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Id: biblio-1055347
Autor: Camilo, Caroline; Maschietto, Mariana; Vieira, Henrique C; Tahira, Ana C; Gouveia, Gisele R; Feio dos Santos, Ana C; Negrão, André B; Ribeiro, Marcelo; Laranjeira, Ronaldo; Vallada, Homero; Brentani, Helena.
Título: Genome-wide DNA methylation profile in the peripheral blood of cocaine and crack dependents
Fonte: Braz. J. Psychiatry (São Paulo, 1999, Impr.);41(6):485-493, Nov.-Dec. 2019. tab, graf.
Idioma: en.
Projeto: FAPESP; . CAPES; PROEX; . MM and ACT were supported by FAPESP.
Resumo: Objective: Cocaine use disorders (CUDs) represent a major public health problem in many countries. To better understand the interaction between the environmental modulations and phenotype, the aim of the present study was to investigate the DNA methylation pattern of CUD patients, who had concomitant cocaine and crack dependence, and healthy controls. Methods: We studied DNA methylation profiles in the peripheral blood of 23 CUD patients and 24 healthy control subjects using the Illumina Infinium HumanMethylation450 BeadChip arrays. Results: Comparison between CUD patients and controls revealed 186 differentially methylated positions (DMPs; adjusted p-value [adjP] < 10-5) related to 152 genes, with a subset of CpGs confirmed by pyrosequencing. DNA methylation patterns discriminated CUD patients and control groups. A gene network approach showed that the EHMT1, EHMT2, MAPK1, MAPK3, MAP2K1, and HDAC5 genes, which are involved in transcription and chromatin regulation cellular signaling pathways, were also associated with cocaine dependence. Conclusion: The investigation of DNA methylation patterns may contribute to a better understanding of the biological mechanisms involved in CUD.
Descritores: Cocaína Crack
Metilação de DNA
Transtornos Relacionados ao Uso de Cocaína/genética
Transtornos Relacionados ao Uso de Cocaína/sangue
Estudo de Associação Genômica Ampla/métodos
-Estudos de Casos e Controles
Modelos Lineares
Histona-Lisina N-Metiltransferase/genética
Estatísticas não Paramétricas
Proteína Quinase 1 Ativada por Mitógeno/genética
MAP Quinase Quinase 1/genética
Proteína Quinase 3 Ativada por Mitógeno/genética
Redes Reguladoras de Genes
Sequenciamento de Nucleotídeos em Larga Escala
Antígenos de Histocompatibilidade/genética
Histona Desacetilases/genética
Limites: Humanos
Masculino
Adulto
Adulto Jovem
Responsável: BR1.1 - BIREME



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