Base de dados : LILACS
Pesquisa : D08.811.913.696.620.225 [Categoria DeCS]
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Fotocópia
Id: lil-206836
Autor: Padilla P, J; Fielding, W. C; Belcastro, A. N; Gardiner, P. F; Taylor, A. W.
Título: The effect of diazepan and exercise training on selected biochemical and histochemical properties of rat skeletal muscle
Fonte: Acta physiol. pharmacol. ther. latinoam;47(4):203-10, 1997. tab.
Idioma: en.
Resumo: The effects of chronic diazepan (D) treatment and exercise training on total body mass (TBM), microsomal protein yield (MPY), calcium uptake by fragmented sarcoplasmic reticulum (SR), muscle fibre cross-sectional area, and both PFK and SDH activities were investigated in the tibialis anterior (TA), soleus (Sol), and plantaris (Plt) muscles of 50 male albino Sprague-Dawley rats. Rats were assigned randomly to control (C), sprint-trained (S), or endurance-trained (E) groups. Training was of 12 weeks duration. One-half of each group received daily intraperitoneally D doses of 5 mg kg(-1) of TBM. Exercise reduced TBM (p<0.05); increased the relative BM of the TA (E=2.02+0.02, p<0.01) and Plt (E=1.15+0.02, p<0.01; S=1.13+0.03, p<0.01), as well as the Ca++ uptake of the Sol SR (C=0.08+0.02, E=0.16+01, p<0.05). MPY was elevated in S-Sol (C=1.12+0.6, S=1.52+0.1, p<0.01). Delevated Sol MPY as well as TA PFK. S-trained animals had lower mean fibre areas than the E-trained (D-treated and untreated) animals. The elevated relative masses of TA and Plt are explained by a decreased TBM with exercise. The increased Ca++ uptake of the Sol indicates that E enhances this function, and the increased MPY probably implies an increased SR. The D could be responsible for the D-elevated Sol MPY as well as the TA PFK. El D did not reduce neuromuscular activity to a level adversely affecting oxidative enzyme activity, but in the case of PFK activity in the TA muscle, such a reduction was evident.
Descritores: Diazepam/farmacologia
Relaxantes Musculares Centrais/farmacologia
Músculo Esquelético/efeitos dos fármacos
Condicionamento Físico Animal
-Análise de Variância
Peso Corporal
Cálcio/metabolismo
Frutoquinases/metabolismo
Microssomos
Músculo Esquelético/metabolismo
Proteínas
Distribuição Aleatória
Ratos Sprague-Dawley
Succinato Desidrogenase/metabolismo
Limites: Animais
Masculino
Ratos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Fotocópia
Id: lil-56336
Autor: Ureta, Tito; Medina, Carlos; Preller, Ana.
Título: The evolution of exokinases
Fonte: Arch. biol. med. exp;20(3/4):343-57, dic. 1987. ilus, tab.
Idioma: en.
Conferência: Apresentado em: International Symposium Molecular Approaches to the Study of Evolution, Pucón, nov. 1985.
Projeto: Universidad de Chile. Servicio Técnico de Investigación; . Fondo Nacional de Desarrollo Científico y Tecnológico.
Descritores: Hexoquinase/isolamento & purificação
-Frutoquinases
Glucoquinase
Fosfotransferases
Tipo de Publ: Revisão
Responsável: CL1.1 - Biblioteca Central



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