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Id: lil-771938
Autor: Xu, H; Ma, J; Wu, J; Chen, L; Sun, F; Qu, C; Zheng, D; Xu, S.
Título: Gene expression profiling analysis of lung adenocarcinoma
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;49(3):e4861, Mar. 2016. tab, graf.
Idioma: en.
Projeto: Health and Family Planning Commission of Heilongjiang Province.
Resumo: The present study screened potential genes related to lung adenocarcinoma, with the aim of further understanding disease pathogenesis. The GSE2514 dataset including 20 lung adenocarcinoma and 19 adjacent normal tissue samples from 10 patients with lung adenocarcinoma aged 45-73 years was downloaded from Gene Expression Omnibus. Differentially expressed genes (DEGs) between the two groups were screened using the t-test. Potential gene functions were predicted using functional and pathway enrichment analysis, and protein-protein interaction (PPI) networks obtained from the STRING database were constructed with Cytoscape. Module analysis of PPI networks was performed through MCODE in Cytoscape. In total, 535 upregulated and 465 downregulated DEGs were identified. These included ATP5D, UQCRC2, UQCR11 and genes encoding nicotinamide adenine dinucleotide (NADH), which are mainly associated with mitochondrial ATP synthesis coupled electron transport, and which were enriched in the oxidative phosphorylation pathway. Other DEGs were associated with DNA replication (PRIM1, MCM3, and RNASEH2A), cell surface receptor-linked signal transduction and the enzyme-linked receptor protein signaling pathway (MAPK1, STAT3, RAF1, and JAK1), and regulation of the cytoskeleton and phosphatidylinositol signaling system (PIP5K1B, PIP5K1C, and PIP4K2B). Our findings suggest that DEGs encoding subunits of NADH, PRIM1, MCM3, MAPK1, STAT3, RAF1, and JAK1 might be associated with the development of lung adenocarcinoma.
Descritores: Adenocarcinoma/genética
Perfilação da Expressão Gênica/métodos
Neoplasias Pulmonares/genética
Proteínas dos Microfilamentos/genética
-Regulação para Baixo/genética
Redes Reguladoras de Genes
Proteína Quinase 1 Ativada por Mitógeno/genética
Mapas de Interação de Proteínas/genética
Proteínas Proto-Oncogênicas c-raf/genética
Regulação para Cima/genética
Limites: Humanos
Pessoa de Meia-Idade
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME

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