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Coelho, Luiz Gonzaga Vaz
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Id: biblio-915391
Autor: Cota, Bianca Della Croce Vieira; Lima, Karine Sampaio; Murad, André Márcio; Xavier, Marcelo Antônio Pascoal; Cabral, Mônica Maria Demas Álvares; Coelho, Luiz Gonzaga Vaz.
Título: Expression of the c-MET, HGF and VEGF biomarkers in intestinal and diffuse gastric cancer in the Brazilian population: a pilot study for the standardization of the quantitative PCR technique
Fonte: Appl. cancer res;37:1-8, 2017. tab, ilus.
Idioma: en.
Resumo: Background: Gastric carcinoma (GC) is the third leading cause of death among malignant tumors worldwide, causing approximately 900,000 deaths/year. Changes in oncogenes that encode tyrosine kinase receptors play an important role in the pathogenesis of GC. MET gene is a proto-oncogene that encodes a tyrosine kinase receptor c-MET and it is required for embryonic development and tissue repair. The hepatocyte growth factor (HGF) is the only known ligand for c-Met receptor. The MET oncogene activation suppresses apoptosis and promotes the survival, proliferation, migration, differentiation and angiogenesis of cells. Among the angiogenic factors, VEGF is the main regulator. Its biological function includes the promotion of endothelial cells mitosis to stimulate cells proliferation. These biomarkers expression in GC is relatively recent and population-based studies are required to define the expression pattern. The aim of this study was to determine qPCR technical standardization to evaluate quantitatively, in paraffin tissue samples, the presence of gene 23 expression of the MET, HGF and VEGF in diffuse and intestinal GC types. Methods: Twenty GC patients were studied, 10 patients were intestinal-type GC (average age 72.1 years) and 10 diffuse-type (average age 50.1 years). In all patients, tissue samples were analyzed from the tumor and distant areas of the tumor tissue. The relative expressions of the tumor markers c-Met, HGF and VEGF were performed by qPCR technique by comparing tumor and non-tumoral samples and they were normalized with the GAPDH constitutive gene. Statistical analysis was performed through T-test. Results: For c-Met, 18/20 (90%) patients expressed the marker and 9/20 (45%) overexpressed this gene, in which three were intestinal-type GC and six were diffuse-type GC. For HGF, only 7/20 (35%) patients expressed this gene and it was overexpressed in 4/20 (20%), in which two were intestinal-type GC and two were diffuse-type GC. For VEGF, 20/20 (100%) patients expressed this marker and in 12/20 (60%) were observed overexpression, in which eight patients had diffuse-type GC and four had intestinal-type GC. Conclusions: qPCR technique was standardized and suitable for expression analysis of the three biomarkers using paraffin embedded tissue samples. Further studies should be carried out to characterize the expression pattern of these biomarkers in GC in the Brazilian population (AU)
Descritores:
Biomarcadores Tumorais
Parafina
Controle da População
Proteínas Proto-Oncogênicas c-met
Proto-Oncogenes
Estômago
Neoplasias Gástricas/genética
Fator A de Crescimento do Endotélio Vascular
-Reação em Cadeia da Polimerase em Tempo Real
Limites: Humanos
Masculino
Feminino
Responsável: BR30.1 - Biblioteca


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Id: biblio-882478
Autor: Arroyo, Gerardo; Segovia, Rodrigo; Ituarte, Carolina; Rojo, Sandra; Inklemona, Cristina; Salvatierra, Alejandro; Berlinghieri, Graciela; Bramuglia, Guillermo; Bravo, Inés; Saucedo, Silvia; Pichelbauer, Ernestina; Dionisio, María; VidesAlmonacid, Gerardo; Monteros Alvi, Marcelo; Gonorasky, Sara; Molina, Emma; Lamas Godas, Rogelio; Bürgesser, Virginia; Marin, Oscar; Rodríguez Prado, Susana.
Título: Sobreexpresión de C-MET en carcinoma de vesícula y del tracto biliar: prevalencia y correlación clínico-molecular / Overexpression of C-MET in gallbladder and biliary tract carcinoma: prevalence and clinical-molecular correlation
Fonte: Oncol. clín;22(3):77-84, 2017. tab, ilus, graf.
