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Andrade, Carla Lourenco Tavares de
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Id: lil-746624
Autor: Villar, Vanessa Cristina Felippe Lopes; De Seta, Marismary Horsth; Andrade, Carla Lourenço Tavares de; Delamarque, Elizabete Vianna; Azevedo, Ana Cecília Pedrosa de.
Título: Evolution of mammographic image quality in the state of Rio de Janeiro / A evolução da qualidade da imagem em mamografia no Estado do Rio de Janeiro
Fonte: Radiol. bras;48(2):86-92, Mar-Apr/2015. tab.
Idioma: en.
Resumo: Objective: To evaluate the evolution of mammographic image quality in the state of Rio de Janeiro on the basis of parameters measured and analyzed during health surveillance inspections in the period from 2006 to 2011. Materials and Methods: Descriptive study analyzing parameters connected with imaging quality of 52 mammography apparatuses inspected at least twice with a one-year interval. Results: Amongst the 16 analyzed parameters, 7 presented more than 70% of conformity, namely: compression paddle pressure intensity (85.1%), films development (72.7%), film response (72.7%), low contrast fine detail (92.2%), tumor mass visualization (76.5%), absence of image artifacts (94.1%), mammography-specific developers availability (88.2%). On the other hand, relevant parameters were below 50% conformity, namely: monthly image quality control testing (28.8%) and high contrast details with respect to microcalcifications visualization (47.1%). Conclusion: The analysis revealed critical situations in terms of compliance with the health surveillance standards. Priority should be given to those mammography apparatuses that remained non-compliant at the second inspection performed within the one-year interval. .

Objetivo: Avaliar a evolução da qualidade da imagem de mamógrafos localizados no Estado do Rio de Janeiro, de 2006 a 2011, com base em parâmetros medidos e observados durante inspeções sanitárias. Materiais e Métodos: Estudo descritivo sobre a evolução de parâmetros que condicionam a qualidade da imagem focalizou 52 mamógrafos, inspecionados no mínimo duas vezes, com intervalo de um ano. Resultados: Dos 16 parâmetros avaliados, 7 apresentaram mais de 70% de conformidade: força do dispositivo de compressão (85,1%), processamento dos filmes (72,7%), resposta do filme do serviço (72,7%), detalhes lineares de baixo contraste (92,2%), visualização de massas tumorais (76,5%), ausência de artefatos de imagem (94,1%), existência de processadoras específicas para mamografia (88,2%). Importantes parâmetros apresentaram-se abaixo de 50% de conformidade: realização de testes mensais da qualidade de imagem pelo estabelecimento (28,8%) e detalhes de alto contraste, que dizem respeito à visualização de microcalcificações (47,1%). Conclusão: A análise revelou situações críticas da atuação da vigilância sanitária, cuja prioridade deveria ser dirigida aos estacionários, ou seja, os mamógrafos que permaneceram na situação de não conformidade nas inspeções realizadas com intervalo de um ano. .
Descritores: Canais de Cálcio Tipo L/metabolismo
Células Musculares/metabolismo
-Sequência de Aminoácidos
Agonistas dos Canais de Cálcio/farmacologia
CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE TEMEFOS
Proteínas Quinases Dependentes de Cálcio-Calmodulina/metabolismo
Calmodulina/metabolismo
Membrana Celular/efeitos dos fármacos
Membrana Celular/metabolismo
Eletrofisiologia
Ventrículos do Coração/citologia
Ventrículos do Coração/metabolismo
Ativação do Canal Iônico/fisiologia
Ligantes
Dados de Sequência Molecular
Técnicas de Patch-Clamp
Peptídeos/farmacologia
Limites: Animais
Coelhos
Tipo de Publ: Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Responsável: BR1.1 - BIREME


