
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Id: lil-6123
Autor: Bull, P; Zaldivar, J; Wyneken, U; Venegas, A; Valenzuela, P.
Título: Chemical modification of lysyl and cysteinyl residues of yeast RNA polymerase I.
Fonte: Arch. biol. med. exp;14(2):143-7, 1981.
Idioma: en.
Descritores: RNA Polimerase I
Saccharomyces cerevisiae
Responsável: BR1.1 - BIREME



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