Idioma: es.
Resumo: El objetivo fue determinar la sobreexpresión de c-MET en pacientes con cáncer biliar y analizar asociaciones con parámetros clínicos. Este es un estudio descriptivo, longitudinal, retrospectivo y prospectivo. Se determinó la sobreexpresión por inmunohistoquímica en 58 pacientes con resultados: positivo fuerte, positivo débil y negativo. Se construyeron curvas de supervivencia global con el método de KaplanMeier en todos los pacientes y en subgrupos según estadío, género, origen tumoral y grado de diferenciación histológica. La diferencia en supervivencia global entre subgrupos se analizó por el método log-rank. La asociación entre sobreexpresión y grado de diferenciación se estudió por el método chi cuadrado. Las pruebas estadísticas se realizaron a dos colas con un valor de p 0.05. Veintinueve muestras (50%) fueron negativas, 24 (41%) positivas débiles y 5 (9%) positivas fuertes. La mediana de supervivencia fue 18.2, 11.3 y 11.7 meses en pacientes con sobreexpresión negativa, positiva débil y positiva fuerte, respectivamente. Sin embargo, la diferencia en supervivencia global entre pacientes c-MET negativos y positivos (fuerte y débil) no alcanzó significancia estadística (p 0.068). En los subgrupos los resultados fueron similares. La sobreexpresión se asoció al grado de diferenciación (p 0.015), mostrando una relación inversa; y no se correlacionó con tasa de respuesta a la quimioterapia y tiempo a la progresión. La sobreexpresión de c-MET es frecuente en cáncer biliar, se asocia al grado de diferenciación tumoral y podría tener valor pronóstico. Si la vía c-MET es importante, los fármacos inhibidores tendrían impacto en la supervivencia global (AU)

The objective was to determine the overexpression of c-MET in patients with biliary cancer and to analyze associations with clinical parameters. This is a descriptive, longitudinal, retrospective and prospective study. Overexpression was obtained by immunohistochemistry in 58 patients, with the following results: strong positive, weak positive and negative. Overall survival curves were constructed using the Kaplan-Meier method in all patients and in subgroups according to stage, gender, tumor origin and grade of histological differentiation. The difference in overall survival between groups was analyzed by the log-rank test. The association between overexpression and grade of differentiation was studied using the chisquare method. Statistical tests were two-tailed with a p value 0.05. Twenty nine samples (50%) were negative, 24 (41%) weak positive and 5 (9%) strong positive. Median survival was 18.2, 11.3 and 11.7 months in patients with negative, weak positive and strong positive overexpression, respectively. However, the difference in overall survival between negative and positive (strong and weak together) c-MET patients did not reach statistical significance (p 0.068). In the subgroup analyses the results were similar. Overexpression correlated with tumor grade (p 0.015), showing an inverse association; and was not associated neither with chemotherapy response rate nor with time to progression. Overexpression of c-MET is common in biliary cancer, is associated with grade of tumor differentiation and could have prognostic value. If the c-MET pathway is important, the inhibitory drugs would have an impact on overall survival (AU)
Descritores: Neoplasias do Sistema Biliar
Proteínas Proto-Oncogênicas c-met
-Imuno-Histoquímica
Limites: Humanos
Responsável: AR144.1 - CIBCHACO - Centro de Información Biomedica del Chaco


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Texto completo SciELO Brasil
Magalhaes, Livia de Castro
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Id: lil-744710
Autor: Dornelas, Lílian de Fátima; Duarte, Neuza Maria de Castro; Magalhães, Lívia de Castro.
Título: Neuropsychomotor developmental delay: conceptual map, term definitions, uses and limitations / Atraso do desenvolvimento neuropsicomotor: mapa conceitual, definições, usos e limitações do termo
Fonte: Rev. paul. pediatr;33(1):88-103, Jan-Mar/2015. tab, graf.
Idioma: en.