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Texto completo SciELO Saúde Pública
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Id: lil-733342
Autor: Ruelas-González, M Guadalupe; Pelcastre-Villafuerte, Blanca Estela; Reyes-Morales, Hortensia.
Título: Maltrato institucional hacia el adulto mayor: percepciones del prestador de servicios de salud y de los ancianos / Institutional abuse toward the elderly: Perceptions of health care providers and older adults
Fonte: Salud pública Méx;56(6):631-637, nov.-dic. 2014.
Idioma: es.
Resumo: Objetivo. Analizar la percepción que el prestador de servicios de salud y el adulto mayor (AM) tienen sobre el maltrato al AM en los servicios públicos de salud, en ciudades seleccionadas de México. Material y métodos. De 2009 a 2012 se realizó un estudio con diseño cualitativo y estrategia de triangulación de fuentes de datos; se efectuaron entrevistas semiestructuradas a 13 prestadores y a 12 ancianos para recuperar su experiencia en el tema. El análisis utilizó procedimientos de la Teoría Fundamentada. Resultados. El maltrato contra el AM es una práctica naturalizada por el personal y por el anciano, la cual se manifiesta de formas diversas. Conclusiones. La institucionalización, profesionalización histórica y falta de conciencia sobre las necesidades de los AM demandan cambios de planeación, organización y supervisión del Sistema de Salud. El personal requiere intervenciones de formación, capacitación y cambio de actitudes/comportamiento, para otorgar atención integral, digna, humana y de respeto a los Derechos Humanos de los AM.

Objective. To analyze the health care providers (HCP) and elderly patients' perceptions about abuse of the elderly by health personnel of public health services, in selected cities in Mexico. Materials and methods. A qualitative study and a strategy of data triangulation were performed during 2009 and 2012; 13 HCPs and 12 elders were interviewed, in order to obtain their experience regarding elder abuse. Grounded Theory proceedings were used for the analysis. Results. Elder abuse is a naturalized practice, from HCP and elderly people's point of view; these perceptions are showed in different ways. Conclusion. Institutionalization, historical professionalization and lack of consciousness about needs of the elderly (sociocultural and economic), require changes in planning, organization and monitoring process in the Health System; training and educational interventions on staff and exchange attitudes and behavior are necessary in order to offer a health care that is comprehensive, decent, human and with respect for the human rights.
Descritores: Antimetabólitos Antineoplásicos/farmacologia
CDCTEMEFOS-CDCABORTION, HABITUAL KINASES
Ciclinas/metabolismo
Inibidores Enzimáticos/metabolismo
Fenilacetatos/farmacologia
-Elementos Antissenso (Genética)
Neoplasias da Mama
Proteínas Quinases Dependentes de Cálcio-Calmodulina/metabolismo
Divisão Celular/efeitos dos fármacos
CYCLIN-DEPENDENT KINASE INHIBITOR PABORTION APPLICANTS
CYCLIN-DEPENDENT KINASE TEMEFOS
Quinases Ciclina-Dependentes/genética
Quinases Ciclina-Dependentes/metabolismo
Ciclinas/genética
Fibroblastos/citologia
Fibroblastos/efeitos dos fármacos
Fibroblastos/enzimologia
Regulação Neoplásica da Expressão Gênica/fisiologia
Camundongos Knockout
Fosforilação
Proteínas Serina-Treonina Quinases/genética
Proteínas Serina-Treonina Quinases/metabolismo
RNA Mensageiro/metabolismo
Proteína do Retinoblastoma/metabolismo
Transdução de Sinais/fisiologia
Células Tumorais Cultivadas/citologia
Células Tumorais Cultivadas/efeitos dos fármacos
Células Tumorais Cultivadas/enzimologia
Regulação para Cima/efeitos dos fármacos
Limites: Animais
Feminino
Humanos
Camundongos
Responsável: BR1.1 - BIREME


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Texto completo SciELO Chile
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Id: lil-577161
Autor: Meneses, Ismário Silva de; Souza, Rafael Reis de; Jeraldo, Verónica de Lourdes Sierpe; Cavalcante, Danielle Rodrigues Ribeiro; Reis, Francisco Prado; Albuquerque Júnior, Ricardo Luiz Cavalcanti de.
Título: Death-associated protein kinase is underexpressed in high-grade oral squamous cell carcinoma / La expresión de la proteína quinasa asociada a muerte celular (DAP quinasa) está reducida en carcinoma de células escamosas oral de alto grado
Fonte: Int. j. morphol;28(2):609-613, June 2010. ilus.
Idioma: en.
Resumo: An immunohistochemical analysis of 40 cases of oral squamous cell carcinoma was performed to evaluate the relationship between the expression pattern of death-associated protein kinase (DAPk) positive cells with the histological malignancy grading of these lesions. According to our results, eleven cases (27.5 percent) were high-grade malignancy tumours and 29 (72.5 percent) were low-grade ones. We found that 92.86 percent of the low-grade tumours were positive to anti-DAP kinase antibody whereas only 7.14 percent of the high-grade tumours presented positivity, and this difference was statistically significant (p<0.01). Sixteen (55.2 percent) of the low-grade carcinomas exhibited moderate immunoreactivity whereas ten cases (34.5 percent) showed weak staining and three cases (10.3 percent) were negative tumours. Immunostaining was lacking in nine (81.8 percent) of the high-grade carcinomas and "weak" in the two (18.2 percent) remaining cases. Thus, DAPk expression is significantly decreased in high-grade oral carcinomas, and evidences indicate that it might be related to the severity of cytological atypia.