Resumo: OBJECTIVE: To retrieve the origin of the term neuropsychomotor developmental delay" (NPMD), its conceptual evolution over time, and to build a conceptual map based on literature review. DATA SOURCE: A literature search was performed in the SciELO Brazil, Web of Science, Science Direct, OneFile (GALE), Pubmed (Medline), Whiley Online, and Springer databases, from January of 1940 to January of 2013, using the following keywords: NPMD delay, NPMD retardation, developmental delay, and global developmental delay. A total of 71 articles were selected, which were used to build the conceptual map of the term. DATA SYNTHESIS: Of the 71 references, 55 were international and 16 national. The terms developmental delay and global developmental delay were the most frequently used in the international literature and, in Brazil, delayed NPMD was the most often used. The term developmental delay emerged in the mid 1940s, gaining momentum in the 1990s. In Brazil, the term delayed NPMD started to be used in the 1980s, and has been frequently cited and published in the literature. Delayed development was a characteristic of 13 morbidities described in 23 references. Regarding the type of use, 19 references were found, with seven forms of use. Among the references, 34 had definitions of the term, and 16 different concepts were identified. CONCLUSIONS: Developmental delay is addressed in the international and national literature under different names, various applications, and heterogeneous concepts. Internationally, ways to improve communication between professionals have been indicated, with standardized definition of the term and use in very specific situations up to the fifth year of life, which was not found in Brazilian publications. .

OBJETIVO: Resgatar a origem do termo atraso do desenvolvimento neuropsicomotor (DNPM), sua evolução conceitual ao longo do tempo e construir mapa conceitual do termo com base em busca bibliográfica. FONTES DE DADOS: Foi realizada busca nas bases de dados eletrônicas do Portal da Capes, que incluem Scielo Brazil, Web of Science, Science Direct, OneFile (GALE), Pubmed (Medline), Whiley Online e Springer, referente a Janeiro/1940-Janeiro/2013. Palavras-chave: atraso e retardo do DNPM, developmental delay e global developmental delay. Foram selecionados 71 artigos e construído o mapa conceitual do termo. SÍNTESE DE DADOS: Das 71 referências, 55 eram internacionais e 16 nacionais. Os termos mais encontrados foram global developmental delay e developmental delay na literatura internacional e retardo e atraso do DNPM no Brasil. Internacionalmente, o termo surgiu em meados da década de 40 ganhando força nos anos 90. No Brasil, o termo começou a ser usado na década de 80 e vem sendo frequentemente citado na literatura. O atraso é citado em 23 trabalhos como característica presente em 13 tipos de condições clínicas. Com relação ao uso, foram encontrados 19 estudos, com sete situações de uso. Dentre os artigos revisados, 34 deles apresentaram definições, sendo identificados 16 conceitos diferentes. CONCLUSÕES: O atraso do desenvolvimento é abordado na literatura internacional e nacional sob diversos nomes, diferentes aplicações e conceitos heterogêneos. Internacionalmente, apontam-se caminhos para melhorar a comunicação entre profissionais, com definição padronizada do termo e uso em situações específicas até o quinto ano de vida, o que não foi encontrado nas publicações nacionais. .
Descritores: Antineoplásicos/farmacologia
Desenho de Fármacos
Ftalazinas/farmacologia
Inibidores de Proteínas Quinases/farmacologia
Proteínas Proto-Oncogênicas c-met/antagonistas & inibidores
Quinolinas/farmacologia
-Antineoplásicos/química
Antineoplásicos/síntese química
Linhagem Celular Tumoral
Proliferação de Células/efeitos dos fármacos
Relação Dose-Resposta a Droga
Ensaios de Seleção de Medicamentos Antitumorais
HTABORTION, INCOMPLETE CELLS
Modelos Moleculares
Estrutura Molecular
Ftalazinas/química
Ftalazinas/síntese química
Inibidores de Proteínas Quinases/química
Inibidores de Proteínas Quinases/síntese química
Proteínas Proto-Oncogênicas c-met/metabolismo
Quinolinas/química
Quinolinas/síntese química
Relação Estrutura-Atividade
Limites: Humanos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Texto completo SciELO Venezuela
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Id: lil-740326
Autor: Amemiya, Hideki; Peña, Alix; Chiurillo, Miguel; Moscoso, Jaime; Useche, Alejandro; Baffi, Raúl.
Título: Incremento en la expresión del ARNm del receptor c-Met en el cáncer gástrico / Increased expression of the c-Met receptor mRNA in gastric cancer
Fonte: Invest. clín;54(3):284-298, sep. 2013. ilus, tab.
Idioma: es.
Resumo: El cáncer gástrico es una de las patologías malignas más frecuentes en el mundo. En las últimas décadas la atención se ha centrado en posibles alteraciones de factores genéticos que incluyen la activación de proto-oncogenes y/o la inactivación de genes supresores tumorales. El producto del C-MET proto-oncogen y su ligando, el factor de crecimiento del hepatocito (HGF), han sido implicados en la proliferación y migración celular en el cáncer gástrico. En este estudio se analizó a nivel molecular la amplificación del ARNm del receptor c-Met a partir del tejido tumoral gástrico de pacientes a quienes se les practicó gastrectomías, utilizando el método del ácido guanidina-tiocianato-fenol-cloroformo, y el método semicuantitativo de la Reacción en Cadena de la Polimerasa con Transcriptasa Reversa (RT-PCR), encontrándose que los elevados niveles del ARNm del receptor c-Met en las muestras tumorales de los pacientes están relacionados con mayor invasión en la profundidad de la pared gástrica (r = 0,762, p<0,01), incremento en la metástasis a los ganglios linfáticos (r = 0,766, p<0,01), alta frecuencia en tumores pocos diferenciados o indiferenciados (r = 0,912, p<0,001), aumento en el estadiaje del cáncer gástrico (r = 0,838, p<0,001), y en la sobreexpresión por el método inmunohistoquímico (IHQ) de la estreptavidina-biotina marcada de su receptor a nivel proteico (r = 0,858, p<0,001). La amplificación del ARNm y/o la sobreexpresión a nivel proteico del receptor c-Met, pudieran ser utilizados como factores pronósticos en el cáncer gástrico.

Gastric cancer is one of the most common malignancies in the world. In the last decades, the attention has been focused in possible alterations of genetic factors that include proto-oncogene activation and/or the tumor suppressor gene inactivation. The product of the proto-oncogene c-MET and its ligand, hepatocyte growth factor (HGF), have been implicated in cell proliferation and migration in gastric cancer. In this study we analyzed at the molecular level, the amplification of c-Met receptor mRNA from gastric tumor tissue of patients who underwent gastrectomy, using the acid guanidinium-thiocyanate-phenol-chloroform method and the semiquantitative Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR) method. It was found that high levels of c-Met receptor mRNA in tumor samples from patients are associated with greater depth of invasion in the gastric wall (r = 0.762, p<0.01), increase in metastases to lymph nodes (r = 0.766, p<0.01), high frequency of poorly differentiated or undifferentiated tumors (r = 0.912, p<0.001), increase in the gastric cancer staging (r = 0.838, p<0.001), and the overexpression, by the immunohistochemistry method (IHC) of the labeled streptavidin-biotin, of the c-Met receptor at the protein level (r = 0.858, p<0.001). The amplification of mRNA and/or protein level overexpression of the c-Met receptor could be used as prognostic factors in gastric cancer.
Descritores: Carcinoma/genética
Regulação Neoplásica da Expressão Gênica
Proteínas de Neoplasias/biossíntese
Proteínas Proto-Oncogênicas c-met/biossíntese
RNA Mensageiro/biossíntese
RNA Neoplásico/biossíntese
Neoplasias Gástricas/genética
-Diferenciação Celular
Estudos Transversais
Carcinoma/metabolismo
Carcinoma/patologia
Carcinoma/cirurgia
Gastrectomia
Metástase Linfática
Invasividade Neoplásica
Estadiamento de Neoplasias
Proteínas de Neoplasias/genética
Proteínas Proto-Oncogênicas c-met/genética
Neoplasias Gástricas/metabolismo
Neoplasias Gástricas/patologia
Neoplasias Gástricas/cirurgia
Limites: Adulto
Idoso
Feminino
Humanos
Masculino
Pessoa de Meia-Idade
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: VE1.1 - Biblioteca Humberto Garcia Arocha


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Texto completo SciELO Chile
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Id: lil-627549
Autor: Martínez, A; Spencer, M. L; Borlando, J; Flores, M; Rojas, I. G.