Fue realizado un análisis inmunohistoquímico de 40 casos de carcinoma oral de células escamosas para evaluar la relación entre el patrón de expresión de la proteína quinasa (DAPK) asociada a la muerte celular y la clasificación histológica de malignidad de estas lesiones. Según nuestros resultados, 11 casos (27,5 por ciento) eran tumores de alto grado de malignidad y 29 (72,5 por ciento) de bajo grado. Se encontró que 92,86 por ciento de los tumores de bajo grado de malignidad fueron eran positivos para anticuerpos anti-DAP-quinasa, mientras que sólo 7,14 por ciento de los tumores de alto grado presentaron positividad, esta diferencia fue estadísticamente significativa (p <0,01). En 16 casos (55,2 por ciento) los carcinomas de bajo grado de malignidad mostraron inmunorreactividad moderada mientras que 10 casos (34,5 por ciento) mostraron una tinción débil y 3 casos (10,3 por ciento) fueron negativos. La inmunotinción estuvo ausente en 9 (81,8 por ciento) de los carcinomas de alto grado y "débil" grado de malignidad en los 2 (18,2 por ciento) casos restantes. Así, la expresión DAPK se redujo significativamente en los carcinomas orales de alto grado y las evidencias indican que podría estar relacionado con la severidad de la atipia citológica.
Descritores: Apoptose
Carcinoma de Células Escamosas/metabolismo
Carcinoma de Células Escamosas/patologia
Neoplasias Bucais/metabolismo
Neoplasias Bucais/patologia
Proteínas Quinases Dependentes de Cálcio-Calmodulina/biossíntese
-Imuno-Histoquímica
Invasividade Neoplásica
Limites: Humanos
Responsável: CL1.1 - Biblioteca Central


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Id: lil-437505
Autor: Danila, Cristina I; Hamilton, Susan L.
Título: Phosphorylation of ryanodine receptors
Fonte: Biol. Res;37(4):521-525, 2004.
Idioma: en.
Resumo: Both cardiac and skeletal muscle ryanodine receptors (RyRs) are parts of large complexes that include a number of kinases and phosphatases. These RyRs have several potential phosphorylation sites in their cytoplasmic domains, but the functional consequences of phosphorylation and the identity of the enzymes responsible have been subjects of considerable controversy. Hyperphosphorylation of Ser-2809 in RyR2 (cardiac isoform) and Ser-2843 in RyR1 (skeletal isoform) has been suggested to cause the dissociation of the FK506-binding protein (FKBP) from RyRs, producing "leaky channels," but some laboratories find no relationship between phosphorylation and FKBP binding. Also debated is the identity of the kinases that phosphorylate these serines: cAMP-dependent protein kinase (PKA) versus calmodulin kinase II (CaMKII). Phosphorylation of other targets of these kinases could also alter calcium homeostasis. For example, PKA also phosphorylates phospholamban (PLB), altering the Sarco-endoplasmic reticulum Ca2+ ATPase (SERCA) activity. This review summarizes the major findings and controversies associated with phosphorylation of RyRs.
Descritores: Proteínas Quinases Dependentes de Cálcio-Calmodulina
Cálcio/metabolismo
Canal de Liberação de Cálcio do Receptor de Rianodina/metabolismo
Fosfotransferases/metabolismo
Músculo Esquelético/enzimologia
Proteínas Quinases Dependentes de AMP Cíclico/metabolismo
-Fosforilação
Homeostase/fisiologia
Modelos Animais
Limites: Humanos
Animais
Tipo de Publ: Revisão
Responsável: CL1.1 - Biblioteca Central