Título: E-cadherin and c-Met expression in actinic cheilits and lip squamous cell carcinoma
Fonte: Rev. clín. periodoncia implantol. rehabil. oral (Impr.);4(3):122-125, dic. 2011. ilus.
Idioma: en.
Projeto: Chilean Council of Science and Technology (CONICYT). FONDECYT; . University of Concepción.
Resumo: Objective: The aim of this study was to assess epithelial expression of E-cadherin and c-Met in normal lip, in actinic cheilitis and lip squamous cell carcinoma. Study Design: Biopsies of normal lip vermillion (NL, n=18), actinic cheilitis (AC, n=37), and lip SCC (n=22) were processed for E-cadherin and c-Met immunodetection. Epithelial and tumor cell expression was scored for each sample considering staining intensity and percentage. Results: E-cadherin expression was significantly reduced in AC and lip SCC as compared to normal lip (P<0.05), with a significant reduction in lip SCC as compared to AC (P=0.003). Expression of c-Met was significantly higher in AC and lip SCC as compared to NL (P<0.05), with a significant increase in lip SCC as compared to AC (P<0.0001). Conclusion: The results showed that epithelial E-cadherin expression is reduced and c-Met expression is increased as lip carcinogenesis progresses, suggesting that these proteins may be useful markers of malignant transformation.
Descritores: Caderinas/metabolismo
Carcinoma de Células Escamosas/metabolismo
Neoplasias Labiais/metabolismo
Proteínas Proto-Oncogênicas c-met/metabolismo
Queilite/metabolismo
-Biópsia
Carcinoma de Células Escamosas/patologia
Imuno-Histoquímica
Neoplasias Labiais/patologia
Queilite/patologia
Limites: Humanos
Responsável: CL1.1 - Biblioteca Central


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Id: lil-610269
Autor: Pineda B., Pedro; Tapia P., Verónica; Fernández F., Cristina; Gac E., Patricio; Cabané T., Patricio; Lanas M., Alejandra.
Título: Expresión de marcadores de proliferación celular e invasión tisular en cáncer papilar del tiroides y su asociación con metástasis ganglionares / Expression of proliferation and invasion markers in papilary thyroid carcinoma with and without lymph node involvement
Fonte: Rev. chil. endocrinol. diabetes;2(4):204-209, oct. 2009. ilus, graf.
Idioma: es.
Resumo: Background: Several molecules that may have a role in tumor proliferation, differentiation and invasion, have been detected in thyroid carcinoma. Some of these molecules are NIS, c-MET, TIMP1 an ephrinB2. Aim: To detect the presence of these molecules in tissue samples of thyroid carcinoma and relate their expression to the biological behavior of the tumor. Material and Methods: Tissue samples were prospectively obtained from 35 patients operated for a papillary thyroid carcinoma. Twelve patients had regional lymph node involvement. NIS, c-MET, TIMP1 and EphrinB2 were detected by real time polymerase chain reaction(RT-PCR) and immunohistochemistry. Results: The expression of markers by RT-PCR was non significantly higher among tumors with lymph node involvement. Immunohistochemistryshowed a significantly lower nuclear expression and a higher cytoplasmatic expression of EphrinB2 in tumors with lymph node involvement. Conclusions: Immunohistochemical expression of EphrinB2 could be useful for the initial staging of papillary thyroid carcinoma.
Descritores: Adenocarcinoma Papilar/genética
Adenocarcinoma Papilar/metabolismo
Neoplasias da Glândula Tireoide/genética
Neoplasias da Glândula Tireoide/metabolismo
-/genética
EFRINA-BTEMEFOS/genética
/metabolismo
EFRINA-BTEMEFOS/metabolismo
Regulação Neoplásica da Expressão Gênica
Imuno-Histoquímica
Inibidor Tecidual de Metaloproteinase-1/genética
Inibidor Tecidual de Metaloproteinase-1/metabolismo
Metástase Linfática
Biomarcadores Tumorais
Invasividade Neoplásica
Proteínas Proto-Oncogênicas c-met/genética
Proteínas Proto-Oncogênicas c-met/metabolismo
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Simportadores/metabolismo
Limites: Humanos
Responsável: CL1.1 - Biblioteca Central


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Texto completo SciELO Venezuela
Texto completo
Id: lil-574451
Autor: Amemiya, Hideki; Menolascino, Francisco; Peña, Alix.
Título: Papel de la expresión del receptor c-Met en la progresión del cáncer gástrico / Role of the expression of c-Met receptor in the progression of gastric cancer
Fonte: Invest. clín;51(3):369-380, Sept. 2010. ilus, tab.
Idioma: es.
Resumo: El producto del protooncogen C-MET (el receptor c-Met) y su ligando, el factor de crecimiento del hepatocito (HGF), han sido implicados en la progresión del cáncer gástrico. El objetivo de este trabajo fue analizar la expresión del receptor c-Met, HGF y el antígeno nuclear de proliferación celular (PCNA), mediante el método inmunohistoquímico de la estreptavidina-biotina marcada, como también la sobrevida, y se correlacionó con los factores anatomopatológicos en los especímenes de estómago de 40 pacientes a quienes se les practicaron gastrectomías por cáncer gástrico en el Departamento de Cirugía General del Hospital Central Universitario “Antonio María Pineda” de Barquisimeto, Venezuela, durante el período 2001-2004. Se observó alta expresión del receptor c-Met y PCNA en pacientes con estadios avanzados (III y IV), comparados con estadios precoces (I y II) (p<0,01). Además, se encontró sobreexpresión del receptor c-Met en las variables histológicas con bajo grado de diferenciación, invasión tumoral más profunda a la submucosa, metástasis hepática y se reportó una sobrevida menor de los pacientes con mayor expresión del receptor (+++ y ++++) con respecto al grupo de menor expresión (+ y ++) (p<0,01). La expresión del HGF fue constante en ambos grupos de estadios (avanzados y precoces). El receptor c-Met está relacionado con la proliferación y migración celular en el cáncer gástrico en pacientes venezolanos y pudiera utilizarse como factor pronóstico en esta patología.

The product of the proto-oncogene C-MET (the c-Met receptor) and its ligand, hepatocyte growth factor (HGF), have been implicated in the progression of gastric cancer. The aim of this study was to analyze the expression of c-Met receptor, HGF and proliferating cell nuclear antigen (PCNA) by the immunohistochemistry method of labeled streptavidin-biotin, as well as survival, and they were correlated with anatomopathological factors in stomach specimens of 40 patients, who underwent gastrectomy for gastric cancer in the Department of General Surgery, Hospital Central Universitario “Antonio María Pineda” in Barquisimeto, Venezuela, in 2001-2004. High expression of c-Met receptor and PCNA was observed in patients with advanced stages of gastric cancer (III and IV) compared with early stages (I and II) (p<0.01). There was also overexpression of the c-Met receptor in histologic variables with low degree of differentiation, deeper tumor invasion into the submucosa, liver metastases and it is reported a lower survival rate in patients with increased receptor expression (+++ and ++++) when compared with patients with the lowest expression (+ and ++) (p<0.01). The expression of HGF was constant in both, advanced and early groups. The c-Met receptor is associated with proliferation and cell migration in Venezuelan patients with gastric cancer and could be used as a prognostic factor in this pathology.
Descritores: Imuno-Histoquímica/métodos
Antígeno Nuclear de Célula em Proliferação
Proteínas Proto-Oncogênicas c-met
Neoplasias Gástricas
-Oncologia
Sobrevida
Limites: Humanos
Masculino
Feminino
Tipo de Publ: Estudo de Avaliação
Responsável: VE1.1 - Biblioteca Humberto Garcia Arocha



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