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Id: lil-408370
Autor: Maier, L. S.
Título: CaMKIIdelta overexpression in hypertrophy and heart failure: cellular consequences for excitation-contraction coupling
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;38(9):1293-1302, Sept. 2005. ilus, graf.
Idioma: en.
Conferência: Apresentado em: Annual Meeting of the Federação de Sociedades de Biologia Experimental, XIX, Aguas de Lindóia, August 25-29, 2004.
Projeto: Deutsche Forschungsgemeinschaft; . GlaxoSmithKline Research Foundation; . University of Gõttingen Anschubfinanzierung.
Resumo: Ca/calmodulin-dependent protein kinase IIdelta (CaMKIIdelta) is the predominant isoform in the heart. During excitation-contraction coupling (ECC) CaMKII phosphorylates several Ca-handling proteins including ryanodine receptors (RyR), phospholamban, and L-type Ca channels. CaMKII expression and activity have been shown to correlate positively with impaired ejection fraction in the myocardium of patients with heart failure and CaMKII has been proposed to be a possible compensatory mechanism to keep hearts from complete failure. However, in addition to these acute effects on ECC, CaMKII was shown to be involved in hypertrophic signaling, termed excitation-transcription coupling (ETC). Thus, animal models have shown that overexpression of nuclear isoform CaMKIIdeltaB can induce myocyte hypertrophy. Recent study from our laboratory has suggested that transgenic overexpression of the cytosolic isoform CaMKIIdeltaC in mice causes severe heart failure with altered intracellular Ca handling and protein expression leading to reduced sarcoplasmic reticulum (SR) Ca content. Interestingly, the frequency of diastolic spontaneous SR Ca release events (or opening of RyR) was greatly enhanced, demonstrating increased diastolic SR Ca leak. This was attributed to increased CaMKII-dependent RyR phosphorylation, resulting in increased and prolonged openings of RyR since Ca spark frequency could be reduced back to normal levels by CaMKII inhibition. This review focuses on acute and chronic effects of CaMKII in ECC and ETC. In summary, CaMKII overexpression can lead to heart failure and CaMKII-dependent RyR hyperphosphorylation seems to be a novel and important mechanism in ECC due to SR Ca leak which may be important in the pathogenesis of heart failure.
Descritores: Proteínas Quinases Dependentes de Cálcio-Calmodulina/metabolismo
Cardiomegalia/enzimologia
Insuficiência Cardíaca/enzimologia
Contração Miocárdica
-CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE TEMEFOS
Proteínas Quinases Dependentes de Cálcio-Calmodulina/genética
Isoenzimas/metabolismo
Retículo Sarcoplasmático/metabolismo
Limites: Animais
Humanos
Tipo de Publ: Revisão
Responsável: BR1.1 - BIREME


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Id: lil-335986
Autor: Lopez, Luis A.
Título: Factors regulating organelles transport along microtubules
Fonte: Biocell;20(3):313-316, Dec. 1996.
Idioma: en.
Descritores: Microtúbulos/fisiologia
Organelas
-Transporte Biológico
Proteínas Quinases Dependentes de Cálcio-Calmodulina
Dineínas/fisiologia
Cinesina
Modelos Biológicos
Movimento (Física)
Fosforilação
Processamento de Proteína Pós-Traducional
Proteínas Associadas aos Microtúbulos/fisiologia
Vesículas Revestidas/fisiologia
Limites: Animais
Responsável: BR1.1 - BIREME


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Texto completo
Id: lil-304195
Autor: Souza, A. C; De Mesquita, J. F; Panek, A. D; Silva, J. T; Paschoalin, V. M. F.
Título: Evidence for a modulation of neutral trehalase activity by Ca2+ and cAMP signaling pathways in Saccharomyces cerevisiae
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;35(1):11-16, Jan. 2002. ilus, tab.
Idioma: en.
Resumo: Saccharomyces cerevisiae neutral trehalase (encoded by NTH1) is regulated by cAMP-dependent protein kinase (PKA) and by an endogenous modulator protein. A yeast strain with knockouts of CMK1 and CMK2 genes (cmk1cmk2) and its isogenic control (CMK1CMK2) were used to investigate the role of CaM kinase II in the in vitro activation of neutral trehalase during growth on glucose. In the exponential growth phase, cmk1cmk2 cells exhibited basal trehalase activity and an activation ratio by PKA very similar to that found in CMK1CMK2 cells. At diauxie, even though both cells presented comparable basal trehalase activities, cmk1cmk2 cells showed reduced activation by PKA and lower total trehalase activity when compared to CMK1CMK2 cells. To determine if CaM kinase II regulates NTH1 expression or is involved in post-translational modulation of neutral trehalase activity, NTH1 promoter activity was evaluated using an NTH1-lacZ reporter gene. Similar ß-galactosidase activities were found for CMK1CMK2 and cmk1cmk2 cells, ruling out the role of CaM kinase II in NTH1 expression. Thus, CaM kinase II should act in concert with PKA on the activation of the cryptic form of neutral trehalase. A model for trehalase regulation by CaM kinase II is proposed whereby the target protein for Ca2+/CaM-dependent kinase II phosphorylation is not the neutral trehalase itself. The possible identity of this target protein with the recently identified trehalase-associated protein YLR270Wp is discussed
Descritores: Proteínas Quinases Dependentes de Cálcio-Calmodulina
Proteínas Quinases Dependentes de AMP Cíclico
Saccharomyces cerevisiae
Trealase
-Ativação Enzimática
Saccharomyces cerevisiae
Responsável: BR1.1 - BIREME


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Id: lil-300126
Autor: Silva Silva, Hernán.
Título: Mecanismos de acción de los estabilizadores del ánimo / Mechanisms of action of mood stabilizers
Fonte: Rev. chil. neuro-psiquiatr;39(3):219-230, jul.-sept. 2001. ilus.
Idioma: es.
Resumo: Objetivo: analizar los progresos en el conocimiento de los mecanismos de acción de los estabilizadores del ánimo y sus potenciales implicancias para la clínica. Método: revisión de la literatura reciente, con énfasis en los artículos de revisión y de aplicación clínica y análisis crítico de la información. Resultados: los mecanismos iniciales de acción de los estabilizadores del ánimo son variados. No obstante, las acciones más importantes se producen en el largo plazo. Tanto el litio como el valproato producirían inhibición de la glicogen-sintetasa-kinasa 3-beta (GSK-3-beta) y disminución de proteinkinasa C. El litio disminuiría la proteinkinasa C a través de la depleción de inositol. Además el litio y el valproato ejercerían efectos no precisados sobre las proteínas G. Estas acciones afectarían la inducción de factores de transcripción génicos, la expresión de genes tempranos y la producción de factores neurotróficos en el sistema nervioso central. El resultado sería una serie de cambios plásticos en poblaciones neuronales específicas. Conclusión: se ha progresado mucho en el conocimiento acerca de los mecanismos de acción de los estabilizadores del ánimo, en especial sobre sus efectos celulares, genéticos y moleculares. Este conocimiento puede permitir el desarrollo de nuevos fármacos para el tratamiento de los trastornos del estado de ánimo
Descritores: Ácido Valproico/farmacologia
Lítio
Transtorno Afetivo Sazonal
-Anticonvulsivantes
Proteínas Quinases Dependentes de Cálcio-Calmodulina
Expressão Gênica
Proteínas de Ligação ao GTP
Plasticidade Neuronal
Proteína Quinase C
Limites: Humanos
Tipo de Publ: Revisão
Responsável: CL1.1 - Biblioteca Central


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Vianna, M. R. M
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Id: lil-281601
Autor: Vianna, M. R. M; Izquierdo, L. A; Barros, D. M; Souza, M. M. de; Rodrigues, C; Sant'anna, M. K; Medina, J. H; Izquierdo, I.
Título: Pharmacological differences between memory consolidation of habituation to an open field and inhibitory avoidance learning
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;34(2):233-240, Feb. 2001.
Idioma: en.
Resumo: Rats implanted bilaterally with cannulae in the CA1 region of the dorsal hippocampus or the entorhinal cortex were submitted to either a one-trial inhibitory avoidance task, or to 5 min of habituation to an open field. Immediately after training, they received intrahippocampal or intraentorhinal 0.5-æl infusions of saline, of a vehicle (2 percent dimethylsulfoxide in saline), of the glutamatergic N-methyl-D-aspartate (NMDA) receptor antagonist 2-amino-5-phosphono pentanoic acid (AP5), of the protein kinase A inhibitor Rp-cAMPs (0.5 æg/side), of the calcium-calmodulin protein kinase II inhibitor KN-62, of the dopaminergic D1 antagonist SCH23390, or of the mitogen-activated protein kinase kinase inhibitor PD098059. Animals were tested in each task 24 h after training. Intrahippocampal KN-62 was amnestic for habituation; none of the other treatments had any effect on the retention of this task. In contrast, all of them strongly affected memory of the avoidance task. Intrahippocampal Rp-cAMPs, KN-62 and AP5, and intraentorhinal Rp-cAMPs, KN-62, PD098059 and SCH23390 caused retrograde amnesia. In view of the known actions of the treatments used, the present findings point to important biochemical differences in memory consolidation processes of the two tasks
Descritores: 1-(5-Isoquinolinasulfonil)-2-Metilpiperazina/farmacologia
Aprendizagem da Esquiva/efeitos dos fármacos
Proteínas Quinases Dependentes de Cálcio-Calmodulina/farmacologia
Inibidores Enzimáticos/farmacologia
Agonistas de Aminoácidos Excitatórios/farmacologia
Habituação Psicofisiológica/efeitos dos fármacos
Memória/efeitos dos fármacos
-Análise de Variância
Relação Dose-Resposta a Droga
Córtex Entorrinal/efeitos dos fármacos
Hipocampo/efeitos dos fármacos
Ratos Wistar
Análise e Desempenho de Tarefas
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


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Id: lil-234886
Autor: Wenner, C. E; Yan, S.
Título: Perturbation of EGF-induced MAP kinase activation by TGF-ß1
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;32(7):821-5, July 1999.
Idioma: en.
Conferência: Apresentado em: International Symposium on \"Signal Transduction and Gene Expression in Cell Proliferation and Differentiation\", 1, Säo Paulo, Aug. 31-Sept. 2, 1998.
Resumo: TGF-ß1 regulates both cellular growth and phenotypic plasticity important for maintaining a growth advantage and increased invasiveness in progressively malignant cells. Recent studies indicate that TGF-ß-1 stimulates the conversion of epitheliod to fibroblastoid phenotype which presumably leads to the inactivation of growth-inhibitory effects by TGF-ß1 (Portella et al. (1998) Cell Growth and Differentiation, 9: 393-404). Therefore, the investigation of TGF-ß1 signaling that leads to altered growth and migration may provide novel targets for the prevention of increased cell growth and invasion. Although much attention has been paid to TGF-ß1 responses in epithelial cells, the above studies suggest that examination of signal transduction pathways in fibroblasts are important as well. Data from our laboratory are consistent with the concept that TGF-ß1 can act as a regulatory switch in density-dependent C3H 10T1/2 fibroblasts capable of either promoting or delaying G1 traverse. The regulation of this switch is proposed to occur prior to pRb phosphorylation, namely prior to activation of cyclin-dependent kinases. The current study is concerned with the evaluation of a key cyclin (cyclin D1) which activates cdk4 and p27KIP1 which in turn inhibit cdk2 in the proliferative responses of epidermal growth factor (EGF) and platelet-derived growth factor (PDGF) and their modulation by TGF-ß1. Although the molecular events that lead to elevation of cyclin D1 are not completely understood, it appears likely that activation of p42/p44MAPK kinases is involved in its transcriptional regulation. TGF-ß1 delayed EGF- or PDGF-induced cyclin D1 expression and blocked the induction of active p42/p44MAPK. The mechanism by which TGF-ß1 induces a block in p42/p44MAPK activation is being examined and the possibility that TGF-ß1 regulates phosphatase activity is being tested
Descritores: Proteínas Quinases Dependentes de Cálcio-Calmodulina/metabolismo
Transformação Celular Neoplásica/efeitos dos fármacos
Ciclina D1/farmacologia
Fator de Crescimento Epidérmico/farmacologia
Fator de Crescimento Transformador beta/farmacologia
-Ativação Enzimática/efeitos dos fármacos
Limites: Humanos
Tipo de Publ: Revisão
Responsável: BR1.1 - BIREME